GO:0031649

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Name heat generation
Categary Process
Go Slim No
Go Link GO:0031649
Unique Molecular Interactions 57
Total Molecular Interactions 89
Total Single Events 1327
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for heat generation. They are ordered first by their pain relevance and then by number of times they were reported for heat generation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69562 Positive_regulation of AP2M1 Positive_regulation of Regulation of Adrb3 1 0.01 0.19 1.24
2 INT110033 Adrb1 Positive_regulation of Gene_expression of Il12a 1 0.05 0 0.99
3 INT42865 Binding of Adrb2 and Man2a2 1 0.23 1.03 0.85
4 INT42864 Regulation of Binding of Adrb2 and Man2a2 1 0.28 1.03 0.85
5 INT69084 Binding of Adrb1 and Positive_regulation of Positive_regulation of Pdpk1 1 0.02 0.08 0.83
6 INT284306 Tlr4 Positive_regulation of Adrb3 1 0.00 1.19 0.74
7 INT284307 Mir155 Regulation of Adrb3 1 0.00 3.44 0.73
8 INT33575 ADRB1 Positive_regulation of Localization of Ahsp 1 0.00 0.33 0.73
9 INT62250 Fdft1 Regulation of Adrb1 1 0.00 0 0.65
10 INT62249 Ghrh Regulation of Adrb1 1 0.00 0 0.62
11 INT108020 Binding of Adrb1 and Clec4d 1 0.00 1.19 0.61
12 INT84603 Adrb1 Regulation of Gene_expression of Aqp2 1 0.00 0 0.56
13 INT155406 Binding of Adrb2 and Ngf 1 0.05 0.39 0.53
14 INT3218 Adrb2 Positive_regulation of Localization of Ins1 1 0.10 0 0.52
15 INT66188 Binding of ADRB2 and CDSN 1 0.01 0 0.51
16 INT35167 Adrb2 Positive_regulation of Trh 1 0.05 0 0.45
17 INT92744 Binding of ADRB2 and NF2 1 0.00 0.1 0.41
18 INT70663 Adrb3 Regulation of Cck 1 0.14 0 0.4
19 INT84602 Binding of Adrb1 and Avp 1 0.00 0 0.36
20 INT35981 Adrb1 Regulation of Localization of Prl 1 0.00 0 0.36
21 INT263974 Binding of ADRB2 and NR4A3 1 0.01 0.5 0.32
22 INT263978 Binding of ADRB2 and TNFAIP3 1 0.01 0.5 0.32
23 INT153924 Msr1 Regulation of Adrb3 1 0.02 0.24 0.32
24 INT263979 Binding of ADRB2 and ATF3 1 0.01 0.5 0.32
25 INT84607 Oprl1 Regulation of Adrb3 1 0.19 0.25 0.24
26 INT284297 Mir155 Positive_regulation of Adrb3 1 0.01 0.51 0.24
27 INT284299 Adrb3 Positive_regulation of Gene_expression of Mir155 1 0.01 0.51 0.24
28 INT34499 ADRB3 Positive_regulation of ADCY1 1 0.07 0.19 0.23
29 INT29099 Binding of ADRB2 and PPAP2A 1 0.03 0.77 0.22
30 INT143618 Msr1 Positive_regulation of Adrb3 1 0.16 0.85 0.2
31 INT40819 Binding of ADRB3 and AGPAT1 1 0.24 0 0.18
32 INT349659 PYCARD Positive_regulation of ADRB2 1 0.06 0.19 0.17
33 INT128705 Binding of Adrb2 and Ahsg 1 0.00 0.23 0.15
34 INT174892 Binding of ADRB3 and ENPP3 1 0.04 0.4 0.14
35 INT284298 Adrb3 Regulation of Mir155 1 0.00 0.24 0.12
36 INT83827 Negative_regulation of Binding of Adrb1 and Pnmt 1 0.02 0 0.1
37 INT50533 Binding of ADRB3 and Positive_regulation of Gene_expression of CA3 1 0.11 0.61 0.1
38 INT83831 Binding of PNMT and Adrb1 1 0.02 0 0.1
39 INT83828 Binding of Adrb1 and Pnmt 1 0.01 0 0.1
40 INT83832 Negative_regulation of Binding of PNMT and Adrb1 1 0.02 0 0.1
41 INT94411 Positive_regulation of ADRB3 Negative_regulation of Gene_expression of TNF 1 0.19 0.15 0.09
42 INT33806 IL2 Regulation of ADRB3 1 0.28 0.08 0.09
43 INT284310 Mir155 Negative_regulation of Adrb3 1 0.00 0.55 0.08
44 INT284304 Binding of Adrb3 and Gnas 1 0.00 0.23 0
45 INT303758 Binding of ADRB1 and IGHG3 1 0.06 0.09 0
46 INT233526 Tlr4 Regulation of Adrb2 1 0.03 0.07 0
47 INT240546 Binding of ADRB1 and INS 1 0.11 0.34 0
48 INT317778 Binding of ADRB2 and GOPC 1 0.10 0.69 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for heat generation. They are ordered first by their pain relevance and then by number of times they were reported in heat generation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT97 Negative_regulation of Adrb1 102 0.59 32.44 26.9
2 INT170 Negative_regulation of Adrb1 52 0.55 13.46 14.78
3 INT663 Negative_regulation of Adrb3 55 0.59 15.95 14.68
4 INT95 Positive_regulation of Adrb1 34 0.62 11.95 14.41
5 INT110 Regulation of Adrb3 33 0.60 8.09 13.84
6 INT8188 Positive_regulation of Adrb3 27 0.68 7.32 10.44
7 INT59 Regulation of Adrb1 25 0.42 8.32 9.78
8 INT30247 Regulation of Adrb1 18 0.44 4.45 8.93
9 INT29411 Positive_regulation of ADRB2 13 0.65 5.42 8.78
10 INT96 Binding of Adrb1 18 0.48 2.8 8.52
11 INT26115 Gene_expression of Adrb1 14 0.64 5.13 7.78
12 INT23992 Positive_regulation of Adrb1 25 0.56 4.01 7.62
13 INT298 Negative_regulation of ADRB3 23 0.59 6.82 7.56
14 INT7883 Binding of ADRB2 18 0.47 5.49 7.37
15 INT1243 Regulation of ADRB2 16 0.54 1.84 5.66
16 INT13885 Positive_regulation of Adrb2 9 0.49 1.11 5.12
17 INT24930 Binding of Adrb2 6 0.26 4.18 4.44
18 INT4104 Gene_expression of ADRB3 19 0.78 2.68 4.12
19 INT465 Binding of Adrb1 14 0.35 3.04 4.07
20 INT484 Negative_regulation of ADRB2 13 0.59 2.85 3.94
21 INT109 Binding of ADRB3 17 0.47 3.02 3.84
22 INT6882 Binding of Adrb2 5 0.47 1.97 3.55
23 INT16626 Positive_regulation of Adrb2 10 0.30 2.41 3.4
24 INT27100 Binding of Adrb3 10 0.47 3.44 3.07
25 INT41474 Gene_expression of ADRB2 10 0.75 1.56 2.94
26 INT33480 Gene_expression of Adrb2 4 0.66 1.96 2.77
27 INT514 Gene_expression of Adrb2 3 0.53 0.23 2.46
28 INT18202 Localization of Adrb3 7 0.80 2.76 2.44
29 INT25666 Negative_regulation of ADRB1 11 0.44 3.12 2.33
30 INT9764 Gene_expression of Adrb3 10 0.62 4.14 2.33
31 INT4495 Gene_expression of Adrb1 7 0.66 2.43 2.29
32 INT3531 Regulation of Adrb2 7 0.44 1.48 2.25
33 INT30372 Regulation of ADRB3 8 0.60 0.57 2.24
34 INT34500 Positive_regulation of ADRB3 12 0.58 2.59 2.16
35 INT94 Positive_regulation of Negative_regulation of Adrb1 4 0.46 0.97 2.16
36 INT70725 Negative_regulation of Binding of ADRB2 3 0.57 0.4 2.14
37 INT23884 Negative_regulation of Negative_regulation of Adrb1 7 0.38 2.3 1.83
38 INT40832 Localization of ADRB2 5 0.73 2.21 1.81
39 INT32176 Negative_regulation of Negative_regulation of Adrb1 2 0.40 0.4 1.77
40 INT110026 Localization of Adrb1 4 0.72 1.56 1.71
41 INT1731 Localization of Adrb1 5 0.43 0.31 1.67
42 INT43482 Regulation of Binding of ADRB3 4 0.60 1.06 1.54
43 INT5466 Positive_regulation of Negative_regulation of ADRB3 2 0.44 0.17 1.39
44 INT78363 Negative_regulation of Adrb3 2 0.19 3.32 1.38
45 INT38312 Positive_regulation of Gene_expression of Adrb1 2 0.07 0.22 1.33
46 INT68471 Negative_regulation of Positive_regulation of Adrb3 1 0.42 0.14 1.29
47 INT41475 Positive_regulation of Localization of ADRB2 2 0.49 0.18 1.12
48 INT140159 Regulation of Gene_expression of Adrb1 1 0.00 0.17 1.07
49 INT284269 Positive_regulation of Negative_regulation of Adrb3 1 0.01 2.42 1.06
50 INT78362 Gene_expression of Adrb3 2 0.67 3.28 1.02
51 INT49796 Positive_regulation of Binding of Adrb2 1 0.00 0 1.02
52 INT52186 Positive_regulation of Positive_regulation of ADRB2 1 0.14 0 1.02
53 INT49795 Negative_regulation of Binding of Adrb2 1 0.00 0 1.02
54 INT71031 Gene_expression of ADRB1 5 0.55 2.96 1.01
55 INT33442 Regulation of ADRB1 2 0.04 0.38 0.98
56 INT12555 Binding of ADRB1 7 0.39 3.78 0.97
57 INT42420 Negative_regulation of Binding of Adrb1 2 0.58 0.8 0.97
58 INT138548 Negative_regulation of Gene_expression of Adrb2 1 0.41 0.85 0.96
59 INT31828 Transcription of Adrb1 2 0.27 0.18 0.94
60 INT14976 Negative_regulation of Adrb2 3 0.24 0.75 0.86
61 INT70724 Positive_regulation of Negative_regulation of ADRB1 1 0.38 0.2 0.86
62 INT70726 Positive_regulation of Negative_regulation of ADRB2 1 0.49 0.2 0.86
63 INT42863 Regulation of Adrb2 1 0.11 1.02 0.85
64 INT42862 Regulation of Binding of Adrb2 1 0.15 1.03 0.85
65 INT1732 Positive_regulation of Localization of Adrb1 2 0.22 0.06 0.8
66 INT1852 Localization of ADRB3 3 0.75 1.02 0.79
67 INT33481 Positive_regulation of Gene_expression of Adrb2 2 0.48 0.38 0.78
68 INT32751 Regulation of Positive_regulation of Adrb1 2 0.36 0.07 0.77
69 INT31778 Negative_regulation of Adrb2 2 0.07 1.34 0.72
70 INT9980 Positive_regulation of Positive_regulation of Adrb3 2 0.43 0.91 0.71
71 INT18201 Positive_regulation of Localization of Adrb3 2 0.11 1.2 0.69
72 INT43481 Positive_regulation of ADRB1 3 0.19 1.36 0.68
73 INT67452 Positive_regulation of Regulation of ADRB2 1 0.41 0.26 0.68
74 INT24095 Protein_catabolism of Adrb1 2 0.10 0.59 0.61
75 INT83826 Negative_regulation of Binding of Adrb1 3 0.25 0.67 0.6
76 INT29111 Negative_regulation of Positive_regulation of Adrb1 1 0.37 0.14 0.58
77 INT94412 Negative_regulation of Positive_regulation of ADRB3 3 0.38 0.52 0.55
78 INT153922 Transcription of Adrb3 1 0.52 0.34 0.52
79 INT42184 Positive_regulation of Binding of Adrb1 1 0.31 0.19 0.5
80 INT56662 Regulation of Protein_catabolism of Adrb1 1 0.05 0.27 0.5
81 INT56661 Positive_regulation of Protein_catabolism of Adrb1 1 0.06 0.27 0.49
82 INT12836 Positive_regulation of Negative_regulation of Adrb3 2 0.54 0.53 0.44
83 INT124786 Localization of Adrb2 1 0.04 0.07 0.44
84 INT13884 Positive_regulation of Positive_regulation of Adrb2 1 0.34 0 0.42
85 INT143617 Positive_regulation of Adrb3 3 0.20 2.07 0.41
86 INT128845 Phosphorylation of ADRB2 1 0.01 0 0.39
87 INT209145 Negative_regulation of Gene_expression of ADRB3 2 0.43 0.76 0.38
88 INT40833 Negative_regulation of Localization of ADRB2 2 0.40 0.58 0.38
89 INT513 Transcription of Adrb2 2 0.06 0.55 0.37
90 INT63924 Regulation of Binding of Adrb1 1 0.16 0.27 0.34
91 INT52207 Positive_regulation of Positive_regulation of Adrb1 1 0.09 0 0.33
92 INT69187 Regulation of Positive_regulation of Adrb1 1 0.25 0 0.33
93 INT84606 Negative_regulation of Regulation of Adrb3 1 0.29 0 0.31
94 INT43325 Regulation of Binding of ADRB1 1 0.37 0.36 0.3
95 INT280583 Negative_regulation of Gene_expression of ADRB1 2 0.09 1.18 0.29
96 INT36290 Protein_catabolism of Adrb3 2 0.82 0.36 0.29
97 INT78364 Positive_regulation of Gene_expression of Adrb3 2 0.50 0.3 0.28
98 INT10857 Regulation of Negative_regulation of Adrb1 2 0.45 0.65 0.28
99 INT284287 Regulation of Adrb3 1 0.00 0.82 0.28
100 INT354015 Positive_regulation of Gene_expression of ADRB3 1 0.44 0.76 0.27
101 INT317793 Regulation of Gene_expression of ADRB2 1 0.45 0.26 0.27
102 INT61837 Regulation of Regulation of ADRB3 1 0.26 0.06 0.24
103 INT209146 Negative_regulation of Negative_regulation of ADRB1 1 0.31 0 0.21
104 INT115874 Negative_regulation of Positive_regulation of Adrb2 1 0.20 0 0.21
105 INT230389 Binding of Adrb3 1 0.35 1.26 0.2
106 INT209149 Regulation of Gene_expression of ADRB3 1 0.54 0 0.18
107 INT133507 Regulation of Negative_regulation of Adrb2 1 0.18 0 0.17
108 INT44087 Regulation of Negative_regulation of Adrb3 1 0.31 0.28 0.15
109 INT81943 Regulation of Regulation of Adrb2 1 0.29 0 0.12
110 INT81944 Regulation of Positive_regulation of Adrb2 1 0.18 0 0.12
111 INT115419 Positive_regulation of Gene_expression of Adrb3 1 0.37 0.77 0.11
112 INT40871 Regulation of Negative_regulation of Adrb1 1 0.24 0.32 0.1
113 INT36289 Regulation of Protein_catabolism of Adrb3 1 0.42 0.36 0.1
114 INT44040 Negative_regulation of Gene_expression of Adrb1 1 0.35 0.34 0.09
115 INT45551 Regulation of Regulation of Adrb1 1 0.22 0.29 0.08
116 INT209147 Regulation of Transcription of ADRB2 1 0.27 0 0.07
117 INT163263 Transcription of ADRB3 2 0.53 0 0.06
118 INT209148 Transcription of ADRB2 1 0.53 0 0.06
119 INT90474 Positive_regulation of Positive_regulation of ADRB3 1 0.42 0.25 0.06
120 INT284278 Transcription of Adrb3 1 0.01 0.26 0.05
121 INT303767 Localization of ADRB1 1 0.18 0.2 0
122 INT303766 Positive_regulation of Gene_expression of ADRB1 1 0.11 0.15 0
123 INT303768 Negative_regulation of Binding of ADRB1 1 0.09 0.5 0
124 INT349673 Positive_regulation of Gene_expression of ADRB2 1 0.14 0 0
125 INT9763 Negative_regulation of Gene_expression of Adrb3 1 0.42 0 0
126 INT230388 Localization of Adrb2 1 0.51 0.71 0
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