GO:0031402

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Name sodium ion binding
Categary Function
Go Slim No
Go Link GO:0031402
Unique Molecular Interactions 33
Total Molecular Interactions 42
Total Single Events 593
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for sodium ion binding. They are ordered first by their pain relevance and then by number of times they were reported for sodium ion binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT190981 Binding of Npy and Scn2a1 1 0.10 0 1.75
2 INT341480 Binding of SCN1A and SCN4A 1 0.36 1.29 0.98
3 INT140447 Ngf Regulation of Scn9a 1 0.69 0.16 0.84
4 INT188531 Binding of TNF and PDXK 1 0.03 1.99 0.78
5 INT180496 Binding of CTS and PDXK 1 0.04 0.69 0.77
6 INT145646 Binding of Scn2a1 and Scn5a 1 0.36 0 0.76
7 INT190986 Per1 Positive_regulation of Scn2a1 1 0.17 0 0.74
8 INT190979 Per2 Positive_regulation of Scn2a1 1 0.20 0 0.74
9 INT190984 Binding of Scn2a1 and Gria1 1 0.03 0.08 0.71
10 INT28845 su Negative_regulation of Positive_regulation of Scn2a1 1 0.27 1.27 0.61
11 INT190987 Abat Regulation of Scn2a1 1 0.03 0.07 0.59
12 INT190988 Vip Positive_regulation of Gene_expression of Scn2a1 1 0.16 0.1 0.57
13 INT60456 SCN5A Regulation of Scn2a1 1 0.00 0 0.41
14 INT190977 Npy Regulation of Scn2a1 1 0.16 0 0.4
15 INT190739 Adcyap1 Regulation of Gene_expression of Scn2a1 1 0.13 0 0.39
16 INT190998 ADCYAP1 Positive_regulation of Scn2a1 1 0.07 0.45 0.27
17 INT281980 Scn9a Positive_regulation of MDK 1 0.06 0.24 0.26
18 INT279828 Binding of Scn1a and Scn9a 1 0.39 1.64 0.26
19 INT328896 Scn2a1 Regulation of hb 1 0.02 0.27 0.23
20 INT248182 Cxcl1 Regulation of Scn8a 1 0.05 0 0.22
21 INT190985 Vip Regulation of Scn2a1 1 0.09 0 0.18
22 INT279829 Scn1a Regulation of Gene_expression of Scn9a 1 0.42 1.52 0.15
23 INT330156 Scn2a1 Regulation of Transcription of Pcsk1n 1 0.13 0 0.13
24 INT190982 Avp Positive_regulation of Scn2a1 1 0.17 0.17 0.1
25 INT12997 Scn8a Positive_regulation of Localization of Prl 1 0.36 0 0.09
26 INT190976 Binding of Scn2a1 and Gal 1 0.06 0 0.05
27 INT330155 Pcsk1n Regulation of Gene_expression of Scn2a1 1 0.15 0 0
28 INT190980 Binding of Avp and Scn2a1 1 0.12 0 0
29 INT289788 Binding of Comp and Scn8a 1 0.16 1.37 0
30 INT272197 Binding of CAPN3 and DYSF 1 0.42 0.38 0
31 INT227197 Binding of Scn9a and Csf2 1 0.09 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for sodium ion binding. They are ordered first by their pain relevance and then by number of times they were reported in sodium ion binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20003 Gene_expression of Scn2a1 125 0.71 8.78 23.94
2 INT5430 Gene_expression of Scn8a 37 0.75 4.58 14.82
3 INT28843 Positive_regulation of Scn2a1 31 0.68 5.35 10.7
4 INT17674 Localization of Scn2a1 32 0.61 1.73 6.79
5 INT59671 Positive_regulation of Scn8a 7 0.39 1.88 5.92
6 INT760 Negative_regulation of Scn8a 11 0.42 1.65 5.6
7 INT26054 Regulation of Gene_expression of Scn8a 7 0.08 2.86 4.49
8 INT4683 Negative_regulation of PDXK 17 0.55 12.81 4.39
9 INT56159 Regulation of Scn2a1 17 0.51 3.23 4.27
10 INT47992 Gene_expression of Scn8a 14 0.78 4.15 3.83
11 INT190722 Positive_regulation of Gene_expression of Scn2a1 15 0.36 0.5 3.78
12 INT28844 Negative_regulation of Scn2a1 15 0.37 3.84 3.65
13 INT91647 Gene_expression of PDXK 2 0.49 7.71 2.82
14 INT85767 Gene_expression of Scn9a 11 0.76 9.27 2.74
15 INT80733 Binding of Scn2a1 11 0.30 1.09 2.3
16 INT74486 Positive_regulation of SCN1A 4 0.67 1 2.2
17 INT140400 Binding of Scn9a 4 0.36 3.59 2.15
18 INT69690 Gene_expression of Scn9a 6 0.78 2.08 2.09
19 INT157927 Gene_expression of Scn1a 5 0.64 6.55 2.02
20 INT131638 Localization of Scn8a 2 0.53 0 1.99
21 INT34860 Negative_regulation of Gene_expression of Scn2a1 8 0.30 0.97 1.94
22 INT69691 Transcription of Scn9a 2 0.53 1.14 1.68
23 INT12346 Binding of Scn8a 5 0.29 0.75 1.64
24 INT79001 Positive_regulation of Localization of Scn2a1 3 0.36 0.22 1.48
25 INT153599 Gene_expression of SCN1A 8 0.75 7.01 1.47
26 INT211686 Positive_regulation of Positive_regulation of Scn8a 1 0.00 0.85 1.41
27 INT188533 Regulation of PDXK 1 0.05 2.92 1.23
28 INT140446 Positive_regulation of Scn9a 2 0.49 0.35 1.19
29 INT228648 Binding of Scn1a 1 0.27 1.95 1.15
30 INT141116 Transcription of Scn2a1 9 0.45 1.1 1.1
31 INT190964 Regulation of Gene_expression of Scn2a1 7 0.29 1.29 1.02
32 INT57017 Transcription of Scn8a 5 0.52 0.63 0.95
33 INT341484 Negative_regulation of SCN1A 1 0.53 1.27 0.94
34 INT190396 Positive_regulation of Gene_expression of Scn8a 2 0.45 0.77 0.86
35 INT18917 Regulation of Negative_regulation of Scn8a 1 0.23 0 0.86
36 INT279821 Regulation of Scn9a 2 0.44 2.79 0.83
37 INT45960 Negative_regulation of Gene_expression of Scn8a 2 0.42 0.4 0.81
38 INT188543 Negative_regulation of Gene_expression of PDXK 1 0.04 1.51 0.73
39 INT240519 Regulation of Scn8a 3 0.06 0.9 0.71
40 INT272206 Gene_expression of CAPN3 4 0.77 3.83 0.7
41 INT188538 Regulation of Gene_expression of PDXK 1 0.05 1.85 0.69
42 INT111431 Negative_regulation of Gene_expression of Scn8a 4 0.43 0.34 0.68
43 INT39059 Binding of PDXK 2 0.31 1.37 0.65
44 INT190961 Negative_regulation of Positive_regulation of Scn2a1 2 0.27 0.15 0.64
45 INT140399 Regulation of Scn9a 2 0.45 0.74 0.61
46 INT141114 Positive_regulation of Positive_regulation of Scn2a1 1 0.30 0 0.53
47 INT188532 Positive_regulation of PDXK 1 0.05 1.28 0.46
48 INT248179 Positive_regulation of Transcription of Scn8a 1 0.06 0.64 0.45
49 INT188537 Localization of PDXK 1 0.07 0.8 0.43
50 INT151622 Positive_regulation of Gene_expression of Scn9a 1 0.43 1.17 0.43
51 INT188542 Regulation of Positive_regulation of PDXK 1 0.05 1.07 0.42
52 INT188535 Protein_catabolism of PDXK 1 0.09 0.82 0.41
53 INT168691 Regulation of Scn8a 1 0.26 0.17 0.36
54 INT141118 Negative_regulation of Transcription of Scn2a1 1 0.28 0 0.36
55 INT342958 Positive_regulation of Gene_expression of CAPN3 1 0.69 0.66 0.35
56 INT45510 Binding of Scn8a 4 0.31 3.89 0.25
57 INT188541 Positive_regulation of Binding of PDXK 1 0.05 0.79 0.23
58 INT259867 Binding of SCN1A 2 0.36 4.7 0.21
59 INT272202 Negative_regulation of CAPN3 4 0.59 0.99 0.2
60 INT74485 Positive_regulation of Scn9a 2 0.49 0.81 0.19
61 INT342960 Regulation of CAPN3 1 0.45 0.39 0.18
62 INT135625 Negative_regulation of Scn8a 3 0.43 1.74 0.16
63 INT342959 Protein_catabolism of CAPN3 1 0.87 0.41 0.16
64 INT45511 Positive_regulation of Binding of Scn8a 1 0.37 0.35 0.16
65 INT153598 Regulation of Gene_expression of SCN1A 1 0.27 0.25 0.14
66 INT135624 Regulation of Gene_expression of Scn8a 1 0.62 0.26 0.12
67 INT188539 Positive_regulation of Negative_regulation of PDXK 1 0.05 0.63 0.11
68 INT135623 Positive_regulation of Gene_expression of Scn8a 1 0.50 0.34 0.1
69 INT279825 Negative_regulation of Scn9a 1 0.37 0.8 0.08
70 INT188536 Negative_regulation of Binding of PDXK 1 0.04 0.42 0.07
71 INT342956 Positive_regulation of Negative_regulation of CAPN3 1 0.46 0.16 0.06
72 INT227180 Localization of Scn9a 1 0.31 0 0.05
73 INT188540 Negative_regulation of Positive_regulation of PDXK 1 0.04 0.27 0.05
74 INT227182 Regulation of Gene_expression of Scn9a 1 0.17 0 0.04
75 INT253942 Positive_regulation of Scn8a 1 0.02 0.12 0.04
76 INT190959 Positive_regulation of Negative_regulation of Scn2a1 1 0.31 0.1 0.04
77 INT279816 Negative_regulation of Scn1a 1 0.40 1.31 0.04
78 INT279815 Positive_regulation of Gene_expression of Scn9a 1 0.43 0.67 0.03
79 INT272203 Binding of CAPN3 1 0.37 0.23 0
80 INT188534 Positive_regulation of Gene_expression of PDXK 1 0.05 0.06 0
81 INT342957 Positive_regulation of CAPN3 1 0.43 0.18 0
82 INT342954 Positive_regulation of Positive_regulation of CAPN3 1 0.43 0.1 0
83 INT342961 Negative_regulation of Gene_expression of CAPN3 1 0.43 0.1 0
84 INT279824 Positive_regulation of Scn1a 1 0.47 1.22 0
85 INT347888 Regulation of Binding of Scn2a1 1 0.03 0.05 0
86 INT333215 Localization of Scn8a 1 0.04 1.5 0
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