GO:0031835

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Name substance P receptor binding
Categary Function
Go Slim No
Go Link GO:0031835
Unique Molecular Interactions 81
Total Molecular Interactions 119
Total Single Events 1483
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for substance P receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for substance P receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT126335 Binding of Pax3 and Tac1 6 0.07 6.22 5.27
2 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
3 INT135035 Binding of Hk1 and Tac1 1 0.35 0.18 2.14
4 INT24942 Calca Regulation of TAC1 1 0.13 0.7 1.89
5 INT169441 TAC1 Positive_regulation of Tac1 1 0.01 1.7 1.64
6 INT147258 Binding of Tac1 and Penk 1 0.35 0 1.64
7 INT160578 Binding of CALCA and TAC1 1 0.07 0.91 1.61
8 INT73016 PDYN Regulation of TAC1 1 0.29 0.34 1.54
9 INT71543 IFNA1 Negative_regulation of Positive_regulation of TAC1 1 0.20 0.19 1.4
10 INT329452 Binding of Tac1 and Oprd1 1 0.01 0.23 1.4
11 INT51160 Binding of TAC1 and Tacr1 2 0.28 0.55 1.38
12 INT15277 Binding of Tac1 and Gal 1 0.39 0.19 1.35
13 INT185330 Binding of Hrh1 and Tac1 1 0.00 0.1 1.34
14 INT49231 TAC1 Negative_regulation of Penk 1 0.00 0 1.3
15 INT138213 Mzb1 Regulation of Localization of Tac1 1 0.01 0.41 1.29
16 INT138214 Mzb1 Regulation of Tac1 1 0.01 0.41 1.28
17 INT70226 Binding of TAC1 and B3GAT1 4 0.24 4.5 1.26
18 INT48809 Pax3 Negative_regulation of Binding of Tac1 1 0.22 0 1.16
19 INT113540 Binding of OPRM1 and Tac1 1 0.04 0.1 1.1
20 INT314136 Binding of TAC1 and SFTPA1 2 0.03 0.78 1.06
21 INT8416 LIF Regulation of TAC1 1 0.13 0.36 1.04
22 INT84959 Negative_regulation of Tacr1 Negative_regulation of Positive_regulation of Tac1 1 0.48 0.59 1.02
23 INT107951 Pax3 Positive_regulation of Tac1 1 0.11 1.21 0.95
24 INT314142 Binding of TAC1 and Tacr3 1 0.06 0.73 0.94
25 INT24938 TAC1 Regulation of Calca 1 0.22 0.35 0.94
26 INT24940 TAC1 Regulation of Nka1 1 0.10 0.34 0.87
27 INT132977 Tac1 Positive_regulation of Mapk1 1 0.06 0.17 0.79
28 INT213978 Binding of TAC1 and Tac1 1 0.02 0.36 0.78
29 INT73822 TAC1 Positive_regulation of Localization of IL1B 1 0.04 0.56 0.71
30 INT79937 TAC1 Positive_regulation of Gene_expression of VCAM1 1 0.20 0.15 0.68
31 INT109718 Tac1 Negative_regulation of Mpo 1 0.25 0.81 0.67
32 INT147257 Tac1 Regulation of Penk 1 0.19 0 0.67
33 INT63655 Binding of NPY and TAC1 1 0.39 0.17 0.64
34 INT167859 Tac1 Regulation of Gene_expression of Tacr1 1 0.09 0 0.6
35 INT121288 Binding of TAC1 and Cd79a 1 0.12 0.32 0.58
36 INT76248 Tac1 Positive_regulation of Gene_expression of Fos 1 0.34 0.34 0.56
37 INT14387 GAL Regulation of TAC1 1 0.10 0 0.56
38 INT49225 Mdk Regulation of Tac1 1 0.00 0 0.53
39 INT165042 Drd2 Regulation of Tac1 1 0.22 0 0.52
40 INT8438 Cntf Regulation of TAC1 1 0.20 0.18 0.52
41 INT126341 Tac1 Regulation of Gene_expression of Tnfrsf10b 1 0.06 0.71 0.52
42 INT14410 Tac1 Negative_regulation of Calca 1 0.26 0.33 0.52
43 INT126336 Negative_regulation of Binding of Pax3 and Tac1 1 0.01 0.66 0.49
44 INT97487 ADCYAP1 Positive_regulation of Tac1 1 0.02 0 0.48
45 INT88696 Tac1 Regulation of Regulation of Mme 1 0.00 0.39 0.48
46 INT66438 Tac2 Regulation of Binding of TAC1 1 0.01 0.12 0.47
47 INT67733 Binding of Tac1 and SLAMF6 1 0.00 0.17 0.45
48 INT101981 D2Ertd127e Positive_regulation of TAC1 1 0.00 0 0.44
49 INT51025 Klra3 Positive_regulation of Gene_expression of Tac1 1 0.11 0 0.42
50 INT41612 Tac1 Regulation of Localization of Sst 1 0.02 0 0.39
51 INT63707 TACR1 Negative_regulation of TAC1 1 0.03 0.12 0.37
52 INT337114 Tg(CAG-EGFP)D4Nagy Positive_regulation of Gene_expression of TAC1 1 0.04 0.07 0.36
53 INT46147 Dpa Negative_regulation of TAC1 1 0.01 0.09 0.34
54 INT46145 HLA-DQA1 Negative_regulation of TAC1 1 0.04 0.09 0.34
55 INT101968 TAC1 Regulation of PENK 1 0.00 0 0.33
56 INT353128 Negative_regulation of Binding of TAC1 and B3GAT1 1 0.29 1.95 0.33
57 INT101978 Regulation of Tac1 Regulation of PENK 1 0.01 0 0.33
58 INT101979 TAC1 Regulation of Tac1 1 0.01 0 0.33
59 INT101980 Tac1 Regulation of PENK 1 0.01 0 0.33
60 INT222441 Tlr4 Positive_regulation of Gene_expression of Tac1 1 0.00 0.39 0.32
61 INT106893 Ptpn2 Positive_regulation of Tac1 1 0.02 2.02 0.29
62 INT14412 Positive_regulation of Tac1 Negative_regulation of Calca 1 0.28 0.16 0.26
63 INT208936 Tac1 Positive_regulation of Tacr1 1 0.13 0.39 0.25
64 INT278582 Atp6v1e1 Positive_regulation of Positive_regulation of Tac1 1 0.15 0.13 0.24
65 INT66437 Tac2 Regulation of TAC1 1 0.01 0.06 0.23
66 INT180600 MAOB Positive_regulation of TAC1 1 0.00 0.13 0.22
67 INT48509 GRP Positive_regulation of Localization of Tac1 1 0.00 0 0.22
68 INT55827 Bdnf Negative_regulation of Negative_regulation of Tac1 1 0.45 0 0.21
69 INT139358 Tac1 Regulation of Avp 1 0.41 0.08 0.19
70 INT339329 Binding of TAC1 and TAC4 1 0.40 0.08 0.18
71 INT330486 MSR1 Negative_regulation of TAC1 1 0.01 0.23 0.13
72 INT339348 Binding of TAC1 and Nka1 1 0.03 0.07 0.13
73 INT106894 Ptpn2 Negative_regulation of Tac1 1 0.02 1.17 0.1
74 INT65411 Tac1 Positive_regulation of Binding of Sst 1 0.13 0.38 0.1
75 INT65412 Tac1 Positive_regulation of Sst 1 0.13 0.19 0.05
76 INT65413 Tac1 Positive_regulation of Uchl1 1 0.02 0.19 0.05
77 INT278575 Atp6v1e1 Negative_regulation of Gene_expression of Tac1 1 0.14 0 0
78 INT278574 Ppt1 Positive_regulation of Tac1 1 0.17 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for substance P receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in substance P receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4742 Gene_expression of Tac1 177 0.78 69.99 102.66
2 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26
3 INT8690 Localization of Tac1 71 0.80 22.98 50.75
4 INT4985 Positive_regulation of Tac1 81 0.69 35.79 50.67
5 INT8713 Regulation of Tac1 56 0.60 25.29 45.94
6 INT4776 Localization of TAC1 82 0.78 16.89 45.21
7 INT14853 Negative_regulation of Tac1 80 0.59 30.87 45.06
8 INT4850 Binding of Tac1 57 0.47 14.25 42.17
9 INT8837 Positive_regulation of TAC1 59 0.67 21.94 35.97
10 INT4727 Regulation of TAC1 60 0.47 6.74 32.83
11 INT22239 Negative_regulation of TAC1 52 0.57 12.96 31.41
12 INT11773 Gene_expression of Tac1 56 0.77 10 25.72
13 INT8779 Binding of TAC1 50 0.47 11.19 25.57
14 INT12360 Regulation of Tac1 31 0.61 5.9 18
15 INT11980 Positive_regulation of Tac1 27 0.69 6.17 14.5
16 INT4723 Transcription of Tac1 26 0.71 8.33 11.18
17 INT48806 Negative_regulation of Binding of Tac1 11 0.56 0.83 10.52
18 INT12358 Regulation of Gene_expression of Tac1 17 0.60 3.34 8.84
19 INT23331 Positive_regulation of Localization of Tac1 10 0.54 4.63 8.76
20 INT4984 Positive_regulation of Positive_regulation of Tac1 11 0.50 5.34 8.73
21 INT22700 Positive_regulation of Gene_expression of Tac1 13 0.69 6.89 8.2
22 INT51206 Regulation of Gene_expression of Tac1 13 0.45 5.92 7.74
23 INT14548 Localization of Tac1 13 0.78 1.43 7.48
24 INT12359 Negative_regulation of Tac1 26 0.58 8.16 6.89
25 INT11975 Transcription of Tac1 24 0.71 4.06 6.72
26 INT15674 Positive_regulation of Gene_expression of Tac1 17 0.68 4.97 6.56
27 INT129645 Negative_regulation of Gene_expression of TAC1 5 0.42 3.33 5.55
28 INT14771 Regulation of Localization of Tac1 4 0.48 1.77 4.83
29 INT8838 Positive_regulation of Localization of TAC1 7 0.49 0.86 4.7
30 INT41816 Negative_regulation of Localization of Tac1 5 0.35 1.2 4.66
31 INT117561 Positive_regulation of Transcription of Tac1 6 0.69 3.19 3.78
32 INT53142 Negative_regulation of Gene_expression of Tac1 7 0.56 1.59 3.61
33 INT15276 Binding of Tac1 6 0.36 0.56 3.16
34 INT73017 Regulation of Gene_expression of TAC1 5 0.54 0.44 3.08
35 INT74674 Transcription of TAC1 7 0.67 1 3.01
36 INT51307 Negative_regulation of Positive_regulation of TAC1 4 0.42 2 2.82
37 INT73837 Positive_regulation of Gene_expression of TAC1 6 0.67 3.49 2.68
38 INT36927 Regulation of Transcription of Tac1 3 0.26 0.33 2.27
39 INT49139 Positive_regulation of Positive_regulation of Tac1 4 0.68 1.74 2.24
40 INT49183 Positive_regulation of Positive_regulation of TAC1 4 0.49 0.66 2.15
41 INT100498 Negative_regulation of Positive_regulation of Tac1 3 0.41 2.81 2.06
42 INT61650 Protein_catabolism of Tac1 3 0.52 0.88 1.98
43 INT80770 Positive_regulation of Binding of Tac1 2 0.12 0.45 1.37
44 INT82003 Negative_regulation of Localization of Tac1 2 0.20 0.1 1.23
45 INT50174 Negative_regulation of Gene_expression of Tac1 3 0.40 0.32 1.11
46 INT82483 Negative_regulation of Positive_regulation of Tac1 3 0.47 0 1.06
47 INT24851 Negative_regulation of Regulation of TAC1 1 0.02 0 0.93
48 INT60985 Regulation of Transcription of Tac1 4 0.27 1.75 0.88
49 INT23842 Protein_catabolism of TAC1 2 0.96 0.57 0.84
50 INT49181 Regulation of Positive_regulation of Tac1 1 0.12 0 0.81
51 INT113536 Positive_regulation of Phosphorylation of Tac1 1 0.07 0.08 0.79
52 INT84761 Positive_regulation of Binding of TAC1 1 0.32 0 0.78
53 INT113535 Phosphorylation of Tac1 1 0.12 0.08 0.78
54 INT113538 Regulation of Binding of TAC1 2 0.44 0.15 0.66
55 INT14433 Regulation of Binding of Tac1 1 0.13 0.27 0.64
56 INT122470 Negative_regulation of Negative_regulation of TAC1 1 0.41 0 0.62
57 INT41634 Positive_regulation of Negative_regulation of Tac1 1 0.45 0 0.61
58 INT31890 Positive_regulation of Protein_catabolism of Tac1 1 0.06 0 0.56
59 INT65954 Positive_regulation of Transcription of Tac1 2 0.43 0.78 0.55
60 INT113826 Positive_regulation of Negative_regulation of TAC1 1 0.01 0 0.51
61 INT14409 Positive_regulation of Negative_regulation of Tac1 1 0.27 0.31 0.49
62 INT31891 Protein_catabolism of Tac1 1 0.12 0 0.49
63 INT50176 Negative_regulation of Transcription of Tac1 3 0.22 0.07 0.42
64 INT79808 Negative_regulation of Transcription of Tac1 1 0.12 1.21 0.38
65 INT305070 Negative_regulation of Binding of TAC1 2 0.41 1.94 0.36
66 INT53068 Negative_regulation of Binding of Tac1 1 0.42 0.47 0.36
67 INT36926 Regulation of Negative_regulation of Tac1 1 0.24 0 0.31
68 INT82624 Positive_regulation of Regulation of Tac1 1 0.07 0.25 0.28
69 INT14408 Negative_regulation of Regulation of Tac1 1 0.23 0.15 0.25
70 INT70497 Regulation of Localization of TAC1 1 0.26 0 0.21
71 INT65953 Regulation of Regulation of Tac1 1 0.25 0 0.2
72 INT305069 Phosphorylation of TAC1 1 0.19 0 0.19
73 INT134496 Negative_regulation of Localization of TAC1 1 0.57 0.26 0.18
74 INT69750 Regulation of Positive_regulation of TAC1 1 0.16 0.28 0.16
75 INT60984 Negative_regulation of Negative_regulation of Tac1 1 0.19 0.35 0.16
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