GO:0031572

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Name G2/M transition DNA damage checkpoint
Categary Process
Go Slim No
Go Link GO:0031572
Unique Molecular Interactions 62
Total Molecular Interactions 80
Total Single Events 435
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for G2/M transition DNA damage checkpoint. They are ordered first by their pain relevance and then by number of times they were reported for G2/M transition DNA damage checkpoint. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT219277 Mapkapk2 Positive_regulation of Pla2g1b 1 0.03 0.46 0.61
2 INT219278 Mapkapk2 Positive_regulation of Pla2g2a 1 0.05 0.46 0.61
3 INT28119 Atm Negative_regulation of Cck 1 0.42 0 0.56
4 INT160779 Cps1 Positive_regulation of ATM 1 0.01 0.94 0.53
5 INT353454 Binding of BRCA1 and IL17A 1 0.00 2.55 0.36
6 INT353452 Binding of AGRP and BRCA1 1 0.00 3.89 0.34
7 INT353448 BRCA1 Positive_regulation of CCL2 1 0.01 1.37 0.26
8 INT353449 BRCA1 Positive_regulation of IL4 1 0.00 1.37 0.26
9 INT353455 BRCA1 Positive_regulation of IL13 1 0.00 1.37 0.26
10 INT68510 Binding of ATM and PRLR 1 0.01 0 0.19
11 INT179158 ATM Regulation of Gene_expression of GOPC 1 0.01 0 0.18
12 INT179163 ATM Regulation of Gene_expression of IL13 1 0.01 0 0.18
13 INT179161 ATM Regulation of Gene_expression of IL6 1 0.02 0 0.18
14 INT179162 ATM Regulation of Gene_expression of IL8 1 0.01 0 0.18
15 INT194696 TTPA Positive_regulation of Phosphorylation of MAPKAPK2 1 0.01 0.08 0.17
16 INT194737 Binding of TTPA and MAPKAPK2 1 0.01 0.08 0.17
17 INT327326 Binding of Mapkapk2 and Ttpa 1 0.02 0.34 0.14
18 INT353451 Binding of BRCA1 and CRP 1 0.01 1.18 0.14
19 INT353453 Binding of BRCA1 and IL4 1 0.00 1.18 0.14
20 INT327322 Mapkapk2 Regulation of Il6 1 0.02 0.26 0.13
21 INT194671 MAPKAPK2 Positive_regulation of CREB1 1 0.06 0.05 0.1
22 INT194689 MAPKAPK2 Positive_regulation of TFAM 1 0.00 0.05 0.1
23 INT311432 Binding of TSHR and TAOK1 1 0.12 1.05 0.07
24 INT353450 Binding of BRCA1 and VEGFA 1 0.01 0.82 0.05
25 INT221262 Binding of BRCA1 and CD4 1 0.22 0.81 0.03
26 INT234178 Binding of BRCA1 and BRCA2 2 0.40 1.52 0
27 INT207817 Negative_regulation of Parp1 Positive_regulation of Atm 1 0.53 0.2 0
28 INT207815 Parp1 Negative_regulation of Phosphorylation of Atm 1 0.42 0.15 0
29 INT207816 Parp1 Regulation of Positive_regulation of Atm 1 0.51 0.21 0
30 INT333456 ATM Positive_regulation of CHEK2 1 0.20 0 0
31 INT234180 Binding of BRCA1 and BRIP1 1 0.33 1.37 0
32 INT314743 Binding of RAD51 and Brca1 1 0.06 1.06 0
33 INT333446 ATM Positive_regulation of CHEK1 1 0.20 0 0
34 INT271996 Binding of Plk1 and Tsc1 1 0.09 0.32 0
35 INT314740 Binding of ESR1 and Brca1 1 0.16 0.69 0
36 INT333455 ATM Positive_regulation of TP53 1 0.18 0 0
37 INT239406 Binding of MTTP and TAOK1 1 0.02 0.51 0
38 INT333451 ATM Positive_regulation of Negative_regulation of CHEK1 1 0.14 0 0
39 INT232595 Binding of BRCA1 and HEPACAM 1 0.02 0.89 0
40 INT333450 ATM Positive_regulation of Negative_regulation of MDM2 1 0.18 0 0
41 INT333460 ATM Positive_regulation of Negative_regulation of CHEK2 1 0.14 0 0
42 INT303336 MAPKAPK2 Positive_regulation of Hspb2 1 0.04 0.24 0
43 INT228109 Binding of Atm and Chrm2 1 0.09 0.21 0
44 INT296164 Mcph1 Regulation of Chek1 1 0.25 0.19 0
45 INT259091 Binding of BRCA1 and LMO4 1 0.24 0.74 0
46 INT202398 Mapk14 Regulation of Phosphorylation of Mapkapk2 1 0.44 0.1 0
47 INT314745 Binding of TP53 and Brca1 1 0.18 1.17 0
48 INT271997 Binding of Cdk1 and Plk1 1 0.03 0.3 0
49 INT333458 ATM Positive_regulation of MDM2 1 0.25 0 0
50 INT239408 Binding of PADI1 and TAOK1 1 0.01 0.51 0
51 INT78634 ATM Positive_regulation of AGT 1 0.17 0.16 0
52 INT207813 Atm Regulation of Gene_expression of Parp1 1 0.44 0.31 0
53 INT296162 Mcph1 Regulation of Brca1 1 0.26 0.19 0
54 INT333459 TP53 Positive_regulation of CHEK1 1 0.09 0 0
55 INT333452 ATM Positive_regulation of Negative_regulation of TP53 1 0.18 0 0
56 INT249822 Foxm1 Positive_regulation of Transcription of Plk1 1 0.50 0.12 0
57 INT252549 ATM Positive_regulation of Positive_regulation of CHEK2 1 0.02 0 0
58 INT207814 Negative_regulation of Parp1 Positive_regulation of Positive_regulation of Atm 1 0.53 0.08 0
59 INT207812 Binding of Parp1 and Atm 1 0.54 0.99 0
60 INT252909 FZR1 Positive_regulation of APC 1 0.06 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for G2/M transition DNA damage checkpoint. They are ordered first by their pain relevance and then by number of times they were reported in G2/M transition DNA damage checkpoint. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39
2 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17
3 INT221269 Binding of BRCA1 14 0.40 31.77 2.7
4 INT221422 Positive_regulation of BRCA1 5 0.23 12.63 1.53
5 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36
6 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26
7 INT126523 Phosphorylation of Mapkapk2 19 0.79 7.76 0.82
8 INT131433 Phosphorylation of MAPKAPK2 3 0.30 0.99 0.73
9 INT28118 Binding of Atm 13 0.38 12.24 0.68
10 INT202385 Gene_expression of Mapkapk2 4 0.57 2.86 0.64
11 INT48212 Binding of ATM 5 0.47 3.89 0.57
12 INT160778 Transcription of ATM 1 0.40 1.03 0.57
13 INT221420 Positive_regulation of Gene_expression of BRCA1 2 0.24 2.17 0.55
14 INT160776 Positive_regulation of Positive_regulation of ATM 2 0.43 0.94 0.53
15 INT315892 Negative_regulation of Binding of ATM 1 0.07 1.41 0.4
16 INT154768 Negative_regulation of ATM 10 0.57 7.05 0.39
17 INT144275 Negative_regulation of Atm 9 0.59 8.48 0.36
18 INT272875 Localization of Mapkapk2 1 0.23 0.9 0.34
19 INT353457 Positive_regulation of Binding of BRCA1 1 0.09 1.69 0.34
20 INT221419 Regulation of BRCA1 5 0.35 6.18 0.31
21 INT311448 Gene_expression of TAOK1 1 0.21 2.47 0.31
22 INT96569 Negative_regulation of CHEK1 4 0.32 3.08 0.29
23 INT158048 Gene_expression of MAPKAPK2 2 0.28 0.79 0.29
24 INT86771 Positive_regulation of TAOK1 2 0.38 4.55 0.29
25 INT126522 Positive_regulation of Phosphorylation of Mapkapk2 7 0.59 3.8 0.28
26 INT167438 Localization of ATM 3 0.55 1.61 0.27
27 INT197121 Positive_regulation of Atm 24 0.69 6.81 0.25
28 INT35719 Gene_expression of Atm 34 0.78 15.75 0.24
29 INT131426 Negative_regulation of Phosphorylation of Mapkapk2 1 0.04 0.41 0.23
30 INT158050 Regulation of MAPKAPK2 1 0.00 0.8 0.22
31 INT131432 Negative_regulation of Phosphorylation of MAPKAPK2 1 0.11 0.4 0.21
32 INT131434 Binding of MAPKAPK2 2 0.17 0.42 0.2
33 INT221268 Localization of BRCA1 7 0.63 4.83 0.18
34 INT119061 Negative_regulation of Gene_expression of BRCA1 4 0.51 0.85 0.18
35 INT89689 Binding of Brca1 2 0.37 2.55 0.18
36 INT311439 Positive_regulation of Gene_expression of TAOK1 1 0.15 1.48 0.18
37 INT126521 Positive_regulation of Mapkapk2 13 0.49 5.9 0.17
38 INT275513 Regulation of Mapkapk2 1 0.01 0.86 0.16
39 INT194790 Positive_regulation of Phosphorylation of MAPKAPK2 1 0.19 0.09 0.16
40 INT94167 Regulation of CHEK1 1 0.04 1.7 0.16
41 INT327236 Positive_regulation of Gene_expression of Mapkapk2 1 0.36 1.01 0.15
42 INT278288 Regulation of Localization of ATM 1 0.09 0.95 0.13
43 INT167440 Regulation of ATM 2 0.20 0.68 0.12
44 INT187590 Gene_expression of Brca1 12 0.65 4.94 0.11
45 INT208914 Regulation of Brca1 1 0.10 0.79 0.11
46 INT207804 Negative_regulation of Gene_expression of Atm 2 0.59 6.22 0.09
47 INT174155 Negative_regulation of Brca1 4 0.36 1.77 0.07
48 INT207806 Phosphorylation of Atm 8 0.81 3.07 0.06
49 INT139365 Negative_regulation of Negative_regulation of CHEK1 1 0.23 1.67 0.06
50 INT311444 Binding of TAOK1 1 0.11 0.65 0.05
51 INT208224 Protein_catabolism of TAOK1 1 0.05 0.94 0.04
52 INT212459 Positive_regulation of Binding of Atm 1 0.40 0.88 0.04
53 INT207803 Regulation of Atm 3 0.41 1.15 0.03
54 INT187589 Positive_regulation of Gene_expression of Brca1 2 0.55 1.93 0.03
55 INT344009 Negative_regulation of Localization of BRCA1 1 0.30 0.18 0.03
56 INT186409 Negative_regulation of MAPKAPK2 1 0.20 0.06 0.03
57 INT207807 Localization of Atm 4 0.74 0.21 0
58 INT237226 Gene_expression of Plk1 3 0.59 0.78 0
59 INT259116 Transcription of BRCA1 3 0.44 3.77 0
60 INT212457 Phosphorylation of Brca1 2 0.51 0.96 0
61 INT157290 Regulation of Gene_expression of ATM 2 0.44 0.86 0
62 INT212461 Gene_expression of Chek1 2 0.65 0.11 0
63 INT249774 Positive_regulation of Plk1 2 0.41 0.25 0
64 INT252642 Transcription of Atm 1 0.53 0.18 0
65 INT296150 Negative_regulation of Gene_expression of Chek1 1 0.35 0.11 0
66 INT187580 Positive_regulation of Brca1 1 0.10 1.17 0
67 INT252942 Phosphorylation of Chek1 1 0.14 0.63 0
68 INT119064 Regulation of Gene_expression of BRCA1 1 0.53 0.05 0
69 INT309486 Positive_regulation of Chek1 1 0.22 0.6 0
70 INT271928 Binding of Plk1 1 0.07 0.29 0
71 INT186410 Positive_regulation of MAPKAPK2 1 0.22 0 0
72 INT354742 Phosphorylation of ATM 1 0.50 1.74 0
73 INT332370 Regulation of Plk1 1 0.21 0.13 0
74 INT291177 Binding of Mapkapk2 1 0.08 0.3 0
75 INT291178 Positive_regulation of Binding of Mapkapk2 1 0.10 0.3 0
76 INT314706 Transcription of Brca1 1 0.43 0.53 0
77 INT332346 Phosphorylation of Plk1 1 0.62 0 0
78 INT252645 Positive_regulation of Gene_expression of Atm 1 0.50 2.35 0
79 INT329779 Positive_regulation of CHEK1 1 0.22 0.76 0
80 INT249761 Transcription of Plk1 1 0.60 0.12 0
81 INT221271 Negative_regulation of Binding of BRCA1 1 0.28 0.93 0
82 INT249770 Positive_regulation of Gene_expression of Plk1 1 0.44 0.12 0
83 INT252644 Regulation of Gene_expression of Atm 1 0.27 0.39 0
84 INT322739 Localization of TAOK1 1 0.02 1.24 0
85 INT332343 Positive_regulation of Phosphorylation of Plk1 1 0.38 0 0
86 INT334189 Regulation of Binding of BRCA1 1 0.13 0.8 0
87 INT296140 Negative_regulation of Chek1 1 0.35 0.45 0
88 INT207808 Positive_regulation of Positive_regulation of Atm 1 0.50 0.08 0
89 INT234188 Positive_regulation of Localization of BRCA1 1 0.42 0.68 0
90 INT271923 Regulation of Binding of Plk1 1 0.09 0.29 0
91 INT252643 Negative_regulation of Positive_regulation of Atm 1 0.38 0.6 0
92 INT329783 Phosphorylation of CHEK1 1 0.26 0.82 0
93 INT237227 Negative_regulation of Gene_expression of Plk1 1 0.08 0.54 0
94 INT291179 Positive_regulation of Positive_regulation of Mapkapk2 1 0.10 0.36 0
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