GO:0031648

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Name protein destabilization
Categary Process
Go Slim No
Go Link GO:0031648
Unique Molecular Interactions 218
Total Molecular Interactions 332
Total Single Events 2031
Pain Genes Associated 26

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein destabilization. They are ordered first by their pain relevance and then by number of times they were reported for protein destabilization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
2 INT275850 Binding of NDUFAB1 and SNCA 1 0.00 3.78 3.16
3 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
4 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
5 INT210783 Bmp2 Positive_regulation of Tnip1 1 0.40 0.53 0.94
6 INT210791 Bmp2 Positive_regulation of Net1 1 0.38 0.52 0.93
7 INT210799 Bmp2 Positive_regulation of B2m 1 0.35 0.52 0.92
8 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
9 INT72229 Binding of NFKBIL1 and BTRC 1 0.00 0 0.73
10 INT135751 Pomc Positive_regulation of Positive_regulation of Id1 1 0.19 0 0.5
11 INT135753 Pomc Positive_regulation of Gene_expression of Id1 1 0.17 0 0.5
12 INT322048 Prkdc Negative_regulation of Col7a1 1 0.00 0.45 0.5
13 INT135754 Pomc Positive_regulation of Id1 1 0.17 0 0.5
14 INT118485 CST3 Regulation of CTSH 1 0.36 0 0.49
15 INT72230 Binding of BTRC and EMID1 1 0.00 0 0.49
16 INT72227 Binding of BTRC and AP1M2 1 0.00 0 0.49
17 INT114676 Mdm2 Negative_regulation of p53-ps 1 0.10 0.26 0.48
18 INT210793 Bmp2 Positive_regulation of Tsc22d3 1 0.32 0.26 0.46
19 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
20 INT158032 Binding of CDKN2A and KRT20 1 0.28 0.59 0.4
21 INT204071 HP Positive_regulation of Gene_expression of CDKN2A 1 0.00 3.48 0.34
22 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
23 INT224687 Il1 Positive_regulation of Bmp2 1 0.00 0.3 0.31
24 INT166165 Binding of TGFB3 and Bmp2 1 0.00 0 0.3
25 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
26 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
27 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
28 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28
29 INT170719 Binding of Grm5 and Siah1a 1 0.01 1.1 0.28
30 INT125514 Positive_regulation of PRKDC Positive_regulation of Positive_regulation of NFKB1 1 0.07 0.44 0.26
31 INT147593 Binding of CDK4 and CDKN2A 1 0.42 0.23 0.26
32 INT147592 Positive_regulation of Binding of CDK4 and CDKN2A 1 0.44 0.23 0.26
33 INT72231 Negative_regulation of Binding of NFKBIL1 and BTRC 1 0.00 0 0.24
34 INT170721 Siah1a Regulation of Negative_regulation of Grm2 1 0.22 0 0.18
35 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
36 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
37 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
38 INT170724 Binding of Grm8 and Siah1a 1 0.19 0.11 0.15
39 INT136855 Arf5 Positive_regulation of Cdkn2a 1 0.07 1.8 0.15
40 INT314856 Binding of Cdc7 and Cdkn2a 1 0.28 1.34 0.14
41 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
42 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
43 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
44 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11
45 INT350736 PRKDC Negative_regulation of CA2 1 0.02 0.16 0.11
46 INT158141 Binding of HOXD13 and SNCA 1 0.54 0.41 0.11
47 INT350735 PRKDC Negative_regulation of ITPR3 1 0.01 0.16 0.11
48 INT238038 Binding of BMP2 and OPLL 1 0.20 2.45 0.09
49 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
50 INT83270 Snca Regulation of Napepld 1 0.14 0 0.09
51 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
52 INT302178 CDKN1C Regulation of CDKN2A 1 0.09 0.26 0.08
53 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
54 INT297968 Positive_regulation of Binding of BMP2 and IL17C 1 0.21 0.26 0.08
55 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
56 INT136856 Cdkn2a Positive_regulation of Arf5 1 0.01 0.9 0.08
57 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
58 INT302139 LAMTOR1 Regulation of CDKN2A 1 0.08 0.26 0.08
59 INT302157 MRPL28 Regulation of CDKN2A 1 0.09 0.26 0.08
60 INT297970 Binding of BMP2 and IL17C 1 0.15 0.26 0.08
61 INT302148 IFI27 Regulation of CDKN2A 1 0.11 0.26 0.08
62 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
63 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
64 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
65 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
66 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
67 INT170722 Siah1a Regulation of Gene_expression of Grm8 1 0.24 0 0.07
68 INT193790 ITIH4 Regulation of Gene_expression of MDM2 1 0.06 0.45 0.07
69 INT295122 Bmp2 Regulation of Grxcr1 1 0.02 0.66 0.06
70 INT295120 Bmp2 Regulation of Transcription of Pou1f1 1 0.24 0.66 0.06
71 INT204073 Binding of Cdkn2a and Cdk4 1 0.02 0.78 0.05
72 INT249201 PRKDC Regulation of Regulation of CYBB 1 0.01 0.09 0.05
73 INT204072 Binding of Cdkn2a and Cdk6 1 0.02 0.78 0.05
74 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05
75 INT352669 PRKDC Positive_regulation of Memor1 1 0.00 1.02 0.04
76 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
77 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
78 INT173613 BMP2 Positive_regulation of INCENP 1 0.00 0.28 0.03
79 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
80 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03
81 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
82 INT287233 PDLIM7 Positive_regulation of Gene_expression of BMP2 1 0.07 0.12 0.03
83 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
84 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
85 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0
86 INT180040 Binding of D7Cwr3P and Sirt1 1 0.00 0 0
87 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0
88 INT300696 Sirt1 Regulation of Cyb5r3 1 0.03 0 0
89 INT269943 Sox17 Regulation of Binding of Smad3 1 0.37 0.12 0
90 INT314746 Akt1 Positive_regulation of Phosphorylation of MDM2 1 0.32 1.16 0
91 INT329680 BMI1 Negative_regulation of Gene_expression of CDKN2A 1 0.15 1.14 0
92 INT329676 CBX7 Regulation of Localization of CDKN2A 1 0.51 2.4 0
93 INT269915 Binding of Smad2 and Sox17 1 0.21 0.07 0
94 INT215707 Cdkn2a Negative_regulation of Cdkn1b 1 0.01 0 0
95 INT343999 INCENP Positive_regulation of BMP2 1 0.01 0 0
96 INT299444 Foxl2 Positive_regulation of Sirt1 1 0.24 0.31 0
97 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
98 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 0.25 0.32 0
99 INT246914 Binding of CDKN2A and Ifng 1 0.01 0.71 0
100 INT278021 BMP2 Positive_regulation of Gene_expression of RUNX1T1 1 0.02 0.5 0
101 INT249169 PMAIP1 Positive_regulation of PRKDC 1 0.00 0 0
102 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
103 INT311404 Binding of CDKN2A and Celf1 1 0.32 0.07 0
104 INT269919 Sox17 Negative_regulation of Binding of Smad3 1 0.36 0 0
105 INT347162 MDM2 Negative_regulation of TP53 1 0.02 1.09 0
106 INT185281 Binding of CDK6 and CDKN2A 1 0.29 0.87 0
107 INT310191 Flt3 Positive_regulation of Gene_expression of Id1 1 0.03 0.81 0
108 INT225593 Ncoa6 Positive_regulation of Prkdc 1 0.02 0 0
109 INT271996 Binding of Plk1 and Tsc1 1 0.09 0.32 0
110 INT269948 Sox17 Positive_regulation of Gene_expression of Ccnd1 1 0.61 0.19 0
111 INT320714 Gene_expression of MDM2 Negative_regulation of TP53 1 0.16 0.88 0
112 INT205451 Binding of BMP2 and Acvr2a 1 0.02 0.05 0
113 INT204234 Binding of CDKN2A and TP53 1 0.43 1.27 0
114 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0
115 INT304028 MDM2 Regulation of TP53 1 0.19 1.11 0
116 INT306256 MDM2 Negative_regulation of Positive_regulation of TP53 1 0.23 0.44 0
117 INT170723 Binding of Calm2 and Siah1a 1 0.24 0 0
118 INT289534 Sirt1 Regulation of Regulation of Pomc 1 0.04 0.15 0
119 INT269940 Binding of Sox17 and Scn4a 1 0.17 0.15 0
120 INT170718 Siah1a Regulation of Grm8 1 0.24 0 0
121 INT353437 Negative_regulation of Trp53 Positive_regulation of Gene_expression of Cdkn2a 1 0.24 0.59 0
122 INT225480 Binding of Prkdc and Acsl1 1 0.00 0 0
123 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0
124 INT276904 Regulation of Binding of Egfr and Prkdc 1 0.03 0.42 0
125 INT269955 Positive_regulation of Binding of Smad3 and Sox17 1 0.39 0.05 0
126 INT225613 TARBP2 Positive_regulation of Prkdc 1 0.00 0 0
127 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
128 INT269928 Binding of Sox17 and Mgst1 1 0.12 0 0
129 INT289518 Arc Regulation of Sirt1 1 0.10 0.56 0
130 INT352617 Mdm2 Positive_regulation of Positive_regulation of Trp53 1 0.20 2.56 0
131 INT309521 PRKDC Regulation of Gene_expression of Htt 1 0.41 0.08 0
132 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
133 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
134 INT205410 Binding of BMP2 and BMPR2 1 0.07 0.05 0
135 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
136 INT269949 Sox17 Positive_regulation of Ccnd1 1 0.61 0.96 0
137 INT269954 Sox17 Regulation of Gene_expression of Foxa2 1 0.43 0 0
138 INT333450 ATM Positive_regulation of Negative_regulation of MDM2 1 0.18 0 0
139 INT184956 ID1 Negative_regulation of CDKN2A 1 0.42 0.21 0
140 INT344001 INCENP Positive_regulation of Gene_expression of BMP2 1 0.01 0 0
141 INT269950 Sox17 Negative_regulation of Gene_expression of Cdkn2b 1 0.27 0.24 0
142 INT289517 Sirt1 Regulation of Prkag1 1 0.02 0.08 0
143 INT253630 Binding of HNRNPA1 and Npm1 1 0.00 0.19 0
144 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
145 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
146 INT318221 SIRT1 Positive_regulation of FOXO3 1 0.41 0.63 0
147 INT204078 Binding of CDKN2A and Cdk4 1 0.15 0.72 0
148 INT215699 Cdkn2a Negative_regulation of Cdkn1c 1 0.01 0 0
149 INT269947 Sox17 Positive_regulation of Gene_expression of Atxn1 1 0.08 0 0
150 INT269957 Sox17 Negative_regulation of Gene_expression of TGFB1 1 0.04 0 0
151 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
152 INT276905 Binding of Egfr and Prkdc 1 0.04 0.41 0
153 INT215696 Cdkn2a Negative_regulation of Kras 1 0.00 0 0
154 INT295129 Proc Regulation of Bmp2 1 0.00 0.48 0
155 INT289598 Binding of Sirt1 and Sirt1 1 0.41 1.15 0
156 INT269941 Sox17 Regulation of Gene_expression of Foxa1 1 0.56 0 0
157 INT269942 Sox17 Regulation of Smad3 1 0.37 0.12 0
158 INT208152 Binding of CDK4 and MDM2 1 0.01 1.11 0
159 INT269934 Sox17 Regulation of Gopc 1 0.12 0 0
160 INT294523 Binding of MDM2 and PDB1 1 0.40 0.1 0
161 INT263588 SPIC Positive_regulation of TRIM21 1 0.00 0.28 0
162 INT329677 CDKN2A Regulation of CBX7 1 0.31 2.23 0
163 INT252904 Binding of PRKDC and XRCC5 1 0.00 0.14 0
164 INT269951 Binding of Sox17 and Gopc 1 0.11 0 0
165 INT300307 Binding of Tp53 and Sirt1 1 0.24 0.98 0
166 INT247427 CDKN2A Negative_regulation of Negative_regulation of RB1 1 0.07 1.16 0
167 INT271997 Binding of Cdk1 and Plk1 1 0.03 0.3 0
168 INT269930 Binding of Smad3 and Sox17 1 0.40 1.16 0
169 INT289519 Sirt1 Regulation of Rps6kb1 1 0.25 0.13 0
170 INT289530 Sirt1 Regulation of Foxo1 1 0.25 0.42 0
171 INT269945 Sox17 Positive_regulation of Localization of Ccnd1 1 0.39 0 0
172 INT333458 ATM Positive_regulation of MDM2 1 0.25 0 0
173 INT289523 Binding of Foxo1 and Positive_regulation of Sirt1 1 0.36 0.13 0
174 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
175 INT204077 Binding of CDKN2A and Cdk6 1 0.15 0.72 0
176 INT314132 Sirt1 Positive_regulation of Ppargc1a 1 0.50 2.3 0
177 INT299451 Foxl2 Negative_regulation of Gene_expression of Sirt1 1 0.25 0.32 0
178 INT352614 Negative_regulation of Binding of Mdm2 and Trp53 1 0.19 1.16 0
179 INT289531 Acsm3 Positive_regulation of Sirt1 1 0.01 0.27 0
180 INT253013 Binding of PRKDC and Zic2 1 0.00 0.14 0
181 INT294527 Binding of MDM2 and p53 1 0.40 0.1 0
182 INT269922 Sox17 Regulation of Ccnd1 1 0.47 0 0
183 INT314685 TBX2 Negative_regulation of CDKN2A 1 0.32 1.16 0
184 INT321594 Bmp2 Regulation of Gene_expression of Lxn 1 0.42 1.71 0
185 INT269931 Binding of Ccnd1 and Sox17 1 0.33 0.19 0
186 INT294524 Binding of MDM2 and TNF 1 0.03 0.1 0
187 INT329679 CBX7 Regulation of CDKN2A 1 0.31 4.18 0
188 INT269918 Binding of Scn5a and Sox17 1 0.18 0.15 0
189 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 0.36 0.52 0
190 INT294522 Binding of IL2 and MDM2 1 0.40 0.2 0
191 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
192 INT249822 Foxm1 Positive_regulation of Transcription of Plk1 1 0.50 0.12 0
193 INT269916 Sox17 Positive_regulation of Pcna 1 0.16 0 0
194 INT314680 Positive_regulation of TBX2 Negative_regulation of CDKN2A 1 0.34 1.16 0
195 INT214922 Binding of MDM2 and TP53 1 0.08 1.55 0
196 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0
197 INT311403 CDKN2A Regulation of Celf1 1 0.41 0.14 0
198 INT289535 Negative_regulation of Sirt1 Negative_regulation of Binding of Foxo1 1 0.29 0.14 0
199 INT289529 Lep Regulation of Sirt1 1 0.28 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein destabilization. They are ordered first by their pain relevance and then by number of times they were reported in protein destabilization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
2 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
3 INT114674 Gene_expression of Mdm2 15 0.78 3.51 11.85
4 INT114675 Positive_regulation of Gene_expression of Mdm2 1 0.70 1.98 7.9
5 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47
6 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56
7 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
8 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47
9 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38
10 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
11 INT119412 Gene_expression of Snca 15 0.66 11.27 3.39
12 INT110245 Gene_expression of SNCA 11 0.77 8.29 3.36
13 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28
14 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05
15 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01
16 INT54749 Binding of BTRC 7 0.09 0.88 2.9
17 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8
18 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48
19 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46
20 INT170712 Gene_expression of Siah1a 1 0.77 2.33 2.33
21 INT108148 Positive_regulation of Prkdc 2 0.16 0.49 2.31
22 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
23 INT94772 Gene_expression of Cdkn2a 14 0.75 8.25 2.04
24 INT2844 Positive_regulation of ID1 6 0.70 3.92 2.03
25 INT135744 Positive_regulation of Id1 4 0.49 3.08 2.02
26 INT148266 Positive_regulation of SNCA 5 0.67 3.17 1.74
27 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55
28 INT54750 Gene_expression of BTRC 4 0.14 0.99 1.55
29 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
30 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
31 INT130014 Positive_regulation of BMP2 11 0.66 5.34 1.42
32 INT118155 Regulation of Positive_regulation of Prkdc 1 0.10 0.49 1.42
33 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38
34 INT114671 Positive_regulation of Mdm2 1 0.61 0.5 1.38
35 INT26658 Localization of ID1 1 0.32 0.18 1.33
36 INT70619 Regulation of Bmp2 6 0.60 3.1 1.29
37 INT314186 Gene_expression of Npm1 1 0.01 1.78 1.22
38 INT125525 Positive_regulation of PRKDC 7 0.45 2.72 1.21
39 INT110244 Positive_regulation of Gene_expression of SNCA 5 0.69 4.66 1.19
40 INT96424 Transcription of Bmp2 6 0.69 6.34 1.11
41 INT160538 Binding of Bmp2 4 0.40 2.08 1.07
42 INT42104 Regulation of Cdkn2a 4 0.44 5.67 1.06
43 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
44 INT286344 Positive_regulation of Gene_expression of Snca 1 0.41 2.84 1.03
45 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
46 INT114673 Regulation of Gene_expression of Mdm2 1 0.62 0.23 1.02
47 INT338168 Positive_regulation of Binding of CDKN2A 1 0.49 0.52 0.94
48 INT114664 Binding of BMP2 12 0.37 6.54 0.91
49 INT166935 Gene_expression of Prkdc 10 0.65 3.14 0.9
50 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
51 INT9206 Negative_regulation of ID1 5 0.59 2.41 0.79
52 INT144429 Positive_regulation of Cdkn2a 7 0.58 4.05 0.78
53 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76
54 INT125526 Gene_expression of PRKDC 5 0.58 4 0.74
55 INT50855 Gene_expression of TRIM21 4 0.65 3.07 0.71
56 INT251026 Negative_regulation of Phosphorylation of CDKN2A 5 0.42 5.02 0.62
57 INT177886 Positive_regulation of Gene_expression of Cdkn2a 3 0.67 3.42 0.62
58 INT238049 Positive_regulation of Gene_expression of BMP2 8 0.51 2.06 0.59
59 INT147598 Negative_regulation of Positive_regulation of CDKN2A 3 0.41 1.47 0.59
60 INT170695 Binding of Siah1a 1 0.48 1.19 0.59
61 INT242011 Localization of Cdkn2a 4 0.73 2.49 0.54
62 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53
63 INT2845 Gene_expression of ID1 6 0.78 3.97 0.53
64 INT85808 Localization of BMP2 7 0.77 1.94 0.51
65 INT144431 Positive_regulation of Transcription of Cdkn2a 1 0.41 1.11 0.51
66 INT144426 Transcription of Cdkn2a 1 0.42 1.11 0.51
67 INT135749 Gene_expression of Id1 3 0.58 0.57 0.49
68 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
69 INT145301 Regulation of Gene_expression of Bmp2 1 0.32 1.16 0.48
70 INT36603 Positive_regulation of CTSH 1 0.01 0 0.46
71 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
72 INT220088 Positive_regulation of Positive_regulation of CDKN2A 4 0.49 4.04 0.44
73 INT120086 Gene_expression of Bmp2 5 0.27 2.34 0.43
74 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
75 INT252657 Positive_regulation of Phosphorylation of CDKN2A 2 0.45 3.09 0.42
76 INT148264 Transcription of SNCA 1 0.40 0.25 0.42
77 INT42105 Regulation of Positive_regulation of Cdkn2a 1 0.44 0.33 0.42
78 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
79 INT314185 Localization of Npm1 1 0.02 0.44 0.39
80 INT343972 Negative_regulation of Binding of SNCA 1 0.36 0.2 0.39
81 INT84945 Transcription of BMP2 5 0.61 1.8 0.36
82 INT169628 Binding of SNCA 4 0.47 3.53 0.36
83 INT196026 Positive_regulation of Gene_expression of Bmp2 14 0.69 3.19 0.35
84 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
85 INT314188 Regulation of Npm1 1 0.01 0.33 0.33
86 INT196323 Localization of Cdkn2a 8 0.73 9.1 0.32
87 INT251025 Phosphorylation of CDKN2A 4 0.61 3.19 0.32
88 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
89 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
90 INT172957 Negative_regulation of Mdm2 4 0.14 4.28 0.3
91 INT343973 Localization of SNCA 1 0.63 0.07 0.3
92 INT125524 Positive_regulation of Gene_expression of PRKDC 2 0.09 1 0.29
93 INT228477 Positive_regulation of Gene_expression of Cdkn2a 2 0.11 1.3 0.29
94 INT180393 Positive_regulation of Gene_expression of Prkdc 3 0.49 1.17 0.26
95 INT184624 Localization of CDKN2A 8 0.74 7.87 0.25
96 INT238494 Regulation of Transcription of CDKN2A 1 0.16 5.62 0.25
97 INT170714 Regulation of Gene_expression of Siah1a 1 0.61 0.71 0.25
98 INT145305 Positive_regulation of Bmp2 12 0.69 8.65 0.24
99 INT72235 Negative_regulation of BTRC 3 0.02 0 0.24
100 INT109699 Regulation of BMP2 5 0.43 2.21 0.23
101 INT327888 Localization of Prkdc 1 0.14 1.11 0.23
102 INT142052 Binding of Snca 4 0.47 1.02 0.22
103 INT167250 Regulation of Gene_expression of MDM2 1 0.06 0.86 0.21
104 INT88744 Positive_regulation of Gene_expression of MDM2 9 0.43 7.82 0.2
105 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
106 INT172958 Positive_regulation of Mdm2 4 0.56 2.43 0.19
107 INT241687 Binding of Cdkn2a 5 0.31 5.26 0.18
108 INT142708 Gene_expression of CTSH 1 0.75 1.51 0.18
109 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
110 INT148064 Localization of Bmp2 2 0.29 0.14 0.17
111 INT166361 Phosphorylation of SNCA 1 0.70 0.72 0.17
112 INT118367 Positive_regulation of Gene_expression of ID1 2 0.69 0.25 0.16
113 INT126733 Regulation of MDM2 2 0.36 0.73 0.16
114 INT118370 Regulation of ID1 2 0.45 0.58 0.16
115 INT134909 Positive_regulation of TRIM21 1 0.67 0.95 0.16
116 INT157084 Localization of Snca 1 0.51 0.17 0.16
117 INT343974 Negative_regulation of Gene_expression of SNCA 1 0.31 0.09 0.16
118 INT113346 Binding of MDM2 10 0.35 5.73 0.15
119 INT147149 Transcription of CDKN2A 8 0.67 6.85 0.15
120 INT266010 Localization of Mdm2 2 0.75 2.64 0.15
121 INT204054 Negative_regulation of Negative_regulation of Mdm2 2 0.14 2.23 0.15
122 INT106010 Positive_regulation of Bmp2 2 0.26 0.91 0.15
123 INT286764 Regulation of Localization of Mdm2 1 0.14 1.38 0.15
124 INT286748 Regulation of Mdm2 1 0.14 1.37 0.15
125 INT225216 Negative_regulation of Negative_regulation of Cdkn2a 1 0.42 3.16 0.15
126 INT286343 Negative_regulation of Gene_expression of Snca 1 0.26 0.65 0.15
127 INT256111 Regulation of Gene_expression of Sirt1 1 0.32 0.73 0.14
128 INT175517 Gene_expression of Mdm2 18 0.78 16.28 0.13
129 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
130 INT170700 Positive_regulation of Gene_expression of Siah1a 1 0.50 0.36 0.13
131 INT290726 Binding of Prkdc 1 0.03 1.05 0.13
132 INT170710 Negative_regulation of Siah1a 1 0.43 0.1 0.12
133 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
134 INT254992 Negative_regulation of Gene_expression of BMP2 3 0.34 0.56 0.11
135 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
136 INT238044 Positive_regulation of Transcription of BMP2 2 0.43 0.83 0.11
137 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
138 INT170701 Negative_regulation of Localization of Siah1a 1 0.42 0 0.11
139 INT170696 Localization of Siah1a 1 0.74 0 0.11
140 INT153250 Binding of ID1 2 0.25 0.65 0.1
141 INT112001 Binding of Cdkn2a 1 0.24 0.35 0.1
142 INT170699 Positive_regulation of Siah1a 1 0.50 0.08 0.1
143 INT326976 Regulation of Localization of BMP2 1 0.59 0.08 0.1
144 INT196035 Localization of Bmp2 3 0.63 0.23 0.09
145 INT278036 Negative_regulation of BMP2 2 0.34 0.64 0.09
146 INT352666 Regulation of PRKDC 1 0.01 0.36 0.09
147 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09
148 INT114663 Regulation of Binding of BMP2 1 0.38 0.19 0.09
149 INT273604 Regulation of Negative_regulation of Cdkn2a 1 0.12 0.68 0.09
150 INT130400 Negative_regulation of Gene_expression of ID1 2 0.59 0.95 0.08
151 INT249260 Positive_regulation of Phosphorylation of PRKDC 1 0.03 0.06 0.08
152 INT163072 Regulation of Binding of Bmp2 1 0.30 0.52 0.08
153 INT249280 Phosphorylation of PRKDC 2 0.13 0.3 0.07
154 INT87714 Positive_regulation of Negative_regulation of ID1 2 0.29 0.87 0.07
155 INT289574 Negative_regulation of Positive_regulation of Sirt1 1 0.42 0.42 0.07
156 INT256136 Negative_regulation of Binding of Sirt1 1 0.30 0.5 0.07
157 INT170698 Regulation of Siah1a 1 0.45 0.36 0.06
158 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
159 INT170704 Negative_regulation of Binding of Siah1a 1 0.42 0 0.06
160 INT196025 Negative_regulation of Bmp2 2 0.34 0.14 0.05
161 INT256137 Positive_regulation of Regulation of Sirt1 1 0.36 0.32 0.05
162 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
163 INT289587 Negative_regulation of Negative_regulation of Sirt1 1 0.42 0.65 0.05
164 INT256129 Negative_regulation of Gene_expression of Sirt1 1 0.31 0.4 0.05
165 INT315215 Negative_regulation of Binding of Cdkn2a 1 0.35 0.11 0.05
166 INT229753 Positive_regulation of Gene_expression of Bmp2 2 0.11 1.22 0.04
167 INT287282 Regulation of Binding of MDM2 1 0.04 0.63 0.04
168 INT287236 Positive_regulation of Positive_regulation of BMP2 1 0.29 0.08 0.04
169 INT289584 Binding of Sirt1 3 0.48 1.35 0.03
170 INT176240 Phosphorylation of Mdm2 2 0.22 1.28 0.03
171 INT270038 Positive_regulation of Positive_regulation of Sirt1 2 0.43 0.44 0.03
172 INT246622 Phosphorylation of Sirt1 2 0.74 0.56 0.03
173 INT176252 Positive_regulation of Phosphorylation of Mdm2 1 0.14 0.42 0.03
174 INT352653 Positive_regulation of Positive_regulation of PRKDC 1 0.01 0.56 0.03
175 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
176 INT204349 Regulation of SIRT1 8 0.61 1.99 0
177 INT126734 Positive_regulation of MDM2 8 0.49 5.56 0
178 INT256134 Localization of Sirt1 5 0.50 2.99 0
179 INT204353 Transcription of SIRT1 3 0.68 0.67 0
180 INT266011 Positive_regulation of Gene_expression of Mdm2 3 0.47 4.61 0
181 INT237226 Gene_expression of Plk1 3 0.59 0.78 0
182 INT94773 Negative_regulation of Gene_expression of Cdkn2a 3 0.41 0.65 0
183 INT189593 Regulation of Gene_expression of BMP2 2 0.33 0.8 0
184 INT203465 Negative_regulation of Id1 2 0.06 0.68 0
185 INT180394 Phosphorylation of Prkdc 2 0.07 0.6 0
186 INT260276 Negative_regulation of MDM2 2 0.42 0.62 0
187 INT276357 Protein_catabolism of MDM2 2 0.32 1.18 0
188 INT282090 Regulation of Cdkn2a 2 0.33 2.02 0
189 INT145300 Positive_regulation of Positive_regulation of Bmp2 2 0.34 1.03 0
190 INT249774 Positive_regulation of Plk1 2 0.41 0.25 0
191 INT308355 Negative_regulation of Gene_expression of Cdkn2a 2 0.48 1.42 0
192 INT276370 Phosphorylation of MDM2 2 0.50 1.99 0
193 INT147151 Positive_regulation of Negative_regulation of CDKN2A 2 0.47 1.74 0
194 INT200864 Positive_regulation of Sox17 2 0.50 0.07 0
195 INT294536 Localization of MDM2 1 0.73 0.09 0
196 INT196031 Binding of Bmp2 1 0.16 0 0
197 INT269903 Localization of Sox17 1 0.75 0.07 0
198 INT121497 Transcription of MDM2 1 0.54 0.12 0
199 INT263602 Negative_regulation of TRIM21 1 0.01 0.28 0
200 INT352658 Negative_regulation of PRKDC 1 0.01 0.33 0
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