GO:0031558

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Name induction of apoptosis in response to chemical stimulus
Categary Process
Go Slim No
Go Link GO:0031558
Unique Molecular Interactions 314
Total Molecular Interactions 363
Total Single Events 3427
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for induction of apoptosis in response to chemical stimulus. They are ordered first by their pain relevance and then by number of times they were reported for induction of apoptosis in response to chemical stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
2 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
3 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
4 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
5 INT21570 Binding of Cck and Mapk8 1 0.06 0 1.6
6 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
7 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
8 INT167429 Negative_regulation of Mapk8 Negative_regulation of RYBP 1 0.01 1.11 1.09
9 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
10 INT223875 Negative_regulation of Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.31 0 1.07
11 INT196578 Ephb1 Positive_regulation of Phosphorylation of Mapk9 1 0.13 0.5 0.85
12 INT196576 Trib3 Positive_regulation of Phosphorylation of Mapk9 1 0.02 0.5 0.85
13 INT140280 Negative_regulation of Binding of Adora2a and Grina 1 0.21 0.64 0.82
14 INT140281 Binding of Adora2a and Grina 1 0.19 0.64 0.82
15 INT222024 Mapk8 Regulation of Mapk14 2 0.17 0.83 0.79
16 INT158684 MAPK8 Positive_regulation of Gene_expression of BCL2L11 1 0.51 0.44 0.78
17 INT152234 Mapk8 Positive_regulation of Localization of Nfkb1 1 0.33 0.26 0.78
18 INT152235 Mapk8 Positive_regulation of Localization of Tlr4 1 0.38 0.26 0.78
19 INT72017 Binding of Adora2a and Ptprg 2 0.07 0 0.77
20 INT76498 Binding of Tacr1 and Adora2a 1 0.09 0 0.77
21 INT116803 Phosphorylation of Camk2b Positive_regulation of Camk4 1 0.03 0 0.76
22 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
23 INT116805 Phosphorylation of Camk2b Positive_regulation of Camk2a 1 0.07 0 0.76
24 INT82040 Adora2a Positive_regulation of Phosphorylation of Ppp1r1b 1 0.11 0 0.75
25 INT98179 Aap Positive_regulation of Mapk8 1 0.01 0.75 0.74
26 INT168420 Positive_regulation of Mapk8 Positive_regulation of Phosphorylation of Jun 1 0.30 0.88 0.74
27 INT128813 Mapk8 Regulation of Gene_expression of Nos2 1 0.23 0.46 0.74
28 INT82041 Positive_regulation of Adora2a Positive_regulation of Phosphorylation of Ppp1r1b 1 0.12 0 0.72
29 INT223873 Mapk8 Regulation of Positive_regulation of Ltp 1 0.24 0 0.71
30 INT223869 Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.20 0 0.68
31 INT194857 Positive_regulation of Adora2a Positive_regulation of Gene_expression of Vegfa 1 0.23 0.74 0.67
32 INT110458 Binding of Atf2 and Mapk8 1 0.35 0 0.66
33 INT330046 Mapk8 Negative_regulation of Prkcg 1 0.13 0.4 0.66
34 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
35 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
36 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
37 INT239501 Binding of Adora2a and Mtx1 1 0.24 0.95 0.64
38 INT158685 ROS1 Regulation of Positive_regulation of MAPK8 1 0.21 0.39 0.64
39 INT100030 TNF Positive_regulation of Mapk8 1 0.12 1.57 0.63
40 INT169295 PTPLA Positive_regulation of MAPK8 1 0.10 0.15 0.63
41 INT128812 Mapk8 Negative_regulation of Gene_expression of Nos2 1 0.19 0.37 0.61
42 INT112699 Bid Regulation of Bax 1 0.25 0.51 0.61
43 INT178437 Mapk8 Positive_regulation of Jun 3 0.40 2.69 0.58
44 INT278689 TNF Positive_regulation of MAPK8 1 0.04 0.79 0.56
45 INT215644 Binding of Drd2 and Adora2a 1 0.03 0.23 0.55
46 INT200913 Dio1 Positive_regulation of Mapk8 1 0.00 0 0.53
47 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
48 INT171910 MAPK1 Positive_regulation of MAPK9 1 0.10 1.55 0.52
49 INT115184 Regulation of CASP1 Positive_regulation of MAPK9 1 0.09 0 0.49
50 INT115183 CASP1 Positive_regulation of Positive_regulation of MAPK9 1 0.16 0 0.48
51 INT115185 CASP1 Positive_regulation of MAPK9 1 0.15 0 0.48
52 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
53 INT254225 Mapk14 Positive_regulation of Mapk8 1 0.02 0.87 0.46
54 INT254198 Mapk1 Positive_regulation of Mapk8 1 0.01 0.87 0.46
55 INT238638 Gopc Negative_regulation of Gene_expression of Bax 1 0.04 0.85 0.45
56 INT278950 MAPK8 Negative_regulation of Localization of EPHB2 1 0.25 0.47 0.43
57 INT264476 Il1a Positive_regulation of Gene_expression of Mapk8 1 0.04 0 0.43
58 INT116931 OPRK1 Regulation of MAPK8 1 0.31 0.07 0.43
59 INT264475 Il1a Positive_regulation of Mapk8 1 0.04 0 0.43
60 INT137834 Binding of CAMK2B and CTS 1 0.05 1.38 0.42
61 INT89666 Binding of Adora2a and Drd2 1 0.54 0.4 0.42
62 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
63 INT319312 Socs4 Positive_regulation of Mapk8 1 0.05 0.68 0.41
64 INT302871 Negative_regulation of Adora2a Positive_regulation of Phosphorylation of Th 1 0.26 0.12 0.4
65 INT179938 Negative_regulation of Mapk8 Negative_regulation of TNF 1 0.02 1.09 0.37
66 INT187233 Positive_regulation of Mapk8 Positive_regulation of Jun 1 0.12 0.92 0.37
67 INT264480 Il1a Positive_regulation of Phosphorylation of Mapk8 1 0.04 0 0.37
68 INT309120 Edc4 Negative_regulation of Positive_regulation of Mapk8 1 0.01 1.03 0.36
69 INT112619 Mapk9 Regulation of Il1b 1 0.16 1.11 0.36
70 INT112620 Mapk9 Regulation of Tnf 1 0.16 1.11 0.36
71 INT308653 Proc Regulation of Gene_expression of Mapk8 1 0.00 1.48 0.36
72 INT239503 Binding of Adora2a and Aes 1 0.24 0.85 0.35
73 INT330106 Racgap1 Positive_regulation of Positive_regulation of Mapk8 1 0.01 1.32 0.35
74 INT155061 Stat3 Negative_regulation of Bax 1 0.22 3.71 0.34
75 INT330105 Rac1 Positive_regulation of Mapk8 1 0.15 1.47 0.34
76 INT115162 Adora2a Regulation of Gene_expression of Jun 1 0.49 0.36 0.34
77 INT115161 Adora2a Regulation of Gene_expression of Cpe 1 0.04 0.36 0.33
78 INT330103 Rac1 Positive_regulation of Positive_regulation of Mapk8 1 0.14 1.24 0.32
79 INT348016 Binding of Mapk8 and Mapk8ip3 1 0.04 2.09 0.32
80 INT110461 Binding of Mapk8 and Gtf3a 1 0.03 0 0.32
81 INT282421 Mapk8 Negative_regulation of Ins1 1 0.06 2.48 0.31
82 INT253153 TNF Positive_regulation of Mapk8 1 0.18 0.61 0.31
83 INT167983 Mapk8 Negative_regulation of gr 1 0.02 0.5 0.31
84 INT253155 TNF Positive_regulation of Positive_regulation of Mapk8 1 0.19 0.62 0.31
85 INT254122 Adora2a Regulation of Aliq1 1 0.01 0.85 0.3
86 INT112795 Positive_regulation of CASP1 Positive_regulation of MAPK8 1 0.02 0.16 0.3
87 INT112803 CASP1 Positive_regulation of MAPK8 1 0.02 0.16 0.29
88 INT159964 Tnf Positive_regulation of Phosphorylation of Mapk8 1 0.11 0.94 0.29
89 INT226505 Il1rl1 Positive_regulation of Mapk8 1 0.04 0.4 0.29
90 INT226509 Il1rl1 Positive_regulation of Gene_expression of Mapk8 1 0.05 0.4 0.29
91 INT309122 Edc4 Positive_regulation of Phosphorylation of Mapk8 1 0.02 0.73 0.28
92 INT237679 IRF6 Positive_regulation of MAPK8 1 0.00 0.56 0.28
93 INT132368 Mapk8 Positive_regulation of Nfkb1 1 0.17 0.11 0.27
94 INT132369 Mapk8 Positive_regulation of Positive_regulation of Nfkb1 1 0.18 0.12 0.27
95 INT132366 Lgals1 Positive_regulation of Mapk8 1 0.38 0.13 0.27
96 INT132370 Mapk8 Positive_regulation of Ephb1 1 0.15 0.12 0.27
97 INT171912 MAPK8IP3 Positive_regulation of MAPK9 1 0.06 0.78 0.26
98 INT179928 Binding of Ephb1 and Mapk8 1 0.11 0.91 0.26
99 INT171907 MAPK8 Positive_regulation of Gene_expression of MAPK14 1 0.06 0.77 0.26
100 INT171913 MAPK8 Positive_regulation of MAPK9 1 0.07 0.78 0.26
101 INT88555 Adora2a Negative_regulation of Vegfc 1 0.00 0.17 0.25
102 INT330053 Binding of Ros1 and Mapk8 1 0.02 0.88 0.24
103 INT95741 Creb1 Regulation of Mapk8 1 0.39 0 0.23
104 INT292554 MAP3K5 Positive_regulation of MAPK8 1 0.08 0 0.23
105 INT309124 Dlat Negative_regulation of Positive_regulation of Mapk8 1 0.02 0.27 0.22
106 INT224130 Positive_regulation of Adora2a Positive_regulation of ADCY1 1 0.01 0.11 0.22
107 INT224087 Adrbk1 Negative_regulation of Adora2a 1 0.10 0.13 0.22
108 INT309116 Edc4 Negative_regulation of Mapk8 1 0.01 0.43 0.22
109 INT112802 IL4I1 Positive_regulation of Positive_regulation of MAPK8 1 0.04 0 0.22
110 INT72015 Binding of Adora2a and Gnai2 1 0.01 0 0.21
111 INT223828 Binding of GSTP1 and MAPK8 1 0.06 1.8 0.21
112 INT330051 Mapk8 Positive_regulation of Bcl2l11 1 0.13 0.46 0.21
113 INT131718 Mapk8 Regulation of Penk 1 0.46 0.16 0.2
114 INT266414 Binding of HMGB1 and Mapk8 1 0.03 0.91 0.2
115 INT159794 Tnf Positive_regulation of Mapk9 1 0.01 0.42 0.19
116 INT159793 Tnf Positive_regulation of Gene_expression of Mapk9 1 0.01 0.42 0.19
117 INT179935 Binding of Jun and Mapk8 1 0.04 0.61 0.19
118 INT209934 IL1B Positive_regulation of MAPK8 1 0.06 0.37 0.19
119 INT222023 Gpx3 Regulation of Mapk8 1 0.01 1.43 0.18
120 INT299370 Binding of Mapk8 and Life1 1 0.04 0.73 0.18
121 INT155063 Csf2 Negative_regulation of Gene_expression of Bax 1 0.27 1.46 0.18
122 INT284445 Dep1 Positive_regulation of Mapk8 1 0.00 0.58 0.17
123 INT155066 Csf2 Negative_regulation of Bax 1 0.12 1.89 0.17
124 INT148103 MAPK8 Positive_regulation of STK24 1 0.47 1.82 0.17
125 INT349475 Regulation of Bax Regulation of Bcl2 1 0.07 1.35 0.17
126 INT224094 Adrbk1 Regulation of Negative_regulation of Adora2a 1 0.06 0 0.17
127 INT348034 Mapk8ip3 Negative_regulation of Mapk8 1 0.05 0.98 0.16
128 INT255736 Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.14 2.31 0.16
129 INT348019 Negative_regulation of Binding of Mapk8 and Mapk8ip3 1 0.05 1.04 0.16
130 INT336891 Epo Negative_regulation of Transcription of Bax 1 0.10 0.68 0.16
131 INT349476 Bax Regulation of Bcl2 1 0.07 1.33 0.15
132 INT329168 MAPK8 Positive_regulation of Localization of JUN 1 0.12 0.56 0.15
133 INT179934 Mapk8 Regulation of Gene_expression of Mmp9 1 0.06 0.48 0.15
134 INT329172 Phosphorylation of MAPK8 Positive_regulation of Localization of JUN 1 0.12 0.62 0.15
135 INT177914 PRKG1 Positive_regulation of Phosphorylation of MAPK8 1 0.02 1.07 0.14
136 INT177911 PRKG1 Positive_regulation of MAPK8 1 0.02 1.07 0.14
137 INT224129 Binding of DRD2 and Adora2a 1 0.03 0.19 0.14
138 INT134400 Positive_regulation of PRKG1 Positive_regulation of Phosphorylation of MAPK8 1 0.30 1.13 0.14
139 INT273040 Vip Regulation of Bax 1 0.23 1.69 0.13
140 INT273041 Adcyap1 Regulation of Bax 1 0.21 1.69 0.13
141 INT266531 Mapk8 Positive_regulation of Phosphorylation of Olr447 1 0.00 0 0.13
142 INT344314 PDPN Positive_regulation of Phosphorylation of MAPK8 1 0.35 0.67 0.13
143 INT324082 CD40 Positive_regulation of MAPK9 1 0.21 0.64 0.13
144 INT134399 Negative_regulation of MAPK3 Positive_regulation of Phosphorylation of MAPK8 1 0.39 1.14 0.13
145 INT182886 Ros1 Positive_regulation of Mapk8 3 0.09 2.3 0.12
146 INT226192 Protein_catabolism of Bax Positive_regulation of Gtf3a 1 0.00 0.53 0.12
147 INT147357 Mapk9 Positive_regulation of Htr5a 1 0.06 0.76 0.12
148 INT147362 Mapk9 Positive_regulation of Ddit3 1 0.57 0.76 0.12
149 INT147361 Mapk9 Positive_regulation of Tnfrsf10b 1 0.40 0.76 0.12
150 INT352467 Dusp1 Negative_regulation of Mapk8 1 0.02 0.23 0.12
151 INT348786 Tlr4 Positive_regulation of Mapk8 1 0.33 1.09 0.11
152 INT285030 Binding of Bax and Slc25a4 1 0.03 0.84 0.11
153 INT291251 Map3k8 Regulation of Gene_expression of MAPK8 1 0.05 0.52 0.11
154 INT143648 Negative_regulation of Mapk8 Negative_regulation of Gene_expression of Fas 1 0.39 0.21 0.11
155 INT266904 Plat Positive_regulation of Positive_regulation of Mapk8 1 0.03 0.6 0.11
156 INT181076 Map4k4 Positive_regulation of Mapk8 1 0.11 0.47 0.11
157 INT240903 Mapk8 Positive_regulation of Ros1 2 0.09 1.01 0.1
158 INT181569 Binding of Edn1 and Mapk8 1 0.09 2.7 0.1
159 INT348042 Positive_regulation of Mapk8 Regulation of Gene_expression of VEGFA 1 0.03 0.85 0.1
160 INT223827 MAPK8 Positive_regulation of Gene_expression of GSTP1 1 0.12 0.88 0.1
161 INT292555 Binding of MAPK8 and GTPBP4 1 0.00 0.36 0.09
162 INT292569 F2RL1 Positive_regulation of Negative_regulation of MAPK8 1 0.22 0 0.08
163 INT348025 Mapk8 Regulation of Gene_expression of Proc 1 0.00 0.58 0.08
164 INT301631 Gene_expression of Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.09 0.72 0.08
165 INT301659 Gene_expression of Mapk8 Positive_regulation of Positive_regulation of Srebf1 1 0.33 0.8 0.08
166 INT285032 Bnip3 Positive_regulation of Bax 1 0.28 0.77 0.07
167 INT340401 Positive_regulation of Bax Positive_regulation of Binding of Hrk 1 0.01 0.79 0.07
168 INT325274 IL1RAP Positive_regulation of Mapk8 1 0.14 0 0.07
169 INT325262 Il1rap Positive_regulation of Mapk8 1 0.09 0 0.07
170 INT340395 Binding of Bax and Tg(CAG-EGFP)D4Nagy 1 0.02 0.43 0.07
171 INT173660 Map2k6 Positive_regulation of MAPK8 1 0.15 0.27 0.07
172 INT173659 Map2k3 Positive_regulation of MAPK8 1 0.15 0.28 0.07
173 INT266388 S100a6 Negative_regulation of Mapk8 1 0.03 0.49 0.06
174 INT178438 Mapk8 Positive_regulation of Plau 1 0.06 0.52 0.06
175 INT348030 Mapk8 Regulation of Re 1 0.17 0.95 0.06
176 INT223825 GSTP1 Negative_regulation of MAPK8 1 0.11 1.53 0.06
177 INT218676 Mapk8 Regulation of Mapk14 1 0.00 0.33 0.05
178 INT181571 Binding of Mapk8 and Mapk1 1 0.04 1.24 0.05
179 INT218703 Mapk8 Regulation of EPHB2 1 0.04 0.33 0.05
180 INT242974 Mapk8 Negative_regulation of Positive_regulation of Esr1 1 0.01 1.39 0.05
181 INT286049 Binding of MAPK8 and Wwox 1 0.31 0.26 0.05
182 INT341542 Binding of DUSP4 and MAPK8 1 0.04 0.28 0.05
183 INT218667 Olr811 Regulation of Mapk8 1 0.00 0.33 0.05
184 INT341533 DUSP4 Regulation of MAPK8 1 0.03 0.28 0.05
185 INT194699 MAP2K1 Positive_regulation of MAPK8 1 0.05 0 0.04
186 INT178443 Negative_regulation of Mapk8 Positive_regulation of Negative_regulation of Mapk14 1 0.13 0.76 0.04
187 INT194731 MAP3K4 Positive_regulation of MAPK8 1 0.02 0 0.04
188 INT274078 Binding of Mapk8 and Gmcl1 1 0.05 0.68 0.04
189 INT248703 Mapk8 Positive_regulation of Phosphorylation of Rxrb 1 0.01 0.25 0.04
190 INT340394 Binding of Bax and Bbc3 1 0.01 0.36 0.04
191 INT179927 Litaf Positive_regulation of Mapk8 1 0.02 0.39 0.04
192 INT301647 Negative_regulation of Mapk8 Positive_regulation of Irs1 1 0.08 0.83 0.04
193 INT301626 Mapk8 Positive_regulation of Irs1 1 0.09 0.83 0.04
194 INT311082 DST Regulation of MAPK8 1 0.02 0.07 0.04
195 INT201726 Mapk8 Positive_regulation of Positive_regulation of Trp53 1 0.00 0.41 0.04
196 INT172902 Binding of Bax and Bcl2 5 0.30 3.19 0.03
197 INT297737 Cbr1 Positive_regulation of Bax 1 0.06 0.53 0.03
198 INT237683 Positive_regulation of LDHA Positive_regulation of MAPK8 1 0.02 0.16 0.03
199 INT299368 Mkks Positive_regulation of Mapk8 1 0.41 0.17 0.03
200 INT248698 Mapk8 Positive_regulation of Ppm1e 1 0.00 0.31 0.03

Single Events

The table below shows the top 100 pain related interactions that have been reported for induction of apoptosis in response to chemical stimulus. They are ordered first by their pain relevance and then by number of times they were reported in induction of apoptosis in response to chemical stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
2 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98
3 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52
4 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2
5 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48
6 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25
7 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
8 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24
9 INT104493 Negative_regulation of Mapk8 56 0.53 27.76 16.86
10 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
11 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36
12 INT15042 Gene_expression of Adora2a 37 0.77 3.77 14.24
13 INT95738 Positive_regulation of Phosphorylation of Mapk8 40 0.70 23.46 13.88
14 INT108063 Gene_expression of Adora2a 29 0.78 13.11 13.78
15 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
16 INT50227 Positive_regulation of Adora2a 32 0.50 5.17 12.75
17 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65
18 INT72784 Positive_regulation of Adora2a 26 0.70 16.52 11.47
19 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44
20 INT145695 Regulation of Mapk8 26 0.62 14.67 9.83
21 INT102110 Positive_regulation of Gene_expression of Bax 42 0.67 35.77 9.51
22 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28
23 INT111998 Positive_regulation of Positive_regulation of Mapk8 23 0.69 9.33 8.97
24 INT104481 Regulation of Mapk8 21 0.50 13.87 8.41
25 INT23209 Binding of Adora2a 17 0.38 2.04 8.35
26 INT96912 Positive_regulation of Phosphorylation of Mapk8 29 0.69 18.33 8.14
27 INT54755 Negative_regulation of Adora2a 17 0.58 2.7 7.75
28 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
29 INT99071 Positive_regulation of Gene_expression of Mapk8 16 0.55 9.87 7.58
30 INT102107 Negative_regulation of Gene_expression of Bax 30 0.57 29.48 7.33
31 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41
32 INT128922 Negative_regulation of Gene_expression of Mapk8 6 0.34 3.93 5.36
33 INT145929 Regulation of Bax 20 0.60 18.12 5.35
34 INT83014 Binding of Adora2a 13 0.48 5.57 5.33
35 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23
36 INT135291 Positive_regulation of Positive_regulation of Mapk8 24 0.64 19.37 5.16
37 INT89664 Negative_regulation of Adora2a 11 0.59 7.81 5.07
38 INT109513 Positive_regulation of Gene_expression of Bax 37 0.67 29.52 5.06
39 INT131717 Positive_regulation of Gene_expression of Mapk8 18 0.55 14.25 5.02
40 INT51468 Regulation of Adora2a 8 0.48 1.5 4.84
41 INT108919 Positive_regulation of Mapk9 9 0.34 3.55 4.74
42 INT99504 Negative_regulation of Bax 19 0.56 8.89 4.44
43 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28
44 INT109935 Positive_regulation of Phosphorylation of MAPK8 35 0.68 13.13 4.18
45 INT110181 Negative_regulation of Phosphorylation of MAPK8 20 0.57 9.43 4.06
46 INT123752 Regulation of Bax 19 0.60 16.45 4
47 INT50228 Positive_regulation of Positive_regulation of Adora2a 8 0.39 0.1 4
48 INT112692 Localization of Bax 31 0.80 20.97 3.98
49 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94
50 INT80347 Positive_regulation of Camk2b 2 0.69 0.33 3.67
51 INT101701 Regulation of Adora2a 8 0.45 2.3 3.63
52 INT104480 Phosphorylation of Mapk9 8 0.80 6.59 3.62
53 INT21569 Binding of Mapk8 8 0.48 5.55 3.44
54 INT80345 Gene_expression of Camk2b 3 0.77 0.5 3.44
55 INT109914 Positive_regulation of MAPK9 16 0.56 7.64 3.27
56 INT163529 Negative_regulation of Positive_regulation of Mapk8 14 0.43 8.37 3.2
57 INT110755 Negative_regulation of Positive_regulation of Mapk8 15 0.46 9.91 2.98
58 INT80346 Negative_regulation of Camk2b 3 0.58 0.58 2.81
59 INT95735 Regulation of Phosphorylation of Mapk8 7 0.50 1.88 2.69
60 INT95739 Negative_regulation of Phosphorylation of Mapk8 11 0.42 6.77 2.61
61 INT254118 Negative_regulation of Gene_expression of Adora2a 3 0.42 2.54 2.43
62 INT102146 Phosphorylation of Bax 4 0.66 3.48 2.35
63 INT183167 Positive_regulation of Gene_expression of Adora2a 4 0.70 2.37 2.31
64 INT102908 Phosphorylation of Camk2b 2 0.62 0.42 2.17
65 INT109908 Localization of MAPK8 10 0.73 3.86 2.14
66 INT154970 Localization of Bax 15 0.74 11.12 2.11
67 INT156270 Regulation of Positive_regulation of Mapk8 3 0.41 2.31 2.08
68 INT57939 Negative_regulation of Gene_expression of Adora2a 4 0.36 0.15 2.02
69 INT152696 Negative_regulation of Negative_regulation of Mapk8 1 0.32 0.35 2
70 INT108921 Negative_regulation of Positive_regulation of Mapk9 3 0.25 1.8 1.99
71 INT109313 Binding of Mapk8 6 0.48 1.78 1.98
72 INT96916 Negative_regulation of Phosphorylation of Mapk8 16 0.52 9.68 1.97
73 INT98836 Transcription of Bax 6 0.69 5.04 1.96
74 INT72785 Positive_regulation of Positive_regulation of Adora2a 2 0.10 1.34 1.96
75 INT134442 Transcription of Bax 14 0.67 7.6 1.9
76 INT135540 Negative_regulation of Bax 16 0.48 11.8 1.89
77 INT194847 Negative_regulation of Positive_regulation of Adora2a 3 0.32 4.52 1.88
78 INT134443 Binding of Bax 10 0.47 5.62 1.84
79 INT164864 Positive_regulation of Negative_regulation of Mapk8 1 0.31 1.33 1.82
80 INT109921 Phosphorylation of MAPK9 9 0.67 5.07 1.81
81 INT104478 Positive_regulation of Mapk9 5 0.67 5.56 1.81
82 INT299365 Transcription of Mapk8 9 0.72 5.91 1.75
83 INT104883 Positive_regulation of Positive_regulation of Bax 4 0.45 4.05 1.74
84 INT104479 Negative_regulation of Mapk9 3 0.37 2.83 1.69
85 INT168714 Negative_regulation of Binding of Mapk8 1 0.36 0.18 1.62
86 INT142678 Positive_regulation of Phosphorylation of Mapk9 4 0.51 2.1 1.6
87 INT76496 Localization of Adora2a 3 0.48 0.3 1.54
88 INT142676 Phosphorylation of Mapk9 5 0.61 1.48 1.48
89 INT146785 Positive_regulation of Localization of Bax 7 0.69 6.16 1.47
90 INT109512 Negative_regulation of Gene_expression of Bax 12 0.42 8.04 1.44
91 INT157362 Negative_regulation of MAPK9 7 0.35 4.27 1.44
92 INT159784 Gene_expression of Mapk9 8 0.61 6.28 1.37
93 INT142679 Negative_regulation of Phosphorylation of Mapk9 1 0.17 0.51 1.37
94 INT90226 Gene_expression of Mapk9 3 0.65 1.94 1.34
95 INT112695 Negative_regulation of Protein_catabolism of Bax 3 0.36 1.72 1.3
96 INT154969 Positive_regulation of Localization of Bax 4 0.64 3.42 1.27
97 INT125079 Negative_regulation of Gene_expression of MAPK8 9 0.39 4.87 1.25
98 INT154048 Negative_regulation of Gene_expression of Mapk8 5 0.43 4.43 1.22
99 INT112693 Protein_catabolism of Bax 5 0.74 3.17 1.2
100 INT91595 Regulation of Gene_expression of Adora2a 1 0.52 0 1.19
101 INT157364 Positive_regulation of Phosphorylation of MAPK9 3 0.56 2.33 1.15
102 INT141189 Negative_regulation of Transcription of Bax 1 0.41 1.42 1.14
103 INT80341 Regulation of Gene_expression of Camk2b 1 0.61 0.08 1.08
104 INT140054 Negative_regulation of Mapk9 3 0.25 1.9 1.05
105 INT116801 Negative_regulation of Positive_regulation of Camk2b 1 0.29 0.1 1.02
106 INT52090 Transcription of Adora2a 3 0.41 0.33 0.96
107 INT175507 Regulation of Gene_expression of Bax 13 0.50 10.91 0.95
108 INT72006 Positive_regulation of Negative_regulation of Adora2a 2 0.40 0.26 0.94
109 INT196583 Regulation of Phosphorylation of Mapk9 1 0.37 0.5 0.85
110 INT200900 Localization of Mapk8 9 0.40 5.76 0.84
111 INT104482 Positive_regulation of Phosphorylation of Mapk9 2 0.49 1.55 0.84
112 INT144697 Regulation of Gene_expression of Bax 8 0.37 9.5 0.81
113 INT302869 Phosphorylation of Adora2a 1 0.49 0.25 0.78
114 INT302868 Positive_regulation of Phosphorylation of Adora2a 1 0.41 0.25 0.78
115 INT182293 Binding of MAPK8 11 0.34 4.6 0.77
116 INT165104 Negative_regulation of Negative_regulation of Mapk8 5 0.43 4.21 0.77
117 INT80147 Negative_regulation of Binding of Adora2a 2 0.43 0.15 0.77
118 INT165105 Localization of Mapk8 7 0.69 4.45 0.76
119 INT89663 Localization of Adora2a 1 0.74 0.74 0.75
120 INT194852 Protein_catabolism of Adora2a 1 0.56 0.6 0.75
121 INT164489 Regulation of Gene_expression of Mapk8 2 0.44 0.65 0.74
122 INT177940 Gene_expression of MAPK9 5 0.56 2.77 0.73
123 INT237709 Negative_regulation of Negative_regulation of MAPK8 6 0.25 2.09 0.72
124 INT104488 Negative_regulation of Phosphorylation of Mapk9 1 0.41 1.03 0.72
125 INT224109 Phosphorylation of Adora2a 1 0.52 0.07 0.69
126 INT177936 Positive_regulation of Negative_regulation of MAPK8 3 0.50 2.1 0.63
127 INT102906 Positive_regulation of Gene_expression of Camk2b 1 0.68 0.43 0.63
128 INT102909 Positive_regulation of Phosphorylation of Camk2b 1 0.46 0.43 0.63
129 INT215637 Regulation of Regulation of Adora2a 1 0.14 0.16 0.61
130 INT158689 Positive_regulation of Regulation of MAPK8 1 0.46 0.41 0.6
131 INT141458 Regulation of Gene_expression of Adora2a 2 0.45 0.67 0.57
132 INT104483 Positive_regulation of Positive_regulation of Mapk9 1 0.49 0.75 0.56
133 INT75529 Regulation of MAPK9 1 0.16 1.07 0.56
134 INT200956 Negative_regulation of CAMK2B 1 0.37 0.93 0.56
135 INT104484 Regulation of Mapk9 1 0.12 0.73 0.55
136 INT215639 Positive_regulation of Binding of Adora2a 1 0.24 0.24 0.55
137 INT176242 Binding of Bax 10 0.42 10.18 0.52
138 INT109926 Positive_regulation of Localization of MAPK8 4 0.49 0.87 0.52
139 INT224486 Regulation of Phosphorylation of MAPK8 2 0.33 0.52 0.52
140 INT224106 Regulation of Negative_regulation of Adora2a 1 0.17 0.26 0.51
141 INT102108 Protein_catabolism of Bax 8 0.64 5.69 0.48
142 INT115197 Regulation of Positive_regulation of MAPK9 1 0.33 0 0.48
143 INT134446 Positive_regulation of Binding of Bax 1 0.49 0.72 0.48
144 INT224107 Negative_regulation of Negative_regulation of Adora2a 1 0.28 0.32 0.48
145 INT167975 Negative_regulation of Gene_expression of Mapk9 2 0.02 1.18 0.47
146 INT72143 Regulation of Binding of Adora2a 1 0.17 0 0.45
147 INT301056 Transcription of Mapk8 1 0.06 1.22 0.45
148 INT217067 Regulation of Positive_regulation of MAPK8 7 0.45 3.09 0.43
149 INT137835 Binding of CAMK2B 1 0.08 1.38 0.42
150 INT152059 Regulation of Transcription of Bax 1 0.26 0.07 0.42
151 INT135802 Positive_regulation of Negative_regulation of Bax 2 0.41 0.57 0.4
152 INT109933 Negative_regulation of Positive_regulation of MAPK9 2 0.41 0.68 0.4
153 INT102385 Regulation of Transcription of Adora2a 1 0.21 0.09 0.4
154 INT115190 Binding of MAPK9 1 0.27 0.84 0.39
155 INT187209 Negative_regulation of Localization of Mapk8 1 0.22 0.93 0.39
156 INT102387 Negative_regulation of Transcription of Adora2a 1 0.09 0.24 0.37
157 INT109927 Localization of MAPK9 1 0.32 0.24 0.36
158 INT301047 Negative_regulation of Transcription of Mapk8 1 0.12 0.65 0.36
159 INT342161 Positive_regulation of Gene_expression of Mapk9 1 0.09 0.63 0.35
160 INT204069 Negative_regulation of Positive_regulation of Bax 5 0.31 3.08 0.34
161 INT261685 Regulation of Gene_expression of MAPK8 3 0.26 1.45 0.34
162 INT169538 Negative_regulation of Localization of Bax 3 0.49 1.41 0.34
163 INT109915 Protein_catabolism of MAPK8 3 0.86 1.92 0.34
164 INT184482 Positive_regulation of Positive_regulation of Bax 5 0.41 4.7 0.33
165 INT221191 Negative_regulation of Localization of Bax 4 0.38 2.85 0.33
166 INT221765 Positive_regulation of Gene_expression of Adora2a 2 0.49 0.2 0.27
167 INT102111 Positive_regulation of Protein_catabolism of Bax 2 0.45 1.14 0.27
168 INT224108 Positive_regulation of Localization of Adora2a 1 0.32 0.14 0.27
169 INT224114 Regulation of Localization of Adora2a 1 0.29 0.14 0.27
170 INT291227 Protein_catabolism of Mapk8 1 0.64 0.26 0.26
171 INT109905 Positive_regulation of Protein_catabolism of MAPK8 1 0.49 0.14 0.24
172 INT109909 Protein_catabolism of MAPK9 1 0.38 0.14 0.24
173 INT135543 Negative_regulation of Positive_regulation of Bax 5 0.30 6.4 0.23
174 INT178399 Regulation of Positive_regulation of Mapk8 4 0.44 3.4 0.23
175 INT154934 Negative_regulation of Positive_regulation of Mapk9 1 0.35 0.41 0.23
176 INT140059 Localization of Mapk9 1 0.28 0.61 0.23
177 INT299366 Positive_regulation of Transcription of Mapk8 2 0.70 1.29 0.22
178 INT224117 Negative_regulation of Positive_regulation of Adora2a 1 0.27 0.11 0.22
179 INT224105 Regulation of Phosphorylation of Adora2a 1 0.17 0 0.21
180 INT300463 Regulation of Regulation of Bax 1 0.29 1.33 0.18
181 INT224115 Positive_regulation of Phosphorylation of Adora2a 1 0.32 0 0.16
182 INT177939 Positive_regulation of Negative_regulation of MAPK9 1 0.11 0.74 0.16
183 INT224103 Negative_regulation of Phosphorylation of Adora2a 1 0.27 0 0.16
184 INT177943 Positive_regulation of Gene_expression of MAPK9 2 0.11 0.81 0.15
185 INT200987 Transcription of CAMK2B 2 0.44 0.2 0.14
186 INT200978 Regulation of Transcription of CAMK2B 1 0.29 0.15 0.14
187 INT222016 Regulation of Negative_regulation of Mapk8 1 0.44 0.79 0.12
188 INT140057 Negative_regulation of Negative_regulation of Mapk9 1 0.15 0.31 0.12
189 INT140051 Negative_regulation of Localization of Mapk9 1 0.20 0.31 0.11
190 INT336888 Negative_regulation of Transcription of Bax 1 0.07 0.68 0.11
191 INT109312 Regulation of Gene_expression of Mapk8 3 0.44 1.55 0.1
192 INT304137 Regulation of Localization of Bax 2 0.24 1.7 0.09
193 INT178419 Regulation of Mapk9 1 0.09 0.76 0.08
194 INT241728 Regulation of Transcription of Adora2a 1 0.42 0.27 0.07
195 INT307466 Positive_regulation of Phosphorylation of Bax 1 0.15 0.76 0.07
196 INT241725 Transcription of Adora2a 1 0.67 0.27 0.07
197 INT268622 Regulation of Negative_regulation of Bax 1 0.12 0.81 0.05
198 INT309494 Negative_regulation of Binding of Bax 2 0.38 1.31 0.04
199 INT182282 Negative_regulation of Binding of MAPK8 2 0.39 0.29 0.04
200 INT340387 Regulation of Positive_regulation of Bax 1 0.27 0.61 0.04
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