GO:0031435

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Name mitogen-activated protein kinase kinase kinase binding
Categary Function
Go Slim No
Go Link GO:0031435
Unique Molecular Interactions 519
Total Molecular Interactions 635
Total Single Events 4729
Pain Genes Associated 27

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for mitogen-activated protein kinase kinase kinase binding. They are ordered first by their pain relevance and then by number of times they were reported for mitogen-activated protein kinase kinase kinase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
2 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
3 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
4 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
5 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
6 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
7 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
8 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 0.07 1.35 1.41
9 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41
10 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
11 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
12 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
13 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17
14 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
15 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
16 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
17 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
18 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
19 INT133616 Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
20 INT133614 Map2k1 Regulation of Daxx 1 0.02 0.29 0.97
21 INT133615 Regulation of Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
22 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
23 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
24 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
25 INT223871 Ltp Positive_regulation of Gene_expression of Mapk1 1 0.33 0 0.93
26 INT302828 Mapkapk5 Positive_regulation of Mapk1 1 0.07 1.38 0.91
27 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
28 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
29 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
30 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
31 INT196578 Ephb1 Positive_regulation of Phosphorylation of Mapk9 1 0.13 0.5 0.85
32 INT196576 Trib3 Positive_regulation of Phosphorylation of Mapk9 1 0.02 0.5 0.85
33 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
34 INT262572 Ngf Positive_regulation of Mapk1 2 0.04 0.52 0.81
35 INT161520 H2-M3 Regulation of Positive_regulation of Mapk1 1 0.09 0.47 0.79
36 INT132977 Tac1 Positive_regulation of Mapk1 1 0.06 0.17 0.79
37 INT117909 Mastl Positive_regulation of Mapk1 1 0.04 0 0.79
38 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
39 INT128404 Mapk1 Positive_regulation of Phosphorylation of Gja1 1 0.65 0.73 0.73
40 INT134476 Cdk5 Regulation of Map2k1 1 0.69 0.88 0.71
41 INT166386 Mapk1 Regulation of Gene_expression of Gnb2l1 1 0.46 0.25 0.7
42 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
43 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
44 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
45 INT223868 Mapk1 Positive_regulation of Creb1 2 0.17 0.34 0.68
46 INT223876 Mapk1 Positive_regulation of Atf6b 1 0.10 0 0.68
47 INT211916 Fig4 Positive_regulation of Mapk1 1 0.13 0.25 0.66
48 INT191332 AMPH Positive_regulation of Mapk1 1 0.76 0 0.66
49 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
50 INT148173 Positive_regulation of Grm5 Positive_regulation of Phosphorylation of Mapk1 1 0.01 0.45 0.65
51 INT281092 Adcy1 Positive_regulation of Mapk1 1 0.21 0 0.63
52 INT281090 Prkacb Positive_regulation of Mapk1 1 0.06 0 0.62
53 INT330101 Binding of Map3k11 and Rac1 1 0.16 2.43 0.62
54 INT291262 Positive_regulation of INS Positive_regulation of Mapk1 1 0.03 1.78 0.58
55 INT291258 INS Positive_regulation of Mapk1 1 0.04 1.77 0.58
56 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
57 INT148172 Mapk1 Positive_regulation of Phosphorylation of Kcnd2 1 0.49 0.55 0.57
58 INT201949 CXCL10 Positive_regulation of Phosphorylation of MAPK1 1 0.15 0.79 0.55
59 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
60 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
61 INT85125 IL3 Positive_regulation of MAPK1 1 0.30 0.81 0.53
62 INT85121 CSF2 Positive_regulation of MAPK1 1 0.07 0.8 0.53
63 INT85115 IL5 Positive_regulation of MAPK1 1 0.14 0.81 0.53
64 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
65 INT171910 MAPK1 Positive_regulation of MAPK9 1 0.10 1.55 0.52
66 INT201939 CXCL10 Positive_regulation of MAPK1 1 0.11 0.72 0.52
67 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52
68 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
69 INT122872 SEMA6A Positive_regulation of MAPK1 1 0.56 0 0.52
70 INT97949 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of CDC42 1 0.06 0.72 0.51
71 INT131368 MAPK1 Positive_regulation of Bcar3 1 0.00 0.37 0.51
72 INT131369 MAPK1 Positive_regulation of Il4 1 0.01 0.37 0.51
73 INT356286 Ngf Regulation of Positive_regulation of Mapk1 1 0.03 0.76 0.5
74 INT97953 ST3GAL3 Positive_regulation of CDC42 1 0.09 0.7 0.5
75 INT356279 Gdnf Regulation of Positive_regulation of Mapk1 1 0.03 0.76 0.5
76 INT194676 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL10 1 0.05 0.34 0.5
77 INT102553 HGF Positive_regulation of Phosphorylation of MAPK1 1 0.40 0.49 0.48
78 INT185917 Binding of AR and MAPK1 1 0.07 0.5 0.47
79 INT102555 HGF Positive_regulation of MAPK1 1 0.38 0.47 0.47
80 INT265646 Binding of Mapk1 and Mapk14 1 0.01 1.53 0.46
81 INT254198 Mapk1 Positive_regulation of Mapk8 1 0.01 0.87 0.46
82 INT254216 Mapk14 Positive_regulation of Mapk1 1 0.02 0.87 0.46
83 INT254222 Mapk1 Positive_regulation of Mapk14 1 0.02 0.86 0.46
84 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 0.48 1.85 0.45
85 INT190870 BDNF Positive_regulation of Phosphorylation of Mapk1 1 0.12 0.54 0.44
86 INT343846 MAPK1 Positive_regulation of FOS 1 0.04 1.29 0.44
87 INT223863 Positive_regulation of Mapk1 Positive_regulation of Positive_regulation of Ltp 1 0.31 0 0.43
88 INT264473 Il1a Positive_regulation of Mapk1 1 0.00 0 0.43
89 INT188211 IL6 Regulation of MAPK1 1 0.16 1.13 0.43
90 INT265647 Binding of Ephb1 and Mapk1 1 0.00 1.48 0.43
91 INT264471 Il1a Positive_regulation of Gene_expression of Mapk1 1 0.01 0 0.43
92 INT238913 MAPK3 Regulation of Positive_regulation of MAPK1 1 0.11 0.39 0.42
93 INT161521 Negative_regulation of H2-M3 Positive_regulation of Mapk1 1 0.14 0.41 0.42
94 INT194722 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of CRP 1 0.09 1.49 0.41
95 INT274864 Negative_regulation of Mapk1 Negative_regulation of Gene_expression of TNF 1 0.05 1.15 0.41
96 INT161522 H2-M3 Positive_regulation of Mapk1 1 0.15 0.41 0.41
97 INT274867 Negative_regulation of Mapk1 Negative_regulation of TNF 1 0.03 1.15 0.41
98 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
99 INT124260 Plat Positive_regulation of Mapk1 1 0.14 0.81 0.41
100 INT75489 Binding of SGCG and Tgfbr2 1 0.23 0.83 0.41
101 INT194705 Negative_regulation of MAPK1 Negative_regulation of Positive_regulation of IK 1 0.00 1.46 0.41
102 INT75487 Binding of TGFB1 and Tgfbr2 1 0.31 0.83 0.41
103 INT113474 MAPK1 Negative_regulation of TNF 1 0.13 0.23 0.4
104 INT346222 Positive_regulation of Braf Positive_regulation of Map2k1 1 0.15 0.67 0.39
105 INT152237 Mapk1 Positive_regulation of Localization of Tlr4 1 0.33 0.13 0.39
106 INT152239 Mapk1 Positive_regulation of Localization of Nfkb1 1 0.29 0.13 0.39
107 INT339511 Binding of Tlr4 and Traf6 1 0.05 0.12 0.38
108 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 0.05 0.17 0.38
109 INT194713 MAPK1 Regulation of Gene_expression of TNF 1 0.10 1.66 0.38
110 INT339506 Binding of Irak1 and Traf6 1 0.03 0.12 0.37
111 INT207643 Prkca Positive_regulation of Mapk1 1 0.09 0.17 0.37
112 INT304501 Binding of Ephb1 and Mapk1 1 0.18 0.69 0.36
113 INT274941 Ephb2 Regulation of Phosphorylation of Mapk1 1 0.19 0 0.36
114 INT112619 Mapk9 Regulation of Il1b 1 0.16 1.11 0.36
115 INT112620 Mapk9 Regulation of Tnf 1 0.16 1.11 0.36
116 INT304505 Binding of Mapk1 and Uts2d 1 0.01 0.64 0.36
117 INT304532 Binding of Mdk and Mapk1 1 0.02 0.63 0.35
118 INT274865 Positive_regulation of Mapk1 Negative_regulation of Gene_expression of TNF 1 0.04 1.08 0.35
119 INT304495 Trib3 Positive_regulation of Mapk1 1 0.02 1.4 0.35
120 INT304529 Negative_regulation of Binding of Mdk and Mapk1 1 0.02 0.63 0.35
121 INT144966 MAPK1 Positive_regulation of Localization of EGR1 1 0.08 0.83 0.35
122 INT167156 FPR1 Positive_regulation of MAPK1 1 0.18 0.09 0.35
123 INT188193 Negative_regulation of EGF Positive_regulation of MAPK1 1 0.28 0.54 0.34
124 INT156831 EGF Positive_regulation of MAPK1 2 0.45 0.27 0.33
125 INT324690 Binding of Traf6 and Ticam1 2 0.07 0.23 0.33
126 INT190652 Mdk Positive_regulation of Phosphorylation of Mapk1 2 0.50 0.85 0.33
127 INT274866 Mapk1 Positive_regulation of Gene_expression of TNF 1 0.06 0.35 0.33
128 INT167155 FPR1 Positive_regulation of Phosphorylation of MAPK1 1 0.18 0.17 0.33
129 INT337112 Negative_regulation of Nr1d2-rs2 Positive_regulation of Mapk1 1 0.00 0.14 0.33
130 INT124475 MAP2K1 Positive_regulation of Positive_regulation of CPOX 1 0.04 0.68 0.33
131 INT280814 Positive_regulation of Mapk1 Positive_regulation of Transcription of Fos 1 0.02 0.06 0.33
132 INT151132 Negative_regulation of Map2k7 Negative_regulation of Gene_expression of Litaf 1 0.01 0.29 0.32
133 INT203089 Binding of Il1a and Traf6 1 0.04 0.66 0.32
134 INT348016 Binding of Mapk8 and Mapk8ip3 1 0.04 2.09 0.32
135 INT346286 ELANE Positive_regulation of MAPK1 1 0.06 0.65 0.32
136 INT346281 Binding of ELANE and MAPK1 1 0.04 0.65 0.32
137 INT291240 Map3k8 Positive_regulation of Positive_regulation of Mapk1 1 0.16 0.72 0.32
138 INT203086 Positive_regulation of Binding of Il1a and Traf6 1 0.06 0.67 0.32
139 INT291241 Map3k8 Positive_regulation of Gene_expression of Mapk1 1 0.17 0.72 0.32
140 INT285567 Binding of IL1B and Cdc42 1 0.03 0.77 0.31
141 INT286708 Negative_regulation of Mapk1 Negative_regulation of Casp3 1 0.12 0 0.31
142 INT194710 MAPK1 Regulation of Gene_expression of IK 1 0.00 0.24 0.31
143 INT100029 TNF Positive_regulation of Mapk1 1 0.01 0.78 0.31
144 INT337111 Positive_regulation of Nr1d2-rs2 Negative_regulation of Positive_regulation of Mapk1 1 0.00 0.15 0.31
145 INT330100 Binding of Sh3rf1 and Map3k11 1 0.08 1.21 0.31
146 INT170496 Egf Positive_regulation of Mapk1 3 0.21 0.5 0.3
147 INT112797 Positive_regulation of CASP1 Positive_regulation of MAPK1 1 0.02 0.16 0.3
148 INT356287 Ngf Positive_regulation of Mapk1 1 0.05 0.17 0.3
149 INT304504 Mapk1 Positive_regulation of Nos1 1 0.29 0.93 0.3
150 INT356278 Gdnf Positive_regulation of Mapk1 1 0.05 0.17 0.3
151 INT286702 Positive_regulation of Mapk1 Positive_regulation of Positive_regulation of Rps6ka5 1 0.37 0.18 0.29
152 INT286705 Positive_regulation of Mapk1 Positive_regulation of Phosphorylation of Rps6ka5 1 0.37 0.18 0.29
153 INT291254 MAP3K3 Regulation of Mapk1 1 0.00 1.25 0.29
154 INT291242 Positive_regulation of Mdk Regulation of Mapk1 1 0.03 1.28 0.29
155 INT286703 Mapk1 Positive_regulation of Phosphorylation of Hist1h3f 1 0.22 0.18 0.29
156 INT286706 Mapk1 Positive_regulation of Phosphorylation of Rps6ka5 1 0.37 0.18 0.29
157 INT112805 CASP1 Positive_regulation of MAPK1 1 0.02 0.16 0.29
158 INT286699 Positive_regulation of Mapk1 Positive_regulation of Phosphorylation of Creb1 1 0.22 0.18 0.28
159 INT130107 YY1 Positive_regulation of MAPK1 1 0.45 0 0.28
160 INT132365 Lgals1 Positive_regulation of Mapk1 1 0.03 0.13 0.28
161 INT264472 Mapk1 Regulation of Positive_regulation of Jun 1 0.02 0 0.28
162 INT194821 MAPK1 Regulation of Hand2 1 0.03 1.27 0.28
163 INT286704 Mapk1 Positive_regulation of Phosphorylation of Creb1 1 0.32 0.18 0.28
164 INT280825 Mapk1 Positive_regulation of Avp 1 0.01 0.08 0.28
165 INT130106 Regulation of YY1 Positive_regulation of MAPK1 1 0.41 0 0.28
166 INT323710 TRAF6 Regulation of MIR146A 1 0.06 0.55 0.28
167 INT280807 Mapk1 Positive_regulation of Positive_regulation of Prkcg 1 0.01 0.08 0.28
168 INT286707 Mapk1 Positive_regulation of Positive_regulation of Rps6ka5 1 0.37 0.18 0.28
169 INT130108 DLL3 Negative_regulation of Positive_regulation of MAPK1 1 0.13 0 0.28
170 INT207634 Prkca Negative_regulation of Positive_regulation of Mapk1 1 0.08 0.1 0.28
171 INT291257 Map3k8 Regulation of Positive_regulation of MAPK1 1 0.09 1 0.28
172 INT141109 Sftpa1 Positive_regulation of Mapk1 1 0.77 0.65 0.27
173 INT194682 Negative_regulation of MAPK1 Positive_regulation of Gene_expression of IL10 1 0.05 0.17 0.27
174 INT270256 MAPK1 Positive_regulation of Mknk1 1 0.03 0.52 0.27
175 INT188209 OSM Positive_regulation of MAPK1 1 0.35 0.47 0.27
176 INT171912 MAPK8IP3 Positive_regulation of MAPK9 1 0.06 0.78 0.26
177 INT171384 Egf Negative_regulation of Positive_regulation of Mapk1 1 0.16 0.24 0.26
178 INT314040 THL Regulation of Mapk1 1 0.28 0.67 0.26
179 INT118849 GNA14 Positive_regulation of MAPK1 1 0.00 0.14 0.26
180 INT171911 MAPK8IP3 Positive_regulation of Gene_expression of MAPK14 1 0.05 0.77 0.26
181 INT236005 Positive_regulation of MAPK1 Positive_regulation of Binding of Map2 1 0.04 0 0.25
182 INT132839 TPT1 Regulation of Mapk1 1 0.01 0.07 0.25
183 INT207641 Positive_regulation of Prkca Positive_regulation of Mapk1 1 0.08 0.09 0.24
184 INT236004 Positive_regulation of MAPK1 Positive_regulation of Phosphorylation of Map2 1 0.04 0 0.24
185 INT261650 LGR6 Positive_regulation of MAPK1 1 0.04 0.71 0.24
186 INT144967 MAPK1 Positive_regulation of Positive_regulation of EGR1 1 0.08 0.63 0.24
187 INT207632 Prkca Positive_regulation of Phosphorylation of Mapk1 1 0.08 0 0.23
188 INT194702 MAPK1 Negative_regulation of Gene_expression of IL10 1 0.05 0.16 0.23
189 INT292565 MAP3K5 Positive_regulation of Positive_regulation of CDC42 1 0.02 0 0.23
190 INT161175 Binding of Trpc6 and Mapk1 1 0.32 1.49 0.23
191 INT115143 MAPK1 Positive_regulation of TFAM 2 0.02 0.49 0.22
192 INT188195 GOPC Positive_regulation of MAPK1 2 0.21 0.32 0.22
193 INT283857 APOA5 Positive_regulation of Positive_regulation of MAPK1 1 0.00 0.6 0.22
194 INT112804 IL4I1 Positive_regulation of Positive_regulation of MAPK1 1 0.03 0 0.22
195 INT346224 Braf Negative_regulation of Phosphorylation of Map2k1 1 0.14 0.62 0.22
196 INT103356 Positive_regulation of Binding of Mapk1 and Mapk3 1 0.41 0.17 0.22
197 INT103358 Binding of Mapk1 and Mink1 1 0.07 0.17 0.22
198 INT194725 MAPK1 Regulation of Transcription of IK 1 0.00 0.06 0.22
199 INT103357 Binding of Mapk1 and Mapk3 1 0.32 0.17 0.22
200 INT266038 Atp6v1e1 Positive_regulation of Positive_regulation of Mapk1 1 0.07 0.64 0.22

Single Events

The table below shows the top 100 pain related interactions that have been reported for mitogen-activated protein kinase kinase kinase binding. They are ordered first by their pain relevance and then by number of times they were reported in mitogen-activated protein kinase kinase kinase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
2 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
3 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
4 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
5 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
6 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
7 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
8 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
9 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
10 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
11 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
12 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
13 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
14 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
15 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
16 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31
17 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59
18 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
19 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
20 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
21 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37
22 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25
23 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
24 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41
25 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
26 INT109432 Negative_regulation of Phosphorylation of Mapk1 19 0.54 7.01 8.98
27 INT126848 Positive_regulation of Phosphorylation of Mapk1 30 0.50 15.94 8.34
28 INT135443 Phosphorylation of Map2k1 11 0.80 2.44 8.01
29 INT171367 Phosphorylation of Map2k1 31 0.58 32.87 8
30 INT135441 Positive_regulation of Map2k1 15 0.67 6.6 7.87
31 INT48928 Positive_regulation of Gene_expression of Mapk1 19 0.48 9.38 6.59
32 INT93137 Negative_regulation of Map2k1 17 0.42 4.51 6.49
33 INT139964 Regulation of Phosphorylation of Mapk1 12 0.58 10.04 6.1
34 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
35 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
36 INT135440 Positive_regulation of Phosphorylation of Map2k1 5 0.49 1.32 5.22
37 INT108919 Positive_regulation of Mapk9 9 0.34 3.55 4.74
38 INT158416 Localization of Mapk1 19 0.67 5.32 4.18
39 INT133244 Regulation of Positive_regulation of Mapk1 11 0.43 3.52 4.03
40 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
41 INT113924 Binding of Mapk1 27 0.38 8.64 3.84
42 INT75485 Gene_expression of Tgfbr2 10 0.57 10.98 3.76
43 INT104480 Phosphorylation of Mapk9 8 0.80 6.59 3.62
44 INT133086 Positive_regulation of Phosphorylation of Map2k7 1 0.05 4.34 3.27
45 INT72618 Regulation of Tcf3 5 0.44 1.48 3.16
46 INT171368 Regulation of Phosphorylation of Mapk1 14 0.61 4.77 3.14
47 INT133082 Phosphorylation of Map2k7 5 0.15 4.27 3.05
48 INT134470 Positive_regulation of Map2k1 74 0.49 46.07 3.02
49 INT133085 Gene_expression of Mapk8ip1 7 0.66 6.13 2.98
50 INT200895 Localization of Mapk1 6 0.67 2.08 2.82
51 INT169112 Negative_regulation of Positive_regulation of Mapk1 9 0.59 1.84 2.78
52 INT145821 Negative_regulation of Gene_expression of Mapk1 16 0.41 8.05 2.77
53 INT95737 Positive_regulation of Phosphorylation of Mapk8ip1 2 0.06 3.27 2.74
54 INT152927 Negative_regulation of Mapk1 16 0.41 5.85 2.73
55 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
56 INT133083 Positive_regulation of Gene_expression of Mapk8ip1 1 0.07 3.27 2.47
57 INT186116 Regulation of Gene_expression of MAPK1 9 0.44 5.85 2.32
58 INT95736 Phosphorylation of Mapk8ip1 2 0.10 2.84 2.32
59 INT128926 Gene_expression of Map2k7 5 0.23 3.01 2.31
60 INT170482 Regulation of Gene_expression of Mapk1 5 0.43 5.73 2.1
61 INT127756 Negative_regulation of Map2k1 10 0.41 6.69 2.04
62 INT72616 Negative_regulation of Tcf3 2 0.41 0.97 2.04
63 INT109906 Localization of MAPK1 12 0.54 1.68 2.01
64 INT83709 Negative_regulation of Gene_expression of MAPK1 12 0.41 6.57 2.01
65 INT108921 Negative_regulation of Positive_regulation of Mapk9 3 0.25 1.8 1.99
66 INT104478 Positive_regulation of Mapk9 5 0.67 5.56 1.81
67 INT133084 Positive_regulation of Gene_expression of Map2k7 3 0.17 2.56 1.8
68 INT135444 Regulation of Map2k1 4 0.44 1.15 1.77
69 INT104479 Negative_regulation of Mapk9 3 0.37 2.83 1.69
70 INT169461 Regulation of Gene_expression of Mapk1 7 0.44 1.64 1.61
71 INT142678 Positive_regulation of Phosphorylation of Mapk9 4 0.51 2.1 1.6
72 INT130019 Regulation of Phosphorylation of MAPK1 6 0.49 3.6 1.5
73 INT142676 Phosphorylation of Mapk9 5 0.61 1.48 1.48
74 INT190646 Regulation of Regulation of Mapk1 1 0.30 1.16 1.43
75 INT104121 Positive_regulation of MAP2K1 8 0.61 4.84 1.41
76 INT153627 Binding of Mapk1 5 0.36 2.88 1.4
77 INT159784 Gene_expression of Mapk9 8 0.61 6.28 1.37
78 INT175525 Positive_regulation of Phosphorylation of Map2k1 8 0.33 7.02 1.37
79 INT71782 Gene_expression of MAP2K1 7 0.68 3.17 1.37
80 INT142679 Negative_regulation of Phosphorylation of Mapk9 1 0.17 0.51 1.37
81 INT104027 Negative_regulation of Negative_regulation of MAPK1 6 0.56 2.87 1.35
82 INT90226 Gene_expression of Mapk9 3 0.65 1.94 1.34
83 INT143646 Negative_regulation of Mapk8ip1 5 0.03 5.46 1.28
84 INT190067 Binding of Traf2 5 0.20 3.28 1.27
85 INT298979 Gene_expression of Traf6 5 0.31 1.75 1.21
86 INT72614 Negative_regulation of Regulation of Tcf3 1 0.41 0.17 1.2
87 INT97955 Positive_regulation of CDC42 8 0.49 2.47 1.19
88 INT140054 Negative_regulation of Mapk9 3 0.25 1.9 1.05
89 INT138287 Gene_expression of Map2k1 69 0.65 46.14 1.02
90 INT161682 Positive_regulation of Cdc42 8 0.53 4.55 0.9
91 INT196583 Regulation of Phosphorylation of Mapk9 1 0.37 0.5 0.85
92 INT104482 Positive_regulation of Phosphorylation of Mapk9 2 0.49 1.55 0.84
93 INT71778 Positive_regulation of Gene_expression of MAP2K1 2 0.36 0.37 0.81
94 INT30050 Gene_expression of Tcf3 13 0.48 2.57 0.77
95 INT194780 Regulation of Negative_regulation of MAPK1 3 0.32 3.42 0.76
96 INT211909 Regulation of Positive_regulation of Map2k1 1 0.21 0.47 0.76
97 INT104488 Negative_regulation of Phosphorylation of Mapk9 1 0.41 1.03 0.72
98 INT128925 Negative_regulation of Map2k7 2 0.10 0.66 0.68
99 INT188799 Positive_regulation of Protein_catabolism of Traf6 2 0.19 1.98 0.62
100 INT180107 Regulation of Cdc42 3 0.16 0.18 0.6
101 INT105266 Localization of Tcf3 3 0.32 1.08 0.59
102 INT75524 Positive_regulation of Regulation of MAPK1 1 0.43 1.12 0.59
103 INT154745 Protein_catabolism of Traf2 1 0.86 1.04 0.59
104 INT154750 Positive_regulation of Protein_catabolism of Traf2 1 0.60 1.05 0.59
105 INT294555 Negative_regulation of Traf2 1 0.06 1.24 0.58
106 INT104483 Positive_regulation of Positive_regulation of Mapk9 1 0.49 0.75 0.56
107 INT97956 Negative_regulation of CDC42 3 0.27 1.58 0.55
108 INT104484 Regulation of Mapk9 1 0.12 0.73 0.55
109 INT179405 Positive_regulation of Map2k7 1 0.16 1.32 0.55
110 INT190645 Positive_regulation of Negative_regulation of Mapk1 1 0.44 0.39 0.54
111 INT104120 Positive_regulation of Positive_regulation of MAP2K1 1 0.49 0 0.54
112 INT170475 Negative_regulation of Gene_expression of Mapk1 7 0.41 2.44 0.53
113 INT190074 Positive_regulation of Traf2 1 0.19 0.37 0.52
114 INT151125 Negative_regulation of Localization of Map2k7 1 0.08 0.61 0.51
115 INT128924 Regulation of Map2k7 3 0.08 0.87 0.5
116 INT151121 Localization of Map2k7 1 0.14 0.59 0.5
117 INT236915 Binding of Map2k1 2 0.15 1.51 0.49
118 INT92328 Gene_expression of Map3k11 1 0.06 0.46 0.49
119 INT109911 Positive_regulation of Localization of MAPK1 4 0.33 0.56 0.48
120 INT167975 Negative_regulation of Gene_expression of Mapk9 2 0.02 1.18 0.47
121 INT188800 Protein_catabolism of Traf6 2 0.40 1.6 0.45
122 INT167981 Negative_regulation of Negative_regulation of Mapk8ip1 1 0.01 0.91 0.45
123 INT159151 Negative_regulation of Negative_regulation of Mapk1 1 0.32 0.38 0.45
124 INT209891 Regulation of Gene_expression of TRAF6 2 0.22 1.4 0.41
125 INT202347 Gene_expression of Map2k4 13 0.74 11.68 0.4
126 INT179413 Positive_regulation of Mapk8ip1 1 0.01 0.97 0.4
127 INT138282 Positive_regulation of Gene_expression of Map2k1 13 0.49 7.46 0.39
128 INT274923 Protein_catabolism of Mapk1 1 0.47 0 0.39
129 INT274911 Positive_regulation of Protein_catabolism of Mapk1 1 0.27 0 0.39
130 INT120899 Positive_regulation of Gene_expression of Tgfbr2 1 0.29 0.46 0.38
131 INT304528 Gene_expression of Map2k1 3 0.58 1.76 0.37
132 INT30052 Positive_regulation of Tcf3 3 0.41 0.27 0.37
133 INT128918 Negative_regulation of Gene_expression of Map2k7 1 0.02 0.37 0.37
134 INT274074 Binding of Map2k4 1 0.08 1.98 0.36
135 INT217464 Binding of Traf6 5 0.29 1.28 0.35
136 INT121782 Transcription of Mapk1 3 0.50 1.58 0.35
137 INT342161 Positive_regulation of Gene_expression of Mapk9 1 0.09 0.63 0.35
138 INT109907 Protein_catabolism of MAPK1 2 0.58 1.82 0.34
139 INT130113 Regulation of Regulation of MAPK1 1 0.22 0.16 0.33
140 INT203075 Positive_regulation of Traf6 1 0.16 0.67 0.32
141 INT203074 Positive_regulation of Positive_regulation of Traf6 1 0.16 0.67 0.32
142 INT304526 Binding of Map2k1 1 0.11 0.6 0.32
143 INT330099 Binding of Map3k11 1 0.24 1.21 0.31
144 INT202360 Positive_regulation of Map2k4 2 0.48 9.89 0.29
145 INT240205 Regulation of MAP2K1 3 0.26 0.44 0.28
146 INT209886 Positive_regulation of TRAF6 2 0.39 1.27 0.28
147 INT95740 Negative_regulation of Phosphorylation of Mapk8ip1 1 0.01 0 0.27
148 INT323753 Negative_regulation of Gene_expression of TRAF6 1 0.21 0.52 0.26
149 INT109931 Positive_regulation of Protein_catabolism of MAPK1 1 0.33 0.14 0.24
150 INT194801 Binding of MAPK1 7 0.29 1.9 0.23
151 INT183881 Localization of CDC42 3 0.49 1.92 0.23
152 INT175506 Regulation of Positive_regulation of Map2k1 2 0.32 1.58 0.23
153 INT154934 Negative_regulation of Positive_regulation of Mapk9 1 0.35 0.41 0.23
154 INT140059 Localization of Mapk9 1 0.28 0.61 0.23
155 INT210927 Positive_regulation of Traf6 4 0.32 0.99 0.22
156 INT164149 Negative_regulation of Localization of Mapk1 3 0.33 1.32 0.22
157 INT304519 Positive_regulation of Gene_expression of Map2k1 1 0.15 0.41 0.22
158 INT200898 Positive_regulation of Localization of Mapk1 1 0.30 0 0.22
159 INT261680 Positive_regulation of Negative_regulation of MAPK1 2 0.33 1.2 0.21
160 INT323720 Negative_regulation of TRAF6 1 0.21 0.41 0.21
161 INT254173 Transcription of Traf6 1 0.25 0.26 0.21
162 INT183876 Regulation of CDC42 3 0.30 1.94 0.19
163 INT151131 Negative_regulation of Phosphorylation of Map2k7 1 0.10 0.31 0.19
164 INT178411 Regulation of Negative_regulation of Mapk1 1 0.44 0.94 0.19
165 INT343887 Positive_regulation of Gene_expression of TRAF6 1 0.16 0.21 0.19
166 INT356268 Regulation of Localization of Mapk1 1 0.04 0.35 0.17
167 INT257557 Negative_regulation of MAP3K11 3 0.30 2.38 0.16
168 INT154744 Regulation of Protein_catabolism of Traf2 1 0.39 0.18 0.16
169 INT197290 Gene_expression of Cdc42 9 0.35 2.52 0.15
170 INT190389 Transcription of MAPK1 2 0.44 2.58 0.15
171 INT188688 Regulation of Traf6 1 0.24 0.15 0.15
172 INT254671 Regulation of Map2k1 5 0.43 1.83 0.14
173 INT323747 Regulation of TRAF6 1 0.13 1.15 0.14
174 INT265533 Negative_regulation of Phosphorylation of Map2k1 1 0.41 0 0.14
175 INT175527 Localization of Map2k1 4 0.31 2.41 0.13
176 INT90229 Transcription of Tcf3 2 0.12 0.39 0.13
177 INT167723 Positive_regulation of Localization of Mapk1 2 0.10 0.76 0.13
178 INT251559 Binding of Traf2 1 0.23 1.68 0.13
179 INT206133 Binding of CDC42 3 0.25 0.8 0.12
180 INT236920 Positive_regulation of Binding of Mapk1 2 0.39 0.71 0.12
181 INT323728 Phosphorylation of TRAF6 1 0.39 0.79 0.12
182 INT140057 Negative_regulation of Negative_regulation of Mapk9 1 0.15 0.31 0.12
183 INT254673 Positive_regulation of Positive_regulation of Map2k1 3 0.35 1.65 0.11
184 INT140051 Negative_regulation of Localization of Mapk9 1 0.20 0.31 0.11
185 INT302772 Regulation of Map2k7 1 0.02 0.33 0.11
186 INT188350 Localization of Map2k4 2 0.67 0.46 0.09
187 INT251560 Positive_regulation of Traf2 1 0.13 0.47 0.09
188 INT197282 Positive_regulation of Gene_expression of Cdc42 3 0.26 0.12 0.08
189 INT175210 Binding of TRAF6 2 0.17 0.73 0.08
190 INT274825 Negative_regulation of Negative_regulation of Mapk1 1 0.08 0.06 0.08
191 INT215418 Positive_regulation of Phosphorylation of MAP2K1 1 0.03 0.51 0.08
192 INT215420 Phosphorylation of MAP2K1 1 0.05 0.51 0.08
193 INT347978 Positive_regulation of Phosphorylation of Map2k7 1 0.27 1.08 0.08
194 INT178419 Regulation of Mapk9 1 0.09 0.76 0.08
195 INT280787 Gene_expression of Mapk8ip3 1 0.01 0.24 0.07
196 INT254642 Binding of Mapk8ip1 1 0.32 0.22 0.07
197 INT206169 Gene_expression of CDC42 2 0.26 1.05 0.05
198 INT206167 Positive_regulation of Gene_expression of CDC42 1 0.08 0.05 0.05
199 INT281759 Negative_regulation of Map2k7 1 0.03 0.2 0.05
200 INT202363 Phosphorylation of Map2k4 11 0.79 2.94 0.04
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