GO:0031418

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Name L-ascorbic acid binding
Categary Function
Go Slim No
Go Link GO:0031418
Unique Molecular Interactions 87
Total Molecular Interactions 110
Total Single Events 1363
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for L-ascorbic acid binding. They are ordered first by their pain relevance and then by number of times they were reported for L-ascorbic acid binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT98832 Th Regulation of Dbh 1 0.32 0.53 1.2
2 INT25026 PLOD1 Regulation of FSHR 4 0.19 0.38 1.15
3 INT31549 Binding of Dbh and Vip 1 0.32 0 1.08
4 INT31548 Binding of Th and Dbh 1 0.35 0 0.98
5 INT44442 GNRH1 Positive_regulation of Localization of PLOD1 3 0.50 0.78 0.86
6 INT34740 BID Regulation of Gene_expression of PLOD1 1 0.01 0 0.83
7 INT245350 Abat Regulation of Dbh 1 0.00 0.37 0.8
8 INT28975 Ins1 Positive_regulation of Positive_regulation of Dbh 1 0.21 0 0.66
9 INT45780 GNRH1 Positive_regulation of PLOD1 3 0.07 1.02 0.63
10 INT85489 IRF6 Negative_regulation of PLOD1 1 0.01 0.16 0.61
11 INT85488 Negative_regulation of IRF6 Negative_regulation of PLOD1 1 0.01 0.16 0.61
12 INT45781 Regulation of GNRH1 Positive_regulation of PLOD1 1 0.06 0.16 0.61
13 INT35154 PLOD1 Regulation of PRL 2 0.17 0 0.6
14 INT75490 LEPRE1 Positive_regulation of Gene_expression of COL7A1 1 0.03 0.52 0.57
15 INT23485 HBE1 Positive_regulation of Localization of PLOD1 1 0.04 0 0.54
16 INT23482 HBE1 Positive_regulation of PLOD1 1 0.04 0 0.53
17 INT70244 POMC Positive_regulation of Localization of PLOD1 1 0.21 0 0.53
18 INT23484 Positive_regulation of HBE1 Positive_regulation of PLOD1 1 0.04 0 0.53
19 INT139750 Ubqln1 Regulation of Dbh 1 0.00 0 0.52
20 INT139751 Dbh Regulation of Localization of Prl 1 0.02 0 0.52
21 INT39248 NPL Regulation of PLOD1 1 0.14 0.16 0.49
22 INT168110 Binding of Cnr1 and Dbh 1 0.04 0.64 0.47
23 INT168111 Dbh Positive_regulation of Cnr1 1 0.05 0.64 0.47
24 INT310769 Pam Regulation of Tlr4 1 0.01 0.69 0.46
25 INT157451 Binding of Slc6a3 and Dbh 1 0.04 0.48 0.44
26 INT23481 POMC Regulation of Localization of PLOD1 1 0.20 0 0.42
27 INT76154 Binding of NCOR2 and Negative_regulation of Localization of PLOD1 1 0.02 0 0.42
28 INT34856 Hpd Negative_regulation of Dbh 1 0.00 0 0.39
29 INT310765 Binding of Pam and Tlr2 1 0.01 0.57 0.35
30 INT258762 Binding of Dbh and ADHD1 1 0.08 1.61 0.34
31 INT43388 OPRM1 Positive_regulation of Localization of PLOD1 1 0.27 0 0.34
32 INT31042 Ghrh Positive_regulation of Localization of PLOD1 1 0.08 0 0.32
33 INT31039 Gnrh1 Negative_regulation of Localization of PLOD1 1 0.05 0 0.32
34 INT31043 Ghrh Positive_regulation of PLOD1 1 0.03 0 0.31
35 INT35079 CRH Negative_regulation of Localization of PLOD1 1 0.06 0 0.29
36 INT89911 PLOD1 Positive_regulation of Localization of PRL 1 0.12 0 0.29
37 INT89912 PLOD1 Positive_regulation of Localization of GH1 1 0.04 0 0.29
38 INT89897 PLOD1 Positive_regulation of Localization of POMC 1 0.13 0 0.29
39 INT67768 NPL Positive_regulation of PLOD1 1 0.30 0 0.28
40 INT42354 Dbh Regulation of Localization of Gh1 1 0.07 0 0.28
41 INT78484 Binding of DBH and TH 1 0.09 0 0.28
42 INT67769 Regulation of NPL Positive_regulation of PLOD1 1 0.17 0 0.28
43 INT310771 Pam Positive_regulation of TNF 1 0.02 0.29 0.27
44 INT310768 Pam Positive_regulation of Cxcl2 1 0.01 0.29 0.26
45 INT295430 BRD2 Positive_regulation of PLOD1 1 0.02 0.33 0.22
46 INT35151 PLOD1 Regulation of PGR 1 0.09 0 0.21
47 INT35149 PLOD1 Regulation of GHRH 1 0.02 0 0.21
48 INT35150 PLOD1 Regulation of LHB 1 0.09 0 0.21
49 INT25053 Crh Regulation of PLOD1 1 0.11 0 0.19
50 INT32360 DBI Positive_regulation of Localization of PLOD1 1 0.05 0 0.19
51 INT12521 Binding of PLOD1 and POMC 1 0.26 1.96 0.17
52 INT25050 Crh Negative_regulation of PLOD1 1 0.11 0 0.17
53 INT295433 Binding of PLOD1 and SCN5A 1 0.07 0.25 0.16
54 INT154367 Binding of Pam and Melc 1 0.02 0.15 0.15
55 INT241844 Positive_regulation of GNRH1 Positive_regulation of Localization of PLOD1 1 0.13 0.08 0.15
56 INT211860 PLOD1 Regulation of AGRP 1 0.07 0.15 0.14
57 INT194360 SNRPD1 Negative_regulation of Dbh 1 0.00 0 0.14
58 INT65267 Igf1 Regulation of Gene_expression of Plod3 1 0.07 0 0.13
59 INT65271 Igf1 Positive_regulation of Gene_expression of Plod3 1 0.12 0 0.13
60 INT284891 FSHR Positive_regulation of Gene_expression of PLOD1 2 0.03 1.32 0.11
61 INT294778 PAM Positive_regulation of Gene_expression of TLR2 1 0.01 0.41 0.11
62 INT65676 Binding of CGA and PLOD1 3 0.23 1.68 0.1
63 INT324702 PLOD1 Positive_regulation of CGA 1 0.03 1.1 0.1
64 INT116449 POMC Negative_regulation of Localization of PLOD1 1 0.11 0 0.1
65 INT294776 PAM Positive_regulation of TLR4 1 0.00 0.17 0.1
66 INT294777 PAM Positive_regulation of TLR9 1 0.00 0.17 0.1
67 INT294772 PAM Positive_regulation of TLR2 1 0.00 0.17 0.1
68 INT65896 GNRH1 Regulation of PLOD1 1 0.17 0.36 0.09
69 INT328292 KISS1 Positive_regulation of Localization of PLOD1 1 0.00 0 0.05
70 INT328363 Ghrl Negative_regulation of PLOD1 1 0.02 0.11 0.04
71 INT350119 Positive_regulation of GNRH1 Positive_regulation of PLOD1 1 0.04 0.86 0.03
72 INT189554 Binding of HIF1A and Positive_regulation of EGLN1 1 0.04 0.86 0
73 INT44230 Negative_regulation of Binding of PLOD1 and TRH 1 0.19 0.9 0
74 INT44228 TRH Regulation of PLOD1 1 0.12 0.9 0
75 INT189555 EGLN1 Regulation of Gene_expression of VEGFA 1 0.07 0.57 0
76 INT324705 CGA Positive_regulation of PLOD1 1 0.04 0 0
77 INT350115 GNRH1 Negative_regulation of Localization of PLOD1 1 0.04 0.99 0
78 INT334922 GNRHR Positive_regulation of Gene_expression of PLOD1 1 0.08 0.53 0
79 INT44227 Binding of PLOD1 and TRH 1 0.17 0.9 0
80 INT189552 EGLN1 Positive_regulation of HIF1A 1 0.05 0.98 0
81 INT25049 Crh Negative_regulation of Localization of PLOD1 1 0.10 0 0
82 INT350113 GNRHR Negative_regulation of Localization of PLOD1 1 0.01 1.06 0
83 INT324704 PLOD1 Positive_regulation of HRASLS 1 0.05 0 0
84 INT187673 GNRH1 Regulation of Localization of PLOD1 1 0.06 0.09 0
85 INT44232 FSHR Regulation of PLOD1 1 0.15 0.9 0
86 INT187668 Negative_regulation of GNRH1 Positive_regulation of PLOD1 1 0.06 0.07 0
87 INT334920 GNRH1 Positive_regulation of Gene_expression of PLOD1 1 0.16 0.52 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for L-ascorbic acid binding. They are ordered first by their pain relevance and then by number of times they were reported in L-ascorbic acid binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT920 Localization of PLOD1 223 0.81 42.25 78.7
2 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03
3 INT913 Regulation of Localization of PLOD1 71 0.62 8.64 32.72
4 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51
5 INT1166 Negative_regulation of Dbh 56 0.59 12.54 28.26
6 INT1638 Negative_regulation of PLOD1 92 0.59 21.69 26.61
7 INT917 Positive_regulation of Localization of PLOD1 51 0.69 8.53 22.87
8 INT3382 Positive_regulation of Dbh 33 0.70 11.64 21.67
9 INT14436 Gene_expression of Dbh 42 0.72 9.9 19.85
10 INT2960 Regulation of Dbh 32 0.47 10.32 18.94
11 INT1642 Negative_regulation of Localization of PLOD1 40 0.58 10.67 17.95
12 INT4073 Localization of Dbh 28 0.81 6.06 16.37
13 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54
14 INT5401 Gene_expression of DBH 17 0.78 1.92 8.01
15 INT47546 Binding of Dbh 11 0.44 5.69 7.84
16 INT5400 Positive_regulation of DBH 6 0.70 2.02 3.38
17 INT15253 Binding of DBH 7 0.36 3.21 3.17
18 INT25031 Negative_regulation of Gene_expression of PLOD1 14 0.54 3.86 2.89
19 INT28376 Regulation of Localization of Dbh 1 0.31 0 2.87
20 INT2958 Transcription of Dbh 4 0.71 2.57 2.64
21 INT2695 Regulation of DBH 5 0.45 1.09 2.48
22 INT28971 Positive_regulation of Gene_expression of Dbh 4 0.47 0.58 2.39
23 INT12033 Binding of PLOD1 15 0.48 8.04 2.3
24 INT67737 Negative_regulation of Pam 6 0.51 4.08 2.19
25 INT36534 Negative_regulation of Positive_regulation of PLOD1 5 0.56 1.39 2.14
26 INT75493 Gene_expression of LEPRE1 1 0.32 1.62 2.12
27 INT2961 Regulation of Regulation of Dbh 3 0.24 0.95 2.05
28 INT7974 Regulation of Gene_expression of PLOD1 6 0.42 0.41 1.99
29 INT7973 Positive_regulation of Regulation of PLOD1 5 0.42 0.42 1.99
30 INT7972 Positive_regulation of Gene_expression of PLOD1 15 0.42 5.73 1.96
31 INT22087 Negative_regulation of DBH 3 0.59 1.45 1.84
32 INT25033 Negative_regulation of Negative_regulation of PLOD1 4 0.55 0.36 1.6
33 INT40271 Localization of Pam 1 0.74 0.65 1.51
34 INT4074 Negative_regulation of Localization of Dbh 4 0.59 0.61 1.48
35 INT37886 Positive_regulation of Positive_regulation of PLOD1 1 0.69 0 1.43
36 INT112655 Negative_regulation of PAM 3 0.57 0.97 1.39
37 INT1651 Positive_regulation of Negative_regulation of PLOD1 4 0.46 0.49 1.33
38 INT141233 Negative_regulation of Positive_regulation of Dbh 2 0.42 0.39 1.33
39 INT38650 Positive_regulation of Negative_regulation of Dbh 3 0.50 0 1.16
40 INT71541 Gene_expression of Pam 6 0.77 2.02 1.12
41 INT23716 Localization of DBH 1 0.29 0.06 1.11
42 INT28972 Regulation of Gene_expression of Dbh 2 0.42 0.86 1.08
43 INT40273 Gene_expression of Pam 2 0.57 0.28 1.08
44 INT50812 Regulation of Positive_regulation of Dbh 2 0.45 1.04 1
45 INT58755 Binding of PAM 6 0.34 3.09 0.97
46 INT44446 Regulation of Regulation of PLOD1 3 0.38 1.85 0.97
47 INT75492 Negative_regulation of LEPRE1 2 0.40 0.84 0.96
48 INT30598 Negative_regulation of Transcription of Dbh 1 0.42 0.35 0.91
49 INT255622 Positive_regulation of PAM 7 0.18 4.89 0.87
50 INT29636 Localization of PAM 5 0.73 2.1 0.87
51 INT58759 Positive_regulation of Binding of PAM 1 0.24 0.57 0.85
52 INT64929 Positive_regulation of LEPRE1 3 0.41 0.75 0.78
53 INT28974 Negative_regulation of Negative_regulation of Dbh 1 0.40 0 0.78
54 INT40276 Binding of Pam 2 0.34 0.73 0.75
55 INT2959 Regulation of Transcription of Dbh 2 0.45 1.18 0.73
56 INT18889 Positive_regulation of Pam 2 0.61 0.14 0.73
57 INT38394 Regulation of Pam 2 0.39 0.08 0.69
58 INT4072 Positive_regulation of Positive_regulation of Dbh 3 0.50 1.77 0.67
59 INT38395 Protein_catabolism of Pam 1 0.57 0 0.67
60 INT39865 Regulation of Positive_regulation of PLOD1 2 0.27 0.71 0.66
61 INT154362 Binding of Pam 1 0.45 0.54 0.66
62 INT4785 Gene_expression of PAM 6 0.58 3.47 0.64
63 INT64928 Regulation of LEPRE1 2 0.24 1.26 0.54
64 INT67738 Regulation of Pam 1 0.27 0.56 0.53
65 INT187721 Transcription of PLOD1 4 0.49 4.69 0.51
66 INT187714 Regulation of Negative_regulation of PLOD1 1 0.09 0 0.51
67 INT3381 Positive_regulation of Regulation of Dbh 2 0.44 0.37 0.47
68 INT133179 Transcription of DBH 1 0.70 0.23 0.44
69 INT40274 Negative_regulation of Gene_expression of Pam 1 0.40 0.13 0.41
70 INT154361 Localization of Pam 2 0.76 0.26 0.4
71 INT47547 Positive_regulation of Binding of Dbh 1 0.47 0 0.39
72 INT25048 Negative_regulation of Regulation of PLOD1 2 0.32 0.15 0.32
73 INT65266 Gene_expression of Plod3 1 0.17 0 0.3
74 INT181914 Positive_regulation of EGLN1 1 0.36 2.03 0.25
75 INT13931 Protein_catabolism of Dbh 1 0.58 0 0.2
76 INT262469 Negative_regulation of Binding of PLOD1 1 0.14 0 0.2
77 INT65264 Positive_regulation of Gene_expression of Plod3 1 0.11 0 0.18
78 INT111306 Negative_regulation of Gene_expression of Dbh 1 0.25 0.45 0.17
79 INT314985 Positive_regulation of Negative_regulation of Pam 1 0.05 2.1 0.15
80 INT187715 Regulation of Transcription of PLOD1 1 0.09 0.09 0.15
81 INT189614 Gene_expression of EGLN1 6 0.49 4.3 0.12
82 INT310764 Positive_regulation of Pam 1 0.02 0.5 0.12
83 INT319121 Regulation of PAM 1 0.12 0.6 0.11
84 INT294784 Transcription of PAM 1 0.00 0.18 0.1
85 INT158616 Localization of EGLN1 1 0.73 0.54 0.06
86 INT354597 Positive_regulation of Positive_regulation of PAM 1 0.09 1.41 0.03
87 INT324729 Negative_regulation of Transcription of PLOD1 1 0.25 0.88 0
88 INT189577 Negative_regulation of EGLN1 1 0.31 1.73 0
89 INT189603 Negative_regulation of Transcription of EGLN1 1 0.31 0.94 0
90 INT189605 Regulation of EGLN1 1 0.33 1.65 0
91 INT189617 Transcription of EGLN1 1 0.50 0.94 0
92 INT301145 Positive_regulation of Gene_expression of Pam 1 0.09 0 0
93 INT307000 Negative_regulation of Pam 1 0.10 0 0
94 INT189572 Positive_regulation of Gene_expression of EGLN1 1 0.34 0.92 0
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