GO:0031434

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Name mitogen-activated protein kinase kinase binding
Categary Function
Go Slim No
Go Link GO:0031434
Unique Molecular Interactions 85
Total Molecular Interactions 102
Total Single Events 461
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for mitogen-activated protein kinase kinase binding. They are ordered first by their pain relevance and then by number of times they were reported for mitogen-activated protein kinase kinase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
2 INT114324 RAF1 Positive_regulation of Phosphorylation of ADCY6 1 0.02 0.05 0.85
3 INT114323 Binding of ADCY6 and RAF1 1 0.02 0.05 0.85
4 INT85686 Binding of Arrb1 and Arrb2 1 0.14 0.09 0.79
5 INT330101 Binding of Map3k11 and Rac1 1 0.16 2.43 0.62
6 INT136682 Binding of BRAF and MC1R 2 0.49 3.16 0.57
7 INT323148 PRKCA Positive_regulation of RAF1 1 0.01 0 0.55
8 INT323150 PRKCA Positive_regulation of Phosphorylation of RAF1 1 0.01 0 0.55
9 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
10 INT95404 Map3k1 Positive_regulation of Phosphorylation of Ephb1 1 0.12 0.16 0.46
11 INT95408 Map3k1 Positive_regulation of Ephb1 1 0.12 0.16 0.46
12 INT201610 Binding of Mc1r and Braf 1 0.31 0.75 0.42
13 INT354704 Binding of MAP3K1 and Pick1 1 0.00 0.76 0.41
14 INT105169 RAF1 Regulation of Positive_regulation of ADCY1 1 0.12 0 0.4
15 INT346222 Positive_regulation of Braf Positive_regulation of Map2k1 1 0.15 0.67 0.39
16 INT346221 Positive_regulation of Braf Positive_regulation of Positive_regulation of Map2k2 1 0.11 0.67 0.39
17 INT346219 Positive_regulation of Braf Positive_regulation of Map2k2 1 0.11 0.67 0.39
18 INT124798 RAF1 Regulation of PRKCA 1 0.06 0 0.39
19 INT202810 Pin1 Regulation of Csf2 1 0.03 0.82 0.36
20 INT346226 Binding of TPPP and Braf 1 0.06 0.6 0.33
21 INT348016 Binding of Mapk8 and Mapk8ip3 1 0.04 2.09 0.32
22 INT255934 Tauph Positive_regulation of Map3k1 1 0.00 0.1 0.32
23 INT255946 MAPK14 Positive_regulation of Map3k1 1 0.04 0.1 0.32
24 INT330100 Binding of Sh3rf1 and Map3k11 1 0.08 1.21 0.31
25 INT346220 Binding of Kras and Braf 1 0.03 0.58 0.28
26 INT274932 Binding of Insrr and Map3k1 1 0.00 0 0.28
27 INT274947 Binding of Map3k1 and Grip1 1 0.00 0 0.27
28 INT171912 MAPK8IP3 Positive_regulation of MAPK9 1 0.06 0.78 0.26
29 INT302438 Binding of Raf1 and Rtn4r 1 0.04 0.08 0.26
30 INT118851 GNA14 Positive_regulation of RAF1 1 0.00 0.14 0.26
31 INT171911 MAPK8IP3 Positive_regulation of Gene_expression of MAPK14 1 0.05 0.77 0.26
32 INT149357 Trib3 Negative_regulation of Raf1 1 0.01 0.08 0.25
33 INT149356 Prkaca Negative_regulation of Raf1 1 0.10 0.08 0.25
34 INT346224 Braf Negative_regulation of Phosphorylation of Map2k1 1 0.14 0.62 0.22
35 INT202808 Binding of Pin1 and Hnrpd 1 0.08 0.84 0.22
36 INT274080 Binding of ARHGAP4 and Map3k5 1 0.41 1.92 0.2
37 INT337154 Binding of Iqgap1 and Braf 1 0.13 0.64 0.18
38 INT181144 Raf1 Positive_regulation of Gene_expression of El4 1 0.06 0.35 0.17
39 INT348034 Mapk8ip3 Negative_regulation of Mapk8 1 0.05 0.98 0.16
40 INT348019 Negative_regulation of Binding of Mapk8 and Mapk8ip3 1 0.05 1.04 0.16
41 INT177916 PRKG1 Positive_regulation of Positive_regulation of MAP3K1 1 0.05 1.07 0.14
42 INT202813 Pin1 Positive_regulation of Regulation of TH1L 1 0.50 0 0.14
43 INT254643 Binding of Mapk8ip1 and Slc9a3r2 1 0.00 0.27 0.12
44 INT280488 Bdnf Positive_regulation of Gene_expression of Map3k1 1 0.01 1.49 0.11
45 INT258527 Binding of BRAF and RET 1 0.21 1.49 0.11
46 INT252779 Binding of ESR1 and RAF1 1 0.01 2.03 0.11
47 INT252778 RAF1 Positive_regulation of Positive_regulation of ROS1 1 0.04 2.05 0.11
48 INT314588 Binding of Ifnar1 and Positive_regulation of Raf1 1 0.13 0 0.1
49 INT92389 ALK Positive_regulation of Gene_expression of Map3k1 1 0.01 1.14 0.09
50 INT232559 Map3k1 Positive_regulation of Esr1 1 0.19 0.26 0.09
51 INT202807 Pin1 Regulation of Binding of Hnrpd 1 0.06 0.14 0.08
52 INT297964 Binding of CDK8 and MAP3K11 1 0.26 0.29 0.07
53 INT297969 Positive_regulation of Binding of CDK8 and MAP3K11 1 0.35 0.29 0.07
54 INT143647 Negative_regulation of Mapk8ip1 Negative_regulation of Gene_expression of Fas 1 0.02 0.15 0.05
55 INT250025 Map3k1 Positive_regulation of Regulation of Bcl2 1 0.01 1.1 0.04
56 INT280568 MRAS Positive_regulation of RAF1 1 0.01 0.7 0
57 INT215413 ITC1 Negative_regulation of MAP3K1 1 0.04 0.23 0
58 INT199581 Braf Negative_regulation of Phosphorylation of tk 1 0.05 0.6 0
59 INT303332 ras Positive_regulation of Raf1 1 0.02 0.07 0
60 INT348521 TRAF2 Positive_regulation of MAP3K1 1 0.03 0.46 0
61 INT348689 Fgf2 Regulation of Map3k1 1 0.09 0 0
62 INT350426 Binding of BRAF and KRAS 1 0.05 1.78 0
63 INT199576 Raf1 Negative_regulation of Akt1 1 0.00 0.79 0
64 INT291335 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK3A 1 0.07 0.88 0
65 INT258523 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK 1 0.19 0.64 0
66 INT199580 Braf Negative_regulation of Phosphorylation of Mdk 1 0.11 0.6 0
67 INT225874 Positive_regulation of ras Positive_regulation of RAF1 1 0.00 0 0
68 INT274076 Binding of Map3k5 and Gmcl1 1 0.06 1.23 0
69 INT286420 Binding of Fgf13 and Mapk8ip3 1 0.36 0 0
70 INT199582 Braf Negative_regulation of Akt1 1 0.00 0.79 0
71 INT199579 Tnk1 Negative_regulation of Raf1 1 0.01 0.78 0
72 INT225871 RAF1 Positive_regulation of Mdk 1 0.00 0 0
73 INT258526 IPMK Negative_regulation of BRAF 1 0.01 1.11 0
74 INT215416 MAP3K1 Regulation of MAPK9 1 0.14 0.64 0
75 INT215412 Binding of MAP3K1 and ITC1 1 0.03 0 0
76 INT225875 ras Positive_regulation of RAF1 1 0.00 0 0
77 INT199578 Tnk1 Negative_regulation of Braf 1 0.01 0.78 0
78 INT350433 KRAS Regulation of Gene_expression of BRAF 1 0.08 1.77 0
79 INT291331 Negative_regulation of GSK3A Positive_regulation of Positive_regulation of RAF1 1 0.07 0.94 0
80 INT268396 Binding of BRAF and Ebp 1 0.01 1.72 0
81 INT215415 MAP3K1 Regulation of MAPK8 1 0.62 0.64 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for mitogen-activated protein kinase kinase binding. They are ordered first by their pain relevance and then by number of times they were reported in mitogen-activated protein kinase kinase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT199560 Binding of Braf 4 0.30 8.83 4.8
2 INT155512 Positive_regulation of Braf 2 0.49 7.88 4.2
3 INT105171 Phosphorylation of RAF1 11 0.74 2.33 4.19
4 INT139807 Gene_expression of Braf 7 0.51 8.78 3.34
5 INT119421 Negative_regulation of RAF1 10 0.41 6.94 3.31
6 INT133085 Gene_expression of Mapk8ip1 7 0.66 6.13 2.98
7 INT346210 Phosphorylation of Braf 1 0.44 5.3 2.77
8 INT95737 Positive_regulation of Phosphorylation of Mapk8ip1 2 0.06 3.27 2.74
9 INT159121 Positive_regulation of Map3k1 10 0.45 8.79 2.6
10 INT196919 Regulation of Braf 3 0.32 6.14 2.55
11 INT133083 Positive_regulation of Gene_expression of Mapk8ip1 1 0.07 3.27 2.47
12 INT202792 Negative_regulation of Pin1 1 0.56 3.77 2.37
13 INT114327 Positive_regulation of RAF1 26 0.51 20.87 2.32
14 INT95736 Phosphorylation of Mapk8ip1 2 0.10 2.84 2.32
15 INT95400 Negative_regulation of Map3k1 3 0.15 0.78 1.92
16 INT71788 Gene_expression of MAP3K1 13 0.70 4.9 1.66
17 INT82143 Gene_expression of Raf1 2 0.18 0.33 1.59
18 INT82140 Negative_regulation of Raf1 3 0.14 1.7 1.38
19 INT82141 Positive_regulation of Raf1 2 0.12 0.81 1.38
20 INT50785 Gene_expression of Map3k1 6 0.44 4.22 1.32
21 INT82139 Positive_regulation of Gene_expression of Raf1 2 0.12 0.28 1.29
22 INT143646 Negative_regulation of Mapk8ip1 5 0.03 5.46 1.28
23 INT127805 Positive_regulation of Phosphorylation of RAF1 3 0.45 1.21 1.17
24 INT82138 Negative_regulation of Gene_expression of Raf1 1 0.01 0.28 1.04
25 INT82142 Negative_regulation of Positive_regulation of Raf1 1 0.01 0.28 1.04
26 INT202790 Binding of Pin1 1 0.46 3.02 0.88
27 INT202786 Regulation of Pin1 1 0.43 2.16 0.83
28 INT71784 Positive_regulation of Gene_expression of MAP3K1 4 0.34 4.8 0.82
29 INT50784 Positive_regulation of Gene_expression of Map3k1 2 0.06 0.94 0.8
30 INT85678 Binding of Arrb1 1 0.20 0.09 0.78
31 INT177933 Positive_regulation of MAP3K1 6 0.42 4.13 0.76
32 INT132521 Gene_expression of BRAF 14 0.65 13.59 0.73
33 INT202806 Gene_expression of Pin1 1 0.74 1.87 0.66
34 INT111602 Negative_regulation of Gene_expression of MAP3K1 1 0.06 0.58 0.58
35 INT202801 Positive_regulation of Pin1 1 0.67 1.37 0.52
36 INT274072 Gene_expression of Map3k5 1 0.60 6.69 0.5
37 INT171362 Gene_expression of Raf1 13 0.66 8.36 0.49
38 INT92328 Gene_expression of Map3k11 1 0.06 0.46 0.49
39 INT274069 Binding of Map3k5 1 0.29 2.68 0.49
40 INT161378 Binding of BRAF 1 0.08 2.24 0.48
41 INT95401 Phosphorylation of Map3k1 1 0.21 0.16 0.46
42 INT167981 Negative_regulation of Negative_regulation of Mapk8ip1 1 0.01 0.91 0.45
43 INT346209 Localization of Braf 1 0.49 0.78 0.44
44 INT323167 Negative_regulation of Phosphorylation of RAF1 1 0.08 0 0.43
45 INT202805 Negative_regulation of Negative_regulation of Pin1 1 0.41 0.77 0.43
46 INT252737 Gene_expression of RAF1 12 0.58 10.97 0.42
47 INT179413 Positive_regulation of Mapk8ip1 1 0.01 0.97 0.4
48 INT156120 Localization of Arrb1 1 0.00 0 0.38
49 INT156119 Positive_regulation of Localization of Arrb1 1 0.00 0 0.38
50 INT346208 Regulation of Positive_regulation of Braf 1 0.19 0.7 0.37
51 INT181130 Positive_regulation of Gene_expression of Raf1 1 0.59 2.29 0.36
52 INT236623 Positive_regulation of BRAF 3 0.45 2.05 0.32
53 INT330099 Binding of Map3k11 1 0.24 1.21 0.31
54 INT102721 Negative_regulation of MAP3K1 2 0.53 8.03 0.3
55 INT202791 Phosphorylation of Pin1 1 0.78 0.61 0.28
56 INT95740 Negative_regulation of Phosphorylation of Mapk8ip1 1 0.01 0 0.27
57 INT177941 Phosphorylation of MAP3K1 2 0.20 1.31 0.24
58 INT199569 Negative_regulation of Braf 4 0.36 3.73 0.23
59 INT274071 Positive_regulation of Map3k5 3 0.38 2.31 0.22
60 INT202789 Positive_regulation of Gene_expression of Pin1 1 0.67 0.62 0.22
61 INT252745 Positive_regulation of Positive_regulation of RAF1 3 0.20 4.62 0.21
62 INT98785 Negative_regulation of Gene_expression of Map3k1 1 0.03 0.69 0.21
63 INT344913 Regulation of Map3k5 1 0.48 0.61 0.2
64 INT224563 Positive_regulation of Positive_regulation of Raf1 1 0.11 0 0.2
65 INT181125 Transcription of Raf1 2 0.59 1.14 0.18
66 INT132524 Positive_regulation of Gene_expression of BRAF 1 0.37 0.95 0.18
67 INT257557 Negative_regulation of MAP3K11 3 0.30 2.38 0.16
68 INT154200 Binding of Map3k1 1 0.06 0.32 0.16
69 INT202796 Regulation of Negative_regulation of Pin1 1 0.59 0.23 0.15
70 INT202797 Negative_regulation of Binding of Pin1 1 0.41 0.74 0.15
71 INT330973 Regulation of Phosphorylation of RAF1 1 0.30 1.09 0.14
72 INT284981 Protein_catabolism of RAF1 2 0.08 1.62 0.12
73 INT315042 Positive_regulation of Gene_expression of RAF1 1 0.05 0.23 0.12
74 INT280585 Negative_regulation of Gene_expression of RAF1 1 0.13 1.88 0.11
75 INT202794 Negative_regulation of Protein_catabolism of Pin1 1 0.41 0.15 0.11
76 INT325046 Negative_regulation of Positive_regulation of Map3k5 1 0.07 0.64 0.11
77 INT202793 Protein_catabolism of Pin1 1 0.63 0.15 0.11
78 INT171373 Positive_regulation of Raf1 3 0.14 0.67 0.1
79 INT173169 Regulation of MAP3K1 2 0.41 1.81 0.09
80 INT92387 Gene_expression of Map3k1 1 0.02 1.13 0.09
81 INT252703 Localization of RAF1 2 0.32 1.3 0.07
82 INT280787 Gene_expression of Mapk8ip3 1 0.01 0.24 0.07
83 INT254642 Binding of Mapk8ip1 1 0.32 0.22 0.07
84 INT252753 Positive_regulation of Localization of RAF1 1 0.06 1.35 0.07
85 INT224326 Binding of RAF1 3 0.13 3.11 0.05
86 INT250022 Regulation of Map3k1 2 0.18 1.02 0.04
87 INT285978 Negative_regulation of Gene_expression of Mapk8ip1 1 0.01 0.66 0.04
88 INT181128 Localization of Raf1 1 0.69 7.07 0.04
89 INT258556 Negative_regulation of BRAF 4 0.42 2.48 0.03
90 INT320723 Negative_regulation of Gene_expression of BRAF 2 0.38 1 0.03
91 INT274068 Positive_regulation of Gene_expression of Map3k5 1 0.53 2.85 0.03
92 INT236620 Regulation of BRAF 2 0.46 1.96 0
93 INT202475 Positive_regulation of Positive_regulation of Map3k1 2 0.33 1.54 0
94 INT143795 Phosphorylation of BRAF 1 0.08 0 0
95 INT215426 Negative_regulation of Negative_regulation of MAP3K1 1 0.39 0.32 0
96 INT274073 Negative_regulation of Map3k5 1 0.33 0.28 0
97 INT286395 Negative_regulation of Transcription of Mapk8ip3 1 0.55 0 0
98 INT224535 Localization of Raf1 1 0.17 0 0
99 INT189990 Negative_regulation of Map3k1 1 0.01 1.48 0
100 INT333617 Transcription of MAP3K1 1 0.23 0.09 0
101 INT215425 Positive_regulation of Negative_regulation of MAP3K1 1 0.45 0.78 0
102 INT286400 Transcription of Mapk8ip3 1 0.68 0 0
103 INT315132 Localization of BRAF 1 0.50 0.26 0
104 INT293481 Negative_regulation of Gene_expression of Raf1 1 0.24 0.38 0
105 INT286397 Negative_regulation of Mapk8ip3 1 0.41 0.06 0
106 INT215419 Regulation of Localization of MAP3K1 1 0.41 0.22 0
107 INT280590 Transcription of RAF1 1 0.52 0.75 0
108 INT286391 Positive_regulation of Mapk8ip3 1 0.44 0.06 0
109 INT215423 Localization of MAP3K1 1 0.68 0.22 0
110 INT333621 Positive_regulation of Transcription of MAP3K1 1 0.16 0.09 0
111 INT215428 Binding of MAP3K1 1 0.44 0.05 0
112 INT199562 Positive_regulation of Binding of Braf 1 0.31 0.25 0
113 INT202470 Negative_regulation of Positive_regulation of Map3k1 1 0.38 0.62 0
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