GO:0031659

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Name positive regulation of cyclin-dependent protein kinase activity involved in G1/S
Categary Process
Go Slim No
Go Link GO:0031659
Unique Molecular Interactions 770
Total Molecular Interactions 1098
Total Single Events 8158
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cyclin-dependent protein kinase activity involved in G1/S. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of cyclin-dependent protein kinase activity involved in G1/S. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
2 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
3 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
4 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
5 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
6 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
7 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
8 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
9 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
10 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
11 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
12 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
13 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
14 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
15 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
16 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
17 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
18 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
19 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
20 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
21 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
22 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
23 INT148327 Binding of Pkd1 and Trpv1 1 0.52 2.23 1.01
24 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
25 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
26 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
27 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
28 INT161455 Mmp7 Positive_regulation of Egfr 1 0.03 0.19 0.92
29 INT169469 Binding of Egfr and Tgfa 1 0.19 1.87 0.91
30 INT317541 Oprd1 Negative_regulation of Akt1 1 0.06 0 0.91
31 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
32 INT249012 Binding of Akt1 and Gabrg1 1 0.01 0 0.9
33 INT132226 Binding of Akt1 and Pik3cg 1 0.30 0.49 0.9
34 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
35 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
36 INT199109 Binding of Akt1 and Arhgdia 1 0.02 2.73 0.87
37 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
38 INT317556 Phosphorylation of Gopc Positive_regulation of Akt1 1 0.10 0.08 0.82
39 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
40 INT317514 Akt1 Regulation of Localization of Oprm1 1 0.21 0.07 0.82
41 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
42 INT322397 Egfr Positive_regulation of Adarb1 1 0.00 0.08 0.8
43 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78
44 INT111888 Akt1 Regulation of Regulation of Oprm1 1 0.04 0 0.77
45 INT102159 Binding of Adam17 and Mmp2 1 0.18 0.87 0.77
46 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
47 INT335592 Ltp Positive_regulation of Positive_regulation of Akt1 1 0.01 0.19 0.74
48 INT106527 Akt1 Positive_regulation of Jun 1 0.05 0.53 0.74
49 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
50 INT104301 Adam17 Regulation of Negative_regulation of Sell 1 0.39 0.58 0.69
51 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
52 INT298728 Akt1 Positive_regulation of Rela 1 0.01 1.03 0.67
53 INT169213 Binding of EGFR and CARTPT 1 0.00 0.22 0.67
54 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
55 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
56 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
57 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
58 INT169293 PTPLA Positive_regulation of AKT1 1 0.10 0.15 0.64
59 INT134047 Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
60 INT134044 Positive_regulation of Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
61 INT278695 MTX1 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.81 0.62
62 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61
63 INT282286 Akt1 Positive_regulation of Pak1 1 0.15 0.24 0.61
64 INT139901 Ins1 Positive_regulation of Akt1 9 0.31 4.58 0.6
65 INT248994 Binding of Akt1 and Ptar1 1 0.00 0 0.58
66 INT169286 CNR1 Positive_regulation of Phosphorylation of EGFR 1 0.45 0.18 0.57
67 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
68 INT302832 Tnfsf10 Positive_regulation of Akt1 1 0.04 1.63 0.56
69 INT201944 CXCL10 Positive_regulation of Phosphorylation of AKT1 1 0.09 0.79 0.55
70 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
71 INT282284 Cpox Positive_regulation of Akt1 1 0.02 0.47 0.54
72 INT282282 Ptger2 Positive_regulation of Akt1 1 0.03 0.47 0.54
73 INT162994 Binding of Akt1 and Trib3 1 0.04 0.09 0.54
74 INT127320 Gpx3 Regulation of Akt1 2 0.00 3.11 0.53
75 INT317523 Oprm1 Positive_regulation of Gene_expression of Akt1 1 0.32 0.05 0.53
76 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
77 INT317574 Oprm1 Positive_regulation of Akt1 1 0.22 0.05 0.52
78 INT97952 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of AKT1 1 0.03 0.72 0.51
79 INT151221 Negative_regulation of SIGMAR1 Negative_regulation of Akt1 1 0.00 0.13 0.51
80 INT97951 ST3GAL3 Positive_regulation of AKT1 1 0.04 0.7 0.5
81 INT102844 Pdc Regulation of Akt1 1 0.03 0 0.49
82 INT220741 Binding of EGFR and SOAT1 1 0.02 0.37 0.49
83 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
84 INT309126 Edc4 Positive_regulation of Akt1 1 0.02 0.99 0.47
85 INT309144 Dlat Positive_regulation of Akt1 1 0.03 0.99 0.47
86 INT276207 Binding of Akt1 and Myo1f 1 0.11 0.05 0.47
87 INT162932 TXNRD1 Negative_regulation of Phosphorylation of AKT1 1 0.14 1.01 0.47
88 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
89 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
90 INT162929 NQO1 Negative_regulation of Phosphorylation of AKT1 1 0.41 1 0.46
91 INT139900 Kcne2 Positive_regulation of Akt1 1 0.06 2.95 0.44
92 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
93 INT348785 Ins1 Positive_regulation of Phosphorylation of Akt1 1 0.17 3.5 0.42
94 INT322396 Hist1h1t Positive_regulation of Akt1 1 0.01 0 0.42
95 INT160048 INPPL1 Regulation of Gene_expression of AKT1 1 0.28 0.6 0.42
96 INT322395 Akt1 Regulation of Pik3cb 1 0.08 0 0.42
97 INT121851 AKT1 Regulation of ROS1 1 0.16 0.52 0.41
98 INT122749 Cyp3a23/3a1 Positive_regulation of Phosphorylation of Akt1 1 0.07 0.24 0.41
99 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
100 INT121854 AKT1 Regulation of BID 1 0.17 0.52 0.41
101 INT276216 Binding of Akt1 and Ins1 2 0.03 2.61 0.4
102 INT108197 AKT1 Regulation of JUN 1 0.29 0.25 0.4
103 INT231842 Pcdh8 Positive_regulation of Akt1 1 0.00 1.59 0.4
104 INT121853 Gene_expression of ROS1 Negative_regulation of AKT1 1 0.25 0.49 0.4
105 INT322409 Positive_regulation of OPRM1 Positive_regulation of Phosphorylation of Akt1 1 0.04 0 0.4
106 INT166155 Ccr9 Positive_regulation of Akt1 1 0.58 2.14 0.39
107 INT272751 EGFR Regulation of Negative_regulation of Prkca 1 0.01 0 0.38
108 INT146611 Ins1 Positive_regulation of Phosphorylation of Akt1 9 0.23 4.34 0.37
109 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
110 INT299288 AKT1 Positive_regulation of RPTOR 1 0.34 0.05 0.36
111 INT148243 Binding of Akt1 and Kit 1 0.03 0.44 0.35
112 INT122758 Positive_regulation of Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
113 INT288208 Binding of Mapk14 and Positive_regulation of Akt1 1 0.01 0.42 0.35
114 INT176135 AKT1 Regulation of Localization of CYCS 1 0.43 2.16 0.35
115 INT122756 Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
116 INT309118 Dlat Positive_regulation of Positive_regulation of Akt1 1 0.03 0.32 0.34
117 INT249019 Gabrg1 Positive_regulation of Akt1 1 0.02 0 0.34
118 INT196820 Negative_regulation of Ppp1cc Positive_regulation of Akt1 1 0.00 0 0.34
119 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33
120 INT324525 PGE Positive_regulation of Positive_regulation of Egfr 1 0.41 1.05 0.33
121 INT324522 PGE Positive_regulation of Phosphorylation of Egfr 1 0.56 1.04 0.33
122 INT324524 PGE Positive_regulation of Egfr 1 0.38 1.05 0.33
123 INT214377 Akt1 Regulation of Amph 1 0.15 0 0.33
124 INT165580 Binding of Akt1 and Grin2b 1 0.02 0.2 0.32
125 INT337410 AKT3 Negative_regulation of AKT1 1 0.09 0.49 0.32
126 INT337414 AKT2 Negative_regulation of AKT1 1 0.10 0.5 0.32
127 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31
128 INT303063 Akt1 Negative_regulation of Gene_expression of Syn1 1 0.09 0.45 0.31
129 INT51859 Pim1 Positive_regulation of Positive_regulation of Pdyn 1 0.02 0 0.31
130 INT165921 Tlr4 Positive_regulation of Akt1 1 0.16 0.75 0.31
131 INT165920 Negative_regulation of Tlr4 Positive_regulation of Akt1 1 0.13 0.75 0.31
132 INT299307 AKT1 Positive_regulation of Positive_regulation of AKT1S1 1 0.10 0 0.3
133 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
134 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29
135 INT185799 Binding of EGFR and SPP1 1 0.19 0.64 0.29
136 INT291202 Positive_regulation of INS Positive_regulation of AKT1 1 0.01 0.76 0.29
137 INT166093 Negative_regulation of ROS1 Negative_regulation of Positive_regulation of EGFR 1 0.12 0.33 0.28
138 INT132367 Lgals1 Positive_regulation of Akt1 1 0.22 0.13 0.28
139 INT317533 Akt1 Positive_regulation of Nos1 1 0.43 0 0.28
140 INT126942 Binding of PKD2 and ZACN 1 0.00 1.38 0.28
141 INT166094 Negative_regulation of CSK Negative_regulation of Positive_regulation of EGFR 1 0.02 0.33 0.28
142 INT149322 Amph Positive_regulation of Akt1 1 0.39 0 0.27
143 INT223930 Binding of Akt1 and Pik3cb 1 0.07 0.35 0.26
144 INT235013 Binding of DSG1 and Adam17 1 0.07 1.34 0.26
145 INT223929 Negative_regulation of Binding of Akt1 and Pik3cb 1 0.08 0.36 0.26
146 INT234980 Positive_regulation of Egfr Positive_regulation of Adam17 1 0.09 1.33 0.26
147 INT303082 Akt1 Negative_regulation of Gene_expression of Mafk 1 0.20 0.37 0.26
148 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25
149 INT314047 THL Negative_regulation of Phosphorylation of Akt1 1 0.14 0.71 0.25
150 INT258521 EGFR Positive_regulation of MMP2 1 0.39 0.91 0.24
151 INT326094 Akt1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.49 0.24
152 INT326092 Gene_expression of Akt1 Negative_regulation of Gopc 1 0.03 0.55 0.24
153 INT326093 Akt1 Positive_regulation of Gopc 1 0.03 0.43 0.23
154 INT258565 EGFR Positive_regulation of Meta 1 0.39 0.89 0.23
155 INT265886 IGF1 Positive_regulation of AKT1 1 0.11 3.06 0.23
156 INT272753 Positive_regulation of Prkaca Positive_regulation of EGFR 1 0.01 0 0.23
157 INT323173 THRA Positive_regulation of Phosphorylation of Akt1 1 0.00 0 0.22
158 INT260844 NRP2 Positive_regulation of Akt1 1 0.00 0.73 0.22
159 INT116467 Vegfa Positive_regulation of Akt1 1 0.33 1.41 0.21
160 INT323174 DBT Positive_regulation of Phosphorylation of Akt1 1 0.01 0 0.21
161 INT120716 Binding of AKT1 and TEP1 1 0.05 0.46 0.21
162 INT116468 VEGFA Positive_regulation of Akt1 1 0.04 1.39 0.21
163 INT289356 Binding of Akt1 and Fgf2 1 0.03 0.82 0.21
164 INT309661 C5 Positive_regulation of Phosphorylation of Akt1 1 0.51 0.45 0.21
165 INT221237 Prkca Regulation of Phosphorylation of Akt1 1 0.01 0.28 0.2
166 INT352355 Binding of CNR1 and EGFR 1 0.19 0.76 0.2
167 INT145152 Binding of EGF and EGFR 4 0.15 2.45 0.19
168 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19
169 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19
170 INT334631 Igf1r Positive_regulation of Phosphorylation of Akt1 1 0.19 0.5 0.18
171 INT303058 Akt1 Negative_regulation of Gene_expression of Syt1 1 0.21 0.43 0.18
172 INT221231 Pdpk1 Positive_regulation of Akt1 1 0.09 0.13 0.18
173 INT221244 Pdpk1 Positive_regulation of Phosphorylation of Akt1 1 0.09 0.13 0.18
174 INT298196 EGFR Positive_regulation of PIK3CD 1 0.04 0.65 0.18
175 INT298192 EGFR Positive_regulation of AKT1 1 0.10 0.65 0.18
176 INT121582 AKT1 Regulation of Gene_expression of GDF15 1 0.21 0.4 0.18
177 INT318324 Binding of AKT1 and PRKCA 1 0.03 0.63 0.18
178 INT253129 Ins1 Regulation of Phosphorylation of Akt1 3 0.11 1.66 0.17
179 INT176133 AKT1 Regulation of BCL2 2 0.12 1.84 0.17
180 INT179841 Il11 Regulation of Positive_regulation of Akt1 1 0.08 0.07 0.17
181 INT105334 PTGER1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.66 0.17
182 INT282858 Bpifa2 Negative_regulation of Akt1 1 0.05 0.91 0.17
183 INT176134 AKT1 Regulation of Gene_expression of BIRC3 1 0.08 1.09 0.17
184 INT226209 Pik3cb Positive_regulation of Phosphorylation of Akt1 1 0.10 1.16 0.17
185 INT282861 Bpifa2 Negative_regulation of Phosphorylation of Akt1 1 0.05 0.91 0.17
186 INT352354 EGFR Regulation of Gene_expression of CNR1 1 0.23 1.16 0.17
187 INT218937 Akt1 Positive_regulation of Parn 1 0.01 0.65 0.16
188 INT316484 Akt1 Positive_regulation of Positive_regulation of Stat3 1 0.01 0.87 0.16
189 INT343475 Epo Regulation of Akt1 1 0.18 0.41 0.16
190 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
191 INT343478 Epo Regulation of Gene_expression of Akt1 1 0.40 0.41 0.16
192 INT112132 Gast Positive_regulation of Positive_regulation of Egfr 1 0.33 0.13 0.16
193 INT218930 Akt1 Positive_regulation of Xiap 1 0.06 0.64 0.16
194 INT224697 TNF Positive_regulation of Akt1 1 0.01 0 0.15
195 INT293698 Positive_regulation of Binding of Akt1 and Plek 1 0.05 0.12 0.15
196 INT292750 Akt1 Positive_regulation of Bcl2 1 0.01 1.67 0.15
197 INT293695 Binding of Akt1 and Plek 1 0.03 0.12 0.15
198 INT292749 Akt1 Positive_regulation of Ctnnd2 1 0.09 1.73 0.15
199 INT231844 Pcdh8 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.63 0.15
200 INT224694 Il1 Positive_regulation of Akt1 1 0.01 0 0.15

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cyclin-dependent protein kinase activity involved in G1/S. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of cyclin-dependent protein kinase activity involved in G1/S. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
2 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
3 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
4 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
5 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
6 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
7 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
8 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
9 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
10 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
11 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
12 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
13 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
14 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
15 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
16 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
17 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
18 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
19 INT75137 Regulation of Akt1 74 0.48 37.89 9.7
20 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98
21 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69
22 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83
23 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59
24 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39
25 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33
26 INT126748 Positive_regulation of Positive_regulation of Akt1 26 0.55 11.15 7.08
27 INT130875 Gene_expression of ADAM17 13 0.78 15.46 6.41
28 INT11154 Binding of EGFR 149 0.48 96.23 6.29
29 INT117721 Positive_regulation of Gene_expression of Akt1 22 0.69 6.26 6.08
30 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06
31 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61
32 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93
33 INT105336 Regulation of AKT1 52 0.56 32.53 4.89
34 INT134657 Localization of Akt1 37 0.68 11.58 4.62
35 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44
36 INT104299 Negative_regulation of Adam17 18 0.47 12.03 4.39
37 INT103914 Phosphorylation of Egfr 35 0.82 16.98 4.31
38 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21
39 INT75136 Binding of Akt1 27 0.27 8.81 4.15
40 INT139898 Negative_regulation of Positive_regulation of Akt1 15 0.42 4.66 4.06
41 INT120715 Positive_regulation of Egfr 15 0.68 5.53 3.77
42 INT119506 Negative_regulation of Egfr 32 0.55 23.75 3.67
43 INT132223 Negative_regulation of Negative_regulation of Akt1 6 0.42 2.75 3.66
44 INT136692 Localization of Akt1 12 0.78 2.14 3.65
45 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45
46 INT157687 Regulation of Gene_expression of Akt1 9 0.62 4.96 3.27
47 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19
48 INT124954 Gene_expression of Egfr 26 0.75 15.08 3.12
49 INT120562 Negative_regulation of Egfr 108 0.59 79.38 3.11
50 INT117348 Regulation of EGFR 75 0.61 47.73 3.09
51 INT117720 Negative_regulation of Gene_expression of Akt1 11 0.37 2.33 3.08
52 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02
53 INT102157 Gene_expression of Adam17 3 0.58 4.17 2.86
54 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8
55 INT117715 Regulation of Phosphorylation of Akt1 15 0.51 3.23 2.78
56 INT214355 Binding of Akt1 13 0.36 3.72 2.59
57 INT118791 Binding of AKT1 32 0.48 15.51 2.25
58 INT138286 Regulation of Positive_regulation of Akt1 13 0.45 4.93 2.22
59 INT103917 Positive_regulation of Phosphorylation of Egfr 12 0.68 7.23 2.18
60 INT101866 Positive_regulation of Gene_expression of AKT1 49 0.52 17.47 2.14
61 INT65545 Localization of EGFR 35 0.79 20.8 1.88
62 INT117346 Positive_regulation of ADAM17 5 0.50 6.69 1.86
63 INT112131 Positive_regulation of Positive_regulation of Egfr 10 0.49 9.95 1.85
64 INT148326 Gene_expression of Pkd1 7 0.76 5.38 1.85
65 INT123130 Positive_regulation of Positive_regulation of AKT1 22 0.49 11.77 1.83
66 INT120563 Positive_regulation of Gene_expression of Egfr 56 0.70 46.19 1.82
67 INT130874 Negative_regulation of Gene_expression of ADAM17 3 0.43 5.03 1.76
68 INT142236 Regulation of Phosphorylation of Akt1 13 0.61 5.02 1.75
69 INT124953 Negative_regulation of Gene_expression of Egfr 6 0.42 1.97 1.75
70 INT165332 Negative_regulation of Negative_regulation of Akt1 5 0.42 3.27 1.7
71 INT117714 Regulation of Positive_regulation of Akt1 3 0.61 0.44 1.61
72 INT130332 Gene_expression of Adam17 14 0.50 4.84 1.56
73 INT118292 Negative_regulation of Phosphorylation of EGFR 27 0.59 13.62 1.54
74 INT96993 Positive_regulation of Phosphorylation of EGFR 15 0.59 5.44 1.37
75 INT78861 Negative_regulation of Transcription of Adam17 2 0.29 1.4 1.32
76 INT78859 Transcription of Adam17 2 0.47 1.39 1.31
77 INT127725 Negative_regulation of Positive_regulation of EGFR 6 0.57 2.69 1.3
78 INT167409 Regulation of Gene_expression of AKT1 8 0.56 4.86 1.23
79 INT234893 Positive_regulation of Adam17 4 0.38 3.78 1.22
80 INT148321 Positive_regulation of Gene_expression of Pkd1 5 0.68 2.93 1.21
81 INT135556 Localization of AKT1 38 0.69 12.78 1.17
82 INT118792 Regulation of Positive_regulation of AKT1 8 0.61 3.73 1.15
83 INT176147 Regulation of Phosphorylation of AKT1 14 0.41 6.41 1.13
84 INT207203 Transcription of Akt1 6 0.67 3.73 1.1
85 INT118293 Regulation of Phosphorylation of EGFR 2 0.61 1.01 1.1
86 INT152404 Regulation of PKD1 2 0.45 2.02 1.04
87 INT191050 Positive_regulation of Negative_regulation of Akt1 6 0.31 1.82 1.03
88 INT132435 Negative_regulation of ADAM17 2 0.50 3.75 1.02
89 INT86384 Negative_regulation of Localization of EGFR 4 0.43 2.5 0.97
90 INT11160 Regulation of Gene_expression of EGFR 27 0.62 22.05 0.96
91 INT134660 Positive_regulation of Localization of Akt1 10 0.32 6.33 0.94
92 INT66273 Positive_regulation of Pim1 3 0.12 0.37 0.93
93 INT66272 Gene_expression of Pim1 3 0.18 0.36 0.92
94 INT163508 Regulation of Gene_expression of Akt1 3 0.45 1.65 0.92
95 INT144415 Regulation of Positive_regulation of Egfr 2 0.27 0.42 0.86
96 INT101892 Gene_expression of PIM1 10 0.65 7.19 0.85
97 INT117347 Positive_regulation of Positive_regulation of EGFR 15 0.69 11.17 0.84
98 INT144416 Regulation of Egfr 5 0.57 4.97 0.83
99 INT171361 Regulation of Egfr 16 0.62 8.36 0.81
100 INT144414 Positive_regulation of Positive_regulation of Egfr 1 0.49 0.65 0.8
101 INT131286 Binding of Egfr 26 0.44 13.58 0.78
102 INT138955 Transcription of EGFR 18 0.71 11.39 0.78
103 INT186119 Protein_catabolism of EGFR 6 0.98 3.68 0.76
104 INT129174 Gene_expression of PKD1 24 0.67 14.91 0.74
105 INT151170 Regulation of Regulation of Akt1 2 0.45 3.28 0.73
106 INT114246 Positive_regulation of Negative_regulation of EGFR 13 0.49 8.67 0.7
107 INT299338 Negative_regulation of Regulation of AKT1 2 0.31 2.32 0.68
108 INT186117 Negative_regulation of Protein_catabolism of EGFR 1 0.42 0.67 0.68
109 INT186118 Positive_regulation of Protein_catabolism of EGFR 1 0.68 0.66 0.68
110 INT207204 Regulation of Transcription of Akt1 3 0.35 1.41 0.66
111 INT166024 Protein_catabolism of AKT1 5 0.46 2.6 0.64
112 INT137850 Gene_expression of PKD2 9 0.65 6.68 0.63
113 INT281466 Negative_regulation of Regulation of Akt1 1 0.33 0.31 0.63
114 INT123131 Negative_regulation of Negative_regulation of AKT1 6 0.42 3.23 0.58
115 INT296583 Gene_expression of Fgf10 3 0.59 2.64 0.57
116 INT320644 Binding of Egfr 7 0.34 5.9 0.56
117 INT296594 Regulation of Fgf10 1 0.15 1.53 0.56
118 INT138678 Transcription of ADAM17 1 0.69 4.9 0.56
119 INT218900 Regulation of Negative_regulation of Akt1 3 0.15 1.73 0.53
120 INT138676 Localization of ADAM17 4 0.73 4.91 0.5
121 INT276189 Regulation of Localization of Akt1 1 0.43 0.2 0.5
122 INT103916 Negative_regulation of Phosphorylation of Egfr 12 0.59 7.03 0.47
123 INT142943 Phosphorylation of Egfr 5 0.81 1.56 0.45
124 INT142942 Positive_regulation of Phosphorylation of Egfr 4 0.68 1.52 0.45
125 INT169355 Localization of Egfr 6 0.75 3.24 0.43
126 INT148322 Localization of Pkd1 1 0.79 1.07 0.41
127 INT251556 Localization of Adam17 2 0.38 2 0.39
128 INT185350 Negative_regulation of Gene_expression of Egfr 24 0.59 13.21 0.35
129 INT138954 Regulation of Transcription of EGFR 2 0.27 0.82 0.35
130 INT145155 Regulation of Positive_regulation of EGFR 6 0.38 4.54 0.33
131 INT186115 Negative_regulation of Negative_regulation of EGFR 5 0.57 3.42 0.33
132 INT78862 Negative_regulation of Adam17 3 0.36 1.76 0.32
133 INT321348 Positive_regulation of Localization of Akt1 1 0.30 0.08 0.32
134 INT187284 Positive_regulation of Gene_expression of Adam17 3 0.20 1.32 0.29
135 INT78944 Positive_regulation of Positive_regulation of Pim1 1 0.01 0.08 0.27
136 INT239464 Regulation of Negative_regulation of Akt1 3 0.31 0.37 0.25
137 INT180101 Phosphorylation of Adam17 3 0.37 0.25 0.24
138 INT223597 Negative_regulation of Binding of EGFR 12 0.43 7.97 0.23
139 INT78943 Binding of Pim1 1 0.01 0.06 0.23
140 INT78865 Localization of Adam17 1 0.43 0.34 0.23
141 INT200666 Transcription of AKT1 8 0.66 4.23 0.2
142 INT230483 Protein_catabolism of Akt1 2 0.10 1.11 0.2
143 INT276192 Transcription of Akt1 1 0.66 0.47 0.18
144 INT276344 Positive_regulation of PIM1 3 0.25 1.07 0.17
145 INT185352 Regulation of Gene_expression of Egfr 5 0.62 2.33 0.16
146 INT176153 Regulation of Negative_regulation of AKT1 3 0.39 2.13 0.16
147 INT171378 Negative_regulation of Binding of Egfr 3 0.43 1.48 0.16
148 INT171365 Negative_regulation of Regulation of Egfr 1 0.33 0.06 0.16
149 INT138679 Regulation of ADAM17 1 0.19 1.13 0.16
150 INT138680 Binding of ADAM17 1 0.36 1.42 0.16
151 INT135557 Positive_regulation of Localization of AKT1 3 0.46 0.49 0.15
152 INT199521 Protein_catabolism of PKD1 2 0.96 0.39 0.15
153 INT148323 Binding of Pkd1 1 0.37 0.5 0.15
154 INT144682 Negative_regulation of Regulation of Egfr 1 0.43 0.41 0.15
155 INT226185 Protein_catabolism of Akt1 7 0.53 2.43 0.14
156 INT175416 Regulation of Negative_regulation of EGFR 4 0.60 3.94 0.14
157 INT302248 Negative_regulation of Binding of AKT1 2 0.25 1 0.14
158 INT299514 Localization of Egfr 2 0.37 0.38 0.14
159 INT148324 Phosphorylation of Pkd1 1 0.81 0.52 0.14
160 INT285902 Positive_regulation of Transcription of AKT1 1 0.06 0.6 0.13
161 INT169349 Regulation of Adam17 1 0.37 0.97 0.13
162 INT233419 Negative_regulation of Positive_regulation of Egfr 2 0.40 0.97 0.12
163 INT214360 Negative_regulation of Binding of Akt1 2 0.41 0.09 0.12
164 INT355216 Positive_regulation of Binding of Akt1 1 0.37 0.35 0.12
165 INT199082 Positive_regulation of Binding of Akt1 4 0.17 1.25 0.11
166 INT138677 Negative_regulation of Transcription of ADAM17 1 0.42 1.18 0.1
167 INT219647 Negative_regulation of Negative_regulation of Egfr 1 0.19 0.13 0.1
168 INT276363 Positive_regulation of Gene_expression of PIM1 4 0.15 2.87 0.09
169 INT187285 Protein_catabolism of Adam17 1 0.12 0.94 0.09
170 INT192239 Positive_regulation of Binding of AKT1 2 0.26 0.91 0.08
171 INT356064 Regulation of Negative_regulation of Adam17 1 0.23 0.24 0.08
172 INT356054 Regulation of Phosphorylation of Adam17 1 0.20 0.25 0.08
173 INT180096 Positive_regulation of Phosphorylation of Adam17 1 0.07 0 0.08
174 INT226648 Negative_regulation of Positive_regulation of Egfr 1 0.10 0 0.08
175 INT211211 Positive_regulation of Negative_regulation of Egfr 1 0.50 1.36 0.08
176 INT229184 Regulation of Protein_catabolism of EGFR 1 0.25 1.11 0.08
177 INT266934 Regulation of Binding of EGFR 3 0.45 1.16 0.07
178 INT307475 Positive_regulation of Negative_regulation of Akt1 1 0.12 0.12 0.07
179 INT182302 Negative_regulation of Localization of AKT1 5 0.39 3.52 0.06
180 INT286583 Localization of PKD2 1 0.35 0.17 0.06
181 INT299512 Regulation of Localization of Egfr 1 0.13 0.11 0.06
182 INT211006 Binding of PKD1 6 0.22 2.69 0.05
183 INT205021 Positive_regulation of Gene_expression of Egfr 3 0.64 4.15 0.05
184 INT261879 Binding of PKD2 3 0.13 2.59 0.05
185 INT279191 Regulation of Negative_regulation of Egfr 2 0.45 1.44 0.05
186 INT180094 Binding of Adam17 1 0.06 0 0.05
187 INT183275 Positive_regulation of Regulation of EGFR 1 0.36 0.21 0.05
188 INT185349 Transcription of Egfr 8 0.72 4.01 0.04
189 INT305667 Binding of PIM1 1 0.03 0.1 0.04
190 INT185347 Negative_regulation of Transcription of Egfr 1 0.59 1.1 0.04
191 INT260760 Positive_regulation of Fgf10 2 0.53 0.43 0.03
192 INT300989 Positive_regulation of Negative_regulation of AKT1 2 0.41 1.27 0.03
193 INT305666 Localization of PIM1 1 0.05 0.08 0.03
194 INT303535 Positive_regulation of Gene_expression of Fgf10 1 0.53 0.34 0.03
195 INT145156 Regulation of Regulation of EGFR 1 0.24 1.31 0.03
196 INT305668 Positive_regulation of Localization of PIM1 1 0.03 0.08 0.03
197 INT288183 Positive_regulation of Regulation of Akt1 1 0.05 0.06 0.03
198 INT266931 Positive_regulation of Binding of EGFR 6 0.50 5.44 0
199 INT268244 Negative_regulation of Localization of Akt1 2 0.28 2 0
200 INT175892 Negative_regulation of PKD1 2 0.42 1.03 0
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