GO:0031982

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Name vesicle
Categary Component
Go Slim No
Go Link GO:0031982
Unique Molecular Interactions 1134
Total Molecular Interactions 1553
Total Single Events 12093
Pain Genes Associated 55

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for vesicle. They are ordered first by their pain relevance and then by number of times they were reported for vesicle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT21276 Binding of Oprd1 and Penk 9 0.54 1.14 8.28
2 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
3 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
4 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
5 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
6 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
7 INT103724 Oprd1 Positive_regulation of Gtpbp4 3 0.30 0.91 4.18
8 INT249566 Binding of Oprd1 and Psmd1 1 0.01 0.82 3.8
9 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
10 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
11 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
12 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
13 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
14 INT137230 Trh Regulation of Gene_expression of Oprd1 1 0.01 1.62 2.75
15 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
16 INT150596 Binding of Oprd1 and Oprk1 1 0.08 0.14 2.59
17 INT69665 Binding of Oprd1 and Pnoc 5 0.35 0.4 2.5
18 INT249567 Positive_regulation of Binding of Oprd1 and Psmd1 1 0.01 0.66 2.5
19 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
20 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
21 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
22 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
23 INT5486 Oprd1 Regulation of Cck 1 0.21 0 2.16
24 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
25 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
26 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
27 INT68272 Binding of Oprd1 and G2e3 1 0.00 0.11 1.93
28 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
29 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
30 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
31 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
32 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
33 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84
34 INT119917 Zfp821 Positive_regulation of Positive_regulation of Oprd1 1 0.01 0 1.82
35 INT70225 oh Regulation of Oprd1 1 0.20 0.13 1.8
36 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
37 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
38 INT129953 Oprd1 Regulation of Cspg5 1 0.17 0.15 1.74
39 INT37840 Binding of Cyp27b1 and Oprd1 1 0.01 0 1.73
40 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
41 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
42 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
43 INT103725 Negative_regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.17 0.38 1.65
44 INT103726 Regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.10 0.38 1.64
45 INT61049 Binding of Oprd1 and Negative_regulation of Gene_expression of Odc1 1 0.21 0 1.64
46 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
47 INT61674 Gpm6a Regulation of Oprd1 1 0.01 0.07 1.62
48 INT21570 Binding of Cck and Mapk8 1 0.06 0 1.6
49 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
50 INT8734 Pebp1 Positive_regulation of Oprd1 1 0.01 0 1.54
51 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
52 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
53 INT166360 Negative_regulation of Crhr1 Negative_regulation of Positive_regulation of Pomc 1 0.02 0.36 1.5
54 INT140028 Ifng Positive_regulation of Gene_expression of Il1b 1 0.48 1.69 1.5
55 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
56 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
57 INT317509 Oprm1 Negative_regulation of Phosphorylation of Oprd1 1 0.00 0 1.46
58 INT329451 Binding of Oprd1 and Tacr1 1 0.05 0.23 1.41
59 INT142852 Oprm1 Positive_regulation of Oprd1 1 0.41 0.06 1.41
60 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
61 INT329452 Binding of Tac1 and Oprd1 1 0.01 0.23 1.4
62 INT6466 Binding of Npr1 and Oprd1 1 0.01 0 1.37
63 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
64 INT356317 Crhr1 Regulation of Gene_expression of Cea 1 0.18 0.65 1.33
65 INT249565 Binding of Gabrg1 and Oprd1 1 0.00 0.1 1.33
66 INT91305 Binding of Npff and Npffr2 2 0.31 0.64 1.32
67 INT356326 Crhr1 Regulation of Gene_expression of Helt 1 0.01 0.65 1.32
68 INT13756 Binding of Oprd1 and Scn4a 1 0.02 0 1.32
69 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
70 INT13755 Binding of Oprd1 and Ap2m1 1 0.20 0 1.32
71 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
72 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
73 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
74 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
75 INT57263 Binding of Oprd1 and Atxn2l 1 0.02 0 1.29
76 INT57262 Binding of Gria4 and Oprd1 1 0.06 0 1.29
77 INT108386 IL1B Positive_regulation of MMP1 3 0.27 1.56 1.28
78 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
79 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27
80 INT34393 Oprd1 Negative_regulation of Adcy1 1 0.36 0 1.27
81 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
82 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
83 INT63864 Oprd1 Regulation of Localization of Prl 2 0.16 0 1.23
84 INT70039 IL1B Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
85 INT70038 IL1B Regulation of PRF1 1 0.05 1.42 1.21
86 INT70031 IL1B Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
87 INT70030 IL1B Regulation of IL10 1 0.07 1.42 1.21
88 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
89 INT209926 IL1B Regulation of PPARA 1 0.21 2.45 1.2
90 INT13203 Oprd1 Negative_regulation of Akr1d1 1 0.01 0 1.18
91 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16
92 INT13205 Oprd1 Negative_regulation of Npr1 2 0.01 0 1.16
93 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
94 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
95 INT326665 Cpe Positive_regulation of Oprd1 1 0.01 1.24 1.15
96 INT199493 Ngf Regulation of Oprd1 1 0.05 1.05 1.15
97 INT94502 Il1b Positive_regulation of Gene_expression of Avp 1 0.28 1.97 1.15
98 INT94509 Il1b Positive_regulation of Gene_expression of AVP 1 0.36 1.96 1.15
99 INT66767 Il1b Positive_regulation of Pla2g10 1 0.05 0.47 1.13
100 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
101 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13
102 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
103 INT66907 Il1b Positive_regulation of Localization of Oxt 2 0.78 0.18 1.12
104 INT21267 Cck Negative_regulation of Binding of Oprd1 1 0.50 0 1.12
105 INT69338 Binding of Oprd1 and Oprm1 1 0.24 0.26 1.11
106 INT209088 Binding of Ceacam3 and Crhr1 1 0.34 1.26 1.11
107 INT167428 Il1b Positive_regulation of Localization of Gpt 1 0.43 1.31 1.11
108 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
109 INT167429 Negative_regulation of Mapk8 Negative_regulation of RYBP 1 0.01 1.11 1.09
110 INT107562 Penk Positive_regulation of Localization of Il1b 1 0.20 0.09 1.09
111 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
112 INT60783 Binding of Oprd1 and Cck 1 0.26 0.47 1.09
113 INT74939 IL1B Positive_regulation of Gene_expression of HGF 1 0.58 0.72 1.09
114 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
115 INT76396 Il10 Negative_regulation of Il1b 2 0.65 1.89 1.08
116 INT107567 Hps4 Positive_regulation of Localization of Il1b 1 0.01 0.09 1.08
117 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
118 INT121089 Binding of Oprd1 and Adarb1 2 0.06 0 1.07
119 INT107564 Hps4 Regulation of Localization of Il1b 1 0.01 0.1 1.07
120 INT145407 Oprd1 Regulation of Positive_regulation of Dbi 1 0.17 0 1.07
121 INT223875 Negative_regulation of Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.31 0 1.07
122 INT6415 Binding of Cpe and Oprd1 1 0.00 0 1.07
123 INT107560 Penk Regulation of Localization of Il1b 1 0.18 0.1 1.07
124 INT87222 Nrg1 Regulation of Oprd1 1 0.00 0 1.07
125 INT122432 Prkci Regulation of Negative_regulation of Oprd1 1 0.01 0 1.06
126 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
127 INT108413 Binding of OPRK1 and Oprd1 1 0.00 0.08 1.04
128 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
129 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
130 INT128297 Il1b Positive_regulation of CRH 1 0.02 0.27 1.03
131 INT150621 Binding of Oprm1 and Oprd1 1 0.00 0.08 1.02
132 INT83903 Penk Positive_regulation of Npff 1 0.49 0 1.02
133 INT79602 Binding of PSMA5 and Oprd1 2 0.19 1.05 1.01
134 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01
135 INT308804 Pld1 Positive_regulation of TNF 1 0.05 2.42 0.99
136 INT102690 IL1B Positive_regulation of ITGAL 1 0.05 0.87 0.99
137 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98
138 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98
139 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
140 INT18890 Penk Regulation of Oprd1 1 0.25 0.45 0.97
141 INT159111 Il1a Regulation of Gene_expression of Il1b 1 0.49 0.38 0.97
142 INT240123 MIR885 Negative_regulation of IL1B 1 0.01 1.57 0.96
143 INT130722 Binding of IL1B and Nfkb1 1 0.28 1.23 0.95
144 INT65463 Bri3 Negative_regulation of Oprd1 1 0.10 0.39 0.94
145 INT130725 Binding of IL1B and Il1rn 1 0.01 1.16 0.93
146 INT81919 Binding of HSF1 and IL1B 1 0.42 0.77 0.93
147 INT82126 CEBPB Regulation of Gene_expression of Oprd1 1 0.00 0 0.93
148 INT82124 IK Positive_regulation of Gene_expression of Oprd1 1 0.00 0 0.92
149 INT72917 Binding of Crh and Crhr1 4 0.32 0.73 0.91
150 INT34271 Positive_regulation of WAS Positive_regulation of Oprd1 1 0.01 0 0.91
151 INT34273 WAS Regulation of Oprd1 1 0.00 0 0.91
152 INT61317 Positive_regulation of Oprd1 Positive_regulation of Gene_expression of Coq10a 1 0.01 0.39 0.91
153 INT34272 WAS Positive_regulation of Oprd1 1 0.01 0 0.91
154 INT54196 Binding of Oprd1 and Agp2 1 0.00 0.18 0.91
155 INT317541 Oprd1 Negative_regulation of Akt1 1 0.06 0 0.91
156 INT52114 Oprd1 Regulation of ADCY1 2 0.05 0.46 0.9
157 INT161655 Gsr Regulation of Gene_expression of Il1b 1 0.20 1.84 0.9
158 INT52759 Oprd1 Regulation of Sptan1 1 0.03 0 0.9
159 INT86589 Oprd1 Regulation of Localization of Pomc 1 0.18 0 0.9
160 INT52760 Oprd1 Regulation of Drd1a 1 0.02 0 0.9
161 INT91270 Oprd1 Regulation of Gene_expression of Il6 1 0.00 0 0.89
162 INT161916 Binding of POMC and Oprd1 1 0.01 0 0.89
163 INT161917 Negative_regulation of Binding of POMC and Oprd1 1 0.01 0 0.89
164 INT59503 Binding of Oprd1 and Insrr 1 0.00 0 0.89
165 INT257304 Pde5a Positive_regulation of Oprd1 1 0.15 0.48 0.89
166 INT54194 Binding of Oprd1 and Pag1 1 0.01 0.18 0.89
167 INT63943 Il1b Positive_regulation of Localization of Calca 2 0.46 0.98 0.88
168 INT82125 IK Regulation of Gene_expression of Oprd1 1 0.00 0 0.88
169 INT151630 Il1rn Negative_regulation of Dock9 1 0.03 1.33 0.88
170 INT136349 Il1b Positive_regulation of Positive_regulation of Oprl1 1 0.22 0.27 0.88
171 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
172 INT224585 IL1B Positive_regulation of IL1RN 1 0.02 1.3 0.87
173 INT80792 Prkcg Regulation of Oprd1 1 0.19 0.2 0.86
174 INT37839 Positive_regulation of Binding of Cyp27b1 and Oprd1 1 0.01 0 0.86
175 INT52390 OPRD1 Regulation of ADCY1 1 0.09 0.13 0.86
176 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84
177 INT21534 Binding of Oprd1 and Il1 1 0.00 0 0.84
178 INT69424 Binding of Agt and Oprd1 1 0.14 0 0.84
179 INT84414 Folr2 Regulation of Binding of Oprd1 1 0.03 0.18 0.84
180 INT149628 Il1b Regulation of Gene_expression of Ptgs2 1 0.30 0.84 0.84
181 INT113972 Regulation of Binding of Oprd1 and Smu1 1 0.00 0.45 0.84
182 INT113971 Binding of Oprd1 and Smu1 1 0.00 0.45 0.84
183 INT150733 Negative_regulation of Tlr3 Negative_regulation of Positive_regulation of Il1b 1 0.48 1.34 0.83
184 INT10275 Il1b Positive_regulation of Gene_expression of Penk 1 0.49 0.75 0.83
185 INT149626 Il1b Regulation of Gene_expression of Tnf 1 0.41 0.83 0.83
186 INT84717 Il1b Regulation of Cpox 1 0.00 0.37 0.83
187 INT65011 IL1B Positive_regulation of PTGER2 4 0.08 0.92 0.82
188 INT102201 Tnf Regulation of Il1b 3 0.39 2.57 0.82
189 INT187226 Vip Positive_regulation of Gene_expression of Il1rn 1 0.04 0.96 0.82
190 INT16438 Atp6v0d2 Regulation of Localization of Lnpep 1 0.01 0 0.81
191 INT150348 Oprd1 Regulation of Pat 1 0.01 0.38 0.81
192 INT112842 Positive_regulation of Binding of Pdyn and Oprd1 1 0.00 0 0.81
193 INT83094 IL1B Positive_regulation of Positive_regulation of BDKRB1 1 0.45 0.2 0.81
194 INT16435 Ubqln1 Regulation of Localization of Lnpep 1 0.01 0 0.81
195 INT112841 Binding of Pdyn and Oprd1 1 0.00 0 0.81
196 INT50793 Oprd1 Regulation of Phosphorylation of Oprd1 1 0.00 0 0.8
197 INT222024 Mapk8 Regulation of Mapk14 2 0.17 0.83 0.79
198 INT21543 Binding of Oprd1 and Cish 2 0.09 0.15 0.78
199 INT77526 Oprd1 Regulation of Positive_regulation of Odc1 1 0.01 0.12 0.78
200 INT152234 Mapk8 Positive_regulation of Localization of Nfkb1 1 0.33 0.26 0.78

Single Events

The table below shows the top 100 pain related interactions that have been reported for vesicle. They are ordered first by their pain relevance and then by number of times they were reported in vesicle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5660 Binding of Oprd1 477 0.48 71.86 342.06
2 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32
3 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41
4 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
5 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9
6 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11
7 INT12569 Localization of Oprd1 94 0.81 23.81 104.56
8 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
9 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
10 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35
11 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
12 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
13 INT6849 Localization of IL1B 229 0.81 112.56 69.63
14 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54
15 INT10668 Positive_regulation of Gene_expression of Oprd1 61 0.69 15.21 52.12
16 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
17 INT32718 Gene_expression of OPRD1 82 0.76 9.43 48.38
18 INT7828 Positive_regulation of Oprd1 55 0.69 14.11 42.86
19 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
20 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48
21 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
22 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58
23 INT4843 Gene_expression of Npff 50 0.78 12.92 36.37
24 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98
25 INT6484 Binding of IL1B 122 0.47 75.84 35.07
26 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29
27 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52
28 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2
29 INT9347 Localization of Il1b 58 0.81 26.13 31.53
30 INT12397 Gene_expression of Oprd1 53 0.78 9.1 31.31
31 INT15000 Transcription of Oprd1 32 0.72 5.7 29.22
32 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29
33 INT5771 Binding of Oprd1 37 0.48 2.6 27.54
34 INT6382 Regulation of Binding of Oprd1 36 0.61 7 26.48
35 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21
36 INT6934 Binding of OPRD1 51 0.48 7.72 25.73
37 INT5948 Regulation of Il1b 44 0.60 22.8 25.4
38 INT5690 Negative_regulation of Binding of Oprd1 36 0.59 8.29 24.52
39 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24
40 INT16431 Localization of Lnpep 62 0.70 6.28 23.94
41 INT51029 Negative_regulation of Il1b 34 0.57 29.34 23.62
42 INT30386 Negative_regulation of OPRD1 33 0.52 4.34 23.06
43 INT48081 Localization of Il1b 46 0.80 21.59 22.4
44 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25
45 INT31393 Positive_regulation of Localization of Oprd1 10 0.66 7.32 21.23
46 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34
47 INT27529 Phosphorylation of Oprd1 23 0.47 1.16 20.18
48 INT4841 Localization of Npff 26 0.80 4.36 19.91
49 INT31905 Positive_regulation of Binding of Oprd1 21 0.66 3.31 18.44
50 INT33542 Gene_expression of Il1rn 41 0.76 32.47 18.08
51 INT8332 Positive_regulation of OPRD1 30 0.61 3.88 17.65
52 INT16155 Positive_regulation of Npff 25 0.70 6.21 17.58
53 INT36054 Transcription of IL1B 53 0.72 32.64 17.31
54 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24
55 INT104493 Negative_regulation of Mapk8 56 0.53 27.76 16.86
56 INT6066 Negative_regulation of Positive_regulation of Oprd1 15 0.43 1.36 16.63
57 INT4769 Regulation of OPRD1 20 0.44 2.05 15.97
58 INT9751 Localization of Crhr1 26 0.78 10.47 15.69
59 INT49606 Gene_expression of Il1rn 30 0.66 15.78 14.82
60 INT29352 Negative_regulation of Oprd1 16 0.58 6.51 14.6
61 INT25266 Positive_regulation of Localization of IL1B 38 0.69 15.89 14.35
62 INT54284 Negative_regulation of Gene_expression of Oprd1 16 0.42 4.56 14.34
63 INT46582 Binding of Npff 20 0.48 1.49 13.99
64 INT11069 Positive_regulation of Pf4 35 0.68 27.7 13.96
65 INT95738 Positive_regulation of Phosphorylation of Mapk8 40 0.70 23.46 13.88
66 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68
67 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63
68 INT4842 Regulation of Npff 13 0.54 4.59 13.62
69 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18
70 INT58226 Negative_regulation of Gene_expression of Il1b 24 0.57 18.09 12.68
71 INT51028 Regulation of Il1b 28 0.60 21.15 12.47
72 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65
73 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44
74 INT104039 Positive_regulation of Crhr1 15 0.70 8.34 10.99
75 INT14962 Gene_expression of Pf4 27 0.76 22.48 10.88
76 INT50196 Transcription of Il1b 25 0.69 19.08 10.43
77 INT48131 Gene_expression of Slc2a4 32 0.78 14.64 10.16
78 INT145695 Regulation of Mapk8 26 0.62 14.67 9.83
79 INT62919 Regulation of Gnas 22 0.43 5.61 9.55
80 INT48078 Regulation of Gene_expression of Il1b 15 0.62 14.78 9.53
81 INT111998 Positive_regulation of Positive_regulation of Mapk8 23 0.69 9.33 8.97
82 INT7572 Regulation of Crhr1 8 0.45 5.6 8.93
83 INT81597 Transcription of Npff 10 0.69 5.52 8.53
84 INT104481 Regulation of Mapk8 21 0.50 13.87 8.41
85 INT96912 Positive_regulation of Phosphorylation of Mapk8 29 0.69 18.33 8.14
86 INT7813 Regulation of SRI 25 0.61 6.18 8.13
87 INT31394 Negative_regulation of Localization of Oprd1 3 0.39 2.38 7.89
88 INT10627 Positive_regulation of Lnpep 24 0.69 3.36 7.85
89 INT66926 Transcription of Il1b 15 0.69 13.16 7.81
90 INT99430 Positive_regulation of Gene_expression of Slc2a4 18 0.66 10.45 7.79
91 INT48077 Positive_regulation of Localization of Il1b 17 0.69 8.8 7.68
92 INT50195 Positive_regulation of Positive_regulation of Il1b 12 0.67 7.41 7.64
93 INT7570 Transcription of Crhr1 7 0.66 6.6 7.6
94 INT99071 Positive_regulation of Gene_expression of Mapk8 16 0.55 9.87 7.58
95 INT74326 Gene_expression of Crhr1 25 0.66 9.7 7.48
96 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36
97 INT80161 Positive_regulation of Crhr1 13 0.67 9.66 7.33
98 INT20845 Positive_regulation of Negative_regulation of Oprd1 7 0.70 1.81 7.33
99 INT11378 Negative_regulation of Positive_regulation of IL1B 23 0.59 10.28 7.26
100 INT6239 Regulation of Regulation of Oprd1 7 0.45 0.34 7.26
101 INT5311 Regulation of Negative_regulation of Oprd1 11 0.43 0.99 7.23
102 INT36053 Positive_regulation of Positive_regulation of IL1B 22 0.70 11.41 6.84
103 INT69980 Negative_regulation of Il1rn 11 0.33 7.75 6.7
104 INT4840 Positive_regulation of Localization of Npff 7 0.69 0.79 6.69
105 INT54062 Transcription of Oprd1 11 0.68 1.05 6.65
106 INT48076 Negative_regulation of Localization of Il1b 10 0.59 3.46 6.58
107 INT9753 Positive_regulation of Localization of Crhr1 8 0.49 1.72 6.55
108 INT48954 Positive_regulation of Localization of Il1b 13 0.53 8.16 6.44
109 INT67130 Negative_regulation of Localization of Il1b 7 0.57 1.36 6.42
110 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33
111 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32
112 INT85655 Gene_expression of Crhr1 17 0.68 9.34 6.31
113 INT84716 Negative_regulation of Positive_regulation of Il1b 9 0.57 5.34 6.27
114 INT54747 Localization of OPRD1 7 0.73 0.69 6.27
115 INT126395 Positive_regulation of Gene_expression of Il1rn 11 0.41 7.66 6.25
116 INT81596 Positive_regulation of Gene_expression of Npff 6 0.69 3.41 6.1
117 INT91575 Positive_regulation of Phosphorylation of Oprd1 8 0.02 0.23 6.07
118 INT677 Positive_regulation of CST3 20 0.67 17.47 6
119 INT19941 Negative_regulation of Pf4 13 0.42 10.35 5.97
120 INT80750 Binding of Il1b 11 0.47 7.97 5.95
121 INT107441 Positive_regulation of Gene_expression of Il1rn 7 0.46 3.24 5.95
122 INT26555 Regulation of Positive_regulation of Oprd1 6 0.59 2.47 5.76
123 INT10624 Regulation of Lnpep 13 0.61 3.27 5.6
124 INT55578 Regulation of Gene_expression of Il1b 7 0.62 4.74 5.55
125 INT10705 Binding of Il1b 9 0.36 2.8 5.53
126 INT114180 Negative_regulation of Il1rn 22 0.57 11.06 5.44
127 INT50197 Positive_regulation of Transcription of Il1b 11 0.50 8.95 5.41
128 INT128922 Negative_regulation of Gene_expression of Mapk8 6 0.34 3.93 5.36
129 INT14501 Gene_expression of CST3 28 0.75 25.77 5.16
130 INT135291 Positive_regulation of Positive_regulation of Mapk8 24 0.64 19.37 5.16
131 INT16432 Positive_regulation of Localization of Lnpep 12 0.32 1.15 5.05
132 INT131717 Positive_regulation of Gene_expression of Mapk8 18 0.55 14.25 5.02
133 INT53959 Negative_regulation of Npff 6 0.57 0.55 4.86
134 INT3476 Phosphorylation of Npc1 7 0.48 0 4.84
135 INT114183 Positive_regulation of Il1rn 17 0.55 11.31 4.83
136 INT18245 Negative_regulation of Localization of Crhr1 4 0.17 0.28 4.81
137 INT7568 Negative_regulation of Crhr1 8 0.43 4.63 4.77
138 INT53442 Gene_expression of Npff 12 0.76 0.57 4.75
139 INT16047 Negative_regulation of Positive_regulation of Il1b 11 0.57 5.27 4.66
140 INT76683 Positive_regulation of Il1rn 9 0.51 9.3 4.41
141 INT98357 Binding of Gnas 11 0.41 1.87 4.35
142 INT23738 Regulation of Transcription of Oprd1 6 0.26 0.48 4.3
143 INT107113 Gene_expression of Pld1 6 0.78 2.71 4.28
144 INT102654 Positive_regulation of Pln 10 0.48 3.53 4.19
145 INT48080 Positive_regulation of Positive_regulation of Il1b 5 0.50 4.3 4.19
146 INT19190 Regulation of Localization of IL1B 14 0.50 8.71 4.12
147 INT29671 Regulation of Localization of Oprd1 4 0.24 1.04 3.92
148 INT65460 Positive_regulation of Gene_expression of Oprd1 8 0.69 1.87 3.87
149 INT71322 Positive_regulation of Binding of Oprd1 4 0.33 0.97 3.87
150 INT3127 Gene_expression of SRI 38 0.68 26.29 3.82
151 INT39786 Transcription of Lnpep 3 0.69 0.52 3.61
152 INT18282 Binding of SRI 10 0.36 3.31 3.59
153 INT85537 Regulation of Crhr1 4 0.45 1.64 3.53
154 INT83646 Binding of Il1rn 12 0.37 4.41 3.51
155 INT41296 Protein_catabolism of Oprd1 8 0.85 0.79 3.48
156 INT60646 Regulation of Gene_expression of Oprd1 4 0.60 1.76 3.46
157 INT32517 Positive_regulation of LRPAP1 13 0.49 7.4 3.44
158 INT21569 Binding of Mapk8 8 0.48 5.55 3.44
159 INT52392 Positive_regulation of Gene_expression of OPRD1 6 0.64 0.23 3.43
160 INT40232 Transcription of Il1rn 8 0.53 9.6 3.37
161 INT12388 Negative_regulation of Crhr1 17 0.59 9.47 3.33
162 INT32340 Negative_regulation of Lnpep 14 0.49 2.63 3.26
163 INT74962 Phosphorylation of OPRD1 5 0.82 0.18 3.26
164 INT163529 Negative_regulation of Positive_regulation of Mapk8 14 0.43 8.37 3.2
165 INT193827 Gene_expression of Pld1 31 0.72 13.41 3.19
166 INT127336 Positive_regulation of Transcription of Crhr1 3 0.48 3.37 3.19
167 INT54060 Regulation of Transcription of Oprd1 3 0.57 0.59 3.18
168 INT82035 Negative_regulation of Phosphorylation of Oprd1 3 0.13 0 3.16
169 INT10869 Regulation of Npff 3 0.45 0.37 3.15
170 INT66922 Positive_regulation of Transcription of Il1b 7 0.49 6.58 3.14
171 INT171888 Binding of Il1rn 13 0.38 5.53 3.13
172 INT17673 Negative_regulation of Localization of Lnpep 8 0.09 2.63 3.12
173 INT31912 Regulation of Binding of OPRD1 3 0.25 0.93 3.11
174 INT59455 Localization of Oprd1 3 0.20 0.22 3.01
175 INT200670 Gene_expression of AKT2 25 0.75 16.25 3
176 INT57145 Transcription of OPRD1 6 0.61 0.34 2.99
177 INT110755 Negative_regulation of Positive_regulation of Mapk8 15 0.46 9.91 2.98
178 INT103910 Binding of NOD2 19 0.47 12.24 2.93
179 INT54632 Negative_regulation of Gene_expression of Oprd1 5 0.58 2.22 2.9
180 INT41358 Localization of Pf4 11 0.79 6.06 2.89
181 INT32394 Regulation of Pf4 12 0.23 6.07 2.85
182 INT9752 Regulation of Localization of Crhr1 3 0.44 0.36 2.82
183 INT28729 Negative_regulation of Negative_regulation of Oprd1 3 0.43 0.33 2.79
184 INT12903 Gene_expression of Lnpep 14 0.71 1.3 2.78
185 INT6479 Negative_regulation of Binding of IL1B 10 0.43 5.1 2.78
186 INT34501 Positive_regulation of Positive_regulation of Oprd1 4 0.43 0.31 2.77
187 INT112147 Positive_regulation of Negative_regulation of Il1b 3 0.49 3.42 2.77
188 INT16715 Positive_regulation of Transcription of Oprd1 3 0.66 0.6 2.74
189 INT95735 Regulation of Phosphorylation of Mapk8 7 0.50 1.88 2.69
190 INT10350 Negative_regulation of Regulation of Il1b 3 0.41 0.58 2.69
191 INT49759 Negative_regulation of CETP 43 0.58 52 2.68
192 INT115250 Positive_regulation of Slc2a4 16 0.67 8.13 2.64
193 INT11379 Positive_regulation of Negative_regulation of IL1B 9 0.49 7.2 2.64
194 INT95739 Negative_regulation of Phosphorylation of Mapk8 11 0.42 6.77 2.61
195 INT144057 Transcription of SRI 5 0.67 7.94 2.6
196 INT15144 Protein_catabolism of IL1B 11 0.92 4.67 2.58
197 INT65603 Positive_regulation of SRI 8 0.41 2.32 2.56
198 INT118374 Negative_regulation of Npff 2 0.42 0.59 2.56
199 INT76679 Positive_regulation of Transcription of Il1rn 1 0.37 9.13 2.55
200 INT62064 Negative_regulation of Gene_expression of Il1rn 6 0.32 4.81 2.53
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