GO:0031802

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Name type 5 metabotropic glutamate receptor binding
Categary Function
Go Slim No
Go Link GO:0031802
Unique Molecular Interactions 37
Total Molecular Interactions 48
Total Single Events 608
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for type 5 metabotropic glutamate receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for type 5 metabotropic glutamate receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT140280 Negative_regulation of Binding of Adora2a and Grina 1 0.21 0.64 0.82
2 INT140281 Binding of Adora2a and Grina 1 0.19 0.64 0.82
3 INT72017 Binding of Adora2a and Ptprg 2 0.07 0 0.77
4 INT76498 Binding of Tacr1 and Adora2a 1 0.09 0 0.77
5 INT152949 Homer1 Regulation of Sgk1 1 0.28 0.18 0.76
6 INT152946 Homer1 Regulation of Cap1 1 0.32 0.18 0.76
7 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
8 INT82040 Adora2a Positive_regulation of Phosphorylation of Ppp1r1b 1 0.11 0 0.75
9 INT152948 Homer1 Regulation of Gpr88 1 0.36 0.18 0.75
10 INT82041 Positive_regulation of Adora2a Positive_regulation of Phosphorylation of Ppp1r1b 1 0.12 0 0.72
11 INT194857 Positive_regulation of Adora2a Positive_regulation of Gene_expression of Vegfa 1 0.23 0.74 0.67
12 INT239501 Binding of Adora2a and Mtx1 1 0.24 0.95 0.64
13 INT215644 Binding of Drd2 and Adora2a 1 0.03 0.23 0.55
14 INT81064 Negative_regulation of Nts Negative_regulation of Gene_expression of Homer1 1 0.01 0 0.48
15 INT283714 Positive_regulation of Binding of Id2 and Homer1 1 0.08 1.34 0.42
16 INT89666 Binding of Adora2a and Drd2 1 0.54 0.4 0.42
17 INT283713 Binding of Id2 and Homer1 1 0.06 1.34 0.42
18 INT302871 Negative_regulation of Adora2a Positive_regulation of Phosphorylation of Th 1 0.26 0.12 0.4
19 INT239503 Binding of Adora2a and Aes 1 0.24 0.85 0.35
20 INT115162 Adora2a Regulation of Gene_expression of Jun 1 0.49 0.36 0.34
21 INT115161 Adora2a Regulation of Gene_expression of Cpe 1 0.04 0.36 0.33
22 INT254122 Adora2a Regulation of Aliq1 1 0.01 0.85 0.3
23 INT88555 Adora2a Negative_regulation of Vegfc 1 0.00 0.17 0.25
24 INT224130 Positive_regulation of Adora2a Positive_regulation of ADCY1 1 0.01 0.11 0.22
25 INT150582 Creb1 Positive_regulation of Gene_expression of Homer1 1 0.00 0 0.22
26 INT224087 Adrbk1 Negative_regulation of Adora2a 1 0.10 0.13 0.22
27 INT72015 Binding of Adora2a and Gnai2 1 0.01 0 0.21
28 INT174679 Homer1 Regulation of Luc7l3 1 0.02 0.67 0.21
29 INT224094 Adrbk1 Regulation of Negative_regulation of Adora2a 1 0.06 0 0.17
30 INT58179 Gtf3a Positive_regulation of Gene_expression of Homer1 1 0.07 0.1 0.16
31 INT224129 Binding of DRD2 and Adora2a 1 0.03 0.19 0.14
32 INT265982 Homer1 Regulation of Grm5 1 0.04 0.38 0.12
33 INT101880 Oxt Positive_regulation of Gene_expression of Homer1 1 0.23 0.14 0.1
34 INT265981 Homer1 Regulation of Localization of Grm5 1 0.04 0.06 0.09
35 INT265983 Homer1 Regulation of Ryr1 1 0.37 0.15 0.07
36 INT132849 Homer1 Regulation of Srf 1 0.01 0.15 0
37 INT287077 Chrm2 Positive_regulation of Homer1 1 0.05 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for type 5 metabotropic glutamate receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in type 5 metabotropic glutamate receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7898 Gene_expression of Homer1 123 0.78 31.52 53.67
2 INT7899 Positive_regulation of Gene_expression of Homer1 41 0.70 7.29 25.98
3 INT47818 Positive_regulation of Homer1 48 0.70 11.11 24.05
4 INT15042 Gene_expression of Adora2a 37 0.77 3.77 14.24
5 INT108063 Gene_expression of Adora2a 29 0.78 13.11 13.78
6 INT50227 Positive_regulation of Adora2a 32 0.50 5.17 12.75
7 INT72784 Positive_regulation of Adora2a 26 0.70 16.52 11.47
8 INT60995 Negative_regulation of Positive_regulation of Homer1 9 0.38 1.63 9.63
9 INT15242 Regulation of Gene_expression of Homer1 14 0.62 4.33 9.28
10 INT23209 Binding of Adora2a 17 0.38 2.04 8.35
11 INT54755 Negative_regulation of Adora2a 17 0.58 2.7 7.75
12 INT83014 Binding of Adora2a 13 0.48 5.57 5.33
13 INT89664 Negative_regulation of Adora2a 11 0.59 7.81 5.07
14 INT53974 Regulation of Homer1 14 0.39 4.71 4.9
15 INT51468 Regulation of Adora2a 8 0.48 1.5 4.84
16 INT50228 Positive_regulation of Positive_regulation of Adora2a 8 0.39 0.1 4
17 INT9798 Negative_regulation of Gene_expression of Homer1 10 0.41 2.04 3.77
18 INT101701 Regulation of Adora2a 8 0.45 2.3 3.63
19 INT60714 Regulation of Positive_regulation of Homer1 3 0.04 0.64 3.46
20 INT58173 Negative_regulation of Homer1 5 0.43 1 2.79
21 INT82278 Positive_regulation of Positive_regulation of Homer1 5 0.13 2.32 2.73
22 INT254118 Negative_regulation of Gene_expression of Adora2a 3 0.42 2.54 2.43
23 INT183167 Positive_regulation of Gene_expression of Adora2a 4 0.70 2.37 2.31
24 INT57939 Negative_regulation of Gene_expression of Adora2a 4 0.36 0.15 2.02
25 INT72785 Positive_regulation of Positive_regulation of Adora2a 2 0.10 1.34 1.96
26 INT194847 Negative_regulation of Positive_regulation of Adora2a 3 0.32 4.52 1.88
27 INT61845 Transcription of Homer1 9 0.72 2.28 1.85
28 INT63520 Localization of Homer1 4 0.75 0.38 1.63
29 INT76496 Localization of Adora2a 3 0.48 0.3 1.54
30 INT82279 Regulation of Negative_regulation of Homer1 1 0.02 0 1.36
31 INT91595 Regulation of Gene_expression of Adora2a 1 0.52 0 1.19
32 INT52090 Transcription of Adora2a 3 0.41 0.33 0.96
33 INT72006 Positive_regulation of Negative_regulation of Adora2a 2 0.40 0.26 0.94
34 INT9797 Binding of Homer1 2 0.48 1.14 0.9
35 INT302869 Phosphorylation of Adora2a 1 0.49 0.25 0.78
36 INT302868 Positive_regulation of Phosphorylation of Adora2a 1 0.41 0.25 0.78
37 INT80147 Negative_regulation of Binding of Adora2a 2 0.43 0.15 0.77
38 INT89663 Localization of Adora2a 1 0.74 0.74 0.75
39 INT194852 Protein_catabolism of Adora2a 1 0.56 0.6 0.75
40 INT224109 Phosphorylation of Adora2a 1 0.52 0.07 0.69
41 INT215637 Regulation of Regulation of Adora2a 1 0.14 0.16 0.61
42 INT76505 Positive_regulation of Transcription of Homer1 3 0.21 0.48 0.59
43 INT141458 Regulation of Gene_expression of Adora2a 2 0.45 0.67 0.57
44 INT84854 Regulation of Transcription of Homer1 1 0.00 0.15 0.57
45 INT215639 Positive_regulation of Binding of Adora2a 1 0.24 0.24 0.55
46 INT92523 Phosphorylation of Homer1 3 0.63 0.15 0.52
47 INT224106 Regulation of Negative_regulation of Adora2a 1 0.17 0.26 0.51
48 INT224107 Negative_regulation of Negative_regulation of Adora2a 1 0.28 0.32 0.48
49 INT72143 Regulation of Binding of Adora2a 1 0.17 0 0.45
50 INT102385 Regulation of Transcription of Adora2a 1 0.21 0.09 0.4
51 INT102387 Negative_regulation of Transcription of Adora2a 1 0.09 0.24 0.37
52 INT221765 Positive_regulation of Gene_expression of Adora2a 2 0.49 0.2 0.27
53 INT224108 Positive_regulation of Localization of Adora2a 1 0.32 0.14 0.27
54 INT224114 Regulation of Localization of Adora2a 1 0.29 0.14 0.27
55 INT224117 Negative_regulation of Positive_regulation of Adora2a 1 0.27 0.11 0.22
56 INT224105 Regulation of Phosphorylation of Adora2a 1 0.17 0 0.21
57 INT224115 Positive_regulation of Phosphorylation of Adora2a 1 0.32 0 0.16
58 INT224103 Negative_regulation of Phosphorylation of Adora2a 1 0.27 0 0.16
59 INT241728 Regulation of Transcription of Adora2a 1 0.42 0.27 0.07
60 INT241725 Transcription of Adora2a 1 0.67 0.27 0.07
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