GO:0031663

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Name lipopolysaccharide-mediated signaling pathway
Categary Process
Go Slim No
Go Link GO:0031663
Unique Molecular Interactions 3613
Total Molecular Interactions 5002
Total Single Events 41852
Pain Genes Associated 71

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for lipopolysaccharide-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for lipopolysaccharide-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
2 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
3 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
4 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
5 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
6 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
7 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
8 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
9 INT69032 IL18 Positive_regulation of IFNA1 12 0.23 7.87 3.83
10 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81
11 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
12 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
13 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
14 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
15 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 1 0.15 0.68 3.17
16 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
17 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
18 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
19 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9
20 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
21 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
22 INT91649 Binding of Lbp and SPECC1 1 0.12 2.88 2.78
23 INT69030 IL18 Positive_regulation of IL12A 3 0.31 5.57 2.72
24 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
25 INT212505 Binding of pr and Lbp 1 0.01 4.26 2.62
26 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
27 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
28 INT189490 Binding of Ccr3 and Ccl5 1 0.33 8.54 2.6
29 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
30 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
31 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46
32 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
33 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
34 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
35 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
36 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
37 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3
38 INT131257 ITIH4 Positive_regulation of Gene_expression of Nfkbia 1 0.23 1.41 2.3
39 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
40 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
41 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
42 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
43 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
44 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
45 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
46 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
47 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
48 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
49 INT128997 Cxcl1 Positive_regulation of Localization of Ccl2 1 0.72 1.54 2.16
50 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
51 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
52 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
53 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
54 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
55 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
56 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
57 INT128996 Ccl2 Positive_regulation of Localization of Calca 1 0.68 1.43 2
58 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
59 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
60 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
61 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
62 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
63 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
64 INT161224 Ccl2 Positive_regulation of Ccr2 1 0.52 2.09 1.88
65 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
66 INT135582 Prok2 Positive_regulation of Localization of Prkce 1 0.06 1.02 1.87
67 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
68 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
69 INT314210 Ngf Regulation of Phosphorylation of Mapk14 1 0.34 0.85 1.84
70 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
71 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
72 INT302646 ARSA Positive_regulation of TGFB1 1 0.10 0.52 1.76
73 INT129717 TGFB1 Positive_regulation of Gene_expression of TNFRSF10D 3 0.38 4.29 1.71
74 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
75 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
76 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
77 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
78 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
79 INT278223 Binding of NOS3 and ACSM3 1 0.41 6.32 1.65
80 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
81 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 0.47 1.01 1.63
82 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
83 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
84 INT167202 TNF Regulation of Gene_expression of Ngf 1 0.10 1.47 1.6
85 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59
86 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 0.01 1.69 1.59
87 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
88 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
89 INT314214 Mapk14 Positive_regulation of Ngf 1 0.43 1.97 1.56
90 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
91 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
92 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
93 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54
94 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
95 INT167201 Gtf3a Regulation of TNF 1 0.01 1.39 1.52
96 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
97 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
98 INT253863 Binding of LBP and PNP 1 0.13 1.5 1.5
99 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
100 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
101 INT140028 Ifng Positive_regulation of Gene_expression of Il1b 1 0.48 1.69 1.5
102 INT222185 Binding of Ccr1 and Ccl3 4 0.23 2.7 1.47
103 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
104 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
105 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
106 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
107 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
108 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42
109 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
110 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 0.07 1.35 1.41
111 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41
112 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4
113 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
114 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
115 INT176368 IL18 Positive_regulation of Gene_expression of IFNA1 1 0.16 2.53 1.35
116 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
117 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
118 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
119 INT160585 IL18 Positive_regulation of Gene_expression of OPRM1 1 0.09 0.54 1.35
120 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
121 INT314213 Mapk14 Positive_regulation of Agtrap 1 0.04 1.15 1.34
122 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
123 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
124 INT300864 Ngf Positive_regulation of Mapk14 2 0.60 1.38 1.32
125 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
126 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
127 INT131256 Positive_regulation of Nfkb1 Positive_regulation of Gene_expression of Nfkbia 1 0.38 0.94 1.31
128 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
129 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
130 INT130333 FUT3 Negative_regulation of Positive_regulation of Tnf 1 0.01 0.36 1.29
131 INT108386 IL1B Positive_regulation of MMP1 3 0.27 1.56 1.28
132 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27
133 INT314209 Ngf Positive_regulation of Binding of Mapk14 1 0.43 1.48 1.27
134 INT181436 Binding of Ccl2 and Eae1 1 0.05 5.14 1.27
135 INT70037 TNF Regulation of IL10 2 0.09 2.11 1.26
136 INT296796 Tbrs1 Positive_regulation of Gene_expression of TNF 1 0.00 1.58 1.26
137 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
138 INT254210 Binding of Cxcr2 and Ccl2 1 0.08 2.39 1.25
139 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
140 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
141 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
142 INT314198 Mapk14 Positive_regulation of Gene_expression of Trpv1 1 0.48 1.09 1.24
143 INT314212 Mapk14 Positive_regulation of Gene_expression of Agtrap 1 0.06 1.09 1.24
144 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
145 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
146 INT131807 Bpifa2 Positive_regulation of Localization of Tnf 1 0.32 2.09 1.22
147 INT70035 TNF Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
148 INT70039 IL1B Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
149 INT70032 TNF Regulation of PRF1 1 0.05 1.42 1.21
150 INT70040 TNF Regulation of Negative_regulation of IL10 1 0.09 1.42 1.21
151 INT70038 IL1B Regulation of PRF1 1 0.05 1.42 1.21
152 INT200455 OPRK1 Positive_regulation of Gene_expression of CCL2 1 0.19 0.07 1.21
153 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
154 INT70031 IL1B Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
155 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
156 INT70030 IL1B Regulation of IL10 1 0.07 1.42 1.21
157 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
158 INT209926 IL1B Regulation of PPARA 1 0.21 2.45 1.2
159 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 0.24 2.23 1.2
160 INT328742 Il1 Positive_regulation of Mapk14 1 0.01 1.4 1.2
161 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
162 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
163 INT75483 Binding of SGCG and TGFB1 1 0.52 2.27 1.19
164 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19
165 INT142077 TGFB1 Negative_regulation of Binding of IDO1 1 0.15 2.07 1.19
166 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18
167 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
168 INT150835 Gper Positive_regulation of Localization of Prkce 1 0.15 0.62 1.18
169 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17
170 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
171 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16
172 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
173 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
174 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
175 INT314206 Mapk14 Positive_regulation of Pax3 1 0.08 0.67 1.15
176 INT94502 Il1b Positive_regulation of Gene_expression of Avp 1 0.28 1.97 1.15
177 INT94509 Il1b Positive_regulation of Gene_expression of AVP 1 0.36 1.96 1.15
178 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
179 INT190771 Gene_expression of Il4 Negative_regulation of Gene_expression of Mapk14 1 0.15 1.14 1.13
180 INT66767 Il1b Positive_regulation of Pla2g10 1 0.05 0.47 1.13
181 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
182 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13
183 INT190770 Il4 Negative_regulation of Gene_expression of Mapk14 1 0.20 1.14 1.13
184 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
185 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
186 INT66907 Il1b Positive_regulation of Localization of Oxt 2 0.78 0.18 1.12
187 INT260810 Binding of CXCL10 and CCL2 1 0.10 1.37 1.12
188 INT147660 Positive_regulation of Prkce Positive_regulation of TRPV1 1 0.04 0.69 1.12
189 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
190 INT167428 Il1b Positive_regulation of Localization of Gpt 1 0.43 1.31 1.11
191 INT107264 Binding of TNF and NCR3 1 0.30 1.42 1.1
192 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
193 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1
194 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1
195 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1
196 INT167426 Tlr4 Positive_regulation of Localization of Gpt 1 0.25 1.26 1.1
197 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
198 INT130656 Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
199 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
200 INT107562 Penk Positive_regulation of Localization of Il1b 1 0.20 0.09 1.09

Single Events

The table below shows the top 100 pain related interactions that have been reported for lipopolysaccharide-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in lipopolysaccharide-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
2 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
3 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
4 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
5 INT6852 Localization of TNF 883 0.81 705.95 270.84
6 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
7 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
8 INT6481 Binding of TNF 624 0.48 510.2 214.82
9 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
10 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
11 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61
12 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02
13 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
14 INT9660 Regulation of TNF 363 0.62 312.94 139.99
15 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
16 INT1026 Binding of Lbp 207 0.48 150.96 119.16
17 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
18 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
19 INT82878 Gene_expression of Ccl2 201 0.78 164.95 101.35
20 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
21 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46
22 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51
23 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
24 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79
25 INT10166 Localization of Tnf 237 0.81 153.95 88.64
26 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
27 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59
28 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35
29 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
30 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
31 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
32 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
33 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
34 INT6849 Localization of IL1B 229 0.81 112.56 69.63
35 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
36 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41
37 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
38 INT9664 Binding of LBP 127 0.48 94.9 63.42
39 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
40 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85
41 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
42 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18
43 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
44 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09
45 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
46 INT1027 Gene_expression of Lbp 132 0.77 106.7 54.16
47 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32
48 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
49 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57
50 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
51 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
52 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
53 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
54 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05
55 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42
56 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22
57 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
58 INT13354 Transcription of TNF 108 0.72 85.81 42.32
59 INT82883 Positive_regulation of Ccl2 105 0.69 84.96 42.27
60 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
61 INT9372 Negative_regulation of Lbp 86 0.58 46.54 41.71
62 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56
63 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48
64 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
65 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
66 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
67 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
68 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
69 INT104551 Gene_expression of Il18 156 0.76 115.51 36.95
70 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81
71 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17
72 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
73 INT6484 Binding of IL1B 122 0.47 75.84 35.07
74 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
75 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
76 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89
77 INT19759 Gene_expression of LBP 77 0.77 56.44 33.23
78 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
79 INT65698 Localization of CCL2 118 0.81 77.54 32.69
80 INT84170 Positive_regulation of Gene_expression of Ccl2 58 0.69 48.79 32.43
81 INT35406 Localization of Tnf 94 0.81 64.63 31.65
82 INT9347 Localization of Il1b 58 0.81 26.13 31.53
83 INT56809 Binding of Tlr4 184 0.48 106.02 31.18
84 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
85 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
86 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08
87 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29
88 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19
89 INT82882 Localization of Ccl2 61 0.80 41.96 28
90 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
91 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76
92 INT78251 Positive_regulation of LBP 38 0.69 39.98 26.73
93 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59
94 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21
95 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95
96 INT9088 Negative_regulation of LBP 48 0.58 33.06 25.89
97 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
98 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
99 INT5948 Regulation of Il1b 44 0.60 22.8 25.4
100 INT130186 Gene_expression of Ccl5 101 0.74 79.96 25.01
101 INT1030 Localization of Lbp 52 0.74 38.92 24.91
102 INT106272 Positive_regulation of Positive_regulation of Mapk14 39 0.70 32.08 24.71
103 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24
104 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
105 INT51029 Negative_regulation of Il1b 34 0.57 29.34 23.62
106 INT134651 Binding of TLR4 89 0.48 66.96 23.19
107 INT99069 Positive_regulation of Gene_expression of Mapk14 42 0.53 29.84 23.16
108 INT48081 Localization of Il1b 46 0.80 21.59 22.4
109 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33
110 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23
111 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2
112 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03
113 INT78057 Localization of Tlr4 140 0.77 67.75 21.72
114 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37
115 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63
116 INT78901 Localization of CCL5 67 0.78 40.79 20.59
117 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34
118 INT125411 Negative_regulation of Phosphorylation of Mapk14 31 0.57 18.55 19.98
119 INT53574 Regulation of Tnf 45 0.62 40.68 19.71
120 INT138696 Positive_regulation of Ccl2 57 0.67 59.57 19.58
121 INT66751 Negative_regulation of Localization of Tnf 48 0.59 26 19.36
122 INT66755 Transcription of Tnf 45 0.72 37.1 19.11
123 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
124 INT89594 Gene_expression of Ccl5 44 0.54 24.08 18.62
125 INT87861 Gene_expression of Il18 33 0.78 30.44 18.42
126 INT66857 Regulation of CCL2 39 0.53 28.55 18.35
127 INT52179 Regulation of Lbp 39 0.61 25.4 18.32
128 INT84171 Negative_regulation of Gene_expression of Ccl2 30 0.58 26.37 18.28
129 INT55880 Negative_regulation of Gene_expression of CCL2 49 0.59 22.37 18.09
130 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01
131 INT55878 Regulation of Gene_expression of CCL2 34 0.62 15.71 17.97
132 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
133 INT113602 Positive_regulation of Gene_expression of Ccl2 48 0.70 48.71 17.85
134 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71
135 INT111531 Negative_regulation of Phosphorylation of Mapk14 37 0.50 20 17.68
136 INT104550 Positive_regulation of Il18 67 0.70 55.14 17.48
137 INT12081 Localization of TGFB1 64 0.81 35.4 17.47
138 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33
139 INT36054 Transcription of IL1B 53 0.72 32.64 17.31
140 INT10169 Positive_regulation of Localization of Tnf 44 0.70 27.71 16.75
141 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51
142 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31
143 INT49986 Transcription of Tnf 25 0.72 18.3 16.22
144 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59
145 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49
146 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
147 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
148 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17
149 INT96911 Positive_regulation of Phosphorylation of Mapk14 46 0.70 43.03 15.15
150 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6
151 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53
152 INT151120 Negative_regulation of Tlr4 18 0.59 21.09 14.46
153 INT25266 Positive_regulation of Localization of IL1B 38 0.69 15.89 14.35
154 INT10173 Binding of Tnf 45 0.48 35.6 14.32
155 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
156 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74
157 INT111529 Phosphorylation of Mapk3 41 0.80 21.14 13.72
158 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68
159 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63
160 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31
161 INT104954 Negative_regulation of Positive_regulation of Mapk14 29 0.58 17.71 13.31
162 INT141014 Positive_regulation of Gene_expression of Il18 46 0.68 47.63 13.3
163 INT20376 Gene_expression of Ccl3 39 0.75 45.42 13.15
164 INT83200 Positive_regulation of Gene_expression of Nos3 48 0.70 24.75 12.99
165 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9
166 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82
167 INT110025 Positive_regulation of Positive_regulation of Mapk14 39 0.63 20.67 12.71
168 INT121242 Positive_regulation of Gene_expression of Nos3 37 0.69 31.96 12.71
169 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71
170 INT58226 Negative_regulation of Gene_expression of Il1b 24 0.57 18.09 12.68
171 INT96850 Negative_regulation of CCL2 42 0.59 24.89 12.55
172 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48
173 INT51028 Regulation of Il1b 28 0.60 21.15 12.47
174 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37
175 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25
176 INT117113 Regulation of Mapk14 28 0.45 16.71 11.99
177 INT118906 Regulation of Mapk14 21 0.44 17.95 11.63
178 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61
179 INT88650 Negative_regulation of Prkce 13 0.57 11.93 11.16
180 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
181 INT118742 Positive_regulation of Tlr4 32 0.69 27.55 11.09
182 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07
183 INT168409 Positive_regulation of Ccl5 47 0.64 45.84 10.83
184 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75
185 INT133030 Positive_regulation of Gene_expression of TLR2 53 0.65 38.15 10.65
186 INT4240 Positive_regulation of CCL5 32 0.58 20.55 10.65
187 INT128364 Positive_regulation of Ccl3 20 0.70 23.96 10.65
188 INT103923 Negative_regulation of Positive_regulation of Mapk14 23 0.53 13.95 10.64
189 INT60434 Negative_regulation of Positive_regulation of Tnf 20 0.46 10.01 10.64
190 INT81538 Phosphorylation of Nfkbia 27 0.62 8.86 10.49
191 INT150540 Binding of TLR2 50 0.45 35.86 10.43
192 INT50196 Transcription of Il1b 25 0.69 19.08 10.43
193 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41
194 INT87451 Positive_regulation of Mapk3 34 0.67 12.82 10.38
195 INT91948 Positive_regulation of Prkce 16 0.64 11.36 10.32
196 INT78895 Regulation of CCL5 30 0.46 20.45 10.18
197 INT57000 Localization of LBP 21 0.78 11.01 10.01
198 INT83450 Positive_regulation of Localization of CCL2 28 0.70 22.14 9.83
199 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78
200 INT106200 Binding of Ccl2 22 0.42 16.7 9.75
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