GO:0031711

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Name bradykinin receptor binding
Categary Function
Go Slim No
Go Link GO:0031711
Unique Molecular Interactions 125
Total Molecular Interactions 171
Total Single Events 2108
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for bradykinin receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for bradykinin receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
2 INT326509 Binding of ACE and VWF 1 0.05 2.07 1.59
3 INT162343 Positive_regulation of KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
4 INT162344 KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
5 INT24796 ACE Positive_regulation of Localization of HMMR 1 0.00 0.58 1.16
6 INT352295 Binding of P2RY2 and Agtr1a 1 0.01 0.08 1.02
7 INT127876 ACE Positive_regulation of Protein_catabolism of CALCA 1 0.28 0.63 0.75
8 INT77689 Binding of Ace and Tenc1 1 0.28 0.65 0.7
9 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68
10 INT141063 Agt Regulation of Agtr1a 1 0.28 1.18 0.68
11 INT259776 Fbn2 Regulation of Negative_regulation of Agtr1a 1 0.00 1.42 0.66
12 INT259768 Positive_regulation of Agtr1a Regulation of Etf1 1 0.00 1.32 0.62
13 INT21607 ACE Positive_regulation of ANGPT2 1 0.03 0.13 0.61
14 INT181619 ACE Positive_regulation of KNG1 1 0.33 0.97 0.58
15 INT79809 Binding of Agtr1a and Adra1a 1 0.02 0.23 0.53
16 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
17 INT342633 ACE Regulation of Gene_expression of AGT 1 0.01 0.14 0.46
18 INT182489 Gene_expression of AGTR2 Positive_regulation of Gene_expression of AGTR1 1 0.26 0.92 0.4
19 INT191493 Binding of AGTR1 and NLRP3 2 0.03 2.35 0.39
20 INT278932 Binding of Agtr1a and H3 1 0.00 0 0.39
21 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39
22 INT229222 Negative_regulation of ACE Negative_regulation of Protein_catabolism of KNG1 1 0.06 0.53 0.37
23 INT230786 Binding of AGT and ACE 4 0.15 2.53 0.34
24 INT330122 Agt Positive_regulation of Gene_expression of Agtr1a 1 0.03 0.69 0.34
25 INT330121 Agtr1a Positive_regulation of Gene_expression of Bdkrb1 1 0.05 0.68 0.34
26 INT230852 ACE Regulation of KNG1 2 0.03 0.72 0.32
27 INT229363 Negative_regulation of Binding of Agt and Agtr1a 2 0.22 0.9 0.32
28 INT265826 Binding of ACE and SERPINE1 1 0.24 1.08 0.3
29 INT224131 Binding of CAV1 and Agtr1a 1 0.00 0.08 0.3
30 INT230745 Negative_regulation of Ace Negative_regulation of Icam1 1 0.05 1.22 0.29
31 INT200639 Ace Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
32 INT182499 Binding of AGTR1 and AGTR2 3 0.20 2.79 0.28
33 INT64726 Ace Negative_regulation of KNG1 1 0.01 0.26 0.25
34 INT64727 Ace Positive_regulation of KNG1 1 0.01 0.26 0.25
35 INT191500 ACE Positive_regulation of Localization of KNG1 1 0.10 0.17 0.24
36 INT239238 Ace Positive_regulation of Protein_catabolism of KNG1 1 0.01 0.46 0.24
37 INT124078 Binding of Ace and Cpox 1 0.09 0.14 0.24
38 INT265828 ACE Regulation of Gene_expression of KNG1 1 0.32 0.83 0.22
39 INT200637 Binding of Abpa and Ace 1 0.01 4.62 0.22
40 INT297257 Agtr1a Positive_regulation of Agtr2 1 0.27 0.59 0.22
41 INT229360 Agt Positive_regulation of Agtr1a 2 0.48 1.26 0.2
42 INT230749 Crp Regulation of Agtr1a 1 0.07 1.33 0.19
43 INT224086 Binding of Agtr1a and Hspa8 1 0.00 0.1 0.19
44 INT265827 ACE Negative_regulation of ANGPT2 1 0.09 0.59 0.17
45 INT224126 Binding of Hspa8 and Agtr1a 1 0.00 0.09 0.17
46 INT352290 Binding of Agtr1a and P2ry1 1 0.00 0 0.16
47 INT8164 Ace Positive_regulation of Gene_expression of Fos 1 0.24 0.32 0.16
48 INT258812 Sugt1 Positive_regulation of Ace 1 0.05 1.26 0.16
49 INT75058 Negative_regulation of ACE Negative_regulation of HHIP 1 0.25 0.43 0.15
50 INT307807 Ace Positive_regulation of ras 1 0.38 3 0.15
51 INT293124 Agtr1a Regulation of Gene_expression of Aqp2 1 0.17 0.36 0.14
52 INT293119 Agtr1a Regulation of Positive_regulation of Crh 1 0.12 0.37 0.14
53 INT344946 AGT Regulation of Negative_regulation of ACE 1 0.21 0.61 0.14
54 INT293123 Agtr1a Regulation of Negative_regulation of Agt 1 0.14 0.25 0.14
55 INT102885 Binding of ANG and ACE 2 0.17 0.37 0.13
56 INT256020 Ace Negative_regulation of Gene_expression of Agtr2 1 0.03 0.37 0.13
57 INT256021 Ace Negative_regulation of Gene_expression of Agtrap 1 0.05 0.37 0.13
58 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13
59 INT329317 ACE Regulation of Positive_regulation of KNG1 1 0.02 1.05 0.12
60 INT110176 Nts Regulation of Negative_regulation of Agtr1a 1 0.24 0.09 0.12
61 INT329325 ACE Regulation of Negative_regulation of Agtr2 1 0.01 0.93 0.12
62 INT43095 Binding of Ace and Mme 1 0.26 0 0.12
63 INT229359 Agt Positive_regulation of Binding of Agtr1a 1 0.25 0.9 0.12
64 INT229364 Ace Positive_regulation of Protein_catabolism of KNG1 1 0.02 0.86 0.11
65 INT171162 Negative_regulation of Ace Negative_regulation of Gene_expression of Ccl2 1 0.02 1.18 0.1
66 INT334893 ACE Negative_regulation of Gene_expression of AGT 1 0.03 1.41 0.1
67 INT336990 Binding of AGTR1 and BDKRB2 1 0.03 0 0.1
68 INT270731 Binding of AGTR1 and ACE 1 0.02 0.67 0.09
69 INT104737 Ace Positive_regulation of Gene_expression of Ren1 1 0.35 0.09 0.09
70 INT265829 ACE Positive_regulation of Protein_catabolism of KNG1 1 0.33 0.73 0.09
71 INT279707 Positive_regulation of AGTR1 Regulation of TYRP1 1 0.00 0 0.09
72 INT279706 Positive_regulation of AGTR1 Regulation of TRPC6 1 0.00 0 0.09
73 INT344945 Negative_regulation of ACE Positive_regulation of REN 1 0.23 0.64 0.09
74 INT249994 Binding of Agtr1a and Igkv4-55 1 0.01 0.38 0.08
75 INT307805 Ace Positive_regulation of Ang 1 0.32 1.52 0.07
76 INT281900 Positive_regulation of Binding of AGT and AGTR1 1 0.12 0.16 0.07
77 INT307806 Ace Positive_regulation of Agt 1 0.28 1.51 0.07
78 INT200641 Binding of ACE and Agtr1a 1 0.12 0.92 0.06
79 INT281909 Binding of AGT and AGTR1 1 0.09 0.16 0.06
80 INT200638 Binding of ACE and Agtr2 1 0.10 0.93 0.06
81 INT200635 Binding of Ace and Spink1 1 0.37 1.4 0.05
82 INT336132 Binding of AGTR1 and ANG 1 0.00 0.38 0.05
83 INT29521 Ace Positive_regulation of ACE 1 0.19 0 0.04
84 INT258020 Binding of AGTR1 and ANGPT2 1 0.03 0.29 0.04
85 INT283226 Binding of ACE and CC2D1A 1 0.11 2.37 0.04
86 INT104736 Ace Positive_regulation of Ren1 1 0.35 0 0.04
87 INT340502 Agtr1a Negative_regulation of Phosphorylation of Jak2 1 0.12 2.32 0
88 INT109818 Ace Regulation of ras 1 0.04 0.3 0
89 INT322250 Ace Regulation of Gene_expression of Agt 1 0.43 0.63 0
90 INT340504 Agtr1a Negative_regulation of Phosphorylation of Pik3cb 1 0.06 1.16 0
91 INT307804 Ace Positive_regulation of Gene_expression of Scrib 1 0.21 2.43 0
92 INT322240 Ace Regulation of Gene_expression of Htr2a 1 0.13 0.63 0
93 INT322239 Ace Regulation of Gene_expression of Agtrap 1 0.44 0.63 0
94 INT1181 Negative_regulation of Ace Positive_regulation of Ren 1 0.52 0.23 0
95 INT322253 Agt Regulation of Gene_expression of Ace 1 0.43 0.63 0
96 INT229362 Negative_regulation of Agtr1a Positive_regulation of Positive_regulation of Agtr2 1 0.05 1 0
97 INT65004 Negative_regulation of Ace Positive_regulation of Agt 1 0.40 0 0
98 INT333044 Positive_regulation of Binding of AGTR1 and Trpv4 1 0.48 0 0
99 INT307808 Ace Positive_regulation of Gene_expression of Ace2 1 0.22 2.43 0
100 INT322238 Slc6a4 Regulation of Gene_expression of Ace 1 0.37 0.63 0
101 INT333045 Binding of AGTR1 and Gopc 1 0.05 0 0
102 INT322256 Ace Regulation of Gene_expression of Slc6a4 1 0.37 0.63 0
103 INT200488 Binding of ACE and SUGT1 1 0.01 0.28 0
104 INT333043 Binding of AGTR1 and Trpv4 1 0.50 0 0
105 INT213584 Binding of AGTR2 and ACE 1 0.17 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for bradykinin receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in bradykinin receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48
2 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46
3 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08
4 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19
5 INT79703 Gene_expression of Agtr1a 46 0.76 14.18 13.77
6 INT53038 Positive_regulation of Agtr1a 35 0.67 23.76 11.68
7 INT10982 Negative_regulation of Agtr1a 42 0.58 22.42 10.29
8 INT20664 Binding of ACE 60 0.48 35.27 9.16
9 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31
10 INT389 Gene_expression of Ace 21 0.67 10.31 8.1
11 INT25958 Regulation of Ace 26 0.59 11.88 7.87
12 INT1771 Positive_regulation of Ace 31 0.68 10.47 7.46
13 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27
14 INT42038 Localization of ACE 26 0.80 8.88 7.06
15 INT102891 Positive_regulation of AGTR1 31 0.67 30.57 5.29
16 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15
17 INT26477 Regulation of ACE 26 0.45 16.31 4.33
18 INT29327 Positive_regulation of Ace 13 0.67 8.79 4.33
19 INT387 Regulation of Ace 18 0.45 5.24 4.24
20 INT53040 Binding of Agtr1a 22 0.47 7.36 4.15
21 INT1722 Protein_catabolism of ACE 10 0.88 2.61 3.76
22 INT111195 Negative_regulation of Gene_expression of Agtr1a 7 0.58 3.2 3.16
23 INT8652 Protein_catabolism of Ace 10 0.94 4.7 2.74
24 INT63418 Regulation of Agtr1a 8 0.44 3.67 2.43
25 INT74695 Gene_expression of Ace 41 0.73 53.33 2.33
26 INT388 Positive_regulation of Gene_expression of Ace 4 0.42 1.04 2.13
27 INT45646 Protein_catabolism of Ace 5 0.98 3.14 1.95
28 INT43084 Binding of Ace 10 0.46 4.7 1.93
29 INT33096 Negative_regulation of Gene_expression of ACE 9 0.43 2.84 1.93
30 INT55606 Binding of Ace 14 0.37 10.73 1.82
31 INT182505 Positive_regulation of Gene_expression of AGTR1 12 0.65 13.18 1.77
32 INT22335 Regulation of Negative_regulation of ACE 10 0.44 7.01 1.77
33 INT182514 Binding of AGTR1 18 0.47 13.35 1.48
34 INT182511 Regulation of AGTR1 7 0.44 8.25 1.4
35 INT61223 Positive_regulation of Negative_regulation of ACE 6 0.49 5.92 1.37
36 INT83553 Positive_regulation of Positive_regulation of Agtr1a 3 0.59 4.12 1.37
37 INT44145 Negative_regulation of Gene_expression of Ace 5 0.40 4.5 1.33
38 INT148072 Gene_expression of Agtr1a 5 0.75 9.41 1.13
39 INT88948 Localization of Ace 9 0.69 9.18 1.11
40 INT182516 Negative_regulation of Negative_regulation of ACE 9 0.42 6.84 0.99
41 INT182512 Positive_regulation of Positive_regulation of AGTR1 5 0.47 4.88 0.97
42 INT229710 Localization of Agtr1a 3 0.60 0.57 0.84
43 INT83995 Positive_regulation of Gene_expression of ACE 8 0.68 8.09 0.82
44 INT230803 Regulation of Negative_regulation of Ace 2 0.39 1.89 0.81
45 INT102894 Localization of AGTR1 5 0.73 1.75 0.74
46 INT259902 Regulation of Gene_expression of ACE 3 0.45 1.87 0.7
47 INT111196 Negative_regulation of Negative_regulation of Agtr1a 2 0.42 0.49 0.65
48 INT72446 Negative_regulation of Binding of ACE 4 0.42 2.48 0.62
49 INT56045 Positive_regulation of Localization of ACE 3 0.69 1.38 0.6
50 INT200636 Regulation of Gene_expression of Ace 1 0.26 1.64 0.6
51 INT267971 Regulation of Localization of AGTR1 1 0.16 1.46 0.57
52 INT159150 Negative_regulation of Positive_regulation of Agtr1a 1 0.38 0.72 0.56
53 INT22333 Regulation of Negative_regulation of Ace 3 0.45 0.72 0.52
54 INT36764 Localization of Ace 7 0.80 1.53 0.51
55 INT43091 Positive_regulation of Negative_regulation of Ace 3 0.30 1.51 0.48
56 INT171150 Negative_regulation of Binding of Ace 2 0.17 2.67 0.44
57 INT44032 Regulation of Positive_regulation of Ace 1 0.38 0.1 0.43
58 INT107385 Regulation of Negative_regulation of AGTR1 2 0.15 1.26 0.42
59 INT182507 Negative_regulation of Gene_expression of AGTR1 1 0.40 1.13 0.4
60 INT330125 Transcription of AGTR1 1 0.52 1.29 0.39
61 INT114063 Negative_regulation of Localization of Ace 1 0.29 0.31 0.39
62 INT60040 Negative_regulation of Negative_regulation of Ace 6 0.43 3.64 0.38
63 INT181635 Positive_regulation of Protein_catabolism of ACE 1 0.15 0.41 0.38
64 INT77686 Transcription of Ace 2 0.65 2.65 0.37
65 INT229626 Negative_regulation of Localization of ACE 3 0.41 2 0.36
66 INT267844 Positive_regulation of Gene_expression of Ace 10 0.57 15.35 0.35
67 INT224111 Phosphorylation of Agtr1a 1 0.01 0 0.35
68 INT102889 Positive_regulation of Localization of AGTR1 3 0.38 0.43 0.34
69 INT96863 Transcription of ACE 3 0.69 0.38 0.29
70 INT230864 Regulation of Binding of ACE 1 0.22 0.79 0.29
71 INT288846 Negative_regulation of Transcription of ACE 1 0.43 0 0.29
72 INT229358 Negative_regulation of Protein_catabolism of Ace 1 0.40 0.93 0.27
73 INT47070 Positive_regulation of Localization of Ace 2 0.32 0.55 0.26
74 INT229357 Regulation of Binding of Ace 1 0.43 0.86 0.26
75 INT263255 Negative_regulation of Negative_regulation of AGTR1 2 0.30 2.88 0.25
76 INT63417 Regulation of Negative_regulation of Agtr1a 1 0.26 0.1 0.25
77 INT65003 Negative_regulation of Negative_regulation of Ace 5 0.37 3.45 0.23
78 INT247022 Transcription of Agtr1a 2 0.46 1.47 0.21
79 INT307794 Negative_regulation of Gene_expression of Ace 7 0.48 5.95 0.2
80 INT230740 Regulation of Agtr1a 2 0.15 3.5 0.19
81 INT69192 Positive_regulation of Positive_regulation of Ace 1 0.02 0 0.19
82 INT108414 Negative_regulation of Regulation of ACE 1 0.43 0.67 0.17
83 INT44051 Positive_regulation of Protein_catabolism of Ace 1 0.41 0 0.16
84 INT209796 Positive_regulation of Agtr1a 1 0.15 0.56 0.15
85 INT59791 Positive_regulation of Negative_regulation of Ace 3 0.49 0.57 0.13
86 INT288916 Negative_regulation of Positive_regulation of AGTR1 2 0.44 1.2 0.13
87 INT355657 Negative_regulation of Transcription of Agtr1a 1 0.38 1.17 0.13
88 INT355655 Regulation of Transcription of Agtr1a 1 0.29 1.15 0.13
89 INT99725 Negative_regulation of Agtr1a 5 0.57 1.03 0.12
90 INT249970 Transcription of Ace 3 0.36 1.87 0.12
91 INT229356 Negative_regulation of Binding of Agtr1a 1 0.36 0.89 0.12
92 INT43092 Negative_regulation of Binding of Ace 1 0.31 0 0.12
93 INT79993 Positive_regulation of Positive_regulation of ACE 2 0.49 0.78 0.1
94 INT340501 Regulation of Transcription of Ace 1 0.10 0.84 0.1
95 INT242222 Positive_regulation of Negative_regulation of AGTR1 1 0.35 1.77 0.1
96 INT247024 Positive_regulation of Transcription of Agtr1a 1 0.19 0.33 0.09
97 INT209797 Regulation of Positive_regulation of Agtr1a 1 0.10 0.29 0.08
98 INT340500 Negative_regulation of Transcription of Ace 1 0.10 0.78 0.07
99 INT333041 Regulation of Positive_regulation of AGTR1 1 0.44 0 0.07
100 INT249971 Positive_regulation of Transcription of Ace 1 0.35 0.47 0.06
101 INT128209 Positive_regulation of Regulation of Ace 1 0.42 0.4 0.06
102 INT42326 Negative_regulation of Regulation of Ace 1 0.15 0 0.05
103 INT230809 Positive_regulation of Localization of Ace 1 0.44 0.38 0.05
104 INT182487 Positive_regulation of Gene_expression of Agtr1a 2 0.19 1.32 0.04
105 INT179198 Regulation of Gene_expression of AGTR1 2 0.25 2.04 0.04
106 INT102927 Negative_regulation of Localization of Ace 3 0.58 1 0.03
107 INT288912 Protein_catabolism of AGTR1 1 0.66 0.29 0
108 INT270742 Negative_regulation of Phosphorylation of ACE 1 0.40 0.65 0
109 INT333040 Regulation of Binding of AGTR1 1 0.44 0 0
110 INT270740 Phosphorylation of ACE 1 0.76 0.65 0
111 INT316367 Negative_regulation of Transcription of Ace 1 0.40 0.22 0
112 INT307796 Positive_regulation of Positive_regulation of Ace 1 0.39 1.33 0
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