GO:0031959

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Name mineralocorticoid receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0031959
Unique Molecular Interactions 53
Total Molecular Interactions 65
Total Single Events 632
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for mineralocorticoid receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for mineralocorticoid receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT279166 Binding of Cyp3a23/3a1 and Nr3c2 1 0.00 0.61 0.9
2 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
3 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
4 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
5 INT130335 Binding of Mc4r and Nr3c2 1 0.06 1.87 0.5
6 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
7 INT134045 Jak2 Regulation of Stat3 1 0.26 0.13 0.47
8 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
9 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
10 INT134050 Positive_regulation of Jak2 Regulation of Stat3 1 0.44 0.13 0.47
11 INT49716 PCA Negative_regulation of Nr3c2 1 0.02 0 0.41
12 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39
13 INT328828 Binding of Jak2 and Jak1 1 0.24 0 0.38
14 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
15 INT328820 Binding of Il6 and Jak2 1 0.09 0 0.38
16 INT184084 Jak2 Positive_regulation of Stat1 1 0.33 0.3 0.33
17 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
18 INT336936 Binding of GSR and Nr3c2 1 0.06 2.29 0.31
19 INT336933 Binding of Nr3c2 and Ugcg 1 0.07 2.3 0.31
20 INT49717 PCA Regulation of Nr3c2 1 0.01 0 0.27
21 INT245640 Nr3c2 Regulation of Positive_regulation of Hpse 1 0.08 0.66 0.26
22 INT240536 Il12a Positive_regulation of Jak2 1 0.10 0.74 0.21
23 INT245641 Nr3c2 Regulation of Gene_expression of Hpse 1 0.14 2.67 0.17
24 INT183214 Binding of gr and Nr3c2 1 0.04 0.31 0.16
25 INT188358 Binding of Csf2 and Positive_regulation of Jak2 1 0.34 0.19 0.11
26 INT169340 Binding of UGT8 and Jak2 1 0.36 0.15 0.11
27 INT242480 Ciapin1 Positive_regulation of Gene_expression of Jak2 1 0.27 1.05 0.07
28 INT200807 Jak2 Positive_regulation of Mvd 1 0.18 3.46 0.06
29 INT200821 Binding of Jak2 and Mvd 1 0.14 0.68 0.04
30 INT200813 Jak2 Positive_regulation of Akt1 1 0.26 1.46 0.03
31 INT253578 Csnk2a2 Negative_regulation of Jak2 1 0.09 0 0.03
32 INT253573 Binding of Jak2 and Pik3r1 1 0.06 0 0.03
33 INT200816 Jak2 Positive_regulation of Binding of Mvd 1 0.19 1.51 0.03
34 INT200810 Jak2 Positive_regulation of Src 1 0.29 1.46 0.03
35 INT249597 Jak2 Positive_regulation of Phosphorylation of Stat1 1 0.20 0.13 0.03
36 INT253575 Binding of Jak2 and Pik3r2 1 0.00 0 0.03
37 INT200815 Binding of Epo and Jak2 1 0.36 0.98 0.03
38 INT200822 Akt1 Regulation of Jak2 1 0.25 1.48 0.03
39 INT340502 Agtr1a Negative_regulation of Phosphorylation of Jak2 1 0.12 2.32 0
40 INT253366 Il6 Positive_regulation of Phosphorylation of Jak2 1 0.31 0.2 0
41 INT200819 Epo Positive_regulation of Gene_expression of Jak2 1 0.49 0.91 0
42 INT241535 Abl1 Regulation of Positive_regulation of Jak2 1 0.10 0.53 0
43 INT138304 PNN Negative_regulation of Nr3c2 1 0.00 0.23 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for mineralocorticoid receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in mineralocorticoid receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7573 Positive_regulation of Nr3c2 38 0.67 20 21.84
2 INT12321 Binding of Nr3c2 19 0.46 5.44 13.46
3 INT12315 Gene_expression of Nr3c2 37 0.75 19.28 11.97
4 INT7577 Regulation of Nr3c2 16 0.56 7.7 10.1
5 INT12314 Negative_regulation of Nr3c2 16 0.56 14.82 6.72
6 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
7 INT55552 Regulation of Gene_expression of Nr3c2 5 0.59 5.93 4.53
8 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
9 INT7571 Transcription of Nr3c2 6 0.58 2.15 3.03
10 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
11 INT7574 Positive_regulation of Transcription of Nr3c2 4 0.54 1.26 2.52
12 INT110284 Negative_regulation of Positive_regulation of Nr3c2 4 0.53 2.08 2.48
13 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
14 INT55365 Regulation of Binding of Nr3c2 2 0.56 0.85 2.2
15 INT55364 Negative_regulation of Binding of Nr3c2 2 0.39 0.87 2.17
16 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
17 INT135692 Localization of Nr3c2 7 0.77 4.14 1.98
18 INT90315 Positive_regulation of Gene_expression of Nr3c2 4 0.55 2 1.83
19 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
20 INT96324 Negative_regulation of Gene_expression of Nr3c2 3 0.56 1.01 1.43
21 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37
22 INT245636 Regulation of Positive_regulation of Nr3c2 2 0.59 1.55 1.25
23 INT205912 Negative_regulation of Gene_expression of Jak2 8 0.42 5.1 1.04
24 INT169336 Binding of Jak2 2 0.42 1.31 0.93
25 INT134040 Regulation of Jak2 3 0.41 1.07 0.92
26 INT161295 Phosphorylation of Nr3c2 1 0.07 0.09 0.9
27 INT184027 Phosphorylation of Jak2 6 0.82 2.58 0.87
28 INT134037 Positive_regulation of Phosphorylation of Jak2 1 0.46 0.25 0.86
29 INT237408 Positive_regulation of Positive_regulation of Jak2 1 0.28 1.56 0.79
30 INT135691 Positive_regulation of Binding of Nr3c2 1 0.46 0.4 0.76
31 INT12320 Regulation of Negative_regulation of Nr3c2 3 0.38 1.29 0.56
32 INT167064 Positive_regulation of Positive_regulation of Nr3c2 2 0.44 1.5 0.56
33 INT184062 Binding of Jak2 5 0.37 3.13 0.47
34 INT205890 Transcription of Jak2 1 0.41 0.22 0.43
35 INT145854 Gene_expression of Jak2 4 0.67 3.08 0.41
36 INT107462 Localization of Jak2 2 0.60 0.78 0.4
37 INT229697 Negative_regulation of Phosphorylation of Jak2 1 0.15 0.54 0.39
38 INT200786 Positive_regulation of Gene_expression of Jak2 9 0.69 6.03 0.35
39 INT205910 Negative_regulation of Positive_regulation of Jak2 1 0.33 0.26 0.35
40 INT245639 Regulation of Transcription of Nr3c2 1 0.38 0.93 0.25
41 INT328811 Negative_regulation of Localization of Jak2 1 0.34 0.13 0.17
42 INT200802 Regulation of Jak2 5 0.61 2.86 0.16
43 INT245635 Negative_regulation of Negative_regulation of Nr3c2 1 0.36 1.06 0.15
44 INT278143 Positive_regulation of Negative_regulation of Jak2 1 0.16 0.54 0.11
45 INT245637 Regulation of Regulation of Nr3c2 1 0.38 0.53 0.1
46 INT200792 Regulation of Gene_expression of Jak2 5 0.61 5.69 0.09
47 INT245638 Negative_regulation of Localization of Nr3c2 1 0.41 0.63 0.09
48 INT184018 Negative_regulation of Protein_catabolism of Jak2 1 0.36 1.76 0.08
49 INT184023 Protein_catabolism of Jak2 1 0.61 1.75 0.08
50 INT202420 Transcription of Jak2 1 0.56 0.91 0
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