GO:0031625

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Name ubiquitin protein ligase binding
Categary Function
Go Slim No
Go Link GO:0031625
Unique Molecular Interactions 1998
Total Molecular Interactions 2736
Total Single Events 20138
Pain Genes Associated 121

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ubiquitin protein ligase binding. They are ordered first by their pain relevance and then by number of times they were reported for ubiquitin protein ligase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
2 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
3 INT254001 Binding of Cxcr4 and Mif 1 0.52 14.17 7.18
4 INT251170 Clu Positive_regulation of Trpv1 1 0.28 2.61 6.49
5 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
6 INT211710 Binding of Mc1r and a 7 0.44 0.37 4.78
7 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
8 INT130625 Prkcg Regulation of Prkaca 1 0.23 1.32 3.87
9 INT104977 MITF Regulation of Gene_expression of MC1R 1 0.69 0.91 3.71
10 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52
11 INT166134 Binding of Cxcl12 and Cxcr4 3 0.49 5.69 3.17
12 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
13 INT298456 Prkaca Positive_regulation of Phosphorylation of Adarb1 1 0.00 1.86 2.85
14 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
15 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64
16 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
17 INT131257 ITIH4 Positive_regulation of Gene_expression of Nfkbia 1 0.23 1.41 2.3
18 INT251164 Binding of Clu and Trpv1 1 0.19 0.44 2.23
19 INT32586 H2-Ab1 Regulation of Pomc 1 0.03 0.14 2.19
20 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
21 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
22 INT319581 Binding of PIAS1 and TNFSF14 1 0.02 1.58 2.13
23 INT331105 Vmn1r71 Negative_regulation of Mc1r 1 0.04 0.64 2.07
24 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
25 INT349608 Binding of DIO2 and LMOD1 1 0.23 0.41 2.01
26 INT32585 H2-Ab1 Negative_regulation of Pomc 1 0.03 0.13 2
27 INT110525 Binding of MC1R and OCA2 1 0.41 1.08 1.97
28 INT104855 Prkaca Regulation of TRPV1 3 0.06 1.52 1.92
29 INT116815 Binding of Pias1 and Ppbp 1 0.36 0.86 1.92
30 INT112514 Binding of Prkaca and Trib3 1 0.03 1.18 1.9
31 INT186432 Prkaca Regulation of Creb1 1 0.14 0.45 1.9
32 INT95405 Trib3 Positive_regulation of Phosphorylation of Ephb1 3 0.08 1.33 1.89
33 INT112517 Binding of Ephb1 and Prkaca 3 0.18 0.58 1.85
34 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
35 INT332773 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.04 0.73 1.75
36 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
37 INT186433 Trib3 Regulation of Phosphorylation of Creb1 1 0.03 0.32 1.71
38 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
39 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 1 0.12 0.54 1.63
40 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
41 INT145072 ASIP Negative_regulation of MC1R 1 0.29 0 1.52
42 INT256360 Car2 Positive_regulation of Localization of Rela 1 0.14 0 1.51
43 INT29093 Binding of H2-Ab1 and Rbm39 1 0.06 0 1.5
44 INT121741 Prkaca Negative_regulation of Positive_regulation of Creb1 1 0.10 0.2 1.49
45 INT125845 Positive_regulation of Pag1 Positive_regulation of Gene_expression of Arrb2 1 0.09 0.46 1.48
46 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 0.08 0.18 1.48
47 INT156008 Bcl2 Regulation of Localization of Aifm1 1 0.17 1.92 1.47
48 INT78974 Binding of Prkcg and Prkaca 2 0.31 0.35 1.4
49 INT262568 Prkaca Regulation of Trpv1 2 0.10 0.65 1.38
50 INT161191 CRX Regulation of Gene_expression of Trib3 1 0.00 2 1.38
51 INT50706 Phax Positive_regulation of Localization of Trib3 1 0.04 0.28 1.38
52 INT161185 NMS Regulation of Gene_expression of Trib3 1 0.03 2 1.38
53 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 0.01 2.06 1.34
54 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
55 INT131256 Positive_regulation of Nfkb1 Positive_regulation of Gene_expression of Nfkbia 1 0.38 0.94 1.31
56 INT124926 Negative_regulation of Prkaca Negative_regulation of Localization of Pag1 1 0.00 0.61 1.3
57 INT94367 Binding of ARRB1 and TP53INP2 1 0.25 0 1.3
58 INT95406 Trib3 Positive_regulation of Ephb1 2 0.08 0.96 1.29
59 INT276282 Binding of Atrn and Mc1r 1 0.32 0.41 1.29
60 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27
61 INT71109 Binding of INSRR and MC1R 1 0.01 0 1.27
62 INT141244 Fos Regulation of Prkaca 1 0.18 0.07 1.24
63 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
64 INT195926 Prkaca Positive_regulation of Trpv1 1 0.10 0.44 1.24
65 INT75229 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.44 0 1.22
66 INT76163 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.02 0.08 1.22
67 INT7186 Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
68 INT7184 Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
69 INT140238 HELQ Regulation of MC1R 1 0.01 0.5 1.2
70 INT228681 Fkbp4 Negative_regulation of Trib3 1 0.00 0.57 1.2
71 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18
72 INT228680 Fkbp1a Negative_regulation of Trib3 1 0.01 0.56 1.18
73 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17
74 INT85780 Prkaca Regulation of Prkcg 1 0.29 0.47 1.17
75 INT141246 Trib3 Regulation of Gene_expression of Th 1 0.02 0.17 1.17
76 INT147447 ADCYAP1 Regulation of Localization of RELA 1 0.50 1.12 1.15
77 INT348400 LPA Positive_regulation of Trib3 1 0.00 0.87 1.14
78 INT139188 Binding of Daxx and Fas 1 0.03 0.55 1.14
79 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
80 INT81788 Binding of AGRP and MC4R 4 0.51 0 1.09
81 INT269200 Prkaca Positive_regulation of Phosphorylation of Ceacam3 1 0.03 0.65 1.09
82 INT352453 Calca Positive_regulation of Trib3 1 0.00 0.8 1.08
83 INT352468 Calca Positive_regulation of Prkaca 1 0.11 0.8 1.08
84 INT96906 Plxna3 Regulation of Regulation of Prkaca 1 0.17 0.71 1.08
85 INT331108 Mc1r Positive_regulation of Mc4r 1 0.44 1.05 1.06
86 INT145408 H2-Ab1 Negative_regulation of Gene_expression of Dbi 1 0.05 0 1.06
87 INT269198 Prkaca Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
88 INT269199 Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.03 0.56 1.05
89 INT331107 Vmn1r71 Positive_regulation of Mc1r 1 0.05 0.5 1.05
90 INT146097 Positive_regulation of Binding of Rgs9 and Arrb2 1 0.28 0 1.04
91 INT146098 Binding of Rgs9 and Arrb2 1 0.19 0 1.03
92 INT127997 Binding of MC1R and RHCE 2 0.28 0.41 1.02
93 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
94 INT240453 Prkcg Positive_regulation of Positive_regulation of Prkaca 1 0.23 0.63 1.01
95 INT240455 Ephb1 Positive_regulation of Positive_regulation of Prkaca 1 0.22 0.63 1.01
96 INT186161 Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.11 1.05 1.01
97 INT320021 Prkaca Regulation of Positive_regulation of Kcnma1 1 0.00 0.54 1
98 INT143916 Arrb2 Regulation of Rbm39 1 0.04 0.18 1
99 INT317564 Pik3r1 Regulation of Negative_regulation of Oprm1 1 0.13 0.07 1
100 INT142202 FL Positive_regulation of Bcl2 1 0.05 0.39 0.99
101 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98
102 INT201614 Mc1r Regulation of Uvbi1 1 0.04 1.42 0.98
103 INT133614 Map2k1 Regulation of Daxx 1 0.02 0.29 0.97
104 INT276864 Positive_regulation of Gpr65 Positive_regulation of Prkaca 1 0.16 0.74 0.97
105 INT275409 Binding of ITIH4 and Cxcr4 1 0.09 2.87 0.97
106 INT275386 Binding of Cxcr4 and Htatsf1 1 0.01 3.25 0.97
107 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
108 INT111632 Arrb2 Negative_regulation of Regulation of Rbm39 1 0.03 0 0.96
109 INT256357 Phosphorylation of Rela Positive_regulation of Localization of Ik 1 0.00 0.05 0.96
110 INT182190 Binding of IL8 and CXCR4 1 0.26 1.25 0.95
111 INT182210 Binding of CXCR4 and CXCL13 1 0.32 1.25 0.95
112 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
113 INT252877 Prkaca Positive_regulation of Regulation of Grip2 1 0.01 0.22 0.94
114 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
115 INT182205 Binding of CXCL5 and CXCR4 1 0.29 1.24 0.94
116 INT252878 Prkaca Regulation of Regulation of Grip2 1 0.01 0.22 0.94
117 INT182195 Binding of CXCL1 and CXCR4 1 0.13 1.25 0.94
118 INT81329 Binding of ARRB1 and OPRK1 1 0.05 0.1 0.93
119 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
120 INT252880 Positive_regulation of Prkaca Positive_regulation of Gene_expression of Tacr1 1 0.02 0.29 0.92
121 INT186431 Trib3 Regulation of Creb1 1 0.03 0.23 0.92
122 INT195927 Binding of Prkaca and Trpv1 1 0.07 0.28 0.92
123 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
124 INT112765 Binding of Nfkb1 and Bcl2 1 0.00 1.37 0.91
125 INT166135 Regulation of Binding of Cxcl12 and Cxcr4 1 0.30 0.9 0.91
126 INT252876 Positive_regulation of Prkaca Regulation of Gene_expression of Tacr1 1 0.01 0.28 0.89
127 INT129034 Nfkbia Positive_regulation of Nfkb1 1 0.02 0.67 0.89
128 INT134311 Tnf Positive_regulation of Protein_catabolism of Nfkbia 1 0.18 0.57 0.88
129 INT196834 Prkaca Positive_regulation of Phosphorylation of Ppp1r1b 2 0.15 0 0.87
130 INT251159 Binding of Clu and Positive_regulation of Trpv1 1 0.16 0 0.87
131 INT97735 Trib3 Positive_regulation of Mapk3 1 0.05 0.66 0.87
132 INT112914 Ppp1r1b Negative_regulation of Prkaca 3 0.22 0.13 0.86
133 INT254004 Cxcl12 Positive_regulation of Cxcr4 1 0.47 1.29 0.86
134 INT323698 Gene_expression of MIR146A Regulation of FAF1 1 0.16 1.82 0.86
135 INT166634 Binding of Bcl2 and Becn1 1 0.20 0.5 0.86
136 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
137 INT150864 RYBP Positive_regulation of Positive_regulation of Bcl2 1 0.01 0.66 0.86
138 INT196576 Trib3 Positive_regulation of Phosphorylation of Mapk9 1 0.02 0.5 0.85
139 INT129881 Binding of Calr and Cbll1 1 0.00 0.58 0.84
140 INT261480 Negative_regulation of Trib3 Positive_regulation of Ephb1 1 0.04 0.8 0.84
141 INT34740 BID Regulation of Gene_expression of PLOD1 1 0.01 0 0.83
142 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
143 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
144 INT328501 Sumo1 Negative_regulation of Gene_expression of Pglyrp1 1 0.00 1.54 0.83
145 INT149558 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.00 0 0.82
146 INT162071 Gene_expression of MC1R Negative_regulation of Gene_expression of TNF 1 0.41 0.34 0.82
147 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
148 INT185937 NOS2 Regulation of Prkaca 1 0.03 1.08 0.82
149 INT78972 Prkaca Regulation of Ina 1 0.11 0.09 0.82
150 INT77393 Binding of ARRB1 and OPRM1 1 0.15 0 0.82
151 INT139745 Positive_regulation of Binding of Oprm1 and Arrb2 1 0.28 0.14 0.81
152 INT186428 Trib3 Regulation of Prkcg 1 0.02 0.09 0.81
153 INT262564 Ngf Positive_regulation of Pik3r1 1 0.08 0.36 0.8
154 INT40610 Binding of Prkaca and Oprl1 1 0.02 0.09 0.8
155 INT85686 Binding of Arrb1 and Arrb2 1 0.14 0.09 0.79
156 INT186439 Prkaca Regulation of Phosphorylation of Creb1 1 0.06 0.08 0.79
157 INT130286 MC1R Positive_regulation of Localization of IL10 1 0.24 0.07 0.79
158 INT128041 Bdnf Positive_regulation of Trib3 1 0.10 0.29 0.79
159 INT240454 Ephb1 Regulation of Prkaca 1 0.14 0.51 0.79
160 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
161 INT124385 GRK6 Negative_regulation of MC1R 1 0.42 0.42 0.77
162 INT124384 ADRBK1 Negative_regulation of MC1R 1 0.40 0.42 0.77
163 INT99335 Binding of Agrp and Mc1r 1 0.30 0 0.77
164 INT50708 Phax Positive_regulation of Trib3 1 0.03 0.07 0.77
165 INT161951 Positive_regulation of TGFBR1 Positive_regulation of Gene_expression of Ngf 1 0.27 0.99 0.76
166 INT91239 Prkaca Regulation of Negative_regulation of Oprm1 1 0.43 0 0.76
167 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
168 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
169 INT113222 POMC Regulation of Gene_expression of MC1R 1 0.06 0 0.76
170 INT69692 Helt Regulation of Prkaca 1 0.00 0.33 0.76
171 INT113224 Binding of ASIP and MC1R 1 0.00 0 0.75
172 INT262578 Prkaca Positive_regulation of Localization of Calca 1 0.03 0.71 0.75
173 INT196799 Prkaca Positive_regulation of Phosphorylation of Trh 1 0.02 0 0.74
174 INT131468 Positive_regulation of POMC Positive_regulation of MC1R 1 0.00 0 0.74
175 INT50707 Phax Positive_regulation of Positive_regulation of Trib3 1 0.04 0.16 0.74
176 INT86657 TNF Regulation of H2-Ab1 1 0.02 0.84 0.74
177 INT218935 Cyp3a23/3a1 Regulation of Bcl2 1 0.00 1.08 0.74
178 INT316673 Binding of CALR and LRP1 1 0.39 1.89 0.74
179 INT113225 POMC Regulation of Transcription of MC1R 1 0.03 0 0.74
180 INT104974 MITF Positive_regulation of MC1R 1 0.52 0.16 0.74
181 INT161950 TGFBR1 Negative_regulation of Localization of Ngf 1 0.23 1.01 0.72
182 INT228494 Binding of Ncoa5 and Rela 1 0.00 1.58 0.72
183 INT182201 Binding of CXCR5 and CXCR4 1 0.36 1.15 0.72
184 INT182202 Binding of CXCR2 and CXCR4 1 0.31 1.15 0.72
185 INT244025 Prkaca Regulation of Phosphorylation of Gabrg1 1 0.08 0.18 0.72
186 INT11446 BLZF1 Positive_regulation of Positive_regulation of DECR1 1 0.03 0 0.72
187 INT351350 Prkaca Regulation of Lpar1 1 0.04 0.58 0.72
188 INT317573 Binding of Oprm1 and Pik3r1 1 0.12 0.33 0.71
189 INT153123 NFKBIA Negative_regulation of Phosphorylation of RELA 1 0.03 2.01 0.71
190 INT239538 Binding of CXCR4 and CALCRL 1 0.00 0.35 0.71
191 INT148449 Gene_expression of Inhbe Positive_regulation of Prkaca 1 0.05 0.68 0.71
192 INT155139 Binding of MC1R and PTGES 3 0.09 0 0.7
193 INT161297 Ppp1r1b Negative_regulation of Prkaca 1 0.10 0.16 0.7
194 INT161298 Ppp1r1b Negative_regulation of Trib3 1 0.05 0.16 0.7
195 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
196 INT186162 Phosphorylation of Prkaca Positive_regulation of Phosphorylation of Prkcg 1 0.04 0.22 0.7
197 INT251169 Clu Regulation of Ca2 1 0.03 0.66 0.7
198 INT81787 Binding of AGRP and MC1R 1 0.53 0 0.69
199 INT82022 Binding of Trib3 and Ngf 1 0.08 0.31 0.68
200 INT134652 Binding of MC1R and SUGT1 1 0.02 0.84 0.68

Single Events

The table below shows the top 100 pain related interactions that have been reported for ubiquitin protein ligase binding. They are ordered first by their pain relevance and then by number of times they were reported in ubiquitin protein ligase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT52651 Positive_regulation of Prkaca 136 0.67 40.82 99.16
2 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55
3 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01
4 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54
5 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48
6 INT49111 Negative_regulation of Prkaca 102 0.59 27.44 71.77
7 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52
8 INT21737 Binding of MC1R 129 0.48 45.45 56.54
9 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
10 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01
11 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38
12 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38
13 INT89055 Phosphorylation of Prkaca 60 0.61 13.41 32.49
14 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72
15 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73
16 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
17 INT66381 Regulation of Prkaca 40 0.62 13.38 27.96
18 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52
19 INT12681 Regulation of Trib3 76 0.53 23.92 26.58
20 INT96904 Regulation of Prkaca 33 0.44 10.86 24.51
21 INT15326 Phosphorylation of Trib3 83 0.55 30.96 22.27
22 INT96741 Gene_expression of Cxcr4 62 0.78 32.3 22.14
23 INT10536 Gene_expression of Trib3 67 0.66 27.08 21.58
24 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95
25 INT89805 Gene_expression of Prkaca 45 0.77 11.03 20.77
26 INT101188 Gene_expression of Rela 81 0.56 23.43 19.15
27 INT64442 Regulation of Mc4r 6 0.62 5.22 19.09
28 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
29 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
30 INT84712 Regulation of MC1R 36 0.62 9.34 16.91
31 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
32 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
33 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
34 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
35 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95
36 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51
37 INT38253 Localization of Trib3 35 0.63 10.28 15.42
38 INT64447 Transcription of Mc4r 14 0.61 6.08 15.29
39 INT93482 Localization of Rela 56 0.78 24.52 14.82
40 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35
41 INT77619 Gene_expression of Prkaca 43 0.75 8.55 14.13
42 INT144646 Positive_regulation of Rela 53 0.67 27.78 13.2
43 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18
44 INT97448 Negative_regulation of Mc1r 20 0.58 7.37 12.91
45 INT64445 Gene_expression of Mc4r 17 0.78 5.06 12.91
46 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82
47 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61
48 INT11766 Negative_regulation of H2-Ab1 15 0.43 5.27 12.32
49 INT65304 Positive_regulation of Gene_expression of MC1R 34 0.70 11.32 12.09
50 INT71030 Binding of Mc1r 39 0.48 10.27 12.02
51 INT3699 Gene_expression of H2-Ab1 24 0.74 12.06 11.82
52 INT94981 Gene_expression of Arrb2 12 0.70 2.11 11.75
53 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63
54 INT78970 Positive_regulation of Positive_regulation of Prkaca 14 0.47 3.06 11.49
55 INT2956 Binding of H2-Ab1 19 0.37 3.1 11.18
56 INT13240 Gene_expression of TF 94 0.76 57.81 10.99
57 INT85017 Positive_regulation of Mc4r 13 0.67 7.56 10.86
58 INT89184 Gene_expression of Mc4r 55 0.77 23.85 10.65
59 INT81538 Phosphorylation of Nfkbia 27 0.62 8.86 10.49
60 INT33127 Positive_regulation of Phosphorylation of Trib3 26 0.17 14.04 10
61 INT31780 Binding of DIO2 17 0.36 10.07 10
62 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
63 INT66382 Positive_regulation of Phosphorylation of Prkaca 33 0.49 7.05 9.69
64 INT58986 Gene_expression of Clu 17 0.77 8.35 9.61
65 INT149069 Positive_regulation of Cxcr4 24 0.68 12.21 9.54
66 INT130497 Gene_expression of Cbs 5 0.77 16.93 9.34
67 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28
68 INT64451 Negative_regulation of MC1R 21 0.59 4.94 9.22
69 INT10533 Positive_regulation of Positive_regulation of Trib3 24 0.42 6.59 9.2
70 INT40609 Binding of Prkaca 23 0.36 3.42 9.19
71 INT71494 Positive_regulation of Hspa1b 14 0.67 8.5 9.19
72 INT71478 Positive_regulation of Positive_regulation of Prkaca 21 0.37 5.14 8.85
73 INT66213 Localization of RELA 63 0.78 14.71 8.77
74 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68
75 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66
76 INT80872 Protein_catabolism of Nfkbia 28 0.92 10.56 8.62
77 INT29121 Positive_regulation of DIO2 23 0.67 6.13 8.46
78 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37
79 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27
80 INT95297 Gene_expression of Nfkbia 14 0.68 7.61 8.24
81 INT142526 Positive_regulation of Gene_expression of Prkaca 12 0.46 2.48 8.05
82 INT84765 Positive_regulation of Mc1r 24 0.70 5.95 8.01
83 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86
84 INT64449 Negative_regulation of Gene_expression of Mc4r 7 0.58 2 7.86
85 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71
86 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
87 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41
88 INT81532 Negative_regulation of Protein_catabolism of Nfkbia 21 0.54 8.92 7.38
89 INT91609 Regulation of Gene_expression of MC1R 11 0.62 2.75 7.34
90 INT261511 Localization of CBS 1 0.02 5.06 7.27
91 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
92 INT77404 Gene_expression of ARRB1 19 0.62 1.53 7.22
93 INT93481 Negative_regulation of Protein_catabolism of Nfkbia 14 0.39 7.24 7.21
94 INT90715 Gene_expression of Egr2 12 0.73 1.64 7.17
95 INT88498 Protein_catabolism of Nfkbia 14 0.82 6.94 7.1
96 INT89052 Positive_regulation of Phosphorylation of Prkaca 13 0.37 2.92 7.05
97 INT38254 Positive_regulation of Localization of Trib3 14 0.45 6.14 6.99
98 INT117186 Positive_regulation of CXCR4 29 0.69 24.19 6.84
99 INT29794 Regulation of DIO2 13 0.44 5.02 6.84
100 INT68466 Negative_regulation of Positive_regulation of Prkaca 6 0.57 2.29 6.83
101 INT81541 Negative_regulation of Nfkbia 12 0.51 5.73 6.79
102 INT10568 Regulation of H2-Ab1 9 0.20 1.86 6.79
103 INT100079 Positive_regulation of Gene_expression of Arrb2 7 0.63 2.26 6.77
104 INT104909 Binding of Pias1 11 0.37 3.67 6.72
105 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71
106 INT84685 Regulation of BCL2 67 0.60 72.96 6.65
107 INT256345 Phosphorylation of Rela 21 0.75 9.51 6.56
108 INT77408 Binding of ARRB1 11 0.36 0.31 6.51
109 INT85632 Regulation of Mc1r 14 0.61 3.22 6.5
110 INT94979 Regulation of Arrb2 6 0.54 0.51 6.45
111 INT64444 Negative_regulation of Mc4r 9 0.58 5.12 6.44
112 INT123787 Gene_expression of Bid 25 0.66 16 6.35
113 INT80447 Negative_regulation of ARRB2 5 0.39 3.12 6.3
114 INT14054 Positive_regulation of H2-Ab1 10 0.69 2.98 6.25
115 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
116 INT94986 Positive_regulation of Arrb2 5 0.61 1.3 6.24
117 INT117621 Positive_regulation of HSPA5 17 0.59 13.26 6.06
118 INT73179 Gene_expression of Hspa1b 10 0.73 6.24 6.04
119 INT126481 Gene_expression of Cxcr4 69 0.77 34.99 6
120 INT1493 Positive_regulation of Prkacb 8 0.59 2.75 5.99
121 INT253974 Binding of Cxcr4 22 0.47 12.26 5.95
122 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
123 INT62422 Regulation of Gene_expression of Mc1r 12 0.62 2.28 5.93
124 INT117189 Binding of CXCR4 34 0.37 24.27 5.81
125 INT47976 Protein_catabolism of NFKBIA 17 0.88 7.57 5.79
126 INT85777 Regulation of Negative_regulation of Prkaca 7 0.46 1.85 5.76
127 INT96744 Positive_regulation of Gene_expression of Cxcr4 14 0.68 7.92 5.75
128 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7
129 INT69700 Transcription of MC1R 15 0.71 4.32 5.62
130 INT71477 Negative_regulation of Positive_regulation of Prkaca 10 0.37 1.69 5.57
131 INT50704 Binding of Trib3 13 0.31 6.33 5.46
132 INT51337 Binding of Clu 3 0.12 0.05 5.45
133 INT124370 Positive_regulation of Gene_expression of Gsk3b 47 0.67 24.56 5.4
134 INT113112 Negative_regulation of CXCR4 39 0.58 28.28 5.36
135 INT127112 Phosphorylation of Smad2 19 0.80 11.01 5.36
136 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23
137 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22
138 INT60585 Regulation of TP53 59 0.59 54.55 5.21
139 INT81535 Negative_regulation of Phosphorylation of Nfkbia 15 0.44 5.74 5.18
140 INT22597 Positive_regulation of TF 43 0.68 27.27 5.17
141 INT85685 Gene_expression of Arrb2 5 0.74 0.66 5.13
142 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07
143 INT105609 Negative_regulation of Mc4r 10 0.58 10.4 5.04
144 INT29893 Negative_regulation of Prkacb 4 0.37 1.14 5.04
145 INT143234 Gene_expression of Nfkbia 10 0.62 5.2 5.02
146 INT116744 Binding of Pik3r1 22 0.36 12.77 5.01
147 INT51734 Negative_regulation of Localization of Trib3 10 0.19 2.53 4.97
148 INT71244 Binding of Prkaca 8 0.30 2.64 4.96
149 INT135727 Positive_regulation of Gene_expression of Mc1r 18 0.69 8.69 4.92
150 INT64446 Negative_regulation of Transcription of Mc4r 4 0.43 1.01 4.8
151 INT88496 Positive_regulation of Protein_catabolism of Nfkbia 8 0.53 3.05 4.78
152 INT135374 Binding of Gsk3b 46 0.48 24.36 4.75
153 INT204971 Gene_expression of Pink1 42 0.77 23.95 4.75
154 INT85681 Negative_regulation of Arrb2 5 0.47 0.79 4.71
155 INT131253 Positive_regulation of Gene_expression of Nfkbia 4 0.41 3.28 4.71
156 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
157 INT165058 Negative_regulation of MID1 14 0.37 10.82 4.67
158 INT97878 Positive_regulation of Pias1 6 0.50 2.73 4.65
159 INT116748 Positive_regulation of Gene_expression of Pik3r1 18 0.49 9.83 4.63
160 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
161 INT64441 Regulation of Transcription of Mc4r 3 0.27 2.93 4.62
162 INT62424 Transcription of Mc1r 8 0.71 3.67 4.54
163 INT1490 Regulation of Prkacb 7 0.21 0.5 4.52
164 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51
165 INT24813 Negative_regulation of Positive_regulation of Trib3 10 0.16 1.3 4.48
166 INT55171 Gene_expression of RELA 80 0.75 17.17 4.47
167 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
168 INT4283 Positive_regulation of Cbs 10 0.46 6.85 4.44
169 INT94277 Positive_regulation of Gene_expression of Egr2 7 0.49 0.69 4.4
170 INT108935 Transcription of Arrb2 5 0.59 0.5 4.38
171 INT108354 Negative_regulation of Phosphorylation of Prkaca 18 0.41 6.24 4.37
172 INT87210 Positive_regulation of Nfkbia 9 0.61 3.89 4.35
173 INT154527 Gene_expression of POU5F1 180 0.78 34.01 4.34
174 INT116747 Regulation of Pik3r1 18 0.60 9.33 4.34
175 INT101957 Transcription of Bcl2 30 0.69 16.57 4.3
176 INT92797 Regulation of Arrb2 4 0.44 0.81 4.28
177 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27
178 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21
179 INT94985 Regulation of Gene_expression of Arrb2 2 0.40 0.43 4.2
180 INT93483 Negative_regulation of Localization of Rela 11 0.57 5.1 4.19
181 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17
182 INT144428 Positive_regulation of Gene_expression of Erbb2 41 0.69 41.4 4.13
183 INT158377 Positive_regulation of Positive_regulation of Rela 6 0.49 3.08 4.11
184 INT32205 Regulation of Positive_regulation of Trib3 9 0.11 2.82 4.1
185 INT81543 Positive_regulation of Phosphorylation of Nfkbia 7 0.37 2.51 4.1
186 INT108868 Transcription of Nfkbia 2 0.57 2.91 4.03
187 INT217102 Gene_expression of Egr2 50 0.78 10.91 3.89
188 INT120742 Negative_regulation of Gene_expression of Prkaca 6 0.24 3.76 3.86
189 INT116642 Negative_regulation of Gsk3b 13 0.57 7.16 3.83
190 INT85679 Binding of Arrb2 4 0.39 0.79 3.82
191 INT280193 Positive_regulation of Gene_expression of Cbs 1 0.69 6.59 3.81
192 INT96071 Localization of PIAS1 6 0.71 4.44 3.79
193 INT146946 Gene_expression of Lyn 16 0.76 8.9 3.75
194 INT10535 Positive_regulation of Gene_expression of Trib3 13 0.59 4.93 3.74
195 INT133550 Negative_regulation of Gene_expression of Rela 14 0.40 4.64 3.73
196 INT105882 Phosphorylation of Bcl2 11 0.59 8.15 3.73
197 INT123908 Positive_regulation of HLA-DQB1 12 0.21 10.5 3.71
198 INT120072 Gene_expression of Smad7 38 0.74 20.87 3.69
199 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
200 INT116623 Localization of Prkaca 15 0.73 2.89 3.59
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