GO:0032007

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Name negative regulation of TOR signaling cascade
Categary Process
Go Slim No
Go Link GO:0032007
Unique Molecular Interactions 292
Total Molecular Interactions 387
Total Single Events 2394
Pain Genes Associated 20

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of TOR signaling cascade. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of TOR signaling cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
2 INT108546 BCL2L10 Regulation of MAPKAPK5 1 0.03 1.22 1.1
3 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
4 INT338894 TNFSF14 Negative_regulation of Gsk3a 1 0.00 0.54 1.04
5 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
6 INT135176 Myst2 Regulation of Gene_expression of Hif1a 1 0.24 0.47 0.47
7 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
8 INT135178 Myst2 Regulation of Hif1a 1 0.24 0.44 0.44
9 INT299307 AKT1 Positive_regulation of Positive_regulation of AKT1S1 1 0.10 0 0.3
10 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
11 INT121583 Negative_regulation of GSK3A Negative_regulation of Gene_expression of GDF15 1 0.11 0.49 0.2
12 INT168828 Binding of DDB1 and UBR1 1 0.00 0.67 0.19
13 INT307453 Bdnf Positive_regulation of Phosphorylation of Gsk3a 1 0.06 0.16 0.18
14 INT130932 Negative_regulation of Cpox Positive_regulation of Gene_expression of TSC1 1 0.00 0.42 0.18
15 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
16 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
17 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
18 INT237418 Binding of Hif1a and Bace1 1 0.06 1.18 0.15
19 INT43494 Akt1s1 Regulation of Gene_expression of Ifng 1 0.05 0 0.15
20 INT157275 Binding of PRKAA1 and Adipoq 1 0.01 1.13 0.15
21 INT157273 Adipoq Positive_regulation of PRKAA1 1 0.03 1.16 0.14
22 INT252901 PTTG1 Regulation of Gene_expression of TSC1 1 0.00 1.61 0.13
23 INT323434 Osr1 Regulation of Hif1a 1 0.01 0.79 0.13
24 INT323433 Osr1 Regulation of Protein_catabolism of Hif1a 1 0.01 0.8 0.13
25 INT232787 CYBB Positive_regulation of Positive_regulation of Hif1a 1 0.01 0.66 0.12
26 INT323431 Binding of Hif1a and Vhl 1 0.07 0.68 0.12
27 INT249923 Binding of Pah and Hif1a 1 0.31 1.16 0.12
28 INT289765 Akt1 Regulation of Phosphorylation of Gsk3a 1 0.05 0.45 0.11
29 INT168827 Binding of TRPC4AP and UBR1 1 0.00 0.34 0.1
30 INT272006 Binding of YWHAQ and Tsc2 1 0.27 0.39 0.1
31 INT74014 Binding of TSC1 and XRCC1 1 0.02 1.98 0.09
32 INT276304 PRDM1 Regulation of TSC1 1 0.01 1.29 0.09
33 INT276391 Prdm1 Regulation of TSC1 1 0.00 1.29 0.09
34 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
35 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
36 INT249920 Negative_regulation of Binding of Pah and Hif1a 1 0.37 0.76 0.08
37 INT272012 Binding of TSC1 and Lsamp 1 0.03 2.1 0.08
38 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
39 INT157264 PPARA Positive_regulation of PRKAA1 1 0.03 0.92 0.08
40 INT157271 Adipor1 Positive_regulation of PRKAA1 1 0.01 0.89 0.08
41 INT316127 IL10 Regulation of UBR1 1 0.00 1.06 0.08
42 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
43 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
44 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
45 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
46 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
47 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
48 INT247578 Hif1a Regulation of VEGFA 1 0.02 1.59 0.07
49 INT272003 Binding of Tsc2 and Tsc1 1 0.18 1.1 0.07
50 INT253377 Lep Negative_regulation of Phosphorylation of Prkaa2 1 0.24 1.24 0.06
51 INT307454 Prkcg Regulation of Phosphorylation of Gsk3a 1 0.04 0.13 0.05
52 INT308328 Hif1a Regulation of Positive_regulation of Trib3 1 0.02 0.89 0.05
53 INT304322 Hif1a Positive_regulation of Positive_regulation of VEGFA 1 0.11 0.39 0.05
54 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05
55 INT253413 ATIC Positive_regulation of Gene_expression of Prkaa2 1 0.02 0 0.04
56 INT246793 Binding of Tsc2 and Tsc1 1 0.04 0.71 0.04
57 INT249921 Binding of Hif1a and Asph 1 0.05 0.41 0.04
58 INT307462 Gsk3a Regulation of Ntrk2 1 0.04 0.09 0.04
59 INT253417 ATIC Positive_regulation of Prkaa2 1 0.02 0.31 0.04
60 INT253363 Lep Regulation of Prkaa2 1 0.15 0.08 0.04
61 INT246786 Ogg1 Regulation of Phosphorylation of Tsc2 1 0.20 0.42 0.04
62 INT307455 Gsk3a Regulation of Bdnf 1 0.06 0.09 0.04
63 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
64 INT253365 Il6 Negative_regulation of Prkaa2 1 0.23 0 0.04
65 INT228591 Adipoq Positive_regulation of Phosphorylation of Prkaa2 1 0.31 0.61 0.04
66 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
67 INT302159 TSC1 Positive_regulation of Transcription of CDKN1A 1 0.00 0.28 0.03
68 INT253415 ATIC Regulation of Phosphorylation of Prkaa2 1 0.03 0 0.03
69 INT253418 ATIC Regulation of Prkaa2 1 0.02 0 0.03
70 INT272009 Binding of YWHAQ and Tsc1 1 0.37 0.14 0.03
71 INT246791 Tsc2 Regulation of Ogg1 1 0.27 0.56 0.03
72 INT297159 Gsta3 Negative_regulation of Hif1a 1 0.00 0.54 0.03
73 INT322471 Hif1a Positive_regulation of VEGFA 1 0.05 0.26 0.03
74 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
75 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
76 INT341537 F2RL1 Positive_regulation of TSC1 1 0.01 0.76 0.03
77 INT234975 Binding of Dsg3 and Negative_regulation of Gsk3a 1 0.03 0.3 0.03
78 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
79 INT253370 Lep Negative_regulation of Prkaa2 1 0.29 0.18 0.03
80 INT180040 Binding of D7Cwr3P and Sirt1 1 0.00 0 0
81 INT253359 Positive_regulation of Prkaa2 Negative_regulation of Mtor 1 0.26 0.27 0
82 INT300696 Sirt1 Regulation of Cyb5r3 1 0.03 0 0
83 INT247576 Binding of Hif1a and Vbp1 1 0.01 0.6 0
84 INT246784 Negative_regulation of Tsc2 Positive_regulation of Negative_regulation of Ogg1 1 0.20 0.43 0
85 INT135174 Myst2 Positive_regulation of Binding of Hif1a 1 0.41 0 0
86 INT246811 Ros1 Positive_regulation of Tsc2 1 0.02 0 0
87 INT307458 Ntrk2 Positive_regulation of Phosphorylation of Gsk3a 1 0.05 0 0
88 INT299444 Foxl2 Positive_regulation of Sirt1 1 0.24 0.31 0
89 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
90 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 0.25 0.32 0
91 INT253368 Positive_regulation of Lep Positive_regulation of Prkaa2 1 0.26 0.19 0
92 INT246808 Tsc2 Regulation of Regulation of Tsc1 1 0.02 0.05 0
93 INT246794 Ros1 Positive_regulation of Phosphorylation of Tsc2 1 0.03 0.66 0
94 INT307457 Negative_regulation of Pik3cb Positive_regulation of Gsk3a 1 0.06 0.08 0
95 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
96 INT271990 Tsc1 Positive_regulation of Tsc2 1 0.36 0.31 0
97 INT247574 Ube2e3 Positive_regulation of Hif1a 1 0.04 0.62 0
98 INT272018 Binding of TSC1 and Tsc2 1 0.17 0.48 0
99 INT331222 Tsc1 Negative_regulation of Mtor 1 0.00 0.68 0
100 INT271996 Binding of Plk1 and Tsc1 1 0.09 0.32 0
101 INT297614 ZNF275 Positive_regulation of Gene_expression of TSC1 1 0.00 1.56 0
102 INT289534 Sirt1 Regulation of Regulation of Pomc 1 0.04 0.15 0
103 INT246787 Akt2 Positive_regulation of Phosphorylation of Tsc2 1 0.10 0.16 0
104 INT246789 Pik3c3 Regulation of Tsc2 1 0.02 0.34 0
105 INT271991 Tsc1 Regulation of Tsc2 1 0.23 0.15 0
106 INT272015 Pkd1 Positive_regulation of Localization of TSC1 1 0.18 0.65 0
107 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0
108 INT291335 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK3A 1 0.07 0.88 0
109 INT272017 TBC1D7 Positive_regulation of Protein_catabolism of Tsc1 1 0.08 0.46 0
110 INT246809 Negative_regulation of Tsc2 Positive_regulation of Positive_regulation of Ogg1 1 0.20 0.45 0
111 INT253382 Il6 Positive_regulation of Prkaa2 1 0.42 0.19 0
112 INT247575 Binding of Epo and Hif1a 1 0.09 1.24 0
113 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
114 INT253361 Il6 Negative_regulation of Phosphorylation of Prkaa2 1 0.26 0.16 0
115 INT289518 Arc Regulation of Sirt1 1 0.10 0.56 0
116 INT297613 Negative_regulation of ZNF275 Positive_regulation of Gene_expression of TSC1 1 0.00 1.66 0
117 INT330226 Positive_regulation of Prkaa2 Positive_regulation of Trib3 1 0.00 0.07 0
118 INT246801 Negative_regulation of Akt1 Negative_regulation of Phosphorylation of Tsc2 1 0.17 0 0
119 INT135175 Myst2 Positive_regulation of Hif1a 1 0.41 0 0
120 INT246792 Akt1 Positive_regulation of Phosphorylation of Tsc2 1 0.19 0.78 0
121 INT259093 Binding of TSC1 and LMO4 1 0.02 0.74 0
122 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
123 INT272013 Binding of OGG1 and Tsc2 1 0.09 0.67 0
124 INT217786 TSC1 Regulation of MITF 1 0.00 1.27 0
125 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
126 INT272010 Tsc2 Negative_regulation of OGG1 1 0.17 0.6 0
127 INT271966 Phosphorylation of Rasa1 Positive_regulation of Tsc2 1 0.01 0.31 0
128 INT260496 Hif1a Regulation of Gene_expression of VEGFA 1 0.12 0.93 0
129 INT253369 Prkaa2 Negative_regulation of Mtor 1 0.24 0.27 0
130 INT246798 Akt1 Regulation of Tsc2 1 0.16 0.34 0
131 INT351157 TSC1 Positive_regulation of Gene_expression of CAV1 1 0.01 1.43 0
132 INT271985 Tsc1 Regulation of Cdkn1b 1 0.04 0.1 0
133 INT259092 TSC1 Positive_regulation of Gene_expression of TCEAL1 1 0.01 4.58 0
134 INT289517 Sirt1 Regulation of Prkag1 1 0.02 0.08 0
135 INT268596 Mir10a Regulation of TSC1 1 0.01 0.44 0
136 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
137 INT318221 SIRT1 Positive_regulation of FOXO3 1 0.41 0.63 0
138 INT249924 Cpox Positive_regulation of Hif1a 1 0.01 0.68 0
139 INT331224 Binding of Akt1 and Tsc2 1 0.03 0.33 0
140 INT272008 Tsc1 Negative_regulation of Binding of HERC1 1 0.01 0.32 0
141 INT330225 Binding of Tmprss5 and Positive_regulation of Positive_regulation of Prkaa2 1 0.01 0.18 0
142 INT297615 Binding of TSC1 and HDAC9 1 0.01 0.4 0
143 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
144 INT300337 Gene_expression of MITF Negative_regulation of Gene_expression of TSC1 1 0.00 0.65 0
145 INT262710 Binding of Crem and Hif1a 1 0.00 1.85 0
146 INT289598 Binding of Sirt1 and Sirt1 1 0.41 1.15 0
147 INT330224 Tmprss5 Positive_regulation of Prkaa2 1 0.01 0 0
148 INT253379 Lep Positive_regulation of Prkaa2 1 0.39 0.19 0
149 INT217784 Binding of MITF and TSC1 1 0.00 1.21 0
150 INT272014 Binding of RB1CC1 and Tsc1 1 0.05 0.44 0
151 INT246797 Tgfb1i1 Positive_regulation of Phosphorylation of Tsc2 1 0.01 0.66 0
152 INT253373 Binding of Mtor and Prkaa2 1 0.20 0.26 0
153 INT331223 Negative_regulation of Tsc1 Positive_regulation of Positive_regulation of Mtor 1 0.01 0.33 0
154 INT300307 Binding of Tp53 and Sirt1 1 0.24 0.98 0
155 INT289519 Sirt1 Regulation of Rps6kb1 1 0.25 0.13 0
156 INT253372 Prkaa2 Regulation of Mtor 1 0.13 0.09 0
157 INT271984 Binding of Tsc2 and Skp2 1 0.06 0.34 0
158 INT289530 Sirt1 Regulation of Foxo1 1 0.25 0.42 0
159 INT289523 Binding of Foxo1 and Positive_regulation of Sirt1 1 0.36 0.13 0
160 INT272011 Binding of RAB5A and Tsc2 1 0.02 0.16 0
161 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
162 INT272004 Binding of Hspa1b and Tsc2 1 0.01 0.45 0
163 INT314132 Sirt1 Positive_regulation of Ppargc1a 1 0.50 2.3 0
164 INT271983 Binding of Tsc2 and Rap1a 1 0.02 0.16 0
165 INT307460 P2rx7 Positive_regulation of Phosphorylation of Gsk3a 1 0.02 0 0
166 INT299451 Foxl2 Negative_regulation of Gene_expression of Sirt1 1 0.25 0.32 0
167 INT246806 Gene_expression of Akt1 Positive_regulation of Phosphorylation of Tsc2 1 0.19 0.32 0
168 INT314689 Binding of KITLG and UBR1 1 0.00 0.71 0
169 INT289531 Acsm3 Positive_regulation of Sirt1 1 0.01 0.27 0
170 INT253381 Il6 Regulation of Prkaa2 1 0.16 0 0
171 INT307451 Fig4 Regulation of Phosphorylation of Gsk3a 1 0.01 0.06 0
172 INT286569 Binding of Pkd1 and Tsc2 1 0.06 1.01 0
173 INT322470 Binding of Bcl6 and Hif1a 1 0.06 0.52 0
174 INT246803 Binding of Akt1 and Tsc2 1 0.14 0.85 0
175 INT276212 Binding of Akt1 and Gsk3a 1 0.11 0 0
176 INT217774 TP53 Regulation of TSC1 1 0.02 1.28 0
177 INT271989 Binding of Tsc2 and Psmd9 1 0.02 0.47 0
178 INT217791 TP53 Positive_regulation of TSC1 1 0.04 0.61 0
179 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 0.36 0.52 0
180 INT300631 Binding of TSC1 and TSC2 1 0.15 2.59 0
181 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
182 INT246790 Gene_expression of Ros1 Positive_regulation of Phosphorylation of Tsc2 1 0.02 0 0
183 INT291331 Negative_regulation of GSK3A Positive_regulation of Positive_regulation of RAF1 1 0.07 0.94 0
184 INT272007 Binding of Tsc2 and SCPEP1 1 0.27 0.46 0
185 INT271998 Cdk1 Positive_regulation of Phosphorylation of Tsc1 1 0.17 0.3 0
186 INT268509 MIR146B Regulation of TSC1 1 0.03 0.44 0
187 INT271987 Tsc2 Regulation of Skp2 1 0.10 0.28 0
188 INT246800 Binding of Tsc2 and Ogg1 1 0.16 0.38 0
189 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0
190 INT271986 Tsc1 Regulation of Skp2 1 0.13 0.14 0
191 INT289535 Negative_regulation of Sirt1 Negative_regulation of Binding of Foxo1 1 0.29 0.14 0
192 INT330223 Binding of Tmprss5 and Positive_regulation of Prkaa2 1 0.01 0.18 0
193 INT307452 Negative_regulation of Pik3cb Positive_regulation of Phosphorylation of Gsk3a 1 0.06 0.08 0
194 INT331221 Binding of Akt1 and Tsc1 1 0.03 0.33 0
195 INT289529 Lep Regulation of Sirt1 1 0.28 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of TOR signaling cascade. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of TOR signaling cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94
2 INT116641 Phosphorylation of Gsk3a 12 0.71 4.3 6.22
3 INT135170 Positive_regulation of Hif1a 86 0.67 99.4 6.07
4 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
5 INT112713 Gene_expression of Hif1a 24 0.75 20.48 5.45
6 INT135172 Gene_expression of Hif1a 56 0.76 46.49 5.44
7 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
8 INT128746 Negative_regulation of Gsk3a 11 0.52 8.43 4.61
9 INT112704 Positive_regulation of Hif1a 25 0.67 21.49 4.23
10 INT73463 Positive_regulation of Gene_expression of TSC1 20 0.38 14.59 3.53
11 INT134756 Positive_regulation of Gene_expression of Hif1a 8 0.50 11.14 2.68
12 INT92000 Gene_expression of Gsk3a 12 0.18 4.12 2.39
13 INT121589 Negative_regulation of GSK3A 10 0.53 9.11 2.22
14 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
15 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87
16 INT122597 Transcription of Hif1a 5 0.69 5.56 1.63
17 INT153723 Negative_regulation of Gene_expression of Hif1a 2 0.41 1.25 1.58
18 INT261849 Positive_regulation of Phosphorylation of Gsk3a 3 0.14 1.15 1.57
19 INT135171 Positive_regulation of Gene_expression of Hif1a 15 0.68 16.95 1.51
20 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
21 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
22 INT214073 Binding of TSC1 9 0.37 22 1.34
23 INT232785 Localization of Hif1a 8 0.46 10.37 1.33
24 INT163506 Binding of Gsk3a 4 0.32 1.41 1.31
25 INT108551 Gene_expression of MAPKAPK5 1 0.15 1.23 1.1
26 INT108553 Negative_regulation of Gene_expression of MAPKAPK5 1 0.09 1.23 1.1
27 INT108552 Regulation of MAPKAPK5 1 0.10 1.19 1.08
28 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
29 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
30 INT71747 Positive_regulation of Prkaa2 19 0.46 8.76 0.98
31 INT73465 Transcription of TSC1 4 0.07 3.47 0.96
32 INT253940 Gene_expression of Gsk3a 1 0.08 2.82 0.92
33 INT253938 Positive_regulation of Gsk3a 3 0.06 3.4 0.9
34 INT91995 Positive_regulation of Gsk3a 8 0.14 2.84 0.86
35 INT307469 Regulation of Gsk3a 4 0.09 1.12 0.83
36 INT107161 Positive_regulation of MAPKAPK5 2 0.16 1.15 0.82
37 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
38 INT74019 Regulation of TSC1 27 0.35 23.61 0.79
39 INT135169 Binding of Hif1a 22 0.47 12.48 0.79
40 INT252054 Phosphorylation of TSC2 4 0.80 0.63 0.67
41 INT233837 Negative_regulation of Hif1a 9 0.26 12.72 0.65
42 INT112708 Negative_regulation of Hif1a 5 0.38 2.7 0.64
43 INT136465 Regulation of Hif1a 5 0.39 7.05 0.62
44 INT151663 Regulation of Gsk3a 3 0.16 1.03 0.54
45 INT135173 Regulation of Gene_expression of Hif1a 3 0.44 2.49 0.53
46 INT134758 Positive_regulation of Transcription of Hif1a 2 0.33 2.44 0.53
47 INT85759 Localization of Gsk3a 3 0.55 0.43 0.52
48 INT153065 Regulation of Hif1a 8 0.28 8.57 0.51
49 INT228570 Phosphorylation of Prkaa2 24 0.61 7.9 0.5
50 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
51 INT153067 Positive_regulation of Positive_regulation of Hif1a 10 0.49 11.83 0.47
52 INT271939 Regulation of Tsc1 2 0.41 1.16 0.47
53 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45
54 INT163507 Negative_regulation of Phosphorylation of Gsk3a 3 0.51 0.96 0.45
55 INT307472 Regulation of Negative_regulation of Gsk3a 2 0.05 0.83 0.45
56 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
57 INT307464 Regulation of Phosphorylation of Gsk3a 1 0.12 0.42 0.43
58 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
59 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
60 INT151662 Negative_regulation of Gsk3a 3 0.15 0.55 0.37
61 INT247549 Transcription of Hif1a 7 0.42 8.77 0.36
62 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
63 INT320784 Protein_catabolism of Hif1a 3 0.61 2.41 0.34
64 INT221833 Positive_regulation of TSC2 2 0.23 0.39 0.33
65 INT184803 Localization of TSC1 5 0.37 6.13 0.32
66 INT247563 Negative_regulation of Positive_regulation of Hif1a 1 0.16 9.12 0.32
67 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
68 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
69 INT71752 Negative_regulation of Prkaa2 17 0.39 2.81 0.3
70 INT256540 Regulation of Gene_expression of TSC1 4 0.07 4.74 0.3
71 INT71750 Regulation of Prkaa2 12 0.41 2.98 0.29
72 INT226115 Positive_regulation of PRKAA1 2 0.15 0.45 0.29
73 INT299320 Positive_regulation of AKT1S1 1 0.13 0 0.29
74 INT299337 Phosphorylation of AKT1S1 1 0.17 0 0.29
75 INT228321 Gene_expression of AKT1S1 1 0.16 0.35 0.29
76 INT232786 Positive_regulation of Localization of Hif1a 2 0.31 2.63 0.27
77 INT97779 Negative_regulation of TSC2 3 0.41 3.45 0.26
78 INT322756 Negative_regulation of Tsc1 1 0.07 1.4 0.26
79 INT246762 Phosphorylation of Tsc2 60 0.67 15.71 0.25
80 INT187504 Gene_expression of Prkaa2 5 0.65 1.3 0.22
81 INT154360 Localization of Tsc2 1 0.56 0.16 0.22
82 INT217832 Negative_regulation of Gene_expression of TSC1 5 0.04 5.45 0.21
83 INT253395 Negative_regulation of Phosphorylation of Prkaa2 9 0.39 1.35 0.2
84 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
85 INT121586 Positive_regulation of GSK3A 2 0.23 0.86 0.2
86 INT121585 Negative_regulation of Positive_regulation of GSK3A 1 0.11 0.49 0.2
87 INT247564 Positive_regulation of Transcription of Hif1a 1 0.19 2.05 0.2
88 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
89 INT154710 Gene_expression of UBR1 3 0.47 1.64 0.15
90 INT253401 Positive_regulation of Positive_regulation of Prkaa2 2 0.33 1.39 0.15
91 INT249919 Regulation of Regulation of Hif1a 2 0.29 1.81 0.14
92 INT168841 Protein_catabolism of UBR1 2 0.03 0.42 0.14
93 INT249908 Binding of Hif1a 2 0.31 1.48 0.14
94 INT256111 Regulation of Gene_expression of Sirt1 1 0.32 0.73 0.14
95 INT271943 Phosphorylation of Tsc2 9 0.52 3.35 0.13
96 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
97 INT119228 Gene_expression of TSC2 3 0.75 4.43 0.13
98 INT249913 Regulation of Gene_expression of Hif1a 2 0.32 1.82 0.13
99 INT246776 Negative_regulation of Tsc2 18 0.48 6.82 0.12
100 INT246749 Negative_regulation of Phosphorylation of Tsc2 11 0.35 3.4 0.12
101 INT271941 Binding of Tsc2 12 0.24 2.96 0.11
102 INT259745 Phosphorylation of GSK3A 6 0.20 3 0.11
103 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
104 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
105 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
106 INT289741 Phosphorylation of Gsk3a 1 0.24 0.45 0.11
107 INT187495 Positive_regulation of Gene_expression of Prkaa2 1 0.49 0.09 0.11
108 INT91997 Regulation of Gene_expression of Gsk3a 1 0.03 0.56 0.1
109 INT153064 Positive_regulation of Regulation of Hif1a 1 0.45 1.52 0.1
110 INT253404 Positive_regulation of Phosphorylation of Prkaa2 3 0.29 1.23 0.09
111 INT260478 Negative_regulation of Positive_regulation of Hif1a 2 0.30 1.23 0.09
112 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09
113 INT173222 Negative_regulation of Negative_regulation of TSC1 1 0.01 0.92 0.09
114 INT246772 Regulation of Phosphorylation of Tsc2 1 0.26 1.37 0.09
115 INT260462 Negative_regulation of Binding of Hif1a 1 0.30 1.13 0.09
116 INT253390 Negative_regulation of Positive_regulation of Prkaa2 4 0.28 0.76 0.08
117 INT260451 Positive_regulation of Positive_regulation of Hif1a 1 0.36 1.01 0.08
118 INT190703 Regulation of Negative_regulation of TSC1 3 0.06 3.08 0.07
119 INT307465 Positive_regulation of Positive_regulation of Gsk3a 1 0.10 0.24 0.07
120 INT271938 Binding of Tsc1 1 0.43 3.18 0.07
121 INT297157 Negative_regulation of Negative_regulation of Hif1a 1 0.03 0.54 0.07
122 INT289574 Negative_regulation of Positive_regulation of Sirt1 1 0.42 0.42 0.07
123 INT247560 Negative_regulation of Negative_regulation of Hif1a 1 0.16 2.06 0.07
124 INT256136 Negative_regulation of Binding of Sirt1 1 0.30 0.5 0.07
125 INT11531 Binding of UBR1 1 0.01 0.07 0.07
126 INT307482 Regulation of Regulation of Gsk3a 1 0.05 0 0.07
127 INT247553 Regulation of Negative_regulation of Hif1a 1 0.17 1.36 0.06
128 INT297158 Regulation of Localization of Hif1a 1 0.03 0.32 0.06
129 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
130 INT247559 Regulation of Positive_regulation of Hif1a 2 0.23 1.64 0.05
131 INT247555 Positive_regulation of Binding of Hif1a 2 0.31 1.15 0.05
132 INT256137 Positive_regulation of Regulation of Sirt1 1 0.36 0.32 0.05
133 INT246770 Positive_regulation of Negative_regulation of Tsc2 1 0.20 1.91 0.05
134 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
135 INT289587 Negative_regulation of Negative_regulation of Sirt1 1 0.42 0.65 0.05
136 INT256129 Negative_regulation of Gene_expression of Sirt1 1 0.31 0.4 0.05
137 INT297156 Localization of Hif1a 1 0.06 0.32 0.05
138 INT322464 Regulation of Localization of Hif1a 1 0.28 0.59 0.05
139 INT253387 Negative_regulation of Regulation of Prkaa2 1 0.28 0.08 0.05
140 INT271914 Negative_regulation of Tsc1 5 0.38 3.08 0.04
141 INT271916 Positive_regulation of Phosphorylation of Tsc2 4 0.32 0.52 0.04
142 INT242338 Binding of TSC2 2 0.22 1.56 0.04
143 INT249918 Regulation of Protein_catabolism of Hif1a 1 0.29 0.4 0.04
144 INT249916 Protein_catabolism of Hif1a 1 0.64 0.39 0.04
145 INT271930 Gene_expression of Tsc1 1 0.69 6.88 0.04
146 INT246758 Gene_expression of Tsc1 1 0.11 0.55 0.04
147 INT271937 Positive_regulation of Binding of Tsc2 1 0.25 0 0.04
148 INT119227 Gene_expression of Tsc2 8 0.68 10.67 0.03
149 INT289584 Binding of Sirt1 3 0.48 1.35 0.03
150 INT270038 Positive_regulation of Positive_regulation of Sirt1 2 0.43 0.44 0.03
151 INT190057 Positive_regulation of Negative_regulation of TSC1 2 0.01 1.08 0.03
152 INT246622 Phosphorylation of Sirt1 2 0.74 0.56 0.03
153 INT271960 Positive_regulation of Binding of TSC1 1 0.25 0.88 0.03
154 INT190054 Negative_regulation of Positive_regulation of TSC1 1 0.01 0.83 0.03
155 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
156 INT204349 Regulation of SIRT1 8 0.61 1.99 0
157 INT246774 Positive_regulation of Tsc2 6 0.41 2.4 0
158 INT271919 Gene_expression of Tsc2 6 0.39 2.23 0
159 INT228895 Binding of Tsc2 5 0.30 2.41 0
160 INT256134 Localization of Sirt1 5 0.50 2.99 0
161 INT271936 Phosphorylation of Tsc1 4 0.73 1.76 0
162 INT246755 Regulation of Tsc2 4 0.50 1.01 0
163 INT204353 Transcription of SIRT1 3 0.68 0.67 0
164 INT216011 Regulation of TSC2 2 0.26 3.31 0
165 INT271921 Negative_regulation of Tsc2 2 0.26 1.19 0
166 INT253402 Binding of Prkaa2 2 0.24 0.43 0
167 INT175424 Regulation of Transcription of TSC1 2 0.05 1.39 0
168 INT271944 Negative_regulation of Phosphorylation of Tsc2 2 0.30 0.42 0
169 INT246761 Positive_regulation of Gene_expression of Tsc2 2 0.41 1.17 0
170 INT271963 Phosphorylation of TSC1 2 0.31 2.02 0
171 INT325783 Positive_regulation of UBR1 1 0.01 0.05 0
172 INT246777 Regulation of Gene_expression of Tsc2 1 0.19 0 0
173 INT253408 Positive_regulation of Negative_regulation of Prkaa2 1 0.33 0.44 0
174 INT246754 Negative_regulation of Binding of Tsc2 1 0.18 0.12 0
175 INT271905 Positive_regulation of Protein_catabolism of Tsc2 1 0.35 1.46 0
176 INT271965 Negative_regulation of Binding of TSC1 1 0.33 0.44 0
177 INT246748 Regulation of Tsc1 1 0.04 0.05 0
178 INT204361 Negative_regulation of SIRT1 1 0.42 0.18 0
179 INT289569 Transcription of Sirt1 1 0.71 0.25 0
180 INT246747 Negative_regulation of Negative_regulation of Tsc2 1 0.18 0.56 0
181 INT300686 Regulation of Binding of Sirt1 1 0.44 0.06 0
182 INT325798 Regulation of UBR1 1 0.00 0 0
183 INT271904 Localization of Tsc2 1 0.41 1.31 0
184 INT249915 Regulation of Positive_regulation of Hif1a 1 0.29 0.85 0
185 INT300287 Localization of Sirt1 1 0.66 1.46 0
186 INT330234 Localization of Prkaa2 1 0.21 0 0
187 INT112706 Negative_regulation of Gene_expression of Hif1a 1 0.08 0 0
188 INT289583 Regulation of Transcription of Sirt1 1 0.27 0.25 0
189 INT246773 Phosphorylation of Tsc1 1 0.13 0.05 0
190 INT303317 Binding of AKT1S1 1 0.04 0.1 0
191 INT300683 Positive_regulation of Negative_regulation of Sirt1 1 0.45 0 0
192 INT246780 Protein_catabolism of Tsc2 1 0.28 0.15 0
193 INT286549 Regulation of Tsc2 1 0.11 0.42 0
194 INT322450 Negative_regulation of Binding of Hif1a 1 0.26 0.32 0
195 INT204371 Positive_regulation of Transcription of SIRT1 1 0.49 0.13 0
196 INT253394 Negative_regulation of Negative_regulation of Prkaa2 1 0.28 0.33 0
197 INT246752 Negative_regulation of Gene_expression of Tsc2 1 0.25 0.52 0
198 INT258227 Positive_regulation of Regulation of GSK3A 1 0.15 0 0
199 INT318239 Regulation of Transcription of SIRT1 1 0.26 0.45 0
200 INT271913 Protein_catabolism of Tsc1 1 0.51 0.45 0
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