GO:0031770

From wiki-pain
Jump to: navigation, search
Name growth hormone-releasing hormone receptor binding
Categary Function
Go Slim No
Go Link GO:0031770
Unique Molecular Interactions 333
Total Molecular Interactions 800
Total Single Events 3073
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for growth hormone-releasing hormone receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for growth hormone-releasing hormone receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16531 Ghrh Positive_regulation of Localization of Gh1 31 0.64 2.12 14.2
2 INT26468 Ghrh Positive_regulation of Localization of Gh 21 0.37 3.26 9.21
3 INT10844 Ghrh Regulation of Gh 13 0.13 4.77 4.71
4 INT16221 Ghrh Positive_regulation of Gh 8 0.21 1.89 4.08
5 INT11248 Gh Positive_regulation of Ghrh 2 0.26 0.09 4.04
6 INT13729 GHRH Positive_regulation of Localization of GH1 13 0.62 0.59 3.2
7 INT20411 Ghrh Positive_regulation of Gh1 6 0.56 0.62 2.47
8 INT7367 Ghrh Regulation of Localization of Gh1 5 0.49 1.55 2.25
9 INT18197 Ghrh Positive_regulation of Localization of Ggh 4 0.46 0 2.23
10 INT9180 Ghrh Regulation of Localization of Gh 3 0.24 0.25 2.18
11 INT120319 Ghrh Regulation of Ngf 1 0.25 1.89 2.11
12 INT35502 Ghrh Positive_regulation of Localization of Gnrhr 7 0.57 0.18 2
13 INT16891 GHRH Regulation of GH1 5 0.37 1.94 1.82
14 INT32482 Ghrh Positive_regulation of Prl 3 0.18 0.26 1.62
15 INT34834 Ghrh Positive_regulation of Gene_expression of Gh1 2 0.65 0 1.4
16 INT152428 Ghrh Positive_regulation of Pde6b 1 0.07 0.5 1.18
17 INT32480 Gh1 Positive_regulation of Gene_expression of Ghrh 1 0.35 0 1.15
18 INT32182 PRL Regulation of GHRH 2 0.17 0 1.12
19 INT19887 GHRH Positive_regulation of Positive_regulation of GH1 2 0.56 0.3 1.08
20 INT5106 Gal Positive_regulation of Localization of Ghrh 1 0.21 0 1.07
21 INT120317 Ghrh Regulation of Positive_regulation of Ngf 1 0.25 0.95 1.06
22 INT120311 Ghrh Regulation of Gene_expression of Ngf 1 0.25 0.95 1.06
23 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
24 INT120316 Ghrh Regulation of Il6 1 0.11 0.95 1.05
25 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05
26 INT120310 Ghrh Regulation of Positive_regulation of Il6 1 0.18 0.95 1.05
27 INT35157 GH1 Regulation of GHRH 3 0.17 0.5 0.99
28 INT19758 Ghrh Positive_regulation of Positive_regulation of Gh 1 0.26 0 0.98
29 INT25272 Binding of Ggh and Ghrh 1 0.22 0 0.97
30 INT5108 Gal Positive_regulation of Ghrh 1 0.21 0 0.96
31 INT31108 Ghrh Negative_regulation of Gh1 2 0.55 0 0.95
32 INT295530 Ghrl Regulation of Gene_expression of Ghrh 1 0.30 0.21 0.95
33 INT62106 Ghrh Negative_regulation of Localization of Gh 1 0.06 0 0.94
34 INT35252 Gene_expression of Ghrh Positive_regulation of Localization of Gh1 1 0.49 0 0.93
35 INT295547 Ghrl Regulation of Ghrh 1 0.30 0.06 0.9
36 INT30411 Ghrh Regulation of Gene_expression of Gh1 1 0.40 0.12 0.9
37 INT62111 SLC25A4 Negative_regulation of Regulation of Ghrh 1 0.41 0 0.9
38 INT15730 Ghrh Positive_regulation of Gnrhr 2 0.14 0.08 0.84
39 INT33995 Ghrh Regulation of Gnrhr 2 0.18 0.43 0.77
40 INT152429 Ghrh Positive_regulation of Localization of Gh 4 0.37 0.56 0.75
41 INT31306 Ghrh Regulation of Localization of Gnrhr 2 0.14 1 0.73
42 INT16894 Regulation of GHRH Regulation of GH1 2 0.37 0 0.72
43 INT31307 Ghrh Regulation of Gh1 3 0.27 1.36 0.7
44 INT30125 Binding of Gh and Ghrh 2 0.06 0.36 0.7
45 INT64070 Tp63 Regulation of Ghrh 1 0.04 0.06 0.69
46 INT40470 GH1 Positive_regulation of GHRH 1 0.06 0 0.67
47 INT5105 Gal Regulation of Localization of Ghrh 1 0.19 0 0.66
48 INT62249 Ghrh Regulation of Adrb1 1 0.00 0 0.62
49 INT19011 Binding of Ghrh and Ghsr 1 0.40 0 0.62
50 INT18405 GHRH Positive_regulation of Regulation of SST 1 0.56 0 0.57
51 INT32484 Gnrhr Regulation of GHRH 1 0.01 0 0.55
52 INT69566 Positive_regulation of Ghrh Regulation of Gh 1 0.04 1.66 0.55
53 INT32478 Gh1 Regulation of Gene_expression of Ghrh 1 0.28 0 0.55
54 INT30959 Ghrh Positive_regulation of Localization of SST 1 0.01 0 0.54
55 INT34368 TRH Positive_regulation of GHRH 1 0.23 0.4 0.53
56 INT56671 Negative_regulation of Ghrh Positive_regulation of Gh1 1 0.40 0 0.49
57 INT67984 GHRH Regulation of PRL 1 0.22 0 0.49
58 INT48114 GHRH Positive_regulation of Localization of CGB 1 0.05 0 0.48
59 INT34988 Ghrh Positive_regulation of Calca 1 0.06 0 0.48
60 INT67983 Positive_regulation of HTR1B Positive_regulation of Localization of GHRH 1 0.42 0 0.47
61 INT34990 Calca Positive_regulation of Ghrh 1 0.06 0 0.47
62 INT101001 GHRH Regulation of Localization of INS 1 0.28 0 0.47
63 INT101003 GHRH Regulation of Localization of GGH 1 0.29 0 0.47
64 INT295548 Ghrl Regulation of Regulation of Ghrh 1 0.30 0 0.45
65 INT152430 Regulation of Ghrh Positive_regulation of Pde6b 1 0.04 0.16 0.43
66 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41
67 INT250531 Ghrh Regulation of Gh 1 0.22 0 0.41
68 INT16302 GHRH Regulation of Localization of GH1 1 0.65 0.62 0.4
69 INT62107 Ghrh Negative_regulation of Regulation of Gh 1 0.06 0 0.39
70 INT67553 Ghrh Positive_regulation of Regulation of Gh 1 0.04 0.55 0.39
71 INT152431 Regulation of Ghrh Positive_regulation of Scn7a 1 0.02 0.17 0.38
72 INT152426 Ghrh Positive_regulation of Positive_regulation of Pde6b 1 0.07 0.14 0.38
73 INT152427 Ghrh Positive_regulation of Scn7a 1 0.03 0.17 0.38
74 INT8331 OPRD1 Regulation of Localization of GHRH 1 0.18 0.18 0.37
75 INT34865 Ghrh Positive_regulation of Gene_expression of Gnrhr 1 0.07 0 0.37
76 INT35363 Binding of GH1 and GHRH 2 0.36 0.94 0.36
77 INT84030 Regulation of Ghrh Positive_regulation of Gh 1 0.18 0 0.35
78 INT54930 Gnrhr Regulation of Gene_expression of Ghrh 1 0.10 0.16 0.34
79 INT295539 Gabrg1 Positive_regulation of Gene_expression of Ghrh 1 0.30 0 0.33
80 INT31042 Ghrh Positive_regulation of Localization of PLOD1 1 0.08 0 0.32
81 INT31040 Ghrh Positive_regulation of Localization of FSHR 1 0.05 0 0.31
82 INT31043 Ghrh Positive_regulation of PLOD1 1 0.03 0 0.31
83 INT328299 Binding of GHRH and GHS 1 0.07 2.21 0.31
84 INT31041 Ghrh Positive_regulation of FSHR 1 0.05 0 0.31
85 INT26065 GHRH Regulation of Regulation of GH1 1 0.11 0 0.3
86 INT31036 Ghrh Regulation of Gnrh1 1 0.19 0 0.29
87 INT25169 GHRH Positive_regulation of Localization of Gh 1 0.12 0 0.29
88 INT43837 POMC Positive_regulation of GHRH 1 0.16 0 0.28
89 INT43836 Regulation of POMC Positive_regulation of GHRH 1 0.14 0 0.28
90 INT89910 GHRH Positive_regulation of Localization of POMC 1 0.33 0 0.28
91 INT89896 GHRH Positive_regulation of Localization of PRL 1 0.30 0 0.27
92 INT295531 Ghrl Negative_regulation of Gene_expression of Ghrh 1 0.25 0 0.27
93 INT20029 Ghrh Positive_regulation of Negative_regulation of Gh 1 0.05 0.14 0.26
94 INT295541 Ghrl Positive_regulation of Ghrh 1 0.31 0 0.26
95 INT68872 Ghrh Regulation of IGF1 1 0.09 0.18 0.26
96 INT295535 Gabrg1 Regulation of Ghrh 1 0.16 0.08 0.26
97 INT34784 DIO2 Regulation of Localization of GHRH 1 0.00 0 0.25
98 INT74043 Negative_regulation of Oprd1 Negative_regulation of Localization of GHRH 1 0.02 0 0.25
99 INT34785 DIO2 Positive_regulation of Localization of GHRH 1 0.01 0 0.25
100 INT74044 GHRH Positive_regulation of Localization of Oprd1 1 0.02 0 0.25
101 INT250536 Ghrh Positive_regulation of Negative_regulation of Ptpn6 1 0.09 0 0.24
102 INT32330 POMC Positive_regulation of Localization of GHRH 1 0.12 0 0.24
103 INT50488 Vip Positive_regulation of Localization of Ghrh 1 0.60 0 0.24
104 INT71091 ADCYAP1 Positive_regulation of Localization of GHRH 1 0.26 0.26 0.24
105 INT71090 ADCYAP1 Positive_regulation of GHRH 1 0.12 0.26 0.24
106 INT215037 Ghrh Regulation of Localization of Igf2 1 0.04 2.12 0.24
107 INT20030 Negative_regulation of SST Positive_regulation of Ghrh 1 0.01 0.16 0.23
108 INT58243 Ghrh Regulation of Prl 1 0.04 0.18 0.21
109 INT35149 PLOD1 Regulation of GHRH 1 0.02 0 0.21
110 INT32325 DBI Positive_regulation of GHRH 1 0.02 0 0.21
111 INT35153 FSHR Regulation of GHRH 1 0.04 0 0.21
112 INT32331 DBI Positive_regulation of Localization of GHRH 1 0.02 0 0.21
113 INT257398 Binding of FGD1 and GHRH 1 0.03 0.27 0.2
114 INT268797 Ghrh Positive_regulation of Transcription of Gh 1 0.20 0.33 0.19
115 INT295542 Ghrl Positive_regulation of Gene_expression of Ghrh 1 0.33 0 0.19
116 INT295543 Ghrh Regulation of Gene_expression of Npy 1 0.36 0 0.16
117 INT222509 Ghrh Positive_regulation of Localization of Prl 1 0.28 0.23 0.16
118 INT295536 Ghrh Regulation of Npy 1 0.22 0 0.16
119 INT250533 Ghrh Regulation of Localization of Gh 1 0.13 0 0.15
120 INT250535 Ghrh Regulation of Gene_expression of Gh 1 0.31 0 0.15
121 INT31849 Ghrh Regulation of SST 1 0.09 0 0.14
122 INT31037 Binding of Gnrh1 and Ghrh 1 0.25 0 0.14
123 INT165367 Ghrh Regulation of Gnrh1 1 0.17 0.06 0.14
124 INT328374 GHRH Positive_regulation of Ghrl 1 0.13 0.26 0.13
125 INT29465 NA Regulation of Localization of Ghrh 1 0.01 0 0.13
126 INT203018 GHRH Positive_regulation of Localization of PYY 1 0.01 0.81 0.12
127 INT295538 Ghrh Positive_regulation of Gh 1 0.21 0 0.11
128 INT50300 Igf1 Positive_regulation of Gene_expression of Ghrh 1 0.26 0 0.11
129 INT328294 GHS Positive_regulation of Localization of GHRH 1 0.10 0.12 0.11
130 INT31308 Positive_regulation of Ghrh Regulation of Gh1 1 0.14 0.69 0.1
131 INT328364 Binding of GHRH and Ghrl 1 0.09 0.2 0.1
132 INT328297 GHRH Positive_regulation of Transcription of GH1 1 0.04 0.26 0.1
133 INT42587 EPO Regulation of GHRH 1 0.01 0.19 0.09
134 INT31847 Ghrh Positive_regulation of Positive_regulation of Gh1 1 0.20 0 0.08
135 INT31845 Negative_regulation of Ghrh Positive_regulation of Gh1 1 0.18 0 0.08
136 INT27854 Binding of GHRH and DYM 1 0.01 0 0.07
137 INT54820 Binding of GHRH and SERPINA7 1 0.29 0.52 0.07
138 INT196592 Binding of CFD and GHRH 1 0.02 1.88 0.07
139 INT295550 Binding of Ghrh and Ghrl 1 0.21 0.06 0.07
140 INT78445 Binding of GHRH and IGF1 1 0.20 0.72 0.06
141 INT165364 Ghrh Regulation of Localization of Gnrh1 1 0.09 0 0.05
142 INT339779 IGF1 Regulation of GHRH 1 0.08 0.38 0.05
143 INT222508 Ghrh Regulation of Localization of LH 1 0.07 0 0.05
144 INT83235 SST Negative_regulation of Localization of GHRH 1 0.12 0.26 0.05
145 INT222567 Negative_regulation of Gh1 Negative_regulation of Ghrh 1 0.03 0.19 0.04
146 INT222498 Ghrh Positive_regulation of Gene_expression of Ghrl 1 0.10 0.19 0.04
147 INT328303 Gene_expression of GHS Positive_regulation of Gene_expression of GHRH 1 0.09 0.19 0.04
148 INT239605 Ghrh Negative_regulation of Gh 1 0.01 0.53 0.04
149 INT328301 GHRH Positive_regulation of SCG5 1 0.24 0.13 0.04
150 INT328295 GHRH Positive_regulation of GHS 1 0.10 0.13 0.04
151 INT295532 Ghsr Positive_regulation of Localization of Ghrh 1 0.40 0 0.03
152 INT247085 Binding of CRHBP and GHRH 1 0.01 0.2 0.03
153 INT265881 GHRH Positive_regulation of GHR 1 0.05 0.05 0.03
154 INT328298 GHRH Negative_regulation of Localization of GHS 1 0.08 0.84 0
155 INT294922 GH1 Positive_regulation of Gene_expression of GHRH 1 0.02 0.2 0
156 INT72269 Positive_regulation of GHRH Positive_regulation of Gh 1 0.02 0.06 0
157 INT11606 Regulation of Ghrh Regulation of Gh 1 0.06 0.05 0
158 INT101002 GHRH Positive_regulation of Localization of GGH 1 0.30 0 0
159 INT51876 CCBE1 Regulation of GHRH 1 0.01 1.07 0
160 INT328296 GHRH Negative_regulation of Localization of GH1 1 0.03 0.84 0
161 INT17540 Ghsr Regulation of GHRH 1 0.22 0 0
162 INT72268 GHRH Positive_regulation of Gh 1 0.02 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for growth hormone-releasing hormone receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in growth hormone-releasing hormone receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5095 Localization of Ghrh 185 0.81 28.09 62.08
2 INT249 Localization of GHRH 215 0.80 78.02 51.87
3 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52
4 INT5100 Positive_regulation of Ghrh 100 0.64 24.2 30.21
5 INT250 Regulation of GHRH 65 0.61 17.46 23.19
6 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74
7 INT7364 Regulation of Ghrh 49 0.58 8.05 19.05
8 INT9179 Positive_regulation of Localization of Ghrh 42 0.70 7.05 18.1
9 INT984 Positive_regulation of Localization of GHRH 58 0.70 12.66 16.51
10 INT7366 Negative_regulation of Ghrh 42 0.58 7.72 14.45
11 INT16530 Gene_expression of Ghrh 45 0.77 6.22 13.44
12 INT254 Regulation of Localization of GHRH 30 0.60 5.17 11.46
13 INT19010 Negative_regulation of Localization of Ghrh 27 0.57 4.85 10.5
14 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34
15 INT953 Positive_regulation of Positive_regulation of GHRH 17 0.67 2.38 8.18
16 INT186142 Gene_expression of Ghrh 45 0.66 34.04 6.94
17 INT7925 Transcription of Ghrh 13 0.67 2.36 6.77
18 INT7361 Binding of Ghrh 13 0.45 1.37 5.44
19 INT9178 Regulation of Localization of Ghrh 13 0.45 2.28 5.08
20 INT19900 Binding of GHRH 22 0.37 5.75 5
21 INT19008 Positive_regulation of Positive_regulation of Ghrh 15 0.49 2.4 4.55
22 INT16304 Negative_regulation of Positive_regulation of GHRH 9 0.51 2.56 4.25
23 INT142059 Regulation of Ghrh 15 0.59 3.25 3.94
24 INT986 Negative_regulation of Localization of GHRH 16 0.58 8.57 3.16
25 INT215029 Negative_regulation of Ghrh 15 0.56 11.37 2.62
26 INT20028 Positive_regulation of Gene_expression of Ghrh 9 0.50 1.52 2.62
27 INT16527 Negative_regulation of Positive_regulation of Ghrh 6 0.43 1.01 2.23
28 INT27269 Localization of Ghrh 29 0.76 15.42 2.19
29 INT11604 Regulation of Positive_regulation of Ghrh 4 0.42 0.62 2.05
30 INT54929 Negative_regulation of Transcription of Ghrh 4 0.43 0.69 2.04
31 INT16529 Negative_regulation of Gene_expression of Ghrh 6 0.43 0.34 2.02
32 INT142060 Positive_regulation of Ghrh 15 0.66 7.21 1.83
33 INT954 Positive_regulation of Gene_expression of GHRH 18 0.50 7.6 1.63
34 INT43264 Transcription of GHRH 5 0.59 0.4 1.42
35 INT47102 Regulation of Binding of GHRH 2 0.28 0 1.34
36 INT58421 Positive_regulation of Transcription of GHRH 1 0.43 0.38 1.32
37 INT8334 Regulation of Positive_regulation of GHRH 3 0.43 0.7 1.27
38 INT25432 Negative_regulation of Gene_expression of GHRH 6 0.37 2.9 1.12
39 INT13732 Negative_regulation of Regulation of GHRH 3 0.43 0.84 0.93
40 INT18406 Regulation of Regulation of GHRH 2 0.45 0.93 0.76
41 INT34944 Protein_catabolism of Ghrh 1 0.73 0 0.76
42 INT34943 Positive_regulation of Protein_catabolism of Ghrh 1 0.41 0 0.76
43 INT19891 Regulation of Gene_expression of GHRH 3 0.43 1.46 0.68
44 INT29460 Regulation of Gene_expression of Ghrh 3 0.31 0.3 0.68
45 INT64981 Regulation of Transcription of Ghrh 1 0.26 0.88 0.67
46 INT215025 Negative_regulation of Gene_expression of Ghrh 10 0.41 7.8 0.65
47 INT101674 Regulation of Regulation of Ghrh 1 0.38 0 0.65
48 INT56670 Positive_regulation of Negative_regulation of Ghrh 2 0.49 0.12 0.48
49 INT69423 Positive_regulation of Regulation of Ghrh 1 0.50 0 0.48
50 INT250506 Negative_regulation of Positive_regulation of Ghrh 2 0.41 0.14 0.47
51 INT58420 Negative_regulation of Transcription of GHRH 1 0.37 0.13 0.45
52 INT186141 Regulation of Gene_expression of Ghrh 2 0.29 0.87 0.43
53 INT7360 Regulation of Binding of Ghrh 1 0.45 0.18 0.33
54 INT215024 Positive_regulation of Negative_regulation of Ghrh 2 0.44 1.54 0.3
55 INT187005 Positive_regulation of Gene_expression of Ghrh 9 0.48 8.02 0.29
56 INT72536 Phosphorylation of Ghrh 1 0.63 0 0.27
57 INT16219 Negative_regulation of Regulation of Ghrh 1 0.11 0.5 0.27
58 INT250511 Binding of Ghrh 2 0.35 0 0.24
59 INT27562 Negative_regulation of Negative_regulation of GHRH 1 0.27 0.31 0.18
60 INT27860 Positive_regulation of Phosphorylation of GHRH 1 0.07 0 0.17
61 INT27857 Phosphorylation of GHRH 1 0.11 0 0.16
62 INT33547 Negative_regulation of Negative_regulation of Ghrh 2 0.42 0.62 0.12
63 INT295524 Positive_regulation of Positive_regulation of Ghrh 1 0.48 0 0.1
64 INT295518 Positive_regulation of Binding of Ghrh 1 0.48 0 0
65 INT39204 Positive_regulation of Negative_regulation of GHRH 1 0.49 0 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox