GO:0031726

From wiki-pain
Jump to: navigation, search
Name CCR1 chemokine receptor binding
Categary Function
Go Slim No
Go Link GO:0031726
Unique Molecular Interactions 192
Total Molecular Interactions 335
Total Single Events 2616
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for CCR1 chemokine receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for CCR1 chemokine receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
2 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
3 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
4 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9
5 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
6 INT189490 Binding of Ccr3 and Ccl5 1 0.33 8.54 2.6
7 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46
8 INT222185 Binding of Ccr1 and Ccl3 4 0.23 2.7 1.47
9 INT181450 Binding of Ccr5 and Ccl3 4 0.18 2.19 1.03
10 INT149557 Tgfb1 Positive_regulation of Gene_expression of Ccl5 1 0.00 0 0.82
11 INT87490 CALCA Positive_regulation of Gene_expression of CCL5 1 0.30 0.14 0.81
12 INT123492 TIAF1 Positive_regulation of Gene_expression of CCL4 1 0.00 1.45 0.81
13 INT149493 PNOC Negative_regulation of CCL5 1 0.14 0.16 0.77
14 INT258644 Binding of CCL2 and CCL5 1 0.36 1.6 0.74
15 INT258643 Positive_regulation of Binding of CCL2 and CCL5 1 0.49 1.61 0.74
16 INT120018 VEGFA Positive_regulation of CCL3 1 0.01 1 0.7
17 INT120017 CCL2 Positive_regulation of CCL3 1 0.01 0.99 0.7
18 INT120019 IL8 Positive_regulation of CCL3 1 0.02 0.99 0.7
19 INT297307 Negative_regulation of Binding of Ccr1 and Ccl3 1 0.27 0.73 0.67
20 INT297313 Negative_regulation of Binding of Ccr1 and Ccl5 1 0.28 0.74 0.67
21 INT245299 Ccl5 Positive_regulation of Localization of IL8 1 0.11 2.87 0.66
22 INT106247 Binding of CCR5 and CCL4 1 0.54 0.06 0.64
23 INT316831 CCL5 Positive_regulation of Gene_expression of MMP2 1 0.02 0.51 0.59
24 INT254637 Bdkrb2 Regulation of Gene_expression of Ccl5 1 0.17 1.22 0.56
25 INT244232 Binding of Ccr5 and Ccl4 3 0.17 1.48 0.55
26 INT130312 Ccl4 Negative_regulation of Abcc3 1 0.33 0.28 0.48
27 INT171278 TNFSF12 Positive_regulation of CCL5 1 0.02 0.93 0.48
28 INT130310 Ccl4 Positive_regulation of Abcc2 1 0.44 0.28 0.47
29 INT130311 Ccl4 Positive_regulation of Abcc1 1 0.47 0.28 0.47
30 INT148466 Ccl4 Positive_regulation of Hmox1 1 0.28 0.06 0.47
31 INT181444 Ccl5 Positive_regulation of Csf2 1 0.07 1.88 0.45
32 INT181447 Ccl3 Positive_regulation of Csf2 1 0.06 1.89 0.45
33 INT186758 Il13 Regulation of Ccl5 2 0.17 0.17 0.39
34 INT22921 Ccl4 Positive_regulation of Gpt 1 0.00 0.24 0.39
35 INT316830 TNF Regulation of CCL5 1 0.02 1.02 0.39
36 INT22920 Negative_regulation of Ccl4 Positive_regulation of Gpt 1 0.00 0.24 0.39
37 INT148465 Positive_regulation of Ccl4 Positive_regulation of Gclc 1 0.32 0.06 0.38
38 INT148467 Ccl4 Positive_regulation of Gclc 1 0.32 0.05 0.37
39 INT189491 Icam1 Positive_regulation of Transcription of Ccl5 1 0.19 0.64 0.36
40 INT187219 Vip Negative_regulation of Gene_expression of Ccl3 1 0.32 0.65 0.35
41 INT39971 Ccl4 Positive_regulation of Lpolv 1 0.15 0.32 0.33
42 INT325221 Il13 Regulation of Ccl3 1 0.08 0.17 0.32
43 INT144500 CCL3 Positive_regulation of Gene_expression of Tnfsf11 1 0.77 1.62 0.31
44 INT181432 Csf2 Positive_regulation of Ccl5 1 0.03 0.81 0.29
45 INT181446 Csf2 Positive_regulation of Ccl3 1 0.05 0.81 0.29
46 INT103279 PGR Negative_regulation of Gene_expression of CCL5 1 0.32 0.31 0.27
47 INT237088 Binding of Cxcl9 and Ccl5 1 0.29 1.51 0.26
48 INT246438 Ccl5 Positive_regulation of Gene_expression of Cd79a 1 0.13 0.83 0.26
49 INT275553 Negative_regulation of Binding of Ccr5 and Ccl3 1 0.05 0.73 0.26
50 INT237087 Binding of Cxcl9 and Ccl3 1 0.30 1.51 0.26
51 INT266802 Dlst Positive_regulation of CCL5 1 0.00 0.95 0.25
52 INT252815 Binding of CCL5 and TNF 1 0.02 0.75 0.25
53 INT181449 Ccl7 Regulation of Ccl2 1 0.24 0.73 0.25
54 INT120191 Ccl4 Positive_regulation of Pdlim3 1 0.51 0.24 0.25
55 INT80281 TNF Positive_regulation of CCL7 1 0.09 0.39 0.24
56 INT80280 IL1A Positive_regulation of CCL7 1 0.19 0.39 0.24
57 INT80290 IL4 Positive_regulation of CCL7 1 0.11 0.39 0.24
58 INT80285 CCL7 Positive_regulation of Gene_expression of CCL13 1 0.15 0.39 0.24
59 INT80277 IFNG Positive_regulation of CCL7 1 0.13 0.39 0.24
60 INT80286 IFNG Positive_regulation of Gene_expression of CCL5 1 0.24 0.37 0.23
61 INT80287 IL4 Positive_regulation of Gene_expression of CCL5 1 0.21 0.37 0.23
62 INT156162 Binding of HCFC1 and CREB3 1 0.13 0.35 0.22
63 INT196635 CFTR Positive_regulation of Gene_expression of CCL5 1 0.07 0.44 0.21
64 INT295713 PTGER2 Positive_regulation of Regulation of CCL5 1 0.01 0.82 0.21
65 INT170995 Binding of IFNA1 and Positive_regulation of Localization of CCL5 1 0.03 0.34 0.19
66 INT303937 Positive_regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
67 INT244243 Regulation of Binding of IL8 and Ccl3 1 0.04 0.05 0.18
68 INT303940 Regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
69 INT244241 Binding of IL8 and Ccl3 1 0.05 0.05 0.18
70 INT226344 Gene_expression of IL9 Positive_regulation of CCL5 1 0.07 1.03 0.18
71 INT303938 Binding of GLI2 and CCL5 1 0.01 0 0.18
72 INT244242 Negative_regulation of Binding of IL8 and Ccl3 1 0.06 0.05 0.18
73 INT246437 Ccl5 Positive_regulation of Regulation of Hand1 1 0.19 0.76 0.17
74 INT244235 Binding of Cxcl1 and Ccl3 1 0.14 0.23 0.17
75 INT244236 Binding of Cxcl1 and Ccl4 1 0.11 0.23 0.17
76 INT329795 IL6 Positive_regulation of Transcription of CCL5 1 0.02 0.59 0.17
77 INT246440 Ccl5 Positive_regulation of Positive_regulation of Xcl1 1 0.27 1.28 0.16
78 INT221019 ELANE Positive_regulation of CCL3 1 0.00 0.24 0.15
79 INT148532 Binding of CCL3 and Tnfsf11 1 0.03 0.71 0.14
80 INT47351 Binding of Ralbp1 and Ccl4 1 0.11 0.17 0.14
81 INT47352 Positive_regulation of Binding of Ralbp1 and Ccl4 1 0.14 0.17 0.14
82 INT306270 CCL4 Positive_regulation of Transcription of PTGS2 1 0.34 0.31 0.12
83 INT173725 Binding of Gucy2c and Ccl4 1 0.08 0.53 0.12
84 INT171295 CXCL10 Positive_regulation of CCL5 1 0.04 0.06 0.12
85 INT294452 KLK4 Negative_regulation of CCL4 1 0.00 0 0.1
86 INT213417 Binding of CCL7 and SET 1 0.11 0.17 0.1
87 INT294444 KLK4 Negative_regulation of CCL3 1 0.00 0 0.1
88 INT186767 Ccl11 Regulation of Ccl5 1 0.01 0 0.07
89 INT171297 TNF Positive_regulation of Localization of CCL5 1 0.17 0.66 0.07
90 INT186766 Il5 Regulation of Ccl5 1 0.01 0 0.07
91 INT246441 Ccl5 Positive_regulation of Gene_expression of Aif1 1 0.03 0.71 0.06
92 INT246436 Ccl5 Regulation of Aif1 1 0.01 0.67 0.06
93 INT351856 Ccl4 Positive_regulation of Alb 1 0.28 0.4 0.05
94 INT122216 IL1B Positive_regulation of CCL5 3 0.67 0.53 0.04
95 INT247771 Binding of Ccl7 and Ccrl2 1 0.17 0.29 0.04
96 INT247774 Binding of Ccl5 and Ccrl2 1 0.14 0.29 0.04
97 INT275503 Ccl4 Positive_regulation of Gpt 1 0.20 0 0.04
98 INT171279 IL6 Positive_regulation of CCL5 1 0.04 0.38 0.04
99 INT275502 Ccl4 Positive_regulation of Slc17a5 1 0.09 0 0.04
100 INT171301 TNF Positive_regulation of CCL5 1 0.16 0.38 0.04
101 INT247766 Binding of Ccl2 and Ccl5 1 0.14 0.28 0.04
102 INT122217 IL1B Positive_regulation of Gene_expression of CCL5 2 0.52 0.08 0
103 INT121541 Positive_regulation of Binding of CRH and CCL7 1 0.09 0.07 0
104 INT121542 Binding of CRH and CCL7 1 0.07 0.07 0
105 INT127690 TNF Positive_regulation of Regulation of CCL5 1 0.33 0.17 0
106 INT171282 TNFSF12 Positive_regulation of Gene_expression of CCL5 1 0.01 0 0
107 INT341409 Ccl4 Regulation of Cat 1 0.25 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for CCR1 chemokine receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in CCR1 chemokine receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09
2 INT130186 Gene_expression of Ccl5 101 0.74 79.96 25.01
3 INT78901 Localization of CCL5 67 0.78 40.79 20.59
4 INT89594 Gene_expression of Ccl5 44 0.54 24.08 18.62
5 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01
6 INT20376 Gene_expression of Ccl3 39 0.75 45.42 13.15
7 INT168409 Positive_regulation of Ccl5 47 0.64 45.84 10.83
8 INT4240 Positive_regulation of CCL5 32 0.58 20.55 10.65
9 INT128364 Positive_regulation of Ccl3 20 0.70 23.96 10.65
10 INT78895 Regulation of CCL5 30 0.46 20.45 10.18
11 INT87495 Positive_regulation of Gene_expression of CCL5 26 0.69 13.85 9.46
12 INT155808 Gene_expression of Ccl4 24 0.65 21.36 9.18
13 INT91337 Gene_expression of CCL4 29 0.75 16.23 8.64
14 INT89589 Negative_regulation of Ccl5 9 0.40 4.62 7.39
15 INT153271 Localization of Ccl3 7 0.81 11.29 7.14
16 INT181348 Localization of Ccl5 24 0.65 19.55 6.8
17 INT92470 Negative_regulation of Gene_expression of CCL5 15 0.50 5.46 5.86
18 INT181363 Regulation of Ccl5 16 0.46 13.65 5.09
19 INT181362 Negative_regulation of Ccl5 21 0.40 15.63 4.96
20 INT82887 Positive_regulation of Ccl5 10 0.40 3.4 4.91
21 INT181350 Gene_expression of Ccl7 12 0.61 14.25 4.87
22 INT176614 Positive_regulation of Gene_expression of Ccl5 20 0.59 16.2 4.81
23 INT166878 Regulation of Ccl3 9 0.44 8.21 4.81
24 INT153269 Binding of Ccl3 10 0.48 8.87 4.69
25 INT89590 Negative_regulation of Gene_expression of Ccl5 8 0.36 3.97 4.67
26 INT181042 Binding of Ccl5 18 0.41 9.34 4.51
27 INT4239 Negative_regulation of CCL5 15 0.40 10.92 4.26
28 INT79234 Positive_regulation of CCL3 15 0.67 11.43 4.15
29 INT91327 Positive_regulation of CCL4 12 0.67 8.55 4.1
30 INT144083 Positive_regulation of Gene_expression of Ccl3 10 0.50 8.16 3.81
31 INT103281 Transcription of CCL5 10 0.67 5.95 3.7
32 INT89592 Localization of Ccl5 10 0.61 7.65 3.62
33 INT181378 Negative_regulation of Gene_expression of Ccl5 12 0.46 9.64 3.59
34 INT181357 Negative_regulation of Ccl3 12 0.59 13.09 3.38
35 INT124123 Positive_regulation of Localization of CCL5 12 0.67 7 3.37
36 INT181418 Regulation of Gene_expression of Ccl5 11 0.52 9.86 3.37
37 INT56601 Positive_regulation of Ccl4 9 0.47 6.27 3.28
38 INT82879 Regulation of Ccl5 9 0.30 6.19 3.17
39 INT78898 Regulation of Gene_expression of CCL5 9 0.42 5.7 3.11
40 INT115617 Binding of Ccl5 5 0.33 0.58 3.11
41 INT194661 Binding of CCL5 9 0.46 6.07 2.73
42 INT71681 Positive_regulation of Gene_expression of CCL3 8 0.54 8.21 2.41
43 INT120090 Positive_regulation of Gene_expression of CCL4 5 0.49 3.94 2.32
44 INT115616 Positive_regulation of Binding of Ccl5 3 0.25 0.59 2.04
45 INT155807 Positive_regulation of Gene_expression of Ccl4 8 0.40 5.13 1.9
46 INT103061 Positive_regulation of Gene_expression of Ccl5 4 0.35 1.67 1.9
47 INT120014 Transcription of CCL3 5 0.69 3.03 1.82
48 INT194660 Positive_regulation of Binding of CCL5 1 0.42 2.74 1.72
49 INT91326 Regulation of CCL4 4 0.44 2.86 1.69
50 INT91329 Regulation of Gene_expression of CCL4 2 0.44 1.92 1.64
51 INT38856 Positive_regulation of Ccl4 24 0.69 9.55 1.62
52 INT78896 Negative_regulation of Localization of CCL5 8 0.57 2.43 1.59
53 INT171015 Positive_regulation of Positive_regulation of CCL5 3 0.42 3.63 1.51
54 INT173717 Gene_expression of Ccl4 22 0.65 13.98 1.47
55 INT167678 Localization of Ccl4 3 0.52 2.22 1.37
56 INT115895 Phosphorylation of Ccl5 1 0.55 0 1.31
57 INT181019 Positive_regulation of Ccl7 5 0.42 5.52 1.27
58 INT65699 Localization of CCL3 7 0.78 2.56 1.25
59 INT123828 Regulation of CCL3 3 0.60 0.79 1.25
60 INT153267 Negative_regulation of Binding of Ccl3 2 0.43 2.06 1.14
61 INT149554 Transcription of Ccl5 2 0.59 0.55 1.14
62 INT115893 Negative_regulation of Binding of Ccl5 1 0.37 0 1.14
63 INT47348 Binding of Ccl4 8 0.37 3.24 1.08
64 INT39703 Regulation of Ccl4 3 0.39 0.39 1.08
65 INT181410 Regulation of Gene_expression of Ccl3 2 0.33 3.52 1.06
66 INT181401 Localization of Ccl7 2 0.59 1.33 1.04
67 INT166880 Negative_regulation of Gene_expression of Ccl3 1 0.57 0.81 1.01
68 INT208244 Regulation of Gene_expression of Ccl5 1 0.26 1.92 1.01
69 INT91324 Localization of CCL4 3 0.73 2.08 0.94
70 INT80296 Gene_expression of CCL7 4 0.43 1.65 0.93
71 INT275518 Binding of Ccl4 3 0.26 2.74 0.93
72 INT181351 Transcription of Ccl5 5 0.64 2.19 0.9
73 INT202174 Negative_regulation of CCL3 2 0.26 1.77 0.9
74 INT181385 Regulation of Ccl7 1 0.35 0.95 0.9
75 INT103285 Regulation of Localization of CCL5 3 0.44 1.11 0.89
76 INT295692 Localization of CCL7 1 0.06 1.22 0.89
77 INT79235 Binding of CCL3 3 0.36 2.2 0.88
78 INT149555 Negative_regulation of Positive_regulation of Ccl5 1 0.15 0 0.88
79 INT153272 Positive_regulation of Localization of Ccl3 2 0.50 2.02 0.79
80 INT181390 Negative_regulation of Positive_regulation of Ccl5 2 0.31 2.31 0.77
81 INT120013 Negative_regulation of Transcription of CCL3 1 0.41 1 0.72
82 INT153270 Positive_regulation of Binding of Ccl3 1 0.47 1.44 0.69
83 INT115897 Positive_regulation of Phosphorylation of Ccl5 1 0.41 0 0.66
84 INT181349 Positive_regulation of Localization of Ccl5 2 0.37 0.89 0.62
85 INT91335 Regulation of Localization of CCL4 1 0.44 0.74 0.6
86 INT120190 Negative_regulation of Ccl4 5 0.41 3.17 0.57
87 INT128360 Negative_regulation of Positive_regulation of Ccl3 2 0.41 1.86 0.55
88 INT194225 Positive_regulation of Positive_regulation of Ccl5 1 0.07 1.13 0.55
89 INT221040 Negative_regulation of Gene_expression of CCL3 2 0.20 1.19 0.53
90 INT322701 Positive_regulation of Binding of Ccl4 1 0.33 0.18 0.52
91 INT322706 Negative_regulation of Binding of Ccl4 1 0.28 0.18 0.52
92 INT181381 Positive_regulation of Gene_expression of Ccl7 1 0.54 1.24 0.49
93 INT194658 Positive_regulation of Transcription of CCL5 1 0.45 0.68 0.44
94 INT202178 Negative_regulation of CCL4 1 0.23 0.98 0.44
95 INT181389 Transcription of Ccl7 1 0.42 0.6 0.44
96 INT267606 Protein_catabolism of CCL5 2 0.48 1.39 0.43
97 INT285898 Negative_regulation of Gene_expression of CCL4 1 0.10 0.96 0.41
98 INT268760 Positive_regulation of Binding of Ccl5 1 0.13 0.91 0.39
99 INT322698 Protein_catabolism of Ccl5 1 0.49 0.33 0.38
100 INT329566 Negative_regulation of Gene_expression of Ccl4 4 0.37 2.05 0.33
101 INT195733 Phosphorylation of CCL5 2 0.10 1.04 0.33
102 INT181416 Negative_regulation of Ccl4 3 0.26 2.34 0.32
103 INT79236 Positive_regulation of Positive_regulation of CCL3 1 0.49 1.22 0.28
104 INT103283 Negative_regulation of Transcription of CCL5 1 0.50 0.28 0.27
105 INT322710 Positive_regulation of Transcription of Ccl5 1 0.43 0.56 0.26
106 INT317981 Negative_regulation of Binding of Ccl4 1 0.30 1.16 0.25
107 INT301314 Regulation of Binding of CCL3 1 0.04 0 0.24
108 INT181399 Transcription of Ccl3 2 0.60 0.41 0.22
109 INT282377 Regulation of Positive_regulation of CCL5 1 0.05 1.12 0.22
110 INT311546 Phosphorylation of CREB3 1 0.55 0.6 0.21
111 INT311543 Positive_regulation of Phosphorylation of CREB3 1 0.34 0.6 0.21
112 INT47349 Positive_regulation of Positive_regulation of Ccl4 4 0.49 1.92 0.2
113 INT311544 Positive_regulation of CREB3 1 0.34 0.6 0.2
114 INT317975 Positive_regulation of Positive_regulation of Ccl4 1 0.35 0.76 0.17
115 INT329819 Phosphorylation of CCL3 1 0.23 0.61 0.17
116 INT285899 Positive_regulation of Localization of CCL3 1 0.12 1.08 0.17
117 INT317986 Phosphorylation of Ccl4 1 0.57 0.47 0.17
118 INT317985 Regulation of Gene_expression of Ccl4 1 0.32 0.54 0.17
119 INT312718 Protein_catabolism of CCL3 1 0.31 0.44 0.16
120 INT156168 Negative_regulation of CREB3 1 0.18 0.34 0.16
121 INT344265 Regulation of CCL7 1 0.04 0.55 0.16
122 INT270624 Regulation of Ccl4 1 0.41 1.11 0.16
123 INT89593 Negative_regulation of Localization of Ccl5 1 0.03 0.46 0.15
124 INT233838 Regulation of Binding of Ccl5 1 0.21 1 0.15
125 INT195730 Negative_regulation of Binding of CCL5 1 0.05 0.51 0.13
126 INT312774 Positive_regulation of Gene_expression of Ccl4 3 0.42 1.3 0.1
127 INT246434 Negative_regulation of Negative_regulation of Ccl5 1 0.40 1.72 0.09
128 INT317973 Negative_regulation of Localization of Ccl4 1 0.30 0.88 0.05
129 INT329425 Binding of Ccl7 1 0.32 0.65 0.05
130 INT329565 Protein_catabolism of Ccl4 2 0.76 1.07 0.04
131 INT329567 Negative_regulation of Protein_catabolism of Ccl4 1 0.35 0.55 0.04
132 INT227346 Regulation of Positive_regulation of Ccl4 1 0.44 0.6 0.03
133 INT181157 Regulation of Gene_expression of Ccl4 1 0.39 0.21 0
134 INT341411 Positive_regulation of Protein_catabolism of Ccl4 1 0.43 0.53 0
135 INT139661 Binding of CCL4 1 0.36 0.13 0
136 INT189478 Regulation of Transcription of Ccl5 1 0.38 0.63 0
137 INT139663 Transcription of CCL4 1 0.67 0.11 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox