GO:0031647

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Name regulation of protein stability
Categary Process
Go Slim No
Go Link GO:0031647
Unique Molecular Interactions 341
Total Molecular Interactions 441
Total Single Events 4871
Pain Genes Associated 18

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of protein stability. They are ordered first by their pain relevance and then by number of times they were reported for regulation of protein stability. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
2 INT317526 Binding of Hint1 and Gipc1 1 0.00 0.25 2.38
3 INT156008 Bcl2 Regulation of Localization of Aifm1 1 0.17 1.92 1.47
4 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 0.01 2.06 1.34
5 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
6 INT142202 FL Positive_regulation of Bcl2 1 0.05 0.39 0.99
7 INT112765 Binding of Nfkb1 and Bcl2 1 0.00 1.37 0.91
8 INT166634 Binding of Bcl2 and Becn1 1 0.20 0.5 0.86
9 INT150864 RYBP Positive_regulation of Positive_regulation of Bcl2 1 0.01 0.66 0.86
10 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82
11 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
12 INT218935 Cyp3a23/3a1 Regulation of Bcl2 1 0.00 1.08 0.74
13 INT4915 Binding of Tac2 and Gipc1 1 0.01 0 0.74
14 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
15 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
16 INT281083 Binding of Gria1 and Gipc1 1 0.01 0 0.65
17 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
18 INT111184 Binding of GIPC1 and CHCHD8 1 0.00 0 0.59
19 INT77394 Binding of ARRB1 and GIPC1 1 0.01 0 0.56
20 INT97949 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of CDC42 1 0.06 0.72 0.51
21 INT97953 ST3GAL3 Positive_regulation of CDC42 1 0.09 0.7 0.5
22 INT320121 Binding of PTEN and TNF 1 0.05 0.76 0.49
23 INT302839 MIR15A Negative_regulation of Bcl2 1 0.15 1.41 0.47
24 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
25 INT238639 Cd86 Negative_regulation of Negative_regulation of Bcl2 1 0.01 0.97 0.46
26 INT112772 Binding of Bcl2 and SGSM3 1 0.02 0.69 0.45
27 INT116609 Lnpep Negative_regulation of Bcl2 1 0.05 0.62 0.43
28 INT116606 Lnpep Regulation of Gene_expression of Bcl2 1 0.07 0.62 0.43
29 INT116607 Lnpep Negative_regulation of Gene_expression of Bcl2 1 0.10 0.62 0.43
30 INT160046 INPPL1 Regulation of Gene_expression of PTEN 1 0.41 0.6 0.42
31 INT309143 Dlat Positive_regulation of Bcl2 1 0.06 1.04 0.42
32 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
33 INT309152 Dlat Positive_regulation of Gene_expression of Bcl2 1 0.04 1.05 0.42
34 INT160049 PTEN Regulation of Gene_expression of INPPL1 1 0.41 0.6 0.42
35 INT158032 Binding of CDKN2A and KRT20 1 0.28 0.59 0.4
36 INT235878 Creb1 Positive_regulation of Gene_expression of Bcl2 1 0.05 0.17 0.38
37 INT155062 Csf2 Positive_regulation of Transcription of Bcl2 1 0.31 2.91 0.36
38 INT257741 HRAS Negative_regulation of PTEN 1 0.15 1.06 0.35
39 INT264555 IL15 Positive_regulation of Gene_expression of BCL2 1 0.02 0.92 0.35
40 INT257737 Positive_regulation of HRAS Negative_regulation of PTEN 1 0.17 1.07 0.35
41 INT204071 HP Positive_regulation of Gene_expression of CDKN2A 1 0.00 3.48 0.34
42 INT117589 Binding of C5AR1 and GIPC1 1 0.10 0.39 0.34
43 INT269962 Bcl2 Negative_regulation of Bcl2l11 1 0.15 2.14 0.34
44 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
45 INT155060 Stat3 Negative_regulation of Bcl2 1 0.21 3.7 0.33
46 INT285567 Binding of IL1B and Cdc42 1 0.03 0.77 0.31
47 INT242398 Cyp19a1 Positive_regulation of Bcl2 1 0.00 1.28 0.3
48 INT218928 Cyp3a23/3a1 Regulation of Transcription of Bcl2 1 0.00 0.56 0.28
49 INT260837 NRP2 Negative_regulation of Negative_regulation of Bcl2 1 0.00 0.9 0.28
50 INT172905 Binding of Bad and Bcl2 3 0.08 6.46 0.27
51 INT237927 BCL2 Positive_regulation of BAX 2 0.24 2.22 0.26
52 INT237928 BCL2 Positive_regulation of FAS 1 0.02 1.41 0.26
53 INT272157 Gh1 Negative_regulation of Bcl2 1 0.23 1.2 0.26
54 INT272158 Gh1 Regulation of Bcl2 1 0.15 1.2 0.26
55 INT237925 BCL2 Positive_regulation of Protein_catabolism of PARP1 1 0.02 1.42 0.26
56 INT147593 Binding of CDK4 and CDKN2A 1 0.42 0.23 0.26
57 INT147592 Positive_regulation of Binding of CDK4 and CDKN2A 1 0.44 0.23 0.26
58 INT307207 Ppara Positive_regulation of Apoa2 1 0.10 0.94 0.25
59 INT260840 NRP2 Positive_regulation of Gene_expression of Bcl2 1 0.00 0.85 0.24
60 INT292565 MAP3K5 Positive_regulation of Positive_regulation of CDC42 1 0.02 0 0.23
61 INT302170 PTGER2 Positive_regulation of Gene_expression of BCL2 1 0.04 3.76 0.23
62 INT311613 Binding of Slc6a4 and Pten 1 0.24 0.32 0.21
63 INT203848 Binding of Pten and Lna1 1 0.06 0.4 0.2
64 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19
65 INT281477 Binding of Pten and Th 1 0.28 0.4 0.19
66 INT224680 Tgfb1 Negative_regulation of Pten 1 0.00 1.19 0.18
67 INT176133 AKT1 Regulation of BCL2 2 0.12 1.84 0.17
68 INT285026 Bak1 Regulation of Bcl2 1 0.09 0.71 0.17
69 INT285022 Regulation of Bak1 Regulation of Bcl2 1 0.09 0.71 0.17
70 INT349475 Regulation of Bax Regulation of Bcl2 1 0.07 1.35 0.17
71 INT155233 TXNIP Regulation of BCL2 1 0.23 0.15 0.17
72 INT285024 Bcl2 Regulation of Bak1 1 0.09 0.71 0.17
73 INT229203 Binding of Bcl2 and Cyp2c11 1 0.36 1.2 0.17
74 INT155068 Csf2 Negative_regulation of Bcl2 1 0.12 1.88 0.17
75 INT347445 CD99 Positive_regulation of BCL2 1 0.17 0.95 0.16
76 INT43510 Apoa2 Positive_regulation of Localization of POMC 1 0.03 0 0.16
77 INT136855 Arf5 Positive_regulation of Cdkn2a 1 0.07 1.8 0.15
78 INT292750 Akt1 Positive_regulation of Bcl2 1 0.01 1.67 0.15
79 INT349476 Bax Regulation of Bcl2 1 0.07 1.33 0.15
80 INT208264 Park7 Negative_regulation of Pten 1 0.16 1.16 0.15
81 INT314856 Binding of Cdc7 and Cdkn2a 1 0.28 1.34 0.14
82 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
83 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14
84 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
85 INT95104 TGFBR2 Positive_regulation of BCL2 1 0.08 0.61 0.14
86 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
87 INT309139 Edc4 Positive_regulation of Bcl2 1 0.03 0.12 0.13
88 INT81789 Binding of MC1R and GIPC1 1 0.01 0 0.13
89 INT148594 Binding of BCL2 and CD34 1 0.39 1.17 0.13
90 INT81786 Binding of AGRP and GIPC1 1 0.01 0 0.13
91 INT309142 Edc4 Regulation of Bcl2 1 0.02 0.12 0.13
92 INT246016 Negative_regulation of Timp1 Negative_regulation of Gene_expression of Bcl2 1 0.03 1.07 0.13
93 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13
94 INT348542 BCL2 Negative_regulation of NLRP1 1 0.07 2.02 0.13
95 INT246017 Timp1 Negative_regulation of Gene_expression of Bcl2 1 0.03 1.07 0.13
96 INT172899 Binding of Bcl2 and Bcl2l1 3 0.02 5.54 0.12
97 INT178101 EDN1 Negative_regulation of Phosphorylation of BCL2 1 0.03 1 0.12
98 INT305194 Bcl2 Positive_regulation of Epo 1 0.06 0.29 0.12
99 INT33752 Apoa2 Regulation of Localization of POMC 1 0.06 0 0.12
100 INT33750 Apoa2 Regulation of Agt 1 0.07 0 0.12
101 INT33751 Apoa2 Positive_regulation of Positive_regulation of POMC 1 0.09 0 0.11
102 INT2458 Apoa2 Positive_regulation of Localization of Avp 1 0.10 0 0.11
103 INT256544 Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
104 INT273063 Negative_regulation of Fas Negative_regulation of Positive_regulation of Bcl2 1 0.01 0.72 0.11
105 INT221684 Binding of Bcl2 and FRTS 1 0.01 1.19 0.11
106 INT256545 Positive_regulation of Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
107 INT287267 EGF Positive_regulation of CDC42 1 0.12 0.16 0.11
108 INT265888 BCL2 Regulation of Gene_expression of BAD 1 0.04 1.08 0.1
109 INT265890 BCL2 Regulation of Gene_expression of BAX 1 0.04 1.08 0.1
110 INT239643 Binding of BCL2 and BCL2L11 3 0.16 2.26 0.09
111 INT282094 Apoa2 Negative_regulation of BCL2 1 0.06 1.15 0.09
112 INT275183 Bad Positive_regulation of Gene_expression of Bcl2 1 0.08 0.63 0.09
113 INT265887 IGF1 Negative_regulation of BCL2 1 0.09 1.02 0.09
114 INT294637 Bcl2a1a Positive_regulation of Gene_expression of Bcl2 1 0.15 0.97 0.09
115 INT133481 TNF Positive_regulation of Phosphorylation of PTEN 1 0.13 0.61 0.09
116 INT204300 Bcl2 Negative_regulation of Positive_regulation of Bak1 1 0.02 1.13 0.09
117 INT302178 CDKN1C Regulation of CDKN2A 1 0.09 0.26 0.08
118 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
119 INT136856 Cdkn2a Positive_regulation of Arf5 1 0.01 0.9 0.08
120 INT302139 LAMTOR1 Regulation of CDKN2A 1 0.08 0.26 0.08
121 INT302157 MRPL28 Regulation of CDKN2A 1 0.09 0.26 0.08
122 INT350908 Binding of Bcl2 and Twist1 1 0.04 1.9 0.08
123 INT43121 Apoa2 Regulation of Smc1b 1 0.02 0 0.08
124 INT201456 Hmox1 Positive_regulation of Gene_expression of Bcl2 1 0.06 0.74 0.08
125 INT302148 IFI27 Regulation of CDKN2A 1 0.11 0.26 0.08
126 INT190885 Binding of Apoa2 and Hdl1 1 0.02 0.73 0.07
127 INT204299 Bcl2 Negative_regulation of Localization of Aifm1 1 0.06 1.22 0.07
128 INT297733 Cbr1 Regulation of Gene_expression of Bcl2 1 0.05 0.94 0.07
129 INT302177 PTGER2 Positive_regulation of BCL2 1 0.04 2.08 0.06
130 INT352299 Regulation of Binding of BCL2 and VIM 1 0.10 1.07 0.06
131 INT352298 Binding of BCL2 and VIM 1 0.09 1.06 0.06
132 INT302164 PTEN Regulation of PIK3CD 1 0.16 1.13 0.06
133 INT204073 Binding of Cdkn2a and Cdk4 1 0.02 0.78 0.05
134 INT296023 Positive_regulation of Apoa2 Negative_regulation of APOA1 1 0.50 0.35 0.05
135 INT296024 Apoa2 Negative_regulation of CETP 1 0.39 0.35 0.05
136 INT204072 Binding of Cdkn2a and Cdk6 1 0.02 0.78 0.05
137 INT341375 Sod2 Regulation of Bcl2 1 0.08 1.96 0.05
138 INT190824 Binding of Cl and Bcl2 1 0.02 1.4 0.05
139 INT43124 Apoa2 Positive_regulation of Positive_regulation of NA 1 0.07 0 0.05
140 INT221815 PPARA Negative_regulation of PTEN 1 0.15 0.5 0.05
141 INT296025 Apoa2 Negative_regulation of APOA1 1 0.47 0.35 0.05
142 INT333252 Positive_regulation of Binding of Bcl2 and Mcl1 1 0.03 0.88 0.04
143 INT268664 Ptger2 Positive_regulation of Bcl2 1 0.02 0.9 0.04
144 INT333245 Binding of Bcl2 and Bcl2l11 1 0.03 0.87 0.04
145 INT268666 Ptger2 Positive_regulation of Gene_expression of Bcl2 1 0.02 0.9 0.04
146 INT350905 Binding of Bcl2 and Pcsk4 1 0.03 0.96 0.04
147 INT333253 Binding of Bcl2 and Mcl1 1 0.02 2.14 0.04
148 INT325025 Apoa2 Positive_regulation of Hdl1 1 0.05 1.03 0.04
149 INT250025 Map3k1 Positive_regulation of Regulation of Bcl2 1 0.01 1.1 0.04
150 INT172902 Binding of Bax and Bcl2 5 0.30 3.19 0.03
151 INT192164 Binding of BAK1 and BCL2 3 0.04 2.8 0.03
152 INT192167 Negative_regulation of Binding of BAK1 and BCL2 2 0.05 1.89 0.03
153 INT288538 Il2 Positive_regulation of Gene_expression of Bcl2 1 0.04 1.96 0.03
154 INT129331 Binding of Trpv1 and Gipc1 1 0.01 0 0.03
155 INT217148 MIR21 Regulation of BCL2 1 0.32 0.98 0.03
156 INT256549 Binding of Pten and Mtor 1 0.00 1.02 0.03
157 INT101159 Gene_expression of Bcl2 Positive_regulation of Gene_expression of CHAT 1 0.31 0.96 0.03
158 INT181083 Binding of Akt1 and Cdc42 1 0.00 0.79 0.03
159 INT229204 Olr1254 Negative_regulation of Gene_expression of Bcl2 1 0.02 0.18 0.03
160 INT333259 Bcl2 Regulation of Bax 1 0.03 0.32 0.03
161 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
162 INT172894 Negative_regulation of Lox Negative_regulation of Gene_expression of Bcl2 1 0.03 1.12 0.03
163 INT220445 Bcl2 Negative_regulation of Positive_regulation of Casp9 1 0.01 1.37 0.03
164 INT308658 Binding of Apoa2 and Apoe 1 0.17 0.15 0.03
165 INT192678 PTEN Regulation of Dync1h1 1 0.02 0.5 0.03
166 INT333262 Bcl2 Regulation of Bak1 1 0.04 0.31 0.03
167 INT282995 Binding of Bcl2 and Becn1 21 0.03 9.8 0
168 INT283013 Binding of Bak1 and Bcl2 4 0.06 1.03 0
169 INT178861 Binding of BAX and BCL2 3 0.27 3.07 0
170 INT292454 Binding of BAD and BCL2 2 0.03 1.73 0
171 INT144032 STAT3 Regulation of BCL2 2 0.07 0.86 0
172 INT217150 MIR16-2 Regulation of BCL2 2 0.09 1.89 0
173 INT217137 MIR15B Regulation of BCL2 2 0.15 1.88 0
174 INT295047 Binding of Bcl2 and Nr4a1 1 0.04 0.96 0
175 INT254089 EPO Regulation of Gene_expression of Bcl2 1 0.03 0.63 0
176 INT285031 Binding of Bcl2 and Bcl2l1 1 0.27 0.1 0
177 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0
178 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0
179 INT329680 BMI1 Negative_regulation of Gene_expression of CDKN2A 1 0.15 1.14 0
180 INT329676 CBX7 Regulation of Localization of CDKN2A 1 0.51 2.4 0
181 INT321406 VEGFA Regulation of BCL2 1 0.01 0.75 0
182 INT10903 Apoa2 Positive_regulation of Nppb 1 0.08 0.17 0
183 INT215707 Cdkn2a Negative_regulation of Cdkn1b 1 0.01 0 0
184 INT250659 Negative_regulation of PTEN Positive_regulation of Positive_regulation of PIK3CB 1 0.02 1.18 0
185 INT295046 Bcl2 Regulation of Gene_expression of Nr4a1 1 0.02 0.92 0
186 INT292503 Mlph Regulation of Gene_expression of BCL2 1 0.00 0.4 0
187 INT246914 Binding of CDKN2A and Ifng 1 0.01 0.71 0
188 INT253474 Positive_regulation of Prkaca Positive_regulation of Gene_expression of Bcl2 1 0.04 1.27 0
189 INT191058 Binding of Bcl2 and Positive_regulation of Gene_expression of Bax 1 0.21 0.49 0
190 INT333688 Trp53 Positive_regulation of Bcl2 1 0.45 2.51 0
191 INT47454 ras Positive_regulation of Apoa2 1 0.12 0.21 0
192 INT245041 Binding of Xrcc1 and APTX 1 0.41 0.38 0
193 INT311404 Binding of CDKN2A and Celf1 1 0.32 0.07 0
194 INT348531 Binding of BCL2 and BECN1 1 0.06 0.43 0
195 INT221240 Akt1 Positive_regulation of Phosphorylation of Bcl2 1 0.00 0.89 0
196 INT185281 Binding of CDK6 and CDKN2A 1 0.29 0.87 0
197 INT191062 Esr1 Regulation of Gene_expression of Bcl2 1 0.12 0.73 0
198 INT267255 Bcl2 Positive_regulation of Gene_expression of Ptprj 1 0.04 0.63 0
199 INT191061 Akt1 Positive_regulation of Bcl2 1 0.41 0.33 0
200 INT283003 Igkv1-131 Regulation of Binding of Bcl2 1 0.06 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of protein stability. They are ordered first by their pain relevance and then by number of times they were reported in regulation of protein stability. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
2 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38
3 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73
4 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
5 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
6 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
7 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
8 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18
9 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63
10 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54
11 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68
12 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57
13 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37
14 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27
15 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86
16 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71
17 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47
18 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41
19 INT19146 Negative_regulation of Apoa2 19 0.36 5.34 6.73
20 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71
21 INT84685 Regulation of BCL2 67 0.60 72.96 6.65
22 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7
23 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56
24 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47
25 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38
26 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22
27 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07
28 INT101957 Transcription of Bcl2 30 0.69 16.57 4.3
29 INT2453 Positive_regulation of Apoa2 20 0.54 3.49 4.08
30 INT276198 Positive_regulation of Pten 1 0.52 5.02 3.88
31 INT105882 Phosphorylation of Bcl2 11 0.59 8.15 3.73
32 INT151171 Positive_regulation of Pten 20 0.55 13.3 3.54
33 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4
34 INT208291 Negative_regulation of Pten 2 0.44 5.42 3.36
35 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28
36 INT81642 Regulation of Gene_expression of Bcl2 20 0.44 16.93 3.19
37 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16
38 INT192676 Binding of PTEN 14 0.46 10.58 3.06
39 INT105884 Binding of Bcl2 19 0.35 15.67 3
40 INT184477 Negative_regulation of Pten 27 0.59 15.61 2.8
41 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8
42 INT10556 Regulation of Apoa2 5 0.44 0.51 2.8
43 INT119383 Gene_expression of Pten 11 0.59 10.33 2.73
44 INT211733 Phosphorylation of Gipc1 2 0.01 0 2.68
45 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5
46 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48
47 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46
48 INT147349 Localization of Bcl2 13 0.65 7.83 2.31
49 INT2452 Localization of Apoa2 9 0.55 0 2.3
50 INT142677 Negative_regulation of Positive_regulation of Bcl2 4 0.36 3.09 2.24
51 INT179885 Regulation of PTEN 8 0.26 11.88 2.18
52 INT161978 Positive_regulation of Localization of GIPC1 1 0.19 1.98 2.12
53 INT224615 Negative_regulation of Gene_expression of Pten 7 0.59 2.99 2.09
54 INT276201 Phosphorylation of Pten 1 0.61 1.31 2.08
55 INT94772 Gene_expression of Cdkn2a 14 0.75 8.25 2.04
56 INT86671 Negative_regulation of Positive_regulation of Bcl2 6 0.57 3.83 2.03
57 INT161979 Positive_regulation of Gene_expression of GIPC1 1 0.19 1.96 1.93
58 INT101108 Localization of Bcl2 16 0.72 11.68 1.86
59 INT105883 Positive_regulation of Phosphorylation of Bcl2 8 0.32 5.67 1.86
60 INT21813 Gene_expression of Apoa2 10 0.61 3.68 1.81
61 INT101958 Positive_regulation of Transcription of Bcl2 4 0.50 2.22 1.65
62 INT276171 Positive_regulation of Gene_expression of Pten 3 0.52 7.24 1.64
63 INT137513 Negative_regulation of Positive_regulation of BCL2 6 0.35 5.3 1.62
64 INT42277 Gene_expression of GIPC1 6 0.25 2.06 1.61
65 INT151169 Positive_regulation of Gene_expression of Pten 15 0.45 12.88 1.53
66 INT111186 Positive_regulation of GIPC1 4 0.67 1.44 1.46
67 INT228249 Binding of Pten 7 0.48 3.26 1.45
68 INT281470 Regulation of Gene_expression of Pten 4 0.39 1.13 1.42
69 INT276196 Positive_regulation of Phosphorylation of Pten 1 0.38 0.19 1.41
70 INT304045 Transcription of PTEN 2 0.51 4.12 1.4
71 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38
72 INT276181 Negative_regulation of Gene_expression of Pten 1 0.44 2.48 1.37
73 INT101107 Positive_regulation of Localization of Bcl2 3 0.48 3.13 1.28
74 INT190014 Regulation of Pten 8 0.62 6.03 1.2
75 INT119832 Positive_regulation of Gene_expression of PTEN 12 0.49 7.12 1.19
76 INT97955 Positive_regulation of CDC42 8 0.49 2.47 1.19
77 INT172855 Binding of Bcl2 37 0.32 23.41 1.09
78 INT70021 Localization of BCL2 23 0.74 21.6 1.09
79 INT42104 Regulation of Cdkn2a 4 0.44 5.67 1.06
80 INT338168 Positive_regulation of Binding of CDKN2A 1 0.49 0.52 0.94
81 INT161682 Positive_regulation of Cdc42 8 0.53 4.55 0.9
82 INT180451 Positive_regulation of Apoa2 15 0.67 12.65 0.89
83 INT151115 Regulation of Regulation of Bcl2 4 0.21 4.12 0.88
84 INT59995 Localization of GIPC1 2 0.28 0.66 0.87
85 INT92117 Phosphorylation of BCL2 26 0.80 9.93 0.86
86 INT276177 Regulation of Gene_expression of Pten 1 0.34 1.51 0.84
87 INT70019 Binding of BCL2 25 0.47 17.55 0.79
88 INT144429 Positive_regulation of Cdkn2a 7 0.58 4.05 0.78
89 INT109404 Transcription of BCL2 6 0.69 4.49 0.77
90 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76
91 INT119834 Phosphorylation of PTEN 12 0.79 6.78 0.75
92 INT124844 Regulation of Positive_regulation of Bcl2 3 0.43 2.55 0.75
93 INT155392 Negative_regulation of Negative_regulation of Bcl2 3 0.21 1.64 0.74
94 INT134444 Positive_regulation of Binding of Bcl2 3 0.47 2.67 0.72
95 INT276199 Binding of Pten 2 0.30 0.4 0.67
96 INT25374 Negative_regulation of Negative_regulation of Apoa2 1 0.30 0.24 0.67
97 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63
98 INT276179 Regulation of Pten 1 0.46 0.81 0.63
99 INT251026 Negative_regulation of Phosphorylation of CDKN2A 5 0.42 5.02 0.62
100 INT177886 Positive_regulation of Gene_expression of Cdkn2a 3 0.67 3.42 0.62
101 INT180107 Regulation of Cdc42 3 0.16 0.18 0.6
102 INT147598 Negative_regulation of Positive_regulation of CDKN2A 3 0.41 1.47 0.59
103 INT70025 Positive_regulation of Positive_regulation of BCL2 3 0.27 0.96 0.58
104 INT161322 Localization of PTEN 9 0.73 5.65 0.57
105 INT178128 Negative_regulation of Phosphorylation of BCL2 7 0.27 3.94 0.56
106 INT77397 Phosphorylation of GIPC1 1 0.01 0 0.56
107 INT97956 Negative_regulation of CDC42 3 0.27 1.58 0.55
108 INT242011 Localization of Cdkn2a 4 0.73 2.49 0.54
109 INT155090 Regulation of Positive_regulation of BCL2 3 0.26 1.78 0.54
110 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53
111 INT10983 Binding of Apoa2 7 0.45 4.21 0.52
112 INT144696 Regulation of Transcription of Bcl2 5 0.44 2.96 0.51
113 INT144431 Positive_regulation of Transcription of Cdkn2a 1 0.41 1.11 0.51
114 INT144426 Transcription of Cdkn2a 1 0.42 1.11 0.51
115 INT176146 Positive_regulation of Localization of PTEN 3 0.36 1.69 0.5
116 INT52920 Phosphorylation of Gipc1 1 0.04 0 0.5
117 INT134445 Positive_regulation of Positive_regulation of Bcl2 3 0.47 2.43 0.49
118 INT221676 Protein_catabolism of Bcl2 4 0.24 2.77 0.48
119 INT43397 Positive_regulation of Localization of Apoa2 1 0.09 0 0.48
120 INT276174 Regulation of Negative_regulation of Pten 1 0.34 0.63 0.47
121 INT204052 Transcription of Bcl2 5 0.51 3.25 0.45
122 INT220088 Positive_regulation of Positive_regulation of CDKN2A 4 0.49 4.04 0.44
123 INT140295 Protein_catabolism of BCL2 4 0.64 5.7 0.44
124 INT220424 Positive_regulation of Negative_regulation of Bcl2 2 0.14 1.81 0.44
125 INT276180 Positive_regulation of Negative_regulation of Pten 1 0.35 0.89 0.43
126 INT252657 Positive_regulation of Phosphorylation of CDKN2A 2 0.45 3.09 0.42
127 INT276202 Negative_regulation of Protein_catabolism of Pten 1 0.32 0.78 0.42
128 INT42105 Regulation of Positive_regulation of Cdkn2a 1 0.44 0.33 0.42
129 INT174753 Gene_expression of Apoa2 15 0.75 13.82 0.41
130 INT276204 Protein_catabolism of Pten 1 0.75 0.77 0.41
131 INT203816 Localization of Pten 4 0.75 1.37 0.4
132 INT46545 Binding of Gipc1 2 0.02 0 0.38
133 INT155724 Negative_regulation of Transcription of Bcl2 6 0.53 2.35 0.37
134 INT151167 Phosphorylation of Pten 3 0.72 1.69 0.35
135 INT151166 Positive_regulation of Phosphorylation of Pten 2 0.40 1.54 0.35
136 INT119612 Positive_regulation of Gipc1 1 0.01 0 0.35
137 INT105934 Gene_expression of APTX 1 0.00 0 0.35
138 INT196323 Localization of Cdkn2a 8 0.73 9.1 0.32
139 INT251025 Phosphorylation of CDKN2A 4 0.61 3.19 0.32
140 INT47453 Positive_regulation of Positive_regulation of Apoa2 3 0.31 1.17 0.32
141 INT281469 Transcription of Pten 2 0.72 1.12 0.32
142 INT281474 Regulation of Transcription of Pten 1 0.62 0.35 0.32
143 INT263819 Regulation of Gene_expression of PTEN 1 0.25 0.63 0.32
144 INT43396 Regulation of Localization of Apoa2 1 0.09 0 0.3
145 INT228477 Positive_regulation of Gene_expression of Cdkn2a 2 0.11 1.3 0.29
146 INT178114 Positive_regulation of Phosphorylation of BCL2 11 0.49 4.44 0.28
147 INT297322 Binding of Apoa2 3 0.36 1.7 0.27
148 INT133488 Negative_regulation of Phosphorylation of PTEN 4 0.41 1.88 0.26
149 INT42278 Binding of GIPC1 3 0.03 0.33 0.26
150 INT184624 Localization of CDKN2A 8 0.74 7.87 0.25
151 INT67227 Positive_regulation of Binding of Apoa2 2 0.26 1.31 0.25
152 INT238494 Regulation of Transcription of CDKN2A 1 0.16 5.62 0.25
153 INT292743 Negative_regulation of Binding of Bcl2 1 0.05 1.97 0.24
154 INT2450 Negative_regulation of Positive_regulation of Apoa2 1 0.21 0 0.24
155 INT183881 Localization of CDC42 3 0.49 1.92 0.23
156 INT285003 Positive_regulation of Regulation of Bcl2 1 0.46 0.68 0.23
157 INT2449 Negative_regulation of Localization of Apoa2 1 0.19 0 0.22
158 INT108563 Negative_regulation of Regulation of Bcl2 1 0.32 0.74 0.22
159 INT323965 Protein_catabolism of Apoa2 1 0.01 0.34 0.22
160 INT180454 Negative_regulation of Apoa2 6 0.42 7.42 0.2
161 INT183876 Regulation of CDC42 3 0.30 1.94 0.19
162 INT10984 Negative_regulation of Binding of Apoa2 2 0.35 0.7 0.19
163 INT241687 Binding of Cdkn2a 5 0.31 5.26 0.18
164 INT220426 Regulation of Negative_regulation of Bcl2 1 0.05 0.81 0.18
165 INT224616 Regulation of Negative_regulation of Pten 1 0.13 1.21 0.18
166 INT67225 Positive_regulation of Gene_expression of Apoa2 2 0.28 1.3 0.17
167 INT183242 Negative_regulation of Gene_expression of PTEN 6 0.55 3.81 0.16
168 INT238507 Regulation of Regulation of BCL2 3 0.44 5.14 0.16
169 INT101109 Negative_regulation of Localization of Bcl2 1 0.03 0.62 0.16
170 INT197290 Gene_expression of Cdc42 9 0.35 2.52 0.15
171 INT147149 Transcription of CDKN2A 8 0.67 6.85 0.15
172 INT229235 Regulation of Localization of BCL2 2 0.29 3.7 0.15
173 INT102109 Protein_catabolism of Bcl2 1 0.65 0.55 0.15
174 INT225216 Negative_regulation of Negative_regulation of Cdkn2a 1 0.42 3.16 0.15
175 INT110957 Positive_regulation of Positive_regulation of Bcl2 3 0.35 2.3 0.13
176 INT68177 Negative_regulation of APTX 1 0.20 0.33 0.13
177 INT206133 Binding of CDC42 3 0.25 0.8 0.12
178 INT239373 Positive_regulation of Positive_regulation of PTEN 3 0.25 4.98 0.12
179 INT179038 Positive_regulation of Regulation of Bcl2 1 0.39 3.49 0.12
180 INT264861 Regulation of Apoa2 5 0.44 4.25 0.11
181 INT279650 Transcription of Apoa2 1 0.02 0.79 0.1
182 INT112001 Binding of Cdkn2a 1 0.24 0.35 0.1
183 INT279651 Positive_regulation of Transcription of Apoa2 1 0.02 0.84 0.1
184 INT180452 Localization of Apoa2 2 0.73 2.83 0.09
185 INT40116 Regulation of Gipc1 1 0.01 0 0.09
186 INT273604 Regulation of Negative_regulation of Cdkn2a 1 0.12 0.68 0.09
187 INT197282 Positive_regulation of Gene_expression of Cdc42 3 0.26 0.12 0.08
188 INT67224 Negative_regulation of Gene_expression of Apoa2 1 0.32 0.47 0.08
189 INT263690 Negative_regulation of Gipc1 1 0.01 0 0.08
190 INT282084 Negative_regulation of Gene_expression of Apoa2 1 0.04 1.17 0.07
191 INT105935 Positive_regulation of APTX 1 0.00 0 0.07
192 INT67226 Regulation of Gene_expression of Apoa2 1 0.15 0.51 0.07
193 INT105936 Regulation of APTX 1 0.00 0 0.07
194 INT206169 Gene_expression of CDC42 2 0.26 1.05 0.05
195 INT35232 Regulation of Positive_regulation of Apoa2 1 0.48 0.18 0.05
196 INT206167 Positive_regulation of Gene_expression of CDC42 1 0.08 0.05 0.05
197 INT335124 Positive_regulation of APOA2 1 0.15 0.43 0.05
198 INT315215 Negative_regulation of Binding of Cdkn2a 1 0.35 0.11 0.05
199 INT302229 Negative_regulation of Negative_regulation of BCL2 3 0.21 2.69 0.04
200 INT236108 Positive_regulation of Positive_regulation of Pten 3 0.39 2.3 0.04
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