GO:0031638

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Name zymogen activation
Categary Process
Go Slim No
Go Link GO:0031638
Unique Molecular Interactions 91
Total Molecular Interactions 138
Total Single Events 594
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for zymogen activation. They are ordered first by their pain relevance and then by number of times they were reported for zymogen activation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33
2 INT17300 Prss12 Positive_regulation of Localization of Acot1 4 0.11 0 3.28
3 INT150455 Binding of Prss12 and Nts 3 0.24 1.42 2.66
4 INT150457 Binding of Sort1 and Prss12 3 0.21 1.36 2.64
5 INT17299 Prss12 Regulation of Localization of Acot1 3 0.05 0 2.07
6 INT192161 Mmp14 Positive_regulation of Mmp2 2 0.19 1.23 1.81
7 INT777 Prss12 Positive_regulation of Prl 1 0.19 0 1.33
8 INT20530 Nts Regulation of Prss12 5 0.24 0.74 1.23
9 INT154258 Binding of Abat and Prss12 1 0.03 0 0.87
10 INT154257 Binding of Prss12 and Cfp 1 0.02 0 0.87
11 INT113472 TNF Positive_regulation of Localization of MMP14 1 0.47 0.45 0.75
12 INT8367 Tacr1 Positive_regulation of Localization of Prss12 1 0.05 0 0.72
13 INT784 Prss12 Positive_regulation of Gh1 1 0.06 0 0.7
14 INT783 Prss12 Positive_regulation of Positive_regulation of Oprl1 1 0.05 0 0.7
15 INT224678 Binding of Mmp14 and Mmp23 1 0.00 0.85 0.69
16 INT13595 Penk Positive_regulation of Localization of Prss12 1 0.12 0 0.67
17 INT224683 Mmp14 Positive_regulation of Binding of Mmp9 1 0.01 0.81 0.65
18 INT780 Prss12 Positive_regulation of Gene_expression of Prl 1 0.14 0 0.65
19 INT781 Prss12 Positive_regulation of Gene_expression of Gnrhr 1 0.10 0 0.65
20 INT40762 Trh Negative_regulation of Prss12 1 0.06 0 0.65
21 INT224684 Binding of Mmp14 and Mmp9 1 0.01 0.81 0.64
22 INT113473 RETNLB Positive_regulation of MMP14 1 0.01 0.37 0.64
23 INT773 Prss12 Positive_regulation of Gnrhr 1 0.04 0 0.64
24 INT144071 TRPV1 Positive_regulation of Gene_expression of MMP14 1 0.21 0.5 0.58
25 INT46434 Prss12 Negative_regulation of Prl 1 0.16 0 0.54
26 INT192162 Furin Positive_regulation of Mmp14 1 0.10 0.79 0.53
27 INT192159 Mmp14 Regulation of Protein_catabolism of Col1a1 1 0.02 1.01 0.52
28 INT118485 CST3 Regulation of CTSH 1 0.36 0 0.49
29 INT345306 Binding of MMP14 and TIMP2 1 0.04 0.21 0.48
30 INT149894 Ihh Positive_regulation of Localization of Mmp14 1 0.04 2.06 0.47
31 INT39076 Prss12 Regulation of Penk 1 0.04 0.44 0.46
32 INT39077 Agt Negative_regulation of Prss12 1 0.05 0.44 0.46
33 INT327090 Negative_regulation of F12 Negative_regulation of Gene_expression of KNG1 1 0.00 0.51 0.45
34 INT10550 Prss12 Positive_regulation of Localization of Abat 1 0.06 0 0.45
35 INT345305 MMP14 Positive_regulation of MMP13 1 0.00 0.33 0.45
36 INT345304 MMP14 Positive_regulation of MMP2 1 0.08 0.2 0.45
37 INT10549 Prss12 Regulation of Localization of Abat 1 0.04 0 0.43
38 INT113471 RETNLB Regulation of Localization of MMP14 1 0.01 0.24 0.43
39 INT342622 Binding of MMP14 and Mmp2 1 0.39 1.15 0.37
40 INT39093 Negative_regulation of Prss12 Positive_regulation of Localization of Ren 1 0.10 0 0.37
41 INT342606 Binding of MMP14 and VEGFA 1 0.08 1.16 0.37
42 INT39096 Prss12 Negative_regulation of Ren 1 0.12 0 0.37
43 INT150458 Prss12 Regulation of Helt 1 0.00 0 0.34
44 INT113476 IL1A Positive_regulation of Localization of MMP14 1 0.10 0.22 0.34
45 INT149897 Ihh Positive_regulation of Mmp14 1 0.03 0.93 0.33
46 INT113475 RETNLB Positive_regulation of Localization of MMP14 1 0.01 0.18 0.32
47 INT46432 Prl Negative_regulation of Prss12 1 0.16 0 0.3
48 INT328223 Mmp14 Regulation of Positive_regulation of Mmp13 1 0.07 0.69 0.29
49 INT149898 Ihh Regulation of Localization of Mmp14 1 0.03 1.29 0.27
50 INT46433 Nts Negative_regulation of Prss12 1 0.12 0 0.27
51 INT244687 Mmp14 Positive_regulation of Mmp2 1 0.23 0.48 0.25
52 INT119717 Binding of ADRA1D and F12 1 0.35 0.23 0.23
53 INT149900 Gli1 Regulation of Localization of Mmp14 1 0.02 1.17 0.22
54 INT332700 Binding of F12 and KNG1 1 0.15 1.05 0.21
55 INT215944 Mmp14 Regulation of Eae1 1 0.03 0.95 0.2
56 INT215942 Regulation of Mmp14 Regulation of Eae1 1 0.03 0.95 0.2
57 INT250550 Binding of F12 and CHDH 1 0.05 2.26 0.17
58 INT8161 Fos Regulation of Gene_expression of Prss12 1 0.07 0.31 0.13
59 INT45518 Prss12 Positive_regulation of Localization of LH 1 0.07 0.36 0.13
60 INT45516 Prss12 Regulation of Regulation of LH 1 0.07 0.36 0.13
61 INT232015 SERPING1 Negative_regulation of F12 2 0.24 1.19 0.12
62 INT264389 MMP14 Regulation of Positive_regulation of MMP13 1 0.31 0.06 0.12
63 INT264411 MMP14 Regulation of Positive_regulation of MMP1 1 0.20 0.06 0.12
64 INT264400 MMP9 Regulation of MMP14 1 0.08 0.06 0.11
65 INT264406 MMP3 Regulation of MMP14 1 0.09 0.06 0.11
66 INT264402 MMP2 Regulation of MMP14 1 0.10 0.06 0.11
67 INT232017 F12 Positive_regulation of PLG 1 0.03 0.52 0.11
68 INT232019 F12 Positive_regulation of TRGC1 1 0.00 0.57 0.09
69 INT310201 Binding of F12 and Chdh 1 0.04 1.06 0.08
70 INT232009 Positive_regulation of F12 Negative_regulation of Localization of KNG1 1 0.01 0.19 0.05
71 INT265735 VEGFA Positive_regulation of Binding of KLKB1 1 0.04 0.36 0.04
72 INT327162 Binding of SERPING1 and F12 1 0.05 0.29 0.04
73 INT265745 FLT1 Positive_regulation of Binding of KLKB1 1 0.04 0.36 0.04
74 INT168310 Binding of CP and PRSS3 1 0.18 0.12 0
75 INT265760 Binding of KLKB1 and VEGFA 1 0.04 0.14 0
76 INT245103 TNFRSF11B Negative_regulation of MMP14 1 0.02 1.15 0
77 INT265754 Binding of FLT1 and KLKB1 1 0.03 0.07 0
78 INT265747 Binding of KLKB1 and KL 1 0.02 0 0
79 INT218040 Binding of DNAH8 and PRSS3 1 0.01 1.32 0
80 INT282880 MMP14 Regulation of MUC1 1 0.02 0.17 0
81 INT282881 MUC1 Positive_regulation of Gene_expression of MMP14 1 0.04 0.17 0
82 INT265728 Positive_regulation of Binding of KLKB1 and VEGFA 1 0.04 0 0
83 INT218041 Positive_regulation of Binding of DNAH8 and PRSS3 1 0.01 1.37 0
84 INT45517 Prss12 Regulation of Gene_expression of LH 1 0.07 0.25 0
85 INT310200 Binding of Serping1 and F12 1 0.21 0.05 0
86 INT265738 NRP1 Positive_regulation of KLKB1 1 0.03 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for zymogen activation. They are ordered first by their pain relevance and then by number of times they were reported in zymogen activation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT8362 Localization of Prss12 53 0.78 5.09 27
2 INT99898 Gene_expression of Mmp14 37 0.56 28.54 16.39
3 INT10546 Positive_regulation of Prss12 12 0.44 4.57 10.05
4 INT8360 Positive_regulation of Localization of Prss12 14 0.26 1.72 9.38
5 INT13593 Binding of Prss12 13 0.36 4.35 9.37
6 INT8160 Gene_expression of Prss12 20 0.67 4.83 8.17
7 INT10547 Regulation of Prss12 11 0.41 3.11 5.74
8 INT13594 Regulation of Localization of Prss12 5 0.30 1.55 4.88
9 INT107605 Gene_expression of MMP14 26 0.64 25.88 4.49
10 INT53787 Transcription of Prss12 7 0.21 3.29 4.4
11 INT113485 Localization of MMP14 11 0.77 3.44 4.19
12 INT11661 Negative_regulation of Prss12 7 0.37 0.78 4.16
13 INT215926 Regulation of Gene_expression of Mmp14 1 0.45 5.33 3.15
14 INT27465 Positive_regulation of F12 21 0.70 8.09 3.06
15 INT115857 Gene_expression of PRSS3 10 0.72 4.13 2.96
16 INT46201 Gene_expression of KLKB1 21 0.53 3.01 2.87
17 INT99895 Positive_regulation of Mmp14 10 0.58 6.64 2.72
18 INT99897 Positive_regulation of Gene_expression of Mmp14 7 0.36 6.33 2.51
19 INT73347 Positive_regulation of Positive_regulation of Prss12 1 0.09 1.23 2.38
20 INT215914 Localization of Mmp14 4 0.59 2.26 1.98
21 INT107607 Negative_regulation of MMP14 10 0.37 6.05 1.83
22 INT11481 Positive_regulation of F12 11 0.58 5.53 1.8
23 INT115858 Positive_regulation of PRSS3 5 0.50 2.06 1.72
24 INT192152 Negative_regulation of Mmp14 3 0.24 1.69 1.72
25 INT113479 Transcription of MMP14 3 0.51 1.81 1.7
26 INT215921 Regulation of Mmp14 1 0.33 2.8 1.7
27 INT125245 Positive_regulation of Mmp14 4 0.44 4.38 1.67
28 INT153156 Negative_regulation of KLKB1 5 0.48 7.88 1.6
29 INT8359 Negative_regulation of Localization of Prss12 2 0.32 0 1.6
30 INT23251 Positive_regulation of KLKB1 10 0.67 2.98 1.59
31 INT176468 Transcription of Mmp14 3 0.52 2.47 1.51
32 INT77164 Binding of F12 8 0.47 2.66 1.48
33 INT115861 Transcription of PRSS3 2 0.67 1.45 1.4
34 INT119522 Positive_regulation of Gene_expression of Prss12 1 0.60 2.34 1.39
35 INT150728 Positive_regulation of Gene_expression of PRSS3 1 0.09 1.19 1.36
36 INT11496 Negative_regulation of F12 6 0.59 3.41 1.27
37 INT10133 Negative_regulation of F12 16 0.49 5.21 1.26
38 INT27155 Binding of F12 8 0.36 1.61 1.21
39 INT58567 Negative_regulation of Positive_regulation of Prss12 2 0.21 0 1.21
40 INT78686 Protein_catabolism of PRSS3 2 0.88 1.5 1.15
41 INT125248 Negative_regulation of Mmp14 1 0.06 3.06 1.07
42 INT58606 Negative_regulation of Binding of Prss12 4 0.20 0 1.01
43 INT192155 Negative_regulation of Negative_regulation of Mmp14 1 0.17 0.88 0.94
44 INT90370 Gene_expression of Mmp14 3 0.49 3.71 0.93
45 INT44001 Negative_regulation of Positive_regulation of F12 5 0.59 2.53 0.73
46 INT144073 Positive_regulation of Gene_expression of MMP14 4 0.24 6.13 0.72
47 INT224633 Binding of Mmp14 1 0.06 0.83 0.69
48 INT46202 Positive_regulation of Gene_expression of KLKB1 2 0.04 0 0.68
49 INT90699 Regulation of F12 4 0.45 2.7 0.67
50 INT265802 Regulation of KLKB1 9 0.04 1.01 0.64
51 INT149889 Localization of Mmp14 5 0.47 2.58 0.61
52 INT113484 Positive_regulation of Localization of MMP14 1 0.58 0.34 0.6
53 INT196352 Positive_regulation of Transcription of MMP14 1 0.06 0.91 0.58
54 INT215918 Negative_regulation of Positive_regulation of Mmp14 1 0.31 0.45 0.56
55 INT138125 Positive_regulation of MMP14 5 0.49 4.04 0.52
56 INT192153 Protein_catabolism of Mmp14 1 0.31 1.01 0.52
57 INT282919 Regulation of MMP14 1 0.12 1.53 0.52
58 INT221932 Gene_expression of F12 4 0.66 2.61 0.5
59 INT345323 Protein_catabolism of MMP14 1 0.33 0.12 0.49
60 INT130732 Binding of MMP14 4 0.36 2.58 0.47
61 INT36603 Positive_regulation of CTSH 1 0.01 0 0.46
62 INT36793 Binding of KLKB1 3 0.40 0.51 0.42
63 INT113481 Regulation of Localization of MMP14 1 0.43 0.24 0.42
64 INT10129 Gene_expression of F12 4 0.65 3.4 0.37
65 INT11660 Regulation of Negative_regulation of Prss12 1 0.16 0 0.37
66 INT107608 Regulation of Negative_regulation of MMP14 1 0.17 0.4 0.34
67 INT77162 Regulation of Binding of F12 2 0.33 0.52 0.28
68 INT36795 Localization of KLKB1 3 0.78 1.05 0.27
69 INT115860 Regulation of PRSS3 1 0.25 0.11 0.27
70 INT77165 Regulation of Positive_regulation of F12 1 0.38 0.28 0.23
71 INT77160 Positive_regulation of Binding of F12 1 0.42 0.28 0.23
72 INT77156 Regulation of Binding of F12 1 0.13 0.25 0.23
73 INT77153 Positive_regulation of Binding of F12 1 0.14 0.26 0.22
74 INT220857 Negative_regulation of Transcription of Mmp14 1 0.05 1.04 0.2
75 INT215917 Regulation of Regulation of Mmp14 1 0.33 0.95 0.2
76 INT142708 Gene_expression of CTSH 1 0.75 1.51 0.18
77 INT119715 Localization of F12 3 0.67 1.24 0.17
78 INT58589 Regulation of F12 3 0.39 1.9 0.16
79 INT96541 Negative_regulation of Binding of F12 2 0.41 0.32 0.16
80 INT119714 Protein_catabolism of F12 1 0.84 0.14 0.14
81 INT10128 Negative_regulation of Gene_expression of F12 2 0.01 0.33 0.12
82 INT316316 Negative_regulation of Binding of F12 1 0.18 1.1 0.12
83 INT232026 Positive_regulation of Gene_expression of F12 1 0.03 0.58 0.11
84 INT310198 Positive_regulation of Positive_regulation of F12 1 0.38 1.63 0.09
85 INT123574 Localization of F12 1 0.15 0.25 0.09
86 INT265776 Regulation of Binding of KLKB1 1 0.04 0.36 0.04
87 INT265791 Protein_catabolism of KLKB1 1 0.07 0 0
88 INT326466 Regulation of Gene_expression of F12 1 0.03 0.6 0
89 INT340719 Regulation of Positive_regulation of PRSS3 1 0.03 0.14 0
90 INT326467 Regulation of Gene_expression of F12 1 0.44 0.6 0
91 INT265786 Positive_regulation of Positive_regulation of KLKB1 1 0.04 0.24 0
92 INT265789 Negative_regulation of Protein_catabolism of KLKB1 1 0.03 0 0
93 INT244680 Positive_regulation of Gene_expression of Mmp14 1 0.44 0 0
94 INT244684 Binding of Mmp14 1 0.23 0.1 0
95 INT265782 Regulation of Gene_expression of KLKB1 1 0.04 0 0
96 INT250579 Transcription of F12 1 0.62 0.77 0
97 INT245109 Negative_regulation of Binding of MMP14 1 0.12 1.14 0
98 INT218048 Negative_regulation of PRSS3 1 0.03 0.19 0
99 INT177470 Localization of PRSS3 1 0.05 0.1 0
100 INT218047 Negative_regulation of Gene_expression of PRSS3 1 0.03 0.33 0
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