GO:0031427

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Name response to methotrexate
Categary Process
Go Slim No
Go Link GO:0031427
Unique Molecular Interactions 15
Total Molecular Interactions 18
Total Single Events 196
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to methotrexate. They are ordered first by their pain relevance and then by number of times they were reported for response to methotrexate. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT105917 Binding of SLC22A6 and SLC22A8 2 0.31 0.34 1.67
2 INT323278 Dhfr Negative_regulation of Negative_regulation of Igkv1-131 1 0.02 0.93 1.02
3 INT120293 RYBP Positive_regulation of Abcc2 1 0.04 0.14 0.86
4 INT115811 Binding of Slc22a6 and Mtx1 1 0.02 0.17 0.65
5 INT115812 Binding of Slc22a8 and Mtx1 1 0.08 0.17 0.65
6 INT120294 RYBP Positive_regulation of Positive_regulation of Abcc2 1 0.02 0.15 0.61
7 INT323280 Dhfr Negative_regulation of Igkv1-131 1 0.02 0.47 0.51
8 INT177784 PDCD2 Positive_regulation of ASNS 1 0.04 0.76 0.46
9 INT177794 BUB1B Positive_regulation of Gene_expression of ASNS 1 0.11 0.77 0.46
10 INT177780 BUB1B Positive_regulation of ASNS 1 0.05 0.76 0.46
11 INT28863 Mtr Negative_regulation of Dhfr 1 0.04 0.87 0.45
12 INT28864 Mtx1 Negative_regulation of Dhfr 1 0.19 0.87 0.44
13 INT233304 Binding of SRY and SLC22A8 1 0.34 0.93 0
14 INT219634 Binding of NLRP1 and Slc22a6 1 0.26 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to methotrexate. They are ordered first by their pain relevance and then by number of times they were reported in response to methotrexate. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT104502 Gene_expression of Abcc2 26 0.78 8.37 9.65
2 INT120286 Positive_regulation of Abcc2 11 0.70 4.71 6.2
3 INT95099 Gene_expression of SLC22A8 14 0.67 1.59 5.14
4 INT95101 Binding of SLC22A8 6 0.48 0.75 5.07
5 INT95102 Localization of SLC22A8 3 0.75 0.69 4.24
6 INT96304 Gene_expression of Slc22a8 9 0.66 0.63 3.12
7 INT104134 Binding of SLC22A6 3 0.34 0.52 2.75
8 INT131332 Negative_regulation of Gene_expression of Abcc2 7 0.58 1.25 2.35
9 INT19157 Gene_expression of SLC22A6 5 0.71 1.39 2.18
10 INT120288 Regulation of Gene_expression of Abcc2 5 0.44 1.3 1.52
11 INT12290 Gene_expression of Dhfr 7 0.76 2.04 1.47
12 INT110555 Localization of Abcc2 1 0.69 0 1.47
13 INT110556 Negative_regulation of Localization of Abcc2 1 0.39 0 1.47
14 INT92405 Negative_regulation of Slc22a6 2 0.47 1.52 1.34
15 INT90829 Negative_regulation of SLC22A6 3 0.40 0.75 1.22
16 INT115810 Negative_regulation of Slc22a8 3 0.41 0.27 1.18
17 INT134506 Negative_regulation of Abcc2 2 0.41 0.06 1.17
18 INT120287 Regulation of Abcc2 2 0.24 0.81 1.06
19 INT145443 Positive_regulation of Positive_regulation of Abcc2 1 0.07 0.93 1.06
20 INT123213 Negative_regulation of SLC22A8 2 0.35 1.43 1.05
21 INT108805 Binding of Slc22a8 3 0.18 0.44 0.97
22 INT158436 Transcription of Abcc2 4 0.47 0.15 0.94
23 INT90830 Localization of SLC22A6 3 0.69 0.86 0.89
24 INT168284 Localization of Slc22a8 1 0.78 0.1 0.82
25 INT81604 Transcription of SLC22A6 2 0.63 0.67 0.78
26 INT134505 Positive_regulation of Gene_expression of Abcc2 4 0.69 1.81 0.71
27 INT115809 Binding of Slc22a6 1 0.03 0.17 0.65
28 INT285339 Negative_regulation of Gene_expression of Dhfr 1 0.11 1.93 0.65
29 INT285337 Regulation of Gene_expression of Dhfr 1 0.11 1.93 0.65
30 INT70515 Gene_expression of Slc22a6 7 0.78 1.26 0.63
31 INT90831 Negative_regulation of Gene_expression of SLC22A6 1 0.40 0.39 0.58
32 INT323258 Positive_regulation of Dhfr 1 0.20 0.66 0.49
33 INT177822 Gene_expression of ASNS 1 0.30 1.32 0.46
34 INT177817 Positive_regulation of Gene_expression of ASNS 1 0.19 0.92 0.46
35 INT168285 Negative_regulation of Localization of Slc22a8 1 0.36 0 0.44
36 INT95100 Transcription of SLC22A8 4 0.45 0.57 0.39
37 INT147225 Positive_regulation of Slc22a8 2 0.49 0 0.38
38 INT262284 Negative_regulation of Positive_regulation of Slc22a6 1 0.06 0.79 0.31
39 INT262299 Negative_regulation of Positive_regulation of SLC22A8 1 0.06 0.79 0.31
40 INT262283 Positive_regulation of Slc22a6 1 0.07 0.73 0.3
41 INT262300 Positive_regulation of SLC22A8 1 0.07 0.73 0.3
42 INT126820 Negative_regulation of Gene_expression of Slc22a6 2 0.26 0.85 0.26
43 INT262296 Negative_regulation of Transcription of SLC22A8 1 0.06 0.58 0.26
44 INT262292 Negative_regulation of Gene_expression of SLC22A8 1 0.06 0.58 0.26
45 INT262285 Negative_regulation of Transcription of Slc22a6 1 0.06 0.58 0.26
46 INT262286 Transcription of Slc22a6 1 0.09 0.58 0.26
47 INT128386 Transcription of Slc22a8 1 0.38 0 0.25
48 INT241468 Binding of Dhfr 2 0.13 1.41 0.17
49 INT57182 Negative_regulation of Dhfr 2 0.55 0.37 0.16
50 INT160111 Localization of Slc22a6 1 0.68 0 0
51 INT168333 Negative_regulation of Transcription of Abcc2 1 0.39 0.06 0
52 INT299472 Positive_regulation of Gene_expression of Dhfr 1 0.20 0 0
53 INT126821 Negative_regulation of Gene_expression of Slc22a8 1 0.17 0.27 0
54 INT168334 Regulation of Transcription of Abcc2 1 0.30 0.09 0
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