GO:0031424

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Name keratinization
Categary Process
Go Slim No
Go Link GO:0031424
Unique Molecular Interactions 135
Total Molecular Interactions 167
Total Single Events 963
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for keratinization. They are ordered first by their pain relevance and then by number of times they were reported for keratinization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT150889 Il1a Regulation of Il10 1 0.22 3.49 2.95
2 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
3 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
4 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
5 INT155984 Il1a Negative_regulation of Gene_expression of Cyp3a11 1 0.24 0.92 2.2
6 INT8409 IL1A Positive_regulation of Positive_regulation of Vip 1 0.01 0.63 1.27
7 INT8410 IL1A Positive_regulation of Vip 1 0.02 0.68 1.05
8 INT292530 Il10 Negative_regulation of Localization of Il1a 1 0.06 1.09 0.97
9 INT159111 Il1a Regulation of Gene_expression of Il1b 1 0.49 0.38 0.97
10 INT66536 Il1a Regulation of Gene_expression of Fos 1 0.59 0 0.91
11 INT78062 Il1a Positive_regulation of Localization of Il6 3 0.24 0.48 0.9
12 INT21944 Il1a Negative_regulation of Gnrh1 1 0.34 0 0.89
13 INT255321 Binding of 2E and Sprr1a 1 0.02 0 0.81
14 INT255328 Binding of Nav1 and Sprr1a 1 0.01 0 0.81
15 INT306271 IL1A Positive_regulation of Gene_expression of IL6 1 0.30 0.85 0.8
16 INT196575 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1a 1 0.04 0.44 0.77
17 INT200097 Negative_regulation of Binding of Il1a and Jun 1 0.00 2.76 0.77
18 INT200093 Binding of Il1a and Jun 1 0.00 2.64 0.76
19 INT128684 Binding of TGM1 and RETNLB 1 0.00 2.46 0.72
20 INT5971 Il1a Positive_regulation of Crh 2 0.51 0.57 0.71
21 INT250871 Il1a Positive_regulation of Protein_catabolism of Ecm1 1 0.01 1.44 0.68
22 INT95431 Il1a Regulation of Mmp2 1 0.48 0.25 0.61
23 INT306264 Binding of IL1A and MTX1 1 0.09 0.74 0.61
24 INT95435 Il1a Positive_regulation of Positive_regulation of Mmp3 1 0.59 0.25 0.61
25 INT95436 Il1a Positive_regulation of Mmp3 1 0.59 0.25 0.61
26 INT95434 Mmp9 Positive_regulation of Positive_regulation of Il1a 1 0.42 0.23 0.61
27 INT95432 Il1a Positive_regulation of Positive_regulation of Mmp9 1 0.37 0.25 0.6
28 INT222554 Il1a Positive_regulation of Localization of Ngf 1 0.02 0.07 0.6
29 INT8401 Il1a Regulation of Gene_expression of Nts 1 0.00 0.38 0.56
30 INT8395 Il1a Regulation of Gene_expression of Vip 1 0.01 0.38 0.56
31 INT8396 Il1a Regulation of Nts 1 0.00 0.38 0.53
32 INT8399 Il1a Regulation of Vip 1 0.00 0.38 0.53
33 INT97949 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of CDC42 1 0.06 0.72 0.51
34 INT97953 ST3GAL3 Positive_regulation of CDC42 1 0.09 0.7 0.5
35 INT129911 Skiv2l Negative_regulation of Localization of IL1A 1 0.01 0.74 0.48
36 INT130723 Binding of IL1A and Il1rn 1 0.01 0.59 0.47
37 INT130724 Negative_regulation of Binding of IL1A and Il1rn 1 0.01 0.59 0.47
38 INT222283 Negative_regulation of Casp1 Negative_regulation of Il1a 1 0.00 0.78 0.46
39 INT162396 Binding of LCE3B and LCE3C 1 0.32 1.08 0.45
40 INT264473 Il1a Positive_regulation of Mapk1 1 0.00 0 0.43
41 INT264476 Il1a Positive_regulation of Gene_expression of Mapk8 1 0.04 0 0.43
42 INT264471 Il1a Positive_regulation of Gene_expression of Mapk1 1 0.01 0 0.43
43 INT264475 Il1a Positive_regulation of Mapk8 1 0.04 0 0.43
44 INT264479 Il1a Positive_regulation of Gene_expression of Mapk14 1 0.02 0 0.43
45 INT159438 seb Positive_regulation of Gene_expression of Il1a 1 0.02 0 0.41
46 INT159439 sea Positive_regulation of Gene_expression of Il1a 1 0.07 0 0.41
47 INT222418 Tlr4 Positive_regulation of Gene_expression of Il1a 1 0.00 0.31 0.39
48 INT200096 Negative_regulation of Il1a Negative_regulation of Gene_expression of Ptgs2 1 0.00 1.45 0.39
49 INT264482 Il1a Positive_regulation of Phosphorylation of Mapk14 1 0.02 0 0.37
50 INT264481 Il1a Positive_regulation of Mapk14 1 0.02 0 0.37
51 INT264480 Il1a Positive_regulation of Phosphorylation of Mapk8 1 0.04 0 0.37
52 INT21945 Negative_regulation of Il1a Negative_regulation of LH 1 0.18 0 0.36
53 INT19476 Binding of IL1A and Il6 1 0.00 2.19 0.36
54 INT19477 Binding of IL1A and Csf2 1 0.00 2.19 0.36
55 INT21946 Il1a Negative_regulation of LH 1 0.18 0 0.35
56 INT242363 Binding of Il1a and Il1rn 1 0.05 0.19 0.35
57 INT164904 Binding of IL1A and IL33 1 0.39 0.19 0.35
58 INT113476 IL1A Positive_regulation of Localization of MMP14 1 0.10 0.22 0.34
59 INT97357 IL1A Positive_regulation of Transcription of Timp1 1 0.06 0.47 0.34
60 INT92870 SON Regulation of IL1A 1 0.01 0.31 0.32
61 INT78063 Il1a Positive_regulation of Il1b 1 0.02 0.07 0.32
62 INT203089 Binding of Il1a and Traf6 1 0.04 0.66 0.32
63 INT203085 Positive_regulation of Binding of Il1a and Myd88 1 0.07 0.65 0.32
64 INT203086 Positive_regulation of Binding of Il1a and Traf6 1 0.06 0.67 0.32
65 INT21947 Il1a Positive_regulation of Localization of Pomc 1 0.48 0 0.32
66 INT203087 Binding of Il1a and Myd88 1 0.05 0.65 0.31
67 INT285567 Binding of IL1B and Cdc42 1 0.03 0.77 0.31
68 INT97358 IL1A Regulation of Timp1 1 0.04 0.51 0.31
69 INT102872 IL1A Negative_regulation of Transcription of IL6 1 0.43 0.42 0.31
70 INT229600 Tlr4 Positive_regulation of Il1a 1 0.00 0.41 0.3
71 INT50310 Binding of Il1a and Ptger2 1 0.20 0.06 0.28
72 INT188518 Il1a Negative_regulation of Gene_expression of Ptger2 1 0.00 0.17 0.28
73 INT188517 Il1a Negative_regulation of Gene_expression of Ptges 1 0.00 0.17 0.28
74 INT188524 Il1a Positive_regulation of Ptges 1 0.00 0.31 0.28
75 INT220381 Il1a Positive_regulation of Gene_expression of Igfbp1 1 0.01 0.28 0.27
76 INT71309 Il1a Positive_regulation of Nos2 1 0.21 0.26 0.26
77 INT80288 IL1A Positive_regulation of CCL13 1 0.17 0.39 0.24
78 INT80280 IL1A Positive_regulation of CCL7 1 0.19 0.39 0.24
79 INT80284 IL1A Positive_regulation of Gene_expression of CCL13 1 0.58 0.39 0.24
80 INT140376 TGM1 Positive_regulation of Rhoa 1 0.01 0 0.24
81 INT292565 MAP3K5 Positive_regulation of Positive_regulation of CDC42 1 0.02 0 0.23
82 INT209856 IL1A Negative_regulation of Transcription of CD36 1 0.26 0.1 0.22
83 INT70082 Binding of APP and TGM1 1 0.00 1.22 0.22
84 INT264477 Il1a Positive_regulation of Jun 1 0.02 0.17 0.2
85 INT264470 Il1a Positive_regulation of Il6 1 0.06 0.18 0.2
86 INT102870 PTGER2 Regulation of IL1A 1 0.11 0.28 0.2
87 INT102868 TNF Regulation of IL1A 1 0.27 0.28 0.2
88 INT102873 IL1A Regulation of Gene_expression of IL6 1 0.27 0.28 0.2
89 INT222543 Il1a Regulation of Chat 1 0.01 0.64 0.19
90 INT222525 Il1a Regulation of Localization of Gh1 1 0.00 0.64 0.19
91 INT121632 PTGER1 Positive_regulation of TGM1 1 0.00 0.67 0.19
92 INT222494 Negative_regulation of Il1a Negative_regulation of Positive_regulation of Il6 1 0.00 0.79 0.19
93 INT203088 Il1a Positive_regulation of Gene_expression of Mmp3 1 0.03 0.26 0.18
94 INT66035 FOLR2 Negative_regulation of Il1a 1 0.00 0.56 0.18
95 INT190381 IL1A Regulation of Transcription of DEFB4A 1 0.06 0.93 0.18
96 INT164894 Binding of IL1A and IL1RAP 1 0.08 0.1 0.18
97 INT121631 PDGFD Positive_regulation of TGM1 1 0.01 0.68 0.18
98 INT214380 Binding of IL1A and PRTN3 1 0.00 0.94 0.18
99 INT70090 TGM1 Positive_regulation of Binding of Ache 1 0.03 0.59 0.15
100 INT221352 Tnf Negative_regulation of Il1a 1 0.05 0.3 0.15
101 INT81992 IL1A Positive_regulation of Positive_regulation of Tnfsf11 1 0.05 0.27 0.13
102 INT81983 IL1A Positive_regulation of Positive_regulation of PTGS2 1 0.01 0.27 0.13
103 INT340421 Il1a Positive_regulation of Csk 1 0.00 0.98 0.12
104 INT70084 Negative_regulation of Binding of APP and TGM1 1 0.00 0.61 0.11
105 INT70083 TGM1 Positive_regulation of Binding of APP 1 0.00 0.61 0.11
106 INT71310 Il1a Positive_regulation of NOS1 1 0.07 0.09 0.11
107 INT287267 EGF Positive_regulation of CDC42 1 0.12 0.16 0.11
108 INT71311 Il1a Positive_regulation of Positive_regulation of NOS1 1 0.07 0.09 0.11
109 INT294438 KLK4 Negative_regulation of IL1A 1 0.00 0 0.1
110 INT128696 Il1a Positive_regulation of Phosphorylation of Ephb1 1 0.26 0.82 0.1
111 INT190382 IL1A Regulation of Regulation of DEFB4A 1 0.06 0.57 0.1
112 INT16444 IGHG3 Negative_regulation of Binding of IL1A 1 0.11 0.42 0.09
113 INT222511 Il1a Positive_regulation of Gene_expression of Fst 1 0.01 0.32 0.08
114 INT222662 Il1a Positive_regulation of Gene_expression of INCENP 1 0.00 0.32 0.08
115 INT188519 Il1a Positive_regulation of Ptgis 1 0.03 0.08 0.08
116 INT348029 Re Positive_regulation of Vps54 1 0.01 0.44 0.07
117 INT348030 Mapk8 Regulation of Re 1 0.17 0.95 0.06
118 INT232914 Binding of KRT2 and KRT7 1 0.15 0.63 0.05
119 INT202566 Re Positive_regulation of Localization of IL4 1 0.00 0.44 0.05
120 INT232916 Binding of KRT2 and KRT19 1 0.21 0.62 0.05
121 INT16442 Binding of IGHG3 and IL1A 1 0.10 0.36 0.05
122 INT188525 Il1a Regulation of Ptges 1 0.00 0.07 0.04
123 INT279766 Binding of IGHG3 and TGM1 1 0.01 0.3 0.04
124 INT203094 Il1a Positive_regulation of Gene_expression of B4GALNT1 1 0.00 0.05 0.03
125 INT181083 Binding of Akt1 and Cdc42 1 0.00 0.79 0.03
126 INT232918 Binding of KRT2 and KRT8 1 0.17 0.59 0
127 INT234996 Ctnnd1 Positive_regulation of CDC42 1 0.01 0.07 0
128 INT90283 Binding of APOE and Il1a 1 0.01 0 0
129 INT70546 Binding of Re and IgG 1 0.02 1.23 0
130 INT249149 Binding of Cdc42 and Was 1 0.08 0.18 0
131 INT152401 Binding of Il1a and Il23r 1 0.00 0.06 0
132 INT152402 Binding of Il1a and ERAP1 1 0.00 0.06 0
133 INT66034 FOLR2 Negative_regulation of Gene_expression of Il1a 1 0.00 0.18 0
134 INT181085 Binding of Cdc42 and Errfi1 1 0.08 0.67 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for keratinization. They are ordered first by their pain relevance and then by number of times they were reported in keratinization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38
2 INT5966 Localization of Il1a 50 0.78 22.91 26.54
3 INT11746 Positive_regulation of Il1a 65 0.63 42.94 23.54
4 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19
5 INT5967 Negative_regulation of Il1a 51 0.57 27.09 18.24
6 INT60461 Positive_regulation of Gene_expression of Il1a 40 0.61 17.23 12.35
7 INT19527 Negative_regulation of Gene_expression of Il1a 26 0.51 15.4 11.58
8 INT15768 Gene_expression of Il1a 20 0.71 9.31 8.78
9 INT19475 Positive_regulation of IL1A 20 0.67 17.99 7.57
10 INT5308 Regulation of Il1a 17 0.44 10.8 7.31
11 INT72532 Regulation of Gene_expression of Il1a 13 0.54 4.91 6.71
12 INT23034 Positive_regulation of Il1a 15 0.70 8.75 6.29
13 INT58468 Negative_regulation of Gene_expression of IL1A 10 0.58 9.39 5.57
14 INT58338 Negative_regulation of Localization of Il1a 8 0.25 3.13 5.18
15 INT69310 Negative_regulation of IL1A 10 0.43 7.83 5.05
16 INT50309 Binding of Il1a 22 0.40 5.4 4.49
17 INT59083 Positive_regulation of Gene_expression of IL1A 11 0.70 9.09 4.48
18 INT23035 Regulation of Il1a 6 0.60 5.69 4.25
19 INT15462 Negative_regulation of Il1a 4 0.59 4.68 4.17
20 INT19189 Localization of IL1A 14 0.78 9.02 3.78
21 INT54619 Negative_regulation of Positive_regulation of Il1a 6 0.42 5.68 3.12
22 INT16447 Binding of IL1A 10 0.45 4.01 2.78
23 INT49984 Localization of Il1a 5 0.77 3.61 2.42
24 INT5968 Positive_regulation of Localization of Il1a 4 0.65 1.36 2.42
25 INT178247 Gene_expression of Re 11 0.31 8.57 2.3
26 INT150884 Transcription of Il1a 6 0.47 3.12 2.19
27 INT49988 Positive_regulation of Gene_expression of Il1a 2 0.47 1.49 2.11
28 INT89926 Regulation of IL1A 10 0.60 7.12 1.72
29 INT2620 Regulation of TGM1 1 0.01 3.27 1.5
30 INT2619 Positive_regulation of TGM1 7 0.49 5.97 1.41
31 INT49987 Transcription of Il1a 1 0.68 0.66 1.4
32 INT129253 Positive_regulation of Positive_regulation of Il1a 5 0.49 2.97 1.31
33 INT162757 Regulation of Localization of Il1a 3 0.37 1.22 1.25
34 INT70088 Binding of TGM1 9 0.41 5.3 1.22
35 INT112498 Gene_expression of TGM1 18 0.55 10.76 1.21
36 INT202548 Positive_regulation of Re 4 0.20 2.27 1.2
37 INT59082 Regulation of Gene_expression of IL1A 3 0.45 2.07 1.2
38 INT97955 Positive_regulation of CDC42 8 0.49 2.47 1.19
39 INT53571 Negative_regulation of Localization of Il1a 2 0.50 1.59 0.99
40 INT190077 Regulation of Transcription of Il1a 2 0.02 0.87 0.99
41 INT16446 Transcription of IL1A 4 0.69 1.76 0.96
42 INT202549 Positive_regulation of Gene_expression of Re 3 0.20 1.74 0.96
43 INT344365 Phosphorylation of Il1a 1 0.61 1.01 0.92
44 INT161682 Positive_regulation of Cdc42 8 0.53 4.55 0.9
45 INT83454 Positive_regulation of Negative_regulation of IL1A 1 0.50 0.62 0.81
46 INT23033 Negative_regulation of Positive_regulation of Il1a 2 0.42 0.76 0.78
47 INT157776 Localization of TGM1 2 0.39 2.52 0.74
48 INT53576 Regulation of Gene_expression of Il1a 2 0.41 0.6 0.73
49 INT83453 Negative_regulation of Localization of IL1A 1 0.43 0.39 0.69
50 INT292526 Negative_regulation of Negative_regulation of Il1a 1 0.05 0.87 0.66
51 INT89812 Negative_regulation of Gene_expression of Il1a 1 0.24 0.58 0.66
52 INT180107 Regulation of Cdc42 3 0.16 0.18 0.6
53 INT97956 Negative_regulation of CDC42 3 0.27 1.58 0.55
54 INT89813 Positive_regulation of Localization of Il1a 1 0.28 0.47 0.55
55 INT250838 Protein_catabolism of Il1a 1 0.13 1.16 0.49
56 INT162399 Gene_expression of LCE3C 1 0.60 1.13 0.46
57 INT162400 Gene_expression of LCE3B 1 0.56 1.13 0.46
58 INT250843 Negative_regulation of Protein_catabolism of Il1a 1 0.06 0.9 0.43
59 INT70086 Negative_regulation of Binding of TGM1 1 0.50 1.58 0.4
60 INT292528 Regulation of Positive_regulation of Il1a 1 0.06 0.52 0.39
61 INT328210 Positive_regulation of Negative_regulation of LCE3B 1 0.45 0.65 0.33
62 INT328209 Negative_regulation of LCE3B 1 0.41 0.64 0.32
63 INT328208 Negative_regulation of LCE3C 1 0.41 0.64 0.32
64 INT82758 Positive_regulation of Positive_regulation of IL1A 1 0.45 1.06 0.27
65 INT159502 Positive_regulation of Transcription of IL1A 1 0.45 0.35 0.25
66 INT159501 Regulation of Transcription of IL1A 1 0.44 0.35 0.25
67 INT162564 Gene_expression of KRT2 5 0.59 1.75 0.24
68 INT183881 Localization of CDC42 3 0.49 1.92 0.23
69 INT70087 Negative_regulation of TGM1 2 0.50 2.62 0.21
70 INT90281 Binding of Il1a 1 0.01 0.51 0.21
71 INT183876 Regulation of CDC42 3 0.30 1.94 0.19
72 INT60460 Positive_regulation of Negative_regulation of Il1a 1 0.36 0 0.18
73 INT197290 Gene_expression of Cdc42 9 0.35 2.52 0.15
74 INT206133 Binding of CDC42 3 0.25 0.8 0.12
75 INT347988 Negative_regulation of Re 1 0.13 1.02 0.11
76 INT158591 Regulation of Re 2 0.18 1.93 0.1
77 INT250827 Positive_regulation of Protein_catabolism of Il1a 1 0.07 0.21 0.09
78 INT197282 Positive_regulation of Gene_expression of Cdc42 3 0.26 0.12 0.08
79 INT16448 Negative_regulation of Binding of IL1A 1 0.40 0.41 0.08
80 INT206169 Gene_expression of CDC42 2 0.26 1.05 0.05
81 INT206167 Positive_regulation of Gene_expression of CDC42 1 0.08 0.05 0.05
82 INT188502 Positive_regulation of Binding of Il1a 2 0.07 0 0.04
83 INT226298 Positive_regulation of Gene_expression of TGM1 4 0.24 2.66 0
84 INT254795 Negative_regulation of Cdc42 2 0.12 1.53 0
85 INT233002 Binding of KRT2 1 0.29 0 0
86 INT270614 Localization of Cdc42 1 0.55 0.95 0
87 INT197294 Regulation of Gene_expression of Cdc42 1 0.13 0 0
88 INT336859 Negative_regulation of Gene_expression of Re 1 0.17 0.95 0
89 INT289448 Transcription of TGM1 1 0.19 0.1 0
90 INT282269 Binding of Cdc42 1 0.08 0.33 0
91 INT287281 Positive_regulation of Positive_regulation of CDC42 1 0.26 0 0
92 INT282272 Positive_regulation of Binding of Cdc42 1 0.11 0.33 0
93 INT327160 Negative_regulation of Gene_expression of KRT2 1 0.01 0.15 0
94 INT199005 Localization of KRT2 1 0.05 1.5 0
95 INT203070 Regulation of Negative_regulation of Il1a 1 0.14 0 0
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