GO:0031404

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Name chloride ion binding
Categary Function
Go Slim No
Go Link GO:0031404
Unique Molecular Interactions 89
Total Molecular Interactions 112
Total Single Events 1760
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for chloride ion binding. They are ordered first by their pain relevance and then by number of times they were reported for chloride ion binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT326509 Binding of ACE and VWF 1 0.05 2.07 1.59
2 INT162343 Positive_regulation of KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
3 INT162344 KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
4 INT24796 ACE Positive_regulation of Localization of HMMR 1 0.00 0.58 1.16
5 INT127876 ACE Positive_regulation of Protein_catabolism of CALCA 1 0.28 0.63 0.75
6 INT77689 Binding of Ace and Tenc1 1 0.28 0.65 0.7
7 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68
8 INT21607 ACE Positive_regulation of ANGPT2 1 0.03 0.13 0.61
9 INT181619 ACE Positive_regulation of KNG1 1 0.33 0.97 0.58
10 INT177358 Ptger1 Positive_regulation of Localization of AMY2A 1 0.00 0.56 0.54
11 INT177357 Ptger1 Positive_regulation of Gene_expression of AMY2A 1 0.00 0.56 0.54
12 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
13 INT342633 ACE Regulation of Gene_expression of AGT 1 0.01 0.14 0.46
14 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39
15 INT229222 Negative_regulation of ACE Negative_regulation of Protein_catabolism of KNG1 1 0.06 0.53 0.37
16 INT230786 Binding of AGT and ACE 4 0.15 2.53 0.34
17 INT230852 ACE Regulation of KNG1 2 0.03 0.72 0.32
18 INT265826 Binding of ACE and SERPINE1 1 0.24 1.08 0.3
19 INT230745 Negative_regulation of Ace Negative_regulation of Icam1 1 0.05 1.22 0.29
20 INT200639 Ace Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
21 INT223965 Binding of AMY2A and Bglap 1 0.05 1.5 0.28
22 INT64726 Ace Negative_regulation of KNG1 1 0.01 0.26 0.25
23 INT64727 Ace Positive_regulation of KNG1 1 0.01 0.26 0.25
24 INT191500 ACE Positive_regulation of Localization of KNG1 1 0.10 0.17 0.24
25 INT239238 Ace Positive_regulation of Protein_catabolism of KNG1 1 0.01 0.46 0.24
26 INT124078 Binding of Ace and Cpox 1 0.09 0.14 0.24
27 INT265828 ACE Regulation of Gene_expression of KNG1 1 0.32 0.83 0.22
28 INT200637 Binding of Abpa and Ace 1 0.01 4.62 0.22
29 INT265827 ACE Negative_regulation of ANGPT2 1 0.09 0.59 0.17
30 INT8164 Ace Positive_regulation of Gene_expression of Fos 1 0.24 0.32 0.16
31 INT10291 Trh Regulation of CTSC 1 0.01 0 0.16
32 INT258812 Sugt1 Positive_regulation of Ace 1 0.05 1.26 0.16
33 INT75058 Negative_regulation of ACE Negative_regulation of HHIP 1 0.25 0.43 0.15
34 INT307807 Ace Positive_regulation of ras 1 0.38 3 0.15
35 INT344946 AGT Regulation of Negative_regulation of ACE 1 0.21 0.61 0.14
36 INT102885 Binding of ANG and ACE 2 0.17 0.37 0.13
37 INT256020 Ace Negative_regulation of Gene_expression of Agtr2 1 0.03 0.37 0.13
38 INT256021 Ace Negative_regulation of Gene_expression of Agtrap 1 0.05 0.37 0.13
39 INT329317 ACE Regulation of Positive_regulation of KNG1 1 0.02 1.05 0.12
40 INT329325 ACE Regulation of Negative_regulation of Agtr2 1 0.01 0.93 0.12
41 INT43095 Binding of Ace and Mme 1 0.26 0 0.12
42 INT229364 Ace Positive_regulation of Protein_catabolism of KNG1 1 0.02 0.86 0.11
43 INT171162 Negative_regulation of Ace Negative_regulation of Gene_expression of Ccl2 1 0.02 1.18 0.1
44 INT334893 ACE Negative_regulation of Gene_expression of AGT 1 0.03 1.41 0.1
45 INT270731 Binding of AGTR1 and ACE 1 0.02 0.67 0.09
46 INT104737 Ace Positive_regulation of Gene_expression of Ren1 1 0.35 0.09 0.09
47 INT265829 ACE Positive_regulation of Protein_catabolism of KNG1 1 0.33 0.73 0.09
48 INT344945 Negative_regulation of ACE Positive_regulation of REN 1 0.23 0.64 0.09
49 INT307805 Ace Positive_regulation of Ang 1 0.32 1.52 0.07
50 INT307806 Ace Positive_regulation of Agt 1 0.28 1.51 0.07
51 INT200641 Binding of ACE and Agtr1a 1 0.12 0.92 0.06
52 INT200638 Binding of ACE and Agtr2 1 0.10 0.93 0.06
53 INT200635 Binding of Ace and Spink1 1 0.37 1.4 0.05
54 INT29521 Ace Positive_regulation of ACE 1 0.19 0 0.04
55 INT283226 Binding of ACE and CC2D1A 1 0.11 2.37 0.04
56 INT104736 Ace Positive_regulation of Ren1 1 0.35 0 0.04
57 INT109818 Ace Regulation of ras 1 0.04 0.3 0
58 INT322250 Ace Regulation of Gene_expression of Agt 1 0.43 0.63 0
59 INT307804 Ace Positive_regulation of Gene_expression of Scrib 1 0.21 2.43 0
60 INT322240 Ace Regulation of Gene_expression of Htr2a 1 0.13 0.63 0
61 INT322239 Ace Regulation of Gene_expression of Agtrap 1 0.44 0.63 0
62 INT1181 Negative_regulation of Ace Positive_regulation of Ren 1 0.52 0.23 0
63 INT264679 IGFALS Positive_regulation of CTSC 1 0.02 1.68 0
64 INT103769 AMY2A Positive_regulation of IFNA2 1 0.01 0.26 0
65 INT322253 Agt Regulation of Gene_expression of Ace 1 0.43 0.63 0
66 INT65004 Negative_regulation of Ace Positive_regulation of Agt 1 0.40 0 0
67 INT307808 Ace Positive_regulation of Gene_expression of Ace2 1 0.22 2.43 0
68 INT322238 Slc6a4 Regulation of Gene_expression of Ace 1 0.37 0.63 0
69 INT322256 Ace Regulation of Gene_expression of Slc6a4 1 0.37 0.63 0
70 INT200488 Binding of ACE and SUGT1 1 0.01 0.28 0
71 INT213584 Binding of AGTR2 and ACE 1 0.17 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for chloride ion binding. They are ordered first by their pain relevance and then by number of times they were reported in chloride ion binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48
2 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46
3 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08
4 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19
5 INT20664 Binding of ACE 60 0.48 35.27 9.16
6 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31
7 INT389 Gene_expression of Ace 21 0.67 10.31 8.1
8 INT25958 Regulation of Ace 26 0.59 11.88 7.87
9 INT1771 Positive_regulation of Ace 31 0.68 10.47 7.46
10 INT42038 Localization of ACE 26 0.80 8.88 7.06
11 INT26477 Regulation of ACE 26 0.45 16.31 4.33
12 INT29327 Positive_regulation of Ace 13 0.67 8.79 4.33
13 INT387 Regulation of Ace 18 0.45 5.24 4.24
14 INT1722 Protein_catabolism of ACE 10 0.88 2.61 3.76
15 INT2464 Gene_expression of AMY2A 21 0.75 13.76 2.78
16 INT8652 Protein_catabolism of Ace 10 0.94 4.7 2.74
17 INT74695 Gene_expression of Ace 41 0.73 53.33 2.33
18 INT388 Positive_regulation of Gene_expression of Ace 4 0.42 1.04 2.13
19 INT45646 Protein_catabolism of Ace 5 0.98 3.14 1.95
20 INT43084 Binding of Ace 10 0.46 4.7 1.93
21 INT33096 Negative_regulation of Gene_expression of ACE 9 0.43 2.84 1.93
22 INT55606 Binding of Ace 14 0.37 10.73 1.82
23 INT48253 Positive_regulation of AMY2A 8 0.59 3.86 1.79
24 INT22335 Regulation of Negative_regulation of ACE 10 0.44 7.01 1.77
25 INT163998 Gene_expression of CTSC 9 0.65 11.24 1.69
26 INT61223 Positive_regulation of Negative_regulation of ACE 6 0.49 5.92 1.37
27 INT44145 Negative_regulation of Gene_expression of Ace 5 0.40 4.5 1.33
28 INT1957 Localization of AMY2A 6 0.68 2.85 1.31
29 INT88948 Localization of Ace 9 0.69 9.18 1.11
30 INT223960 Positive_regulation of Transcription of AMY2A 1 0.08 4.88 1.07
31 INT223961 Transcription of AMY2A 1 0.11 4.83 1.06
32 INT182516 Negative_regulation of Negative_regulation of ACE 9 0.42 6.84 0.99
33 INT83995 Positive_regulation of Gene_expression of ACE 8 0.68 8.09 0.82
34 INT230803 Regulation of Negative_regulation of Ace 2 0.39 1.89 0.81
35 INT259902 Regulation of Gene_expression of ACE 3 0.45 1.87 0.7
36 INT72446 Negative_regulation of Binding of ACE 4 0.42 2.48 0.62
37 INT56045 Positive_regulation of Localization of ACE 3 0.69 1.38 0.6
38 INT200636 Regulation of Gene_expression of Ace 1 0.26 1.64 0.6
39 INT67297 Negative_regulation of CTSC 3 0.42 0.5 0.54
40 INT22333 Regulation of Negative_regulation of Ace 3 0.45 0.72 0.52
41 INT62184 Binding of AMY2A 3 0.41 1.06 0.52
42 INT36764 Localization of Ace 7 0.80 1.53 0.51
43 INT43091 Positive_regulation of Negative_regulation of Ace 3 0.30 1.51 0.48
44 INT171150 Negative_regulation of Binding of Ace 2 0.17 2.67 0.44
45 INT44032 Regulation of Positive_regulation of Ace 1 0.38 0.1 0.43
46 INT114063 Negative_regulation of Localization of Ace 1 0.29 0.31 0.39
47 INT60040 Negative_regulation of Negative_regulation of Ace 6 0.43 3.64 0.38
48 INT165472 Localization of CTSC 2 0.68 0.38 0.38
49 INT181635 Positive_regulation of Protein_catabolism of ACE 1 0.15 0.41 0.38
50 INT77686 Transcription of Ace 2 0.65 2.65 0.37
51 INT30370 Negative_regulation of AMY2A 7 0.49 3.36 0.36
52 INT229626 Negative_regulation of Localization of ACE 3 0.41 2 0.36
53 INT267844 Positive_regulation of Gene_expression of Ace 10 0.57 15.35 0.35
54 INT96863 Transcription of ACE 3 0.69 0.38 0.29
55 INT230864 Regulation of Binding of ACE 1 0.22 0.79 0.29
56 INT288846 Negative_regulation of Transcription of ACE 1 0.43 0 0.29
57 INT103771 Regulation of AMY2A 3 0.60 1.65 0.27
58 INT229358 Negative_regulation of Protein_catabolism of Ace 1 0.40 0.93 0.27
59 INT47070 Positive_regulation of Localization of Ace 2 0.32 0.55 0.26
60 INT229357 Regulation of Binding of Ace 1 0.43 0.86 0.26
61 INT65003 Negative_regulation of Negative_regulation of Ace 5 0.37 3.45 0.23
62 INT307794 Negative_regulation of Gene_expression of Ace 7 0.48 5.95 0.2
63 INT69192 Positive_regulation of Positive_regulation of Ace 1 0.02 0 0.19
64 INT108414 Negative_regulation of Regulation of ACE 1 0.43 0.67 0.17
65 INT44051 Positive_regulation of Protein_catabolism of Ace 1 0.41 0 0.16
66 INT110438 Negative_regulation of Positive_regulation of AMY2A 1 0.32 0.15 0.15
67 INT59791 Positive_regulation of Negative_regulation of Ace 3 0.49 0.57 0.13
68 INT249970 Transcription of Ace 3 0.36 1.87 0.12
69 INT43092 Negative_regulation of Binding of Ace 1 0.31 0 0.12
70 INT147832 Regulation of CTSC 2 0.04 0.19 0.1
71 INT79993 Positive_regulation of Positive_regulation of ACE 2 0.49 0.78 0.1
72 INT340501 Regulation of Transcription of Ace 1 0.10 0.84 0.1
73 INT37949 Positive_regulation of CTSC 3 0.42 1.05 0.09
74 INT142088 Regulation of Localization of AMY2A 1 0.14 0 0.09
75 INT340500 Negative_regulation of Transcription of Ace 1 0.10 0.78 0.07
76 INT249971 Positive_regulation of Transcription of Ace 1 0.35 0.47 0.06
77 INT166914 Binding of CTSC 1 0.36 1.3 0.06
78 INT128209 Positive_regulation of Regulation of Ace 1 0.42 0.4 0.06
79 INT290604 Negative_regulation of Regulation of CTSC 1 0.07 0 0.05
80 INT42326 Negative_regulation of Regulation of Ace 1 0.15 0 0.05
81 INT230809 Positive_regulation of Localization of Ace 1 0.44 0.38 0.05
82 INT102927 Negative_regulation of Localization of Ace 3 0.58 1 0.03
83 INT63499 Protein_catabolism of AMY2A 3 0.88 0.47 0
84 INT270742 Negative_regulation of Phosphorylation of ACE 1 0.40 0.65 0
85 INT270740 Phosphorylation of ACE 1 0.76 0.65 0
86 INT316367 Negative_regulation of Transcription of Ace 1 0.40 0.22 0
87 INT307796 Positive_regulation of Positive_regulation of Ace 1 0.39 1.33 0
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