GO:0031686

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Name A1 adenosine receptor binding
Categary Function
Go Slim No
Go Link GO:0031686
Unique Molecular Interactions 36
Total Molecular Interactions 43
Total Single Events 712
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for A1 adenosine receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for A1 adenosine receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT106850 P2ry2 Positive_regulation of Phosphorylation of Creb1 2 0.49 0.73 1.36
2 INT352295 Binding of P2RY2 and Agtr1a 1 0.01 0.08 1.02
3 INT61637 Binding of P2ry2 and Gtpbp4 1 0.02 0.1 0.99
4 INT216654 Binding of P2ry2 and DRGX 1 0.01 1.59 0.71
5 INT216644 Binding of P2ry1 and P2ry2 1 0.24 0.55 0.64
6 INT308894 Adp Regulation of P2ry1 1 0.05 0.49 0.53
7 INT330796 P2ry1 Positive_regulation of Ca2 1 0.05 0.06 0.5
8 INT308892 Adp Positive_regulation of P2ry1 1 0.11 0.44 0.47
9 INT191489 Positive_regulation of P2ry2 Negative_regulation of Positive_regulation of Trpv1 1 0.03 0.08 0.44
10 INT215564 Hmmr Negative_regulation of P2ry2 1 0.00 0 0.44
11 INT258857 Binding of P2rx1 and P2ry2 1 0.22 0.81 0.29
12 INT215683 P2ry2 Positive_regulation of Gene_expression of Il6 1 0.02 0.76 0.29
13 INT258856 P2ry2 Positive_regulation of P9Ehs1 1 0.01 0.76 0.26
14 INT308893 P2ry1 Positive_regulation of Adp 1 0.12 0 0.25
15 INT109845 Binding of P2RX3 and P2RY1 1 0.38 0 0.24
16 INT242245 Binding of P2ry1 and Adp 1 0.00 0.31 0.21
17 INT167113 Binding of P2ry1 and Trpv1 1 0.40 0 0.21
18 INT242250 Binding of P2ry1 and P2ry12 1 0.01 0.3 0.21
19 INT216705 Binding of MARS and P2RY1 1 0.06 0 0.2
20 INT352290 Binding of Agtr1a and P2ry1 1 0.00 0 0.16
21 INT216711 P2RY1 Negative_regulation of P2RY12 1 0.28 0.09 0.16
22 INT108598 Positive_regulation of Oprl1 Positive_regulation of Phosphorylation of P2ry2 1 0.10 0 0.13
23 INT224040 Mtpn Positive_regulation of P2RY1 1 0.00 0.85 0.12
24 INT252421 Gja1 Regulation of P2ry1 1 0.00 0.28 0.09
25 INT215767 Binding of P2ry1 and Ca2 1 0.02 0.2 0.08
26 INT246206 Binding of P2ry2 and P2ry4 1 0.12 0 0.05
27 INT273068 Binding of P2RY2 and TFAP4 1 0.01 0.27 0.05
28 INT351915 P2ry1 Regulation of Gfm1 1 0.01 0.86 0.03
29 INT351914 P2ry1 Regulation of Gene_expression of Gfm1 1 0.01 0.86 0.03
30 INT215691 Binding of P2ry2 and P2rx3 1 0.08 0.46 0.03
31 INT215765 Binding of P2ry1 and P2ry2 1 0.07 0.46 0.03
32 INT215684 Binding of P2ry2 and P2rx4 1 0.06 0.46 0.03
33 INT233504 Tlr4 Regulation of P2ry2 1 0.04 0.07 0
34 INT233500 Tlr4 Negative_regulation of P2ry1 1 0.06 0.18 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for A1 adenosine receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in A1 adenosine receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT37889 Gene_expression of P2ry2 75 0.65 26.01 23.8
2 INT61635 Positive_regulation of P2ry2 35 0.56 12.08 14.68
3 INT69166 Positive_regulation of P2ry1 35 0.67 8.41 13.63
4 INT93122 Gene_expression of P2ry1 32 0.75 11.82 11.42
5 INT105816 Gene_expression of P2RY2 53 0.78 16.47 9.67
6 INT111680 Gene_expression of P2ry2 20 0.58 9.23 7.39
7 INT76253 Positive_regulation of P2RY2 29 0.70 13.99 7.33
8 INT95466 Regulation of P2ry2 23 0.56 3.66 6.86
9 INT95170 Localization of P2ry1 10 0.78 5.08 5.63
10 INT111683 Gene_expression of P2ry1 22 0.74 7.96 5.59
11 INT139238 Positive_regulation of P2ry1 19 0.60 9.22 5.15
12 INT109848 Gene_expression of P2RY1 26 0.62 6.71 4.98
13 INT65509 Regulation of P2ry1 13 0.60 2.38 4.96
14 INT112038 Positive_regulation of P2ry2 8 0.45 2.41 4.4
15 INT118270 Regulation of P2RY2 16 0.45 7.02 3.45
16 INT126560 Binding of P2RY2 12 0.44 6.43 3.4
17 INT102347 Localization of P2ry2 4 0.56 1.23 3.31
18 INT38030 Positive_regulation of P2RY1 15 0.67 5.54 3.17
19 INT215521 Negative_regulation of P2ry1 10 0.56 2.68 2.72
20 INT91284 Negative_regulation of P2ry2 8 0.25 2.66 2.71
21 INT107846 Transcription of P2ry2 6 0.46 2.06 2.52
22 INT150465 Positive_regulation of Gene_expression of P2ry2 3 0.56 3.48 2.33
23 INT137977 Localization of P2RY2 5 0.80 3.07 2.27
24 INT115401 Negative_regulation of P2ry1 6 0.42 1.27 2.25
25 INT151816 Negative_regulation of P2ry2 3 0.02 3.1 2.23
26 INT99844 Localization of P2ry1 7 0.74 4.05 2.19
27 INT103236 Positive_regulation of Positive_regulation of P2ry1 5 0.54 2.39 1.92
28 INT95467 Transcription of P2ry2 7 0.49 1.43 1.87
29 INT102288 Localization of P2ry2 4 0.55 1.02 1.83
30 INT102348 Regulation of P2ry2 6 0.40 2.18 1.79
31 INT111682 Transcription of P2ry1 4 0.52 1.26 1.71
32 INT105815 Positive_regulation of Gene_expression of P2RY2 9 0.50 3.62 1.52
33 INT150466 Regulation of Positive_regulation of P2ry2 1 0.37 1.26 1.42
34 INT61636 Positive_regulation of Positive_regulation of P2ry2 4 0.34 0.13 1.4
35 INT169232 Negative_regulation of Gene_expression of P2ry2 3 0.31 2.29 1.32
36 INT117966 Binding of P2ry2 5 0.36 0.44 1.31
37 INT111681 Regulation of P2ry1 8 0.45 2.64 1.11
38 INT119974 Negative_regulation of P2RY2 3 0.43 1.6 1.04
39 INT129577 Negative_regulation of Positive_regulation of P2ry2 4 0.29 0.45 1
40 INT216611 Regulation of Gene_expression of P2ry2 1 0.30 0.29 0.99
41 INT103235 Regulation of Localization of P2ry1 2 0.44 0.09 0.97
42 INT148117 Positive_regulation of Positive_regulation of P2RY2 2 0.24 0.96 0.94
43 INT233482 Positive_regulation of Gene_expression of P2ry2 4 0.43 0.76 0.92
44 INT95468 Transcription of P2ry1 4 0.60 0 0.86
45 INT167317 Negative_regulation of P2RY1 5 0.34 1.35 0.83
46 INT151817 Positive_regulation of Transcription of P2ry2 2 0.21 1.19 0.82
47 INT148302 Regulation of Regulation of P2ry1 1 0.44 0.09 0.74
48 INT111406 Binding of P2ry1 2 0.36 0.31 0.7
49 INT216662 Regulation of Gene_expression of P2ry1 1 0.24 0.2 0.63
50 INT93647 Regulation of P2RY1 7 0.36 2.13 0.55
51 INT215572 Negative_regulation of Localization of P2ry1 1 0.15 0.08 0.55
52 INT243133 Positive_regulation of Positive_regulation of P2ry2 2 0.24 0.31 0.54
53 INT259774 Negative_regulation of Positive_regulation of P2ry1 1 0.33 1.11 0.54
54 INT233484 Positive_regulation of Gene_expression of P2ry1 4 0.43 0.95 0.5
55 INT308880 Positive_regulation of Negative_regulation of P2ry1 1 0.48 0.13 0.49
56 INT217010 Transcription of P2RY2 3 0.69 1.31 0.41
57 INT185697 Positive_regulation of Positive_regulation of P2RY1 1 0.40 0.36 0.36
58 INT126559 Negative_regulation of Binding of P2RY2 1 0.06 0.21 0.36
59 INT106849 Phosphorylation of P2ry2 2 0.37 0.1 0.35
60 INT217014 Transcription of P2RY1 1 0.23 0.26 0.35
61 INT102287 Binding of P2ry2 2 0.25 0 0.34
62 INT109852 Binding of P2RY1 3 0.35 1.04 0.33
63 INT141814 Regulation of Positive_regulation of P2ry1 1 0.44 0.15 0.33
64 INT95464 Regulation of Transcription of P2ry1 1 0.25 0 0.28
65 INT308883 Negative_regulation of Positive_regulation of P2ry1 1 0.41 0.05 0.2
66 INT351912 Binding of P2ry1 1 0.09 2.15 0.19
67 INT231684 Positive_regulation of Binding of P2RY2 2 0.22 0.13 0.16
68 INT282054 Negative_regulation of Gene_expression of P2ry2 1 0.18 0.54 0.15
69 INT216718 Positive_regulation of Gene_expression of P2RY1 1 0.55 0.15 0.15
70 INT108597 Positive_regulation of Phosphorylation of P2ry2 1 0.21 0 0.13
71 INT216716 Localization of P2RY1 1 0.60 0.33 0.1
72 INT216520 Regulation of Gene_expression of P2ry1 2 0.45 0.43 0.09
73 INT291034 Regulation of Transcription of P2ry2 1 0.28 0.78 0.09
74 INT273079 Negative_regulation of Gene_expression of P2RY2 1 0.59 0.52 0.09
75 INT216730 Negative_regulation of Gene_expression of P2RY1 1 0.34 0 0.09
76 INT216522 Negative_regulation of Localization of P2ry1 1 0.42 0.13 0.07
77 INT273076 Positive_regulation of Transcription of P2RY2 1 0.50 0.25 0.06
78 INT291037 Regulation of Gene_expression of P2ry2 1 0.12 0.64 0.05
79 INT273077 Negative_regulation of Positive_regulation of P2RY2 1 0.43 0.88 0.04
80 INT273078 Regulation of Protein_catabolism of P2RY2 1 0.39 0.47 0.04
81 INT273075 Protein_catabolism of P2RY2 1 0.87 0.41 0.04
82 INT243132 Negative_regulation of Regulation of P2ry2 1 0.16 0 0.03
83 INT216722 Regulation of Positive_regulation of P2RY1 1 0.49 0.16 0.03
84 INT351911 Positive_regulation of Positive_regulation of P2ry1 1 0.13 1.47 0.03
85 INT216615 Positive_regulation of Gene_expression of P2ry1 1 0.25 0.22 0
86 INT273081 Negative_regulation of Transcription of P2RY2 1 0.37 0 0
87 INT273082 Negative_regulation of Regulation of P2RY2 1 0.43 0.62 0
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