GO:0031583

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Name activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway
Categary Process
Go Slim No
Go Link GO:0031583
Unique Molecular Interactions 194
Total Molecular Interactions 280
Total Single Events 2033
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
2 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
3 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
4 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
5 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
6 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
7 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
8 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
9 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
10 INT60208 Binding of Htr1a and Htr2c 2 0.52 0.25 1
11 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
12 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
13 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
14 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
15 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
16 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
17 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
18 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
19 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
20 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
21 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
22 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
23 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
24 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
25 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
26 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
27 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
28 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
29 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
30 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
31 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
32 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
33 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
34 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
35 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
36 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
37 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
38 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
39 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
40 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
41 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
42 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
43 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
44 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
45 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
46 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
47 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
48 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
49 INT99399 Penk Positive_regulation of Edn1 1 0.00 0 0.38
50 INT99400 Gast Positive_regulation of Edn1 1 0.00 0 0.38
51 INT173704 Binding of PCOS1 and Edn1 1 0.01 0.99 0.37
52 INT313701 Calca Negative_regulation of Binding of Edn1 1 0.30 0.14 0.37
53 INT152314 Il18 Regulation of Edn1 1 0.02 0.22 0.36
54 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
55 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
56 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
57 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
58 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
59 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
60 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
61 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
62 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
63 INT71519 Edn1 Positive_regulation of Gene_expression of Adarb1 1 0.02 0.48 0.31
64 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28
65 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26
66 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25
67 INT178095 EDN1 Positive_regulation of MMP3 1 0.04 0.88 0.24
68 INT178076 EDN1 Positive_regulation of MMP2 1 0.04 0.88 0.24
69 INT178085 EDN1 Positive_regulation of MMP7 1 0.06 0.89 0.24
70 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
71 INT178075 EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
72 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24
73 INT178094 Positive_regulation of EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
74 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
75 INT178077 EDN1 Positive_regulation of MMP9 1 0.06 0.88 0.24
76 INT182272 EDN1 Regulation of Gene_expression of MMP13 1 0.26 0.87 0.22
77 INT91686 Mb Positive_regulation of Edn1 1 0.03 0.29 0.22
78 INT182265 EDN1 Positive_regulation of NOS2 1 0.24 0.56 0.22
79 INT182263 EDN1 Positive_regulation of MMP1 1 0.15 0.43 0.21
80 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2
81 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
82 INT182258 EDN1 Positive_regulation of Positive_regulation of MMP1 1 0.15 0.47 0.19
83 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19
84 INT219915 Edn1 Regulation of Positive_regulation of Trpv1 1 0.33 0 0.18
85 INT140096 Gtf3a Positive_regulation of Gene_expression of Edn1 1 0.02 0.44 0.18
86 INT171386 Edn1 Positive_regulation of Mapk1 1 0.05 0.13 0.18
87 INT60778 Edn1 Positive_regulation of EDNRA 1 0.00 0 0.18
88 INT284450 Edn1 Positive_regulation of Gene_expression of MMP9 1 0.01 0.3 0.18
89 INT140094 Ifng Regulation of Gene_expression of Edn1 1 0.18 0.44 0.18
90 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
91 INT203759 Binding of EDN1 and TNF 1 0.16 0.71 0.16
92 INT324899 Edn1 Positive_regulation of Positive_regulation of Mmp9 1 0.10 0.66 0.16
93 INT94022 Positive_regulation of Binding of EDN1 and INSRR 1 0.06 0 0.16
94 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
95 INT94021 Binding of EDN1 and EDN2 1 0.26 0 0.16
96 INT94014 Positive_regulation of Binding of EDN1 and EDN3 1 0.36 0 0.16
97 INT324894 Edn1 Positive_regulation of Gene_expression of Mmp3 1 0.07 0.66 0.16
98 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15
99 INT21509 Agt Regulation of Edn1 1 0.53 0 0.15
100 INT182261 EDN1 Regulation of Gene_expression of MMP1 1 0.17 0.7 0.15
101 INT50500 Edn1 Positive_regulation of PTGS1 1 0.00 0.07 0.14
102 INT324898 Ece1 Regulation of Gene_expression of Edn1 1 0.17 0.8 0.14
103 INT161799 Positive_regulation of Binding of ECE1 and EDN1 1 0.07 0.68 0.14
104 INT332689 Binding of Edn1 and Ros1 1 0.08 0.71 0.14
105 INT161798 Positive_regulation of Binding of EDN1 and ING1 1 0.06 0.66 0.13
106 INT161800 Binding of EDN1 and ING1 1 0.05 0.65 0.13
107 INT178083 EDN1 Positive_regulation of Gene_expression of VEGFA 1 0.09 1.8 0.13
108 INT206065 EDN1 Positive_regulation of IL6 1 0.03 0.47 0.12
109 INT178101 EDN1 Negative_regulation of Phosphorylation of BCL2 1 0.03 1 0.12
110 INT77863 EDN1 Positive_regulation of POMC 1 0.50 0.34 0.12
111 INT182273 EDN1 Regulation of Gene_expression of BAD 1 0.11 0.73 0.12
112 INT180445 Edn1 Positive_regulation of Rhoa 1 0.08 0.57 0.11
113 INT182270 EDN1 Positive_regulation of Gene_expression of MMP1 1 0.18 0.55 0.1
114 INT181569 Binding of Edn1 and Mapk8 1 0.09 2.7 0.1
115 INT181570 Binding of Edn1 and Mapk1 1 0.13 2.72 0.1
116 INT6674 Edn1 Positive_regulation of Gene_expression of FOS 1 0.08 0.19 0.1
117 INT139476 Edn1 Positive_regulation of Ednra 1 0.00 1.07 0.1
118 INT10904 Edn1 Regulation of Localization of Nppb 1 0.22 0.54 0.1
119 INT92956 Edn1 Regulation of Positive_regulation of Nos2 1 0.18 0.17 0.09
120 INT332688 Ros1 Positive_regulation of Binding of Edn1 1 0.10 0.57 0.09
121 INT230750 Crp Positive_regulation of Edn1 1 0.10 0.27 0.09
122 INT174093 Htr2c Regulation of Gene_expression of Csf2 1 0.00 0 0.09
123 INT174070 Htr2c Positive_regulation of Itpr3 1 0.00 0 0.09
124 INT92957 Edn1 Regulation of Gene_expression of Nos2 1 0.18 0.17 0.09
125 INT242257 Binding of EDN1 and ELF3 1 0.17 0.21 0.08
126 INT181584 Binding of EDNRB and Edn1 1 0.46 0.85 0.08
127 INT181583 Binding of Edn1 and Positive_regulation of NOS1 1 0.02 0.86 0.08
128 INT178100 Gene_expression of EDNRB Positive_regulation of EDN1 1 0.17 1.11 0.08
129 INT113369 Edn1 Regulation of Adarb1 1 0.02 0.14 0.08
130 INT178081 Negative_regulation of EDN1 Positive_regulation of HIF1A 1 0.04 1.18 0.08
131 INT178080 EDN1 Positive_regulation of HIF1A 1 0.05 1.05 0.08
132 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07
133 INT182269 EDN1 Positive_regulation of Localization of MMP1 1 0.17 0.31 0.07
134 INT192908 Edn1 Positive_regulation of Ednra 1 0.21 0.35 0.07
135 INT242258 ELF3 Negative_regulation of EDN1 1 0.15 0.09 0.07
136 INT309941 Edn1 Positive_regulation of Tlr2 1 0.02 1.31 0.07
137 INT172382 AGT Positive_regulation of Localization of EDN1 1 0.03 0.34 0.07
138 INT182268 Negative_regulation of MAPK14 Negative_regulation of Gene_expression of EDN1 1 0.22 0.31 0.07
139 INT192907 Edn1 Positive_regulation of Ednrb 1 0.10 0.35 0.07
140 INT182274 MAPK14 Negative_regulation of Gene_expression of EDN1 1 0.22 0.31 0.07
141 INT191219 Edn1 Positive_regulation of Amigo2 1 0.06 1.26 0.07
142 INT324896 Ece1 Positive_regulation of Negative_regulation of Edn1 1 0.19 0.42 0.07
143 INT172381 AVP Positive_regulation of Localization of EDN1 1 0.01 0.34 0.07
144 INT178096 EDN1 Positive_regulation of Gene_expression of EDNRB 1 0.17 1.01 0.07
145 INT181645 Edn1 Positive_regulation of NOS3 1 0.02 0.21 0.07
146 INT178090 EDN1 Positive_regulation of Phosphorylation of GJA1 1 0.09 0.88 0.06
147 INT191216 Binding of Edn1 and Cotl1 1 0.14 0.63 0.05
148 INT182259 EDN1 Positive_regulation of Gene_expression of TIMP1 1 0.01 0.27 0.05
149 INT180668 Edn1 Positive_regulation of Gene_expression of Col1a1 1 0.02 0 0.05
150 INT182264 EDN1 Positive_regulation of Positive_regulation of MAPK14 1 0.26 0.1 0.05
151 INT180667 Edn1 Regulation of Ecm1 1 0.04 0 0.05
152 INT213263 INS Positive_regulation of EDN1 1 0.12 0.54 0.04
153 INT178091 EDN1 Positive_regulation of Gene_expression of PTGER2 1 0.01 0.74 0.04
154 INT353314 Edn1 Positive_regulation of Kalrn 1 0.03 0.21 0.04
155 INT229371 Positive_regulation of Pparg Negative_regulation of Gene_expression of Edn1 1 0.01 0.92 0.04
156 INT178098 EDN1 Positive_regulation of Transcription of VEGFA 1 0.08 0.76 0.04
157 INT332684 Binding of Edn1 and Lep 1 0.09 1.11 0.04
158 INT306514 EDN1 Positive_regulation of EDNRB 1 0.11 0.98 0.04
159 INT353317 Edn1 Positive_regulation of RHOA 1 0.19 0.16 0.04
160 INT178082 EDN1 Positive_regulation of VEGFA 1 0.08 0.77 0.04
161 INT323623 Binding of Adm and Edn1 1 0.04 0.77 0.03
162 INT239229 Regulation of Binding of Edn1 and Ednra 1 0.01 0.37 0.03
163 INT321407 EDN1 Positive_regulation of Phosphorylation of IRS1 1 0.06 1.07 0.03
164 INT345298 NLRP3 Positive_regulation of Localization of Edn1 1 0.01 0.94 0.03
165 INT256228 EDNRB Positive_regulation of EDN1 1 0.26 0.62 0.03
166 INT239225 Binding of Edn1 and Ednrb 1 0.02 0.36 0.03
167 INT292081 Binding of EDN1 and NCOR2 1 0.00 0.98 0.03
168 INT239228 Regulation of Binding of Edn1 and Ednrb 1 0.02 0.37 0.03
169 INT239224 Positive_regulation of Binding of Edn1 and Ednrb 1 0.02 0.37 0.03
170 INT213030 Hdl1 Regulation of Gene_expression of Edn1 1 0.06 0.88 0
171 INT10901 Edn1 Positive_regulation of Localization of Nppb 1 0.39 0.68 0
172 INT6676 Binding of Edn1 and Regulation of Gene_expression of CREB1 1 0.04 0.15 0
173 INT10909 Edn1 Positive_regulation of Nppb 1 0.39 0.16 0
174 INT186689 Binding of ACHE and Edn1 1 0.28 0 0
175 INT186685 Edn1 Regulation of Gene_expression of Il6 1 0.11 1.1 0
176 INT284143 EDN1 Positive_regulation of CA2 1 0.03 0.37 0
177 INT192910 Edn1 Regulation of Col4a1 1 0.16 0.49 0
178 INT10902 Edn1 Regulation of Avp 1 0.27 0.35 0
179 INT182267 EDN1 Regulation of Gene_expression of NOS2 1 0.36 0 0
180 INT111394 Binding of Edn1 and Pscs 1 0.25 0 0
181 INT191220 Cotl1 Positive_regulation of Edn1 1 0.19 0.69 0
182 INT191218 Edn1 Regulation of Positive_regulation of Prkcg 1 0.14 0.32 0
183 INT280620 Fig4 Regulation of Gene_expression of Edn1 1 0.03 0 0
184 INT356497 CGA Regulation of Edn1 1 0.02 0 0
185 INT6662 Edn1 Positive_regulation of Positive_regulation of Fos 1 0.00 0.17 0
186 INT182257 EDN1 Positive_regulation of Phosphorylation of AKT1 1 0.21 0.05 0
187 INT192911 Edn1 Positive_regulation of Positive_regulation of Col4a1 1 0.24 0.13 0
188 INT10905 Edn1 Regulation of Agt 1 0.11 0.35 0
189 INT230723 ERVW-1 Positive_regulation of Gene_expression of EDN1 1 0.00 1.95 0
190 INT247849 Edn1 Regulation of Gene_expression of Aqp4 1 0.12 1.05 0
191 INT192909 Regulation of Edn1 Regulation of Col4a1 1 0.16 0.49 0
192 INT213008 Hdl1 Positive_regulation of Gene_expression of Edn1 1 0.10 0.85 0
193 INT6675 Edn1 Positive_regulation of Negative_regulation of PENK 1 0.07 0.16 0
194 INT199312 Edn1 Negative_regulation of VEGFA 1 0.01 0.76 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
2 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
3 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
4 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
5 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
6 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
7 INT5048 Binding of Edn1 55 0.47 18.86 19.16
8 INT9191 Localization of EDN1 94 0.81 57.01 14.78
9 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
10 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
11 INT6365 Localization of Edn1 56 0.81 18.84 13.83
12 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
13 INT18001 Positive_regulation of Htr2c 21 0.67 7.63 11.39
14 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
15 INT6361 Localization of Edn1 30 0.81 19.09 9.7
16 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
17 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
18 INT56775 Binding of Htr2c 16 0.47 3.77 8.74
19 INT10237 Binding of EDN1 40 0.48 16 8.48
20 INT9032 Regulation of Htr2c 11 0.60 2.77 7.81
21 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
22 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
23 INT49477 Gene_expression of Htr2c 12 0.75 3.26 5.73
24 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
25 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
26 INT52402 Negative_regulation of Htr2c 7 0.42 1.46 4.21
27 INT63621 Transcription of Htr2c 6 0.52 0.62 3.49
28 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
29 INT55236 Regulation of Htr2c 6 0.44 3.31 3.36
30 INT53374 Binding of Edn1 17 0.43 11.66 2.98
31 INT65000 Positive_regulation of Positive_regulation of Htr2c 4 0.67 0.69 2.8
32 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
33 INT77309 Positive_regulation of Htr2c 3 0.49 2.72 2.25
34 INT64505 Localization of Htr2c 3 0.78 0.87 2.24
35 INT69020 Gene_expression of Htr2c 9 0.74 6.09 2.22
36 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
37 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
38 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
39 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
40 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
41 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
42 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
43 INT74088 Negative_regulation of Positive_regulation of Htr2c 1 0.41 0 1.75
44 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
45 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
46 INT15407 Positive_regulation of Positive_regulation of Edn1 5 0.62 3.69 1.49
47 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48
48 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48
49 INT272340 Transcription of Htr2c 1 0.52 2.77 1.28
50 INT17802 Transcription of Edn1 6 0.24 6.31 1.18
51 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12
52 INT69803 Regulation of Localization of Edn1 3 0.62 0.79 0.98
53 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95
54 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95
55 INT49254 Transcription of EDN1 5 0.69 2.42 0.94
56 INT152081 Phosphorylation of Edn1 1 0.53 0.39 0.9
57 INT61591 Negative_regulation of Localization of EDN1 11 0.59 2.09 0.85
58 INT57433 Positive_regulation of Binding of EDN1 3 0.49 0.62 0.82
59 INT61121 Regulation of Regulation of Edn1 1 0.43 0.2 0.75
60 INT59970 Positive_regulation of Binding of Edn1 2 0.40 1.11 0.71
61 INT125261 Positive_regulation of Gene_expression of Htr2c 2 0.67 2.22 0.7
62 INT21957 Negative_regulation of Negative_regulation of Edn1 5 0.43 1.34 0.69
63 INT49252 Positive_regulation of Localization of EDN1 17 0.69 6.55 0.66
64 INT100396 Transcription of Edn1 7 0.69 2.48 0.66
65 INT49256 Regulation of Positive_regulation of EDN1 2 0.45 2.5 0.65
66 INT272356 Positive_regulation of Transcription of Htr2c 1 0.45 1.66 0.63
67 INT7153 Positive_regulation of Regulation of Edn1 2 0.35 1.97 0.57
68 INT100754 Negative_regulation of Binding of Htr2c 1 0.41 0.49 0.57
69 INT135715 Negative_regulation of Localization of Edn1 5 0.42 1.7 0.56
70 INT63910 Regulation of Positive_regulation of Edn1 2 0.43 0.64 0.54
71 INT131641 Negative_regulation of Negative_regulation of Edn1 1 0.37 0.31 0.52
72 INT181581 Regulation of Positive_regulation of Edn1 4 0.23 3.76 0.51
73 INT230986 Positive_regulation of Transcription of Htr2c 1 0.45 0.25 0.49
74 INT55372 Regulation of Localization of Edn1 2 0.38 0.64 0.46
75 INT174055 Negative_regulation of Htr2c 5 0.41 2.63 0.45
76 INT57434 Regulation of Regulation of EDN1 1 0.40 0.47 0.44
77 INT81433 Negative_regulation of Positive_regulation of Edn1 4 0.39 0.81 0.38
78 INT113368 Regulation of Negative_regulation of Edn1 1 0.45 0.71 0.35
79 INT141013 Regulation of Gene_expression of Edn1 2 0.24 0.55 0.34
80 INT211023 Positive_regulation of Gene_expression of Htr2c 2 0.45 2.03 0.33
81 INT16368 Protein_catabolism of Edn1 2 0.72 0.18 0.31
82 INT84038 Protein_catabolism of Edn1 2 0.86 0.69 0.26
83 INT211029 Negative_regulation of Gene_expression of Htr2c 1 0.56 2.54 0.25
84 INT67265 Positive_regulation of Negative_regulation of Edn1 1 0.61 0.05 0.21
85 INT156920 Phosphorylation of EDN1 4 0.61 0.66 0.19
86 INT53372 Positive_regulation of Regulation of Edn1 1 0.50 0 0.19
87 INT100397 Regulation of Transcription of Edn1 1 0.00 0.1 0.19
88 INT174049 Positive_regulation of Negative_regulation of Htr2c 1 0.01 0 0.19
89 INT174053 Phosphorylation of Htr2c 1 0.01 0.06 0.18
90 INT272355 Regulation of Regulation of Htr2c 1 0.44 1.1 0.14
91 INT284152 Regulation of Transcription of EDN1 1 0.32 0.44 0.13
92 INT6362 Negative_regulation of Localization of Edn1 3 0.16 1.92 0.12
93 INT15391 Negative_regulation of Positive_regulation of Edn1 2 0.07 0.1 0.1
94 INT170744 Positive_regulation of Transcription of Edn1 2 0.20 1.3 0.1
95 INT49257 Positive_regulation of Transcription of EDN1 2 0.46 1.1 0.08
96 INT126441 Negative_regulation of Transcription of Edn1 1 0.40 0.17 0.08
97 INT174050 Binding of Htr2c 1 0.01 0 0.06
98 INT211025 Regulation of Gene_expression of Htr2c 1 0.43 1.01 0.06
99 INT280682 Positive_regulation of Transcription of Edn1 1 0.34 0 0
100 INT49261 Negative_regulation of Protein_catabolism of EDN1 1 0.58 0 0
101 INT181578 Negative_regulation of Phosphorylation of Edn1 1 0.37 0.1 0
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