GO:0031295

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Name T cell costimulation
Categary Process
Go Slim No
Go Link GO:0031295
Unique Molecular Interactions 976
Total Molecular Interactions 1447
Total Single Events 8406
Pain Genes Associated 68

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for T cell costimulation. They are ordered first by their pain relevance and then by number of times they were reported for T cell costimulation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73
2 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09
3 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22
4 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12
5 INT67905 Binding of Spn and Fosl1 1 0.24 2.1 2.54
6 INT299783 Binding of Cd28 and Cd80 7 0.14 6.49 2.49
7 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21
8 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14
9 INT319581 Binding of PIAS1 and TNFSF14 1 0.02 1.58 2.13
10 INT165200 Binding of CTLA4 and Crp 1 0.09 1.64 1.91
11 INT203044 Binding of PDCD1 and DTHD1 1 0.02 3.19 1.87
12 INT150232 Samhd1 Positive_regulation of Gene_expression of TNFSF13B 1 0.01 1.74 1.67
13 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53
14 INT174508 Binding of CD4 and HLA-B 1 0.14 4.68 1.53
15 INT201950 IFNA1 Positive_regulation of Binding of DPP4 1 0.12 2.17 1.47
16 INT201946 IFNA1 Positive_regulation of DPP4 1 0.17 2.16 1.46
17 INT299311 Binding of RPTOR and RICTOR 1 0.38 0.21 1.4
18 INT299281 Binding of RPTOR and MAPKAP1 1 0.23 0.21 1.3
19 INT201942 DPP4 Negative_regulation of CXCL10 1 0.33 0.9 1.3
20 INT172141 IL10 Negative_regulation of Gene_expression of HLA-DRA 2 0.14 0.89 1.23
21 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
22 INT184402 Binding of HLA-DRB4 and HLA-E 1 0.00 3.1 1.19
23 INT340439 Binding of HLA-DMA and SUGT1 1 0.00 4.1 1.16
24 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1
25 INT107265 Binding of HLA-DRB1 and ITGAL 1 0.01 1.41 1.1
26 INT107263 Binding of HLA-DRB1 and NCR3 1 0.40 1.42 1.1
27 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
28 INT156238 Binding of F2rl1 and Tnfsf14 1 0.08 2.85 1.08
29 INT239038 Negative_regulation of Binding of Cd28 and Cd86 3 0.17 1.5 1.05
30 INT338894 TNFSF14 Negative_regulation of Gsk3a 1 0.00 0.54 1.04
31 INT338892 TNFSF14 Regulation of Abat 1 0.00 0.61 1.01
32 INT338895 TNFSF14 Regulation of Regulation of Abat 1 0.00 0.62 1.01
33 INT316128 TCF21 Negative_regulation of Gene_expression of HLA-DRA 1 0.07 0.13 0.99
34 INT103928 Binding of Cd28 and Trav6-3 3 0.03 0.55 0.98
35 INT203040 Binding of PDCD1 and PDCD1LG2 3 0.40 4.86 0.98
36 INT338893 TNFSF14 Positive_regulation of Gene_expression of Gria1 1 0.07 0.59 0.94
37 INT265210 Binding of Ctla4 and Cd28 2 0.16 1.45 0.93
38 INT181437 Binding of Ccr7 and Ccl21b 1 0.01 2.23 0.87
39 INT226340 Binding of CD4 and IFNA1 3 0.03 3.84 0.85
40 INT340437 Binding of SERPINH1 and HLA-DRB4 1 0.00 2.26 0.84
41 INT174509 Binding of CD4 and CD28 1 0.26 1.68 0.84
42 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
43 INT188567 IRF6 Positive_regulation of Gene_expression of CD28 1 0.05 1.28 0.82
44 INT156239 Tnfsf14 Positive_regulation of F2rl1 1 0.09 2.4 0.81
45 INT84466 DPP4 Regulation of Localization of Naga 1 0.00 0.87 0.78
46 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
47 INT201947 IFNA1 Positive_regulation of Gene_expression of DPP4 1 0.11 1.09 0.74
48 INT133675 NPY6R Negative_regulation of SRC 1 0.17 0.75 0.74
49 INT121843 HLA-DRB5 Negative_regulation of Accn4 1 0.00 0.54 0.73
50 INT205120 Binding of CD4 and CD8A 3 0.15 2.83 0.72
51 INT139069 Binding of CTLA4 and Cd86 3 0.16 0.65 0.7
52 INT203046 Binding of PDCD1 and CD274 2 0.40 3.97 0.68
53 INT121966 HRAS Positive_regulation of RAC1 1 0.75 0.41 0.67
54 INT89874 Pdyn Positive_regulation of Localization of Tnfsf14 1 0.26 0 0.66
55 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
56 INT169293 PTPLA Positive_regulation of AKT1 1 0.10 0.15 0.64
57 INT169285 PTPLA Positive_regulation of GRAP2 1 0.03 0.15 0.63
58 INT299793 Positive_regulation of Binding of CD86 and CTLA4 1 0.17 1.64 0.63
59 INT169101 Binding of HLA-A and HLA-DRB1 1 0.24 1.09 0.63
60 INT299792 Positive_regulation of Binding of CD80 and CTLA4 1 0.17 1.63 0.63
61 INT174500 Positive_regulation of Binding of CD4 and HLA-B 1 0.21 2.33 0.63
62 INT278695 MTX1 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.81 0.62
63 INT197050 Binding of HLA-DOA and HLA-E 2 0.08 1.73 0.58
64 INT203056 Binding of Cd274 and PDCD1LG2 1 0.13 1.61 0.57
65 INT203041 Binding of CD274 and PDCD1LG2 1 0.03 1.61 0.57
66 INT190181 Positive_regulation of PIK3CA Positive_regulation of MMP12 1 0.01 0.54 0.56
67 INT249624 Negative_regulation of Binding of CD86 and CTLA4 1 0.47 0.57 0.55
68 INT201944 CXCL10 Positive_regulation of Phosphorylation of AKT1 1 0.09 0.79 0.55
69 INT97949 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of CDC42 1 0.06 0.72 0.51
70 INT97952 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of AKT1 1 0.03 0.72 0.51
71 INT62299 Binding of CD4 and SGCG 1 0.39 1.23 0.51
72 INT36084 Binding of HLA-DRB4 and Igkv16-104 1 0.04 1.01 0.51
73 INT103937 Cps1 Negative_regulation of Gene_expression of Cd28 1 0.03 0.19 0.51
74 INT299785 CTLA4 Negative_regulation of Binding of CD28 2 0.17 1.8 0.5
75 INT299766 APCS Positive_regulation of Gene_expression of Cd80 1 0.04 0.86 0.5
76 INT97953 ST3GAL3 Positive_regulation of CDC42 1 0.09 0.7 0.5
77 INT97951 ST3GAL3 Positive_regulation of AKT1 1 0.04 0.7 0.5
78 INT299765 APCS Positive_regulation of Cd80 1 0.04 0.85 0.49
79 INT158400 Binding of CD80 and CD86 3 0.36 0.76 0.48
80 INT352892 Binding of CAV1 and ITGA2 1 0.20 1.61 0.47
81 INT251297 Binding of C2 and CD4 1 0.04 0.35 0.47
82 INT162932 TXNRD1 Negative_regulation of Phosphorylation of AKT1 1 0.14 1.01 0.47
83 INT149121 Binding of CD80 and Cd28 2 0.04 0.95 0.46
84 INT162929 NQO1 Negative_regulation of Phosphorylation of AKT1 1 0.41 1 0.46
85 INT116934 OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
86 INT116933 SRC Positive_regulation of JUN 1 0.33 0.15 0.46
87 INT116937 Positive_regulation of OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
88 INT69637 Binding of CAV1 and Zfp354a 1 0.00 0 0.46
89 INT45035 Binding of HLA-B and HLA-DRB4 2 0.16 0.74 0.44
90 INT206538 Trem2 Regulation of Gene_expression of Cd80 1 0.17 1.26 0.44
91 INT206536 Trem2 Positive_regulation of Gene_expression of Cd80 1 0.30 1.26 0.44
92 INT188565 IRF6 Regulation of Gene_expression of CD28 1 0.03 0.7 0.43
93 INT157343 Binding of AQP4 and HLA-DPB1 1 0.30 0.89 0.43
94 INT340438 Binding of HLA-DMA and MRAP 1 0.02 1.69 0.43
95 INT174501 Binding of HLA-B and HLA-DOA 2 0.03 1.84 0.42
96 INT156234 Tnfsf14 Positive_regulation of Transcription of F2rl1 1 0.09 1.26 0.42
97 INT316121 IL10 Regulation of Gene_expression of HLA-DRA 1 0.09 0.46 0.42
98 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
99 INT201943 Regulation of Binding of DPP4 and CXCL10 1 0.20 0.58 0.42
100 INT160048 INPPL1 Regulation of Gene_expression of AKT1 1 0.28 0.6 0.42
101 INT121851 AKT1 Regulation of ROS1 1 0.16 0.52 0.41
102 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
103 INT208461 Binding of CD4 and IL16 1 0.05 3.04 0.41
104 INT121854 AKT1 Regulation of BID 1 0.17 0.52 0.41
105 INT184407 Binding of HLA-DRB1 and HLA-DRB4 2 0.09 2.26 0.4
106 INT108197 AKT1 Regulation of JUN 1 0.29 0.25 0.4
107 INT184406 Binding of HLA-DRB1 and HLA-E 1 0.00 1.03 0.4
108 INT188572 CD14 Regulation of Gene_expression of CD28 1 0.11 0.6 0.4
109 INT330515 TNFSF10 Regulation of Gene_expression of CD4 1 0.29 1.24 0.4
110 INT157657 Binding of CTLA4 and FCGR1A 1 0.01 0.07 0.4
111 INT121853 Gene_expression of ROS1 Negative_regulation of AKT1 1 0.25 0.49 0.4
112 INT330518 TNFSF10 Regulation of CD4 1 0.29 1.24 0.4
113 INT156237 Binding of F2r and Tnfsf14 1 0.02 1.14 0.4
114 INT287819 Binding of CD80 and Cd28 1 0.25 0.7 0.4
115 INT299786 IL4 Negative_regulation of Gene_expression of CD5 1 0.07 0.82 0.4
116 INT324802 Binding of Cd24a and Siglecg 1 0.03 1.34 0.4
117 INT287818 Negative_regulation of Binding of CD80 and Cd28 1 0.29 0.7 0.4
118 INT156233 Positive_regulation of Tnfsf14 Positive_regulation of F2rl1 1 0.09 1.15 0.4
119 INT222212 TFAM Negative_regulation of Cd28 1 0.02 1.17 0.39
120 INT257738 PIK3CA Regulation of Localization of ACTN4 1 0.16 1.03 0.39
121 INT201948 Binding of DPP4 and CXCL10 1 0.27 0.54 0.39
122 INT194596 Binding of HLA-DRB4 and TNFSF10 3 0.08 6 0.38
123 INT167946 Binding of SRC and Stat5b 1 0.28 0 0.38
124 INT208571 CCL21 Positive_regulation of Gene_expression of CCL16 1 0.51 0.63 0.38
125 INT330517 Binding of CD8A and HLA-DRB4 1 0.08 0.99 0.38
126 INT273172 Negative_regulation of PDE4A Negative_regulation of Localization of CD4 1 0.11 0.74 0.37
127 INT353391 Binding of DRD4 and GRB2 1 0.37 0.62 0.37
128 INT226350 MBTPS1 Negative_regulation of Gene_expression of CD4 1 0.03 0.61 0.37
129 INT353390 Binding of DRD4 and SRC 1 0.25 0.62 0.37
130 INT226374 Negative_regulation of Binding of CD4 and IFNA1 1 0.03 0.66 0.37
131 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
132 INT299288 AKT1 Positive_regulation of RPTOR 1 0.34 0.05 0.36
133 INT176135 AKT1 Regulation of Localization of CYCS 1 0.43 2.16 0.35
134 INT156235 Tnfsf14 Positive_regulation of F2r 1 0.03 1.03 0.35
135 INT353020 Binding of CD80 and Positive_regulation of Gene_expression of CD28 1 0.13 0.35 0.34
136 INT257746 SHC1 Positive_regulation of Positive_regulation of PIK3CA 1 0.26 1.04 0.34
137 INT27030 HERPUD1 Regulation of CD4 1 0.41 0 0.34
138 INT188391 Binding of CD4 and HLA-DRB1 1 0.05 0.96 0.34
139 INT46145 HLA-DQA1 Negative_regulation of TAC1 1 0.04 0.09 0.34
140 INT27037 HERPUD1 Regulation of Gene_expression of CD4 1 0.55 0 0.34
141 INT299780 Binding of Cd28 and Cd80 1 0.21 1.36 0.34
142 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33
143 INT252292 CCL21 Regulation of Binding of Mthfd1 1 0.03 0.41 0.33
144 INT110350 Positive_regulation of Arigg3 Positive_regulation of Positive_regulation of Dpp4 1 0.01 0 0.33
145 INT139068 Binding of CTLA4 and Cd80 1 0.00 0.33 0.33
146 INT109901 RPE Positive_regulation of Positive_regulation of MAP3K14 1 0.54 0.15 0.33
147 INT295722 PTGER2 Positive_regulation of RAC1 1 0.02 2.14 0.32
148 INT206208 MRO Negative_regulation of CD24 1 0.02 1.87 0.32
149 INT311228 DPP4 Negative_regulation of Localization of GLP1R 1 0.31 1.25 0.32
150 INT299791 Negative_regulation of Binding of CD28 and CTLA4 1 0.18 0.77 0.32
151 INT337410 AKT3 Negative_regulation of AKT1 1 0.09 0.49 0.32
152 INT186127 CTLA4 Negative_regulation of CD28 1 0.19 0.74 0.32
153 INT337414 AKT2 Negative_regulation of AKT1 1 0.10 0.5 0.32
154 INT257743 Binding of PIK3CA and SHC1 1 0.21 1.03 0.31
155 INT318323 Binding of GRB2 and HSPA5 1 0.34 0.28 0.31
156 INT352055 Negative_regulation of Binding of Spn and Gpr156 1 0.09 0.28 0.31
157 INT278693 ERAL1 Positive_regulation of CD4 1 0.05 1.1 0.31
158 INT352054 Binding of Spn and Gpr156 1 0.08 0.28 0.31
159 INT278692 ERAL1 Positive_regulation of Positive_regulation of CD4 1 0.05 1.1 0.31
160 INT299307 AKT1 Positive_regulation of Positive_regulation of AKT1S1 1 0.10 0 0.3
161 INT254287 Binding of TNFSF13B and TNFRSF13B 1 0.01 1.33 0.3
162 INT254288 Binding of ZNF623 and TNFSF13B 1 0.00 1.33 0.3
163 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
164 INT224131 Binding of CAV1 and Agtr1a 1 0.00 0.08 0.3
165 INT203055 Binding of PDCD1 and Cd274 1 0.40 0.8 0.29
166 INT252033 Binding of HLA-DQA2 and KLRD1 1 0.00 0.54 0.29
167 INT174499 Binding of CD4 and HLA-E 1 0.04 1.08 0.29
168 INT291202 Positive_regulation of INS Positive_regulation of AKT1 1 0.01 0.76 0.29
169 INT258861 Binding of HLA-DOA and HLA-DRB1 2 0.14 1.88 0.28
170 INT118853 Negative_regulation of SRC Negative_regulation of Positive_regulation of STAT3 1 0.41 0.08 0.28
171 INT257744 Binding of PIK3R2 and SHC1 1 0.08 0.96 0.28
172 INT259936 CTLA4 Regulation of PTPN22 1 0.45 1.64 0.28
173 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
174 INT166094 Negative_regulation of CSK Negative_regulation of Positive_regulation of EGFR 1 0.02 0.33 0.28
175 INT141870 Binding of Slc2a4 and Cav1 1 0.36 0.38 0.28
176 INT316791 Binding of HLA-DRB1 and Traf1 1 0.01 0.96 0.27
177 INT333549 Binding of CTLA4 and PDCD1 1 0.36 1.2 0.27
178 INT118855 Binding of SRC and GNA14 1 0.01 0.13 0.27
179 INT75989 Regulation of RICTOR Positive_regulation of IK 1 0.00 0.15 0.27
180 INT75988 RICTOR Positive_regulation of IK 1 0.00 0.15 0.27
181 INT118848 GNA14 Positive_regulation of RAC1 1 0.01 0.14 0.26
182 INT171939 Binding of HLA-DOA and TNF 1 0.05 6.8 0.26
183 INT355982 Binding of HLA-DQA2 and DCPS 1 0.00 1.33 0.26
184 INT100680 IL4 Positive_regulation of SRC 1 0.42 0.66 0.26
185 INT194670 CREB1 Regulation of Gene_expression of CD4 1 0.05 0.07 0.25
186 INT259937 Binding of CSK and PTPN22 1 0.21 1.69 0.25
187 INT130056 PPARG Positive_regulation of CAV1 1 0.02 0.53 0.25
188 INT261976 Binding of PDCD1 and SUGT1 1 0.00 1.3 0.25
189 INT330521 Binding of CD4 and TNFSF10 1 0.20 0.73 0.24
190 INT118857 PLCB1 Regulation of Phosphorylation of SRC 1 0.01 0.15 0.24
191 INT352081 Binding of CD4 and ADAM11 1 0.09 0.33 0.24
192 INT118858 PRKCA Regulation of Phosphorylation of SRC 1 0.10 0.15 0.24
193 INT158211 TNFSF14 Positive_regulation of Gene_expression of TNF 1 0.03 0.35 0.23
194 INT292561 MAP3K5 Positive_regulation of Positive_regulation of RAC1 1 0.03 0 0.23
195 INT118850 GNA14 Positive_regulation of Phosphorylation of SRC 1 0.02 0.15 0.23
196 INT292565 MAP3K5 Positive_regulation of Positive_regulation of CDC42 1 0.02 0 0.23
197 INT289959 Negative_regulation of Binding of CD28 and CD80 1 0.07 0.24 0.23
198 INT289953 Binding of CD80 and KLF1 1 0.00 0.21 0.23
199 INT265886 IGF1 Positive_regulation of AKT1 1 0.11 3.06 0.23
200 INT288582 Binding of Cav1 and Kcnma1 1 0.11 0 0.22

Single Events

The table below shows the top 100 pain related interactions that have been reported for T cell costimulation. They are ordered first by their pain relevance and then by number of times they were reported in T cell costimulation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01
2 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74
3 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31
4 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96
5 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
6 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
7 INT84464 Gene_expression of DPP4 101 0.78 56.15 17.53
8 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
9 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89
10 INT108480 Gene_expression of CCL21 53 0.77 37.87 14.42
11 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68
12 INT171134 Gene_expression of CD28 67 0.65 32.55 13.61
13 INT132178 Binding of CD80 41 0.47 15.55 12.98
14 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
15 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07
16 INT36287 Binding of CD4 96 0.47 58.93 11.88
17 INT86698 Gene_expression of Cav1 38 0.78 16.37 11.75
18 INT80756 Gene_expression of CD86 77 0.77 46.68 11.36
19 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89
20 INT108479 Positive_regulation of CCL21 18 0.67 19.93 10.76
21 INT23177 Negative_regulation of Gene_expression of HLA-DRA 50 0.44 16.99 10.55
22 INT16404 Regulation of CD4 54 0.61 33.05 10.29
23 INT73504 Binding of CD28 35 0.45 15.99 10.04
24 INT44602 Gene_expression of TNFSF13B 37 0.75 30.98 9.96
25 INT19620 Binding of CD86 30 0.47 12.01 9.89
26 INT96157 Gene_expression of Cd80 74 0.77 31.19 9.78
27 INT132036 Negative_regulation of DPP4 126 0.59 63.24 9.51
28 INT132278 Binding of CTLA4 32 0.39 18.69 8.17
29 INT94125 Gene_expression of Cd28 38 0.67 21.73 7.75
30 INT93914 Gene_expression of CD80 70 0.75 36.35 7.74
31 INT116717 Gene_expression of CCR7 37 0.76 34.1 7.48
32 INT81378 Negative_regulation of Dpp4 18 0.59 7.87 7.42
33 INT5381 Gene_expression of FYN 18 0.75 7.65 7.35
34 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27
35 INT6596 Positive_regulation of HLA-DRB1 33 0.61 27.01 7.26
36 INT17049 Localization of CD4 57 0.75 35.33 6.89
37 INT13520 Binding of HLA-DRB4 30 0.42 32.65 6.74
38 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61
39 INT57256 Gene_expression of HLA-DQA2 52 0.55 23.87 6.27
40 INT17551 Positive_regulation of Gene_expression of HLA-DRA 31 0.70 15.39 6
41 INT18967 Positive_regulation of Gene_expression of HLA-DRB1 14 0.49 13.56 5.99
42 INT122653 Positive_regulation of Gene_expression of CD4 48 0.68 22.5 5.96
43 INT52907 Regulation of Gene_expression of HLA-DRA 28 0.34 5.94 5.96
44 INT115594 Gene_expression of Cd80 9 0.67 7.8 5.92
45 INT69350 Gene_expression of RAC1 23 0.77 12.16 5.54
46 INT23401 Gene_expression of HLA-DOA 91 0.30 38.21 5.52
47 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47
48 INT105336 Regulation of AKT1 52 0.56 32.53 4.89
49 INT203050 Binding of PDCD1 12 0.48 12.93 4.5
50 INT158100 Positive_regulation of Gene_expression of Cd80 4 0.42 4.95 4.5
51 INT116902 Positive_regulation of CD28 17 0.47 13.56 4.27
52 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21
53 INT166966 Gene_expression of Ccr7 14 0.48 7.36 4.2
54 INT110348 Negative_regulation of Dpp4 28 0.46 22.39 4.12
55 INT141443 Phosphorylation of Cav1 6 0.82 4.39 4.03
56 INT23317 Gene_expression of Spn 20 0.48 14.51 4.01
57 INT153666 Gene_expression of CAV1 156 0.77 120.99 3.9
58 INT15133 Regulation of HLA-DRA 19 0.34 5.84 3.9
59 INT108481 Positive_regulation of CCL19 4 0.44 15.22 3.77
60 INT78619 Positive_regulation of RAC1 27 0.65 10.43 3.75
61 INT44717 Gene_expression of TNFSF14 12 0.75 13.44 3.72
62 INT123908 Positive_regulation of HLA-DQB1 12 0.21 10.5 3.71
63 INT108484 Gene_expression of CCL19 4 0.50 12.56 3.63
64 INT13451 Positive_regulation of DPP4 23 0.68 9.33 3.62
65 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6
66 INT79477 Binding of HLA-DMA 19 0.26 13.78 3.47
67 INT121967 Regulation of RAC1 9 0.45 6.14 3.41
68 INT201959 Positive_regulation of Gene_expression of DPP4 13 0.53 6.24 3.4
69 INT188355 Binding of Cd28 25 0.34 8.29 3.38
70 INT111482 Gene_expression of Cd24a 23 0.72 13.74 3.37
71 INT191807 Gene_expression of CD24 75 0.78 53.92 3.34
72 INT28249 Positive_regulation of HLA-DRA 25 0.70 13.63 3.25
73 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19
74 INT97063 Gene_expression of CD5 16 0.77 13.81 3.13
75 INT100688 Gene_expression of SRC 28 0.75 15.51 3.08
76 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02
77 INT201952 Binding of DPP4 11 0.37 8.81 2.91
78 INT155486 Positive_regulation of Gene_expression of CD86 16 0.69 14.6 2.86
79 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83
80 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8
81 INT271447 Positive_regulation of Positive_regulation of HLA-DQB1 1 0.06 5.87 2.8
82 INT126514 Positive_regulation of CCR7 16 0.43 16.21 2.79
83 INT89397 Positive_regulation of PIK3CA 33 0.67 16.98 2.78
84 INT79476 Gene_expression of HLA-DMA 23 0.38 9.5 2.76
85 INT161310 Negative_regulation of LCK 17 0.42 8.75 2.74
86 INT86703 Positive_regulation of Gene_expression of Cav1 7 0.70 3.58 2.73
87 INT75685 Regulation of CD86 12 0.58 3.55 2.66
88 INT174527 Negative_regulation of CD28 13 0.35 5.06 2.65
89 INT203048 Gene_expression of PDCD1 13 0.78 8.5 2.62
90 INT19621 Positive_regulation of CD86 23 0.69 14 2.58
91 INT89281 Negative_regulation of Gene_expression of HLA-DRB1 10 0.30 5.9 2.55
92 INT150218 Transcription of TNFSF13B 1 0.08 2.62 2.55
93 INT18969 Gene_expression of HLA-DQA1 29 0.65 12.19 2.54
94 INT182224 Binding of CCL21 6 0.34 5.91 2.54
95 INT54720 Positive_regulation of HLA-DRB5 9 0.34 6.7 2.51
96 INT81377 Gene_expression of Dpp4 8 0.71 5.15 2.51
97 INT61805 Positive_regulation of Dpp4 4 0.44 0.41 2.49
98 INT108483 Positive_regulation of Gene_expression of CCL21 7 0.69 5.76 2.45
99 INT150222 Positive_regulation of Gene_expression of TNFSF13B 12 0.11 7.49 2.43
100 INT67796 Negative_regulation of CTLA4 13 0.39 8.36 2.39
101 INT203049 Negative_regulation of PDCD1 6 0.43 7.15 2.36
102 INT84465 Localization of DPP4 8 0.75 7.28 2.29
103 INT144652 Negative_regulation of Binding of CD28 6 0.55 3.09 2.28
104 INT34796 Positive_regulation of TNFSF14 7 0.67 4.16 2.26
105 INT118791 Binding of AKT1 32 0.48 15.51 2.25
106 INT136614 Positive_regulation of Cav1 5 0.46 2.28 2.23
107 INT203047 Gene_expression of CD274 16 0.52 12.32 2.21
108 INT227772 Binding of Cd80 11 0.29 7.85 2.2
109 INT14854 Regulation of Gene_expression of HLA-DRB1 10 0.39 5.27 2.19
110 INT101866 Positive_regulation of Gene_expression of AKT1 49 0.52 17.47 2.14
111 INT122671 Positive_regulation of LCK 4 0.13 2.69 2.14
112 INT70987 Binding of RAC1 14 0.37 12.14 2.13
113 INT97134 Negative_regulation of CD80 8 0.57 5.09 2.11
114 INT12965 Negative_regulation of RICTOR 3 0.37 0.32 2
115 INT112089 Gene_expression of Cav1 73 0.75 23.8 1.97
116 INT57339 Negative_regulation of HLA-DRA 17 0.49 7.67 1.96
117 INT155015 Positive_regulation of HLA-DOA 6 0.23 4.45 1.92
118 INT93912 Positive_regulation of CD80 11 0.56 7.01 1.88
119 INT49380 Localization of FYN 4 0.78 0.9 1.87
120 INT98464 Positive_regulation of Positive_regulation of SRC 10 0.67 5.71 1.86
121 INT111675 Regulation of TNFSF14 3 0.26 3.41 1.85
122 INT123130 Positive_regulation of Positive_regulation of AKT1 22 0.49 11.77 1.83
123 INT174511 Positive_regulation of Gene_expression of CD28 7 0.41 4.31 1.83
124 INT150223 Regulation of Gene_expression of TNFSF13B 2 0.21 3.44 1.8
125 INT108486 Positive_regulation of Gene_expression of CCL19 2 0.45 6.2 1.79
126 INT19617 Negative_regulation of CD86 12 0.42 3.68 1.77
127 INT84548 Positive_regulation of HLA-DQA1 5 0.49 1.68 1.75
128 INT147636 Regulation of CD80 3 0.60 1.27 1.73
129 INT135991 Positive_regulation of Gene_expression of Cd80 19 0.54 6.9 1.71
130 INT82609 Phosphorylation of SRC 17 0.80 6.45 1.7
131 INT70322 Gene_expression of MAPKAP1 10 0.65 6.06 1.7
132 INT65524 Regulation of Spn 8 0.21 3.82 1.7
133 INT141444 Positive_regulation of Phosphorylation of Cav1 1 0.70 1.76 1.69
134 INT177509 Regulation of CCL21 6 0.45 5.43 1.66
135 INT82398 Binding of HLA-DMB 3 0.35 3.82 1.66
136 INT135955 Positive_regulation of Cav1 17 0.48 7.73 1.61
137 INT93744 Binding of Dpp4 4 0.48 0.91 1.61
138 INT156229 Binding of Tnfsf14 5 0.23 4.69 1.6
139 INT209896 Positive_regulation of Gene_expression of CD80 19 0.49 11.9 1.59
140 INT221059 Negative_regulation of CCL21 5 0.28 2.48 1.58
141 INT145921 Localization of CCL21 4 0.73 2.41 1.58
142 INT54901 Positive_regulation of Gene_expression of FYN 3 0.02 0.61 1.54
143 INT28679 Gene_expression of Tnfsf13b 5 0.60 2.75 1.53
144 INT209959 Negative_regulation of Binding of CD80 3 0.42 0.9 1.52
145 INT26579 Regulation of RICTOR 2 0.23 0.09 1.51
146 INT150156 Positive_regulation of Gene_expression of HLA-DOA 7 0.20 4.07 1.5
147 INT171133 Localization of CD28 8 0.71 3.42 1.48
148 INT189302 Positive_regulation of Gene_expression of HLA-DQA2 6 0.06 4.44 1.48
149 INT33299 Binding of CCR7 3 0.31 2.88 1.45
150 INT41719 Gene_expression of MTOR 27 0.77 19.43 1.44
151 INT122672 Regulation of Positive_regulation of LCK 1 0.06 1.15 1.44
152 INT206244 Binding of CD24 7 0.48 5.71 1.43
153 INT58930 Negative_regulation of RAC1 14 0.55 7.55 1.4
154 INT65153 Binding of HLA-DPB1 5 0.34 3.29 1.4
155 INT271448 Regulation of HLA-DQB1 1 0.06 2.73 1.4
156 INT174486 Regulation of Gene_expression of CD4 12 0.36 6.09 1.39
157 INT64952 Binding of HLA-DQA2 11 0.10 7.23 1.39
158 INT143083 Regulation of CTLA4 4 0.25 1.06 1.36
159 INT94126 Positive_regulation of Cd28 9 0.50 4.23 1.33
160 INT84463 Regulation of Gene_expression of DPP4 5 0.39 4.81 1.33
161 INT114715 Binding of SRC 8 0.36 4.26 1.32
162 INT311964 Positive_regulation of Cd80 2 0.30 1.96 1.32
163 INT89426 Binding of HLA-DRB3 2 0.41 1.77 1.32
164 INT96153 Negative_regulation of Gene_expression of Cd80 5 0.48 1.68 1.29
165 INT30588 Phosphorylation of TNFSF14 3 0.80 0.11 1.29
166 INT141862 Binding of Cav1 11 0.36 1.32 1.25
167 INT254308 Negative_regulation of TNFSF13B 10 0.42 5.12 1.25
168 INT191804 Transcription of CD24 10 0.72 12.43 1.25
169 INT167409 Regulation of Gene_expression of AKT1 8 0.56 4.86 1.23
170 INT69210 Negative_regulation of MAPKAP1 3 0.07 0 1.23
171 INT119827 Gene_expression of PTPN11 31 0.75 24.21 1.22
172 INT100621 Localization of HLA-DRA 7 0.40 2.86 1.2
173 INT174557 Negative_regulation of Gene_expression of Cd28 7 0.43 4.42 1.2
174 INT97955 Positive_regulation of CDC42 8 0.49 2.47 1.19
175 INT61948 Positive_regulation of FYN 4 0.45 2.49 1.19
176 INT201955 Regulation of DPP4 18 0.45 11.91 1.18
177 INT119187 Gene_expression of HLA-DRB5 5 0.02 4.47 1.18
178 INT135556 Localization of AKT1 38 0.69 12.78 1.17
179 INT37679 Positive_regulation of HLA-DRB4 12 0.34 11.93 1.16
180 INT118792 Regulation of Positive_regulation of AKT1 8 0.61 3.73 1.15
181 INT152010 Positive_regulation of Ccr7 3 0.47 1.46 1.15
182 INT150219 Localization of TNFSF13B 2 0.47 5.91 1.15
183 INT219950 Negative_regulation of Gene_expression of SRC 2 0.29 1.32 1.15
184 INT139764 Negative_regulation of CAV1 10 0.58 6.57 1.14
185 INT58042 Binding of HLA-DQA1 8 0.24 5.03 1.14
186 INT108156 Positive_regulation of MAPKAP1 4 0.08 1.91 1.14
187 INT176147 Regulation of Phosphorylation of AKT1 14 0.41 6.41 1.13
188 INT289470 Transcription of MAPKAP1 1 0.09 2.61 1.13
189 INT23951 Negative_regulation of Spn 4 0.15 2.17 1.12
190 INT108157 Negative_regulation of Negative_regulation of MAPKAP1 1 0.02 0 1.11
191 INT28680 Positive_regulation of Tnfsf13b 5 0.39 6.46 1.1
192 INT139064 Binding of Cd80 3 0.35 1.64 1.07
193 INT174550 Negative_regulation of Cd28 7 0.33 4.7 1.06
194 INT70209 Negative_regulation of FYN 3 0.08 1.07 1.06
195 INT101614 Gene_expression of Dpp4 7 0.78 2.73 1.02
196 INT138543 Negative_regulation of Cd28 3 0.11 2.1 1.01
197 INT181354 Binding of Ccr7 2 0.23 1.94 1.01
198 INT56098 Gene_expression of HLA-DRB3 5 0.59 2.89 0.99
199 INT248588 Gene_expression of LCK 9 0.28 4.9 0.98
200 INT110163 Binding of HLA-DQB1 8 0.25 4.71 0.98
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