GO:0031749

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Name D2 dopamine receptor binding
Categary Function
Go Slim No
Go Link GO:0031749
Unique Molecular Interactions 80
Total Molecular Interactions 106
Total Single Events 1056
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for D2 dopamine receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for D2 dopamine receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT251147 Binding of Grin2b and Dlg2 1 0.33 2.75 2.43
2 INT107578 Kitl Negative_regulation of Grin2b 1 0.12 2.05 2.36
3 INT168608 Binding of Grin2b and Mmp9 1 0.22 0.41 1.57
4 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
5 INT246519 Positive_regulation of Grin2b Positive_regulation of Positive_regulation of Ltp 1 0.25 0.08 1.42
6 INT293200 Positive_regulation of Grin1 Positive_regulation of Phosphorylation of Grin2b 1 0.24 0.4 1.39
7 INT154518 Binding of Ephb6 and Grin2b 1 0.21 0.24 1.28
8 INT112105 Negative_regulation of Dlg2 Negative_regulation of Gene_expression of Grin2b 2 0.40 0.89 1.2
9 INT256295 Binding of Creb1 and Grin2b 1 0.11 1.21 1.19
10 INT122267 Prkcg Positive_regulation of Grin2b 1 0.26 0.61 1.14
11 INT122268 Binding of Grin2b and Grm5 1 0.40 0.52 1.1
12 INT256294 Binding of Grin2b and Ephb1 1 0.28 1.11 1.08
13 INT291966 Pag1 Positive_regulation of Gene_expression of Grin2b 1 0.19 1.91 1.06
14 INT256293 Binding of Grin2b and Insrr 1 0.01 1.06 1.05
15 INT291964 Phex Regulation of Gene_expression of Grin2b 1 0.08 1.39 1.04
16 INT346835 Gene_expression of Efnb2 Positive_regulation of Phosphorylation of Grin2b 1 0.27 1.07 1.03
17 INT353690 Binding of Grin2b and Ca2 1 0.14 1.17 1.01
18 INT344389 Ephb2 Positive_regulation of Phosphorylation of Grin2b 1 0.16 1.46 0.98
19 INT344381 Olfr360 Negative_regulation of Gene_expression of Grin2b 1 0.01 1.17 0.93
20 INT344390 Olfr360 Negative_regulation of Phosphorylation of Grin2b 1 0.01 1.17 0.93
21 INT344388 Efnb1 Positive_regulation of Phosphorylation of Grin2b 1 0.40 1.45 0.92
22 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
23 INT251152 Dlg2 Positive_regulation of Localization of Grin2b 1 0.43 0.6 0.92
24 INT291962 Pag1 Negative_regulation of Gene_expression of Grin2b 1 0.17 1.56 0.92
25 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
26 INT108438 Grin2b Regulation of Pdyn 1 0.16 0.25 0.9
27 INT212290 Binding of Grin2a and Grin2b 2 0.20 1.36 0.82
28 INT296285 Binding of Car1 and Grin2b 1 0.14 0.32 0.72
29 INT186160 Negative_regulation of Grin2b Negative_regulation of Grin1 1 0.37 0.5 0.72
30 INT296282 Grin2b Regulation of Negative_regulation of Kcnip3 1 0.30 0.3 0.72
31 INT296295 Binding of Grin1 and Grin2b 1 0.16 0.31 0.71
32 INT296298 Grin2b Regulation of Negative_regulation of Hmmr 1 0.03 0.29 0.71
33 INT335596 Positive_regulation of Grin2b Positive_regulation of Positive_regulation of Car2 1 0.12 0.19 0.69
34 INT249485 Trib3 Negative_regulation of Phosphorylation of Grin2b 1 0.02 0.64 0.68
35 INT250084 Negative_regulation of Grin2b Negative_regulation of Positive_regulation of Ltp 1 0.18 0.07 0.66
36 INT249489 Src Negative_regulation of Phosphorylation of Grin2b 1 0.20 0.63 0.66
37 INT250078 Negative_regulation of Grin2b Negative_regulation of Ltp 1 0.18 0.07 0.66
38 INT302441 Binding of GRIN1 and Grin2b 1 0.10 1.27 0.63
39 INT186159 Grin2d Negative_regulation of Grin2b 1 0.21 0.82 0.62
40 INT249484 Trib3 Positive_regulation of Phosphorylation of Grin2b 1 0.01 0.57 0.61
41 INT251141 Binding of Dlg4 and Grin2b 1 0.14 0.32 0.55
42 INT251143 Binding of Grin2b and Dlg3 1 0.22 0.32 0.55
43 INT249497 Efnb2 Positive_regulation of Phosphorylation of Grin2b 1 0.02 0.51 0.54
44 INT249479 Binding of Ephb1 and Grin2b 1 0.29 0.37 0.54
45 INT208121 Binding of Grin2a and Grin2b 3 0.35 0.06 0.51
46 INT250080 Grin2b Positive_regulation of Ltp 1 0.22 0.19 0.49
47 INT208119 Grin2b Positive_regulation of Positive_regulation of Ltp 1 0.16 0.21 0.49
48 INT249486 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Grin2b 1 0.33 0.4 0.46
49 INT105733 Grin2b Negative_regulation of Gene_expression of Grin2a 1 0.22 0.09 0.41
50 INT296296 Binding of Grin2b and Kcnip3 1 0.24 0 0.4
51 INT279620 Negative_regulation of Binding of Grin2a and Grin2b 1 0.18 0.99 0.4
52 INT150196 Grm5 Regulation of Grin2b 1 0.45 0 0.36
53 INT249492 Trib3 Regulation of Phosphorylation of Grin2b 1 0.01 0.23 0.35
54 INT236006 HTR1A Regulation of Grin2b 1 0.00 0 0.33
55 INT165580 Binding of Akt1 and Grin2b 1 0.02 0.2 0.32
56 INT263749 Binding of Grin2b and Neto1 1 0.38 0 0.3
57 INT250079 Grin2b Regulation of Ltp 1 0.18 0.31 0.29
58 INT249493 Binding of Grin2b and Src 1 0.17 0.15 0.26
59 INT273237 Cdk5 Positive_regulation of Protein_catabolism of Grin2b 1 0.45 1.31 0.22
60 INT208123 Hpcal1 Regulation of Grin2b 1 0.10 0 0.21
61 INT250074 Grin2b Positive_regulation of Gene_expression of Hpcal4 1 0.04 0.3 0.2
62 INT249495 Binding of Grin2b and Efnb2 1 0.02 0.05 0.11
63 INT263729 Grin2b Positive_regulation of Gene_expression of Car1 1 0.20 0 0.1
64 INT263755 Grin1 Regulation of Localization of Grin2b 1 0.27 0.17 0.07
65 INT263741 Grin2b Regulation of Localization of Dlg4 1 0.17 0.17 0.07
66 INT263728 Grin2b Regulation of Localization of Grin1 1 0.27 0.17 0.07
67 INT263723 Grin2b Regulation of Localization of Gria2 1 0.18 0.17 0.07
68 INT263762 Grin2a Regulation of Localization of Grin2b 1 0.26 0.17 0.07
69 INT263722 Dlg4 Regulation of Localization of Grin2b 1 0.15 0.17 0.07
70 INT263739 Grin2b Regulation of Localization of Vamp2 1 0.24 0.17 0.07
71 INT263768 Grin2b Regulation of Localization of Grin2a 1 0.26 0.17 0.07
72 INT263767 Binding of Camk2a and Grin2b 1 0.18 0 0.06
73 INT231300 Positive_regulation of Grin2b Positive_regulation of Prnp 1 0.39 0.16 0.05
74 INT263763 Localization of Neto1 Regulation of Localization of Grin2b 1 0.36 0.18 0.05
75 INT263727 Binding of Grin2b and Rasgrf1 1 0.18 0 0.05
76 INT250073 Grin2a Regulation of Grin2b 1 0.39 0.9 0.05
77 INT313271 Binding of GRIN1 and GRIN2B 1 0.24 0.06 0
78 INT169858 Grin1 Regulation of Gene_expression of Grin2b 1 0.42 0 0
79 INT263745 Grin2b Positive_regulation of Negative_regulation of Neto1 1 0.40 0 0
80 INT169856 Grin1 Positive_regulation of Grin2b 1 0.46 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for D2 dopamine receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in D2 dopamine receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT104000 Phosphorylation of Grin2b 73 0.82 48.34 93.48
2 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91
3 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42
4 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52
5 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14
6 INT103998 Positive_regulation of Phosphorylation of Grin2b 33 0.69 19.08 36.08
7 INT130479 Phosphorylation of Grin2b 28 0.77 34.82 34.97
8 INT93451 Positive_regulation of Gene_expression of Grin2b 43 0.70 29.09 31.89
9 INT93033 Negative_regulation of Grin2b 48 0.58 20.94 28.54
10 INT107577 Negative_regulation of Grin2b 32 0.59 12.35 24.88
11 INT102281 Positive_regulation of Gene_expression of Grin2b 27 0.70 10.38 20.84
12 INT93037 Regulation of Grin2b 26 0.57 11.9 16.92
13 INT92514 Regulation of Grin2b 22 0.50 11.07 16.92
14 INT103996 Negative_regulation of Phosphorylation of Grin2b 11 0.58 7.81 12.85
15 INT122117 Negative_regulation of Gene_expression of Grin2b 20 0.59 11.3 12.55
16 INT130475 Positive_regulation of Phosphorylation of Grin2b 8 0.47 11.52 10.96
17 INT80006 Regulation of Gene_expression of Grin2b 8 0.57 3.75 9.62
18 INT95342 Gene_expression of GRIN2B 21 0.75 4.99 9.32
19 INT112104 Binding of Grin2b 21 0.44 6.78 8.16
20 INT100658 Negative_regulation of Positive_regulation of Grin2b 7 0.41 1.39 6.17
21 INT74593 Transcription of Grin2b 10 0.66 1.21 5.98
22 INT130472 Negative_regulation of Phosphorylation of Grin2b 4 0.40 4.4 5.78
23 INT127353 Regulation of Phosphorylation of Grin2b 5 0.45 1.6 5.29
24 INT130478 Localization of Grin2b 11 0.75 2.49 5.28
25 INT92541 Localization of Grin2b 11 0.75 2.85 5.14
26 INT79505 Binding of Grin2b 9 0.36 1.43 4.61
27 INT170348 Regulation of Gene_expression of Grin2b 8 0.60 2.29 4.25
28 INT112100 Negative_regulation of Gene_expression of Grin2b 6 0.42 3.71 4.24
29 INT163500 Transcription of Grin2b 3 0.67 3.63 3.8
30 INT139646 Positive_regulation of Positive_regulation of Grin2b 4 0.42 3.89 3.74
31 INT101055 Regulation of GRIN2B 4 0.61 1.39 2.5
32 INT246518 Regulation of Negative_regulation of Grin2b 1 0.38 0.07 1.99
33 INT151942 Regulation of Negative_regulation of Grin2b 2 0.41 0.41 1.92
34 INT74594 Regulation of Transcription of Grin2b 1 0.42 0.17 1.8
35 INT130440 Phosphorylation of GRIN2B 2 0.79 2.93 1.79
36 INT107379 Localization of GRIN2B 2 0.73 0.86 1.48
37 INT296265 Regulation of Phosphorylation of Grin2b 2 0.44 1.06 1.4
38 INT249527 Positive_regulation of Positive_regulation of Grin2b 2 0.37 1.12 1.22
39 INT95347 Negative_regulation of GRIN2B 1 0.57 0 1.19
40 INT143091 Positive_regulation of Negative_regulation of Grin2b 2 0.44 0.9 1.09
41 INT291961 Negative_regulation of Regulation of Grin2b 1 0.30 1.65 1.09
42 INT101056 Positive_regulation of GRIN2B 1 0.23 0.32 0.9
43 INT186168 Negative_regulation of Negative_regulation of Grin2b 2 0.35 0.54 0.85
44 INT143092 Negative_regulation of Negative_regulation of Grin2b 1 0.27 0.33 0.83
45 INT165578 Regulation of Positive_regulation of Grin2b 3 0.41 1.07 0.74
46 INT114524 Binding of GRIN2B 3 0.36 0.44 0.74
47 INT139895 Positive_regulation of Gene_expression of GRIN2B 2 0.49 0.9 0.65
48 INT147397 Negative_regulation of Binding of Grin2b 1 0.16 0.87 0.63
49 INT122116 Negative_regulation of Transcription of Grin2b 1 0.43 0.34 0.62
50 INT271625 Protein_catabolism of Grin2b 1 0.38 0.26 0.57
51 INT296255 Negative_regulation of Localization of Grin2b 1 0.30 0.16 0.56
52 INT156378 Regulation of Binding of Grin2b 1 0.28 0.17 0.52
53 INT163895 Positive_regulation of Phosphorylation of GRIN2B 1 0.09 0.99 0.48
54 INT271632 Negative_regulation of Regulation of Grin2b 2 0.28 1.06 0.47
55 INT250065 Positive_regulation of Localization of Grin2b 1 0.45 0 0.47
56 INT271630 Negative_regulation of Localization of Grin2b 1 0.25 0 0.37
57 INT250062 Positive_regulation of Transcription of Grin2b 1 0.39 0.47 0.34
58 INT163897 Negative_regulation of Phosphorylation of GRIN2B 1 0.08 0.39 0.28
59 INT271629 Positive_regulation of Protein_catabolism of Grin2b 1 0.27 0.13 0.28
60 INT313623 Regulation of Localization of Grin2b 1 0.32 0 0.24
61 INT273223 Positive_regulation of Protein_catabolism of Grin2b 1 0.40 0.73 0.23
62 INT208117 Positive_regulation of Binding of Grin2b 1 0.46 0 0.23
63 INT273229 Protein_catabolism of Grin2b 1 0.57 1.29 0.22
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