GO:0032025

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Name response to cobalt ion
Categary Process
Go Slim No
Go Link GO:0032025
Unique Molecular Interactions 114
Total Molecular Interactions 134
Total Single Events 1987
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to cobalt ion. They are ordered first by their pain relevance and then by number of times they were reported for response to cobalt ion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35
2 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
3 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
4 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19
5 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
6 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
7 INT106751 Pes1 Negative_regulation of Casp3 2 0.23 0 1.54
8 INT137657 Gorasp2 Regulation of Binding of Casp3 1 0.09 0 1.52
9 INT83707 Acyp2-ps1 Regulation of Casp3 1 0.17 0 1.28
10 INT83705 Acyp2-ps1 Regulation of Positive_regulation of Casp3 1 0.17 0 1.28
11 INT145315 D2Mit212 Regulation of Casp3 1 0.00 0 1.24
12 INT145316 D2Mit212 Regulation of Positive_regulation of Casp3 1 0.00 0 1.24
13 INT145317 D2Mit212 Positive_regulation of Casp3 1 0.01 0 1.22
14 INT93435 Binding of Casp3 and Cckbr 1 0.06 0.15 1.18
15 INT98180 Aap Positive_regulation of Positive_regulation of Casp3 1 0.00 1.08 0.97
16 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
17 INT116250 Vta1 Positive_regulation of Casp3 1 0.01 0 0.82
18 INT56236 Casp3 Positive_regulation of Gene_expression of RT1-Cl 1 0.00 0.45 0.82
19 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
20 INT129694 Binding of Casp3 and Casp9 1 0.35 0.86 0.65
21 INT351445 Binding of Vta1 and Positive_regulation of Casp3 1 0.01 0.39 0.64
22 INT106754 Pes1 Positive_regulation of Casp3 1 0.13 0 0.63
23 INT106752 Negative_regulation of Pes1 Positive_regulation of Casp3 1 0.12 0 0.63
24 INT83706 Acyp2-ps1 Positive_regulation of Casp3 1 0.11 0 0.61
25 INT133320 Penk Negative_regulation of Gene_expression of Casp3 1 0.11 0.91 0.6
26 INT141362 EP300 Negative_regulation of Transcription of IL2 1 0.17 0 0.56
27 INT147040 Hmbs Negative_regulation of Nppa 1 0.07 0.95 0.55
28 INT167651 Binding of Oprd1 and Ep300 1 0.02 0.09 0.55
29 INT112399 Olr897-ps Regulation of Gene_expression of Casp3 1 0.03 0 0.54
30 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
31 INT162720 PEG3 Negative_regulation of Positive_regulation of CASP8 1 0.00 0.71 0.52
32 INT74517 Binding of Casp3 and Cnrip1 1 0.31 0 0.51
33 INT167652 Binding of Ep300 and Ngf 1 0.09 0.06 0.51
34 INT167655 Binding of Polr2f and Ep300 1 0.01 0.06 0.51
35 INT351446 Gria2 Negative_regulation of Casp3 1 0.02 0.37 0.47
36 INT155085 CASP1 Negative_regulation of CASP8 1 0.29 1.25 0.44
37 INT121850 CASP8 Positive_regulation of Protein_catabolism of BID 2 0.21 1.81 0.43
38 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
39 INT57236 Casp3 Positive_regulation of Prl 1 0.09 0 0.41
40 INT121855 CASP8 Regulation of ROS1 1 0.05 0.52 0.41
41 INT121849 CASP8 Positive_regulation of CYCS 1 0.35 0.48 0.4
42 INT121852 CASP8 Positive_regulation of Localization of CYCS 1 0.32 0.48 0.4
43 INT57235 Casp3 Positive_regulation of Localization of Prl 1 0.15 0 0.4
44 INT52960 Casp3 Negative_regulation of Positive_regulation of Ltp 1 0.02 0 0.37
45 INT147041 Hmbs Negative_regulation of Negative_regulation of Nppa 1 0.05 0.51 0.3
46 INT256656 Binding of EP300 and HHIP 1 0.22 0 0.24
47 INT289998 CNTF Negative_regulation of Casp3 1 0.04 0.99 0.22
48 INT289981 Cntf Negative_regulation of Casp3 1 0.02 1.01 0.22
49 INT349344 Bdnf Negative_regulation of Casp3 1 0.13 0.96 0.22
50 INT289999 Binding of CNTF and Casp3 1 0.04 0.99 0.22
51 INT181675 Positive_regulation of Casp9 Positive_regulation of Casp3 1 0.06 0.51 0.2
52 INT315384 Adcyap1 Negative_regulation of Positive_regulation of Casp3 1 0.02 0.53 0.2
53 INT175948 TNF Positive_regulation of Positive_regulation of CASP8 1 0.02 1.12 0.2
54 INT175947 TNFSF10 Positive_regulation of Positive_regulation of CASP8 1 0.01 1.12 0.2
55 INT325529 Binding of Stat3 and Ep300 1 0.01 0.22 0.19
56 INT181677 Casp9 Positive_regulation of Casp3 1 0.06 0.5 0.19
57 INT261387 Nsdhl Negative_regulation of Casp3 1 0.03 1.08 0.19
58 INT325531 Positive_regulation of Binding of Stat3 and Ep300 1 0.02 0.22 0.19
59 INT351442 Gria2 Regulation of Gene_expression of Casp3 1 0.01 0 0.18
60 INT275400 Casp3 Positive_regulation of NDRG1 1 0.00 1.36 0.18
61 INT96417 CYC1 Positive_regulation of Casp9 1 0.02 0.96 0.17
62 INT96416 CYC1 Positive_regulation of Casp3 1 0.02 0.96 0.17
63 INT119267 Binding of EP300 and PPM1E 1 0.01 0.46 0.17
64 INT235441 HMBS Regulation of PPARA 1 0.03 0.76 0.16
65 INT149095 PITX2 Positive_regulation of Casp3 1 0.00 1.51 0.15
66 INT292748 Akt1 Negative_regulation of Positive_regulation of Casp3 1 0.01 1.81 0.15
67 INT130923 HMHA1 Positive_regulation of Protein_catabolism of CASP8 1 0.04 1.37 0.14
68 INT226205 Negative_regulation of Akt1 Positive_regulation of Casp3 1 0.04 0.71 0.14
69 INT130920 HMHA1 Positive_regulation of CASP8 1 0.04 1.36 0.14
70 INT275397 Binding of ITIH4 and Casp3 1 0.02 0.64 0.13
71 INT252631 Binding of Casp3 and Tnfrsf1a 1 0.10 0.69 0.13
72 INT275389 Binding of Casp3 and Htatsf1 1 0.00 0.64 0.13
73 INT342309 Apaf1 Positive_regulation of Casp9 1 0.02 1.1 0.13
74 INT252632 Binding of Casp3 and Tradd 1 0.11 0.68 0.12
75 INT349345 Bdnf Negative_regulation of Positive_regulation of Casp3 1 0.13 1.02 0.12
76 INT201754 CASP8 Positive_regulation of Casp3 1 0.00 0.47 0.12
77 INT315391 IFNA1 Positive_regulation of Casp3 1 0.00 0.1 0.12
78 INT315390 Positive_regulation of IFNA1 Positive_regulation of Casp3 1 0.00 0.1 0.12
79 INT142961 Binding of Nfkb1 and Casp3 1 0.00 1.02 0.11
80 INT322019 CASP8 Regulation of Gene_expression of IL1B 1 0.02 0 0.1
81 INT285023 Casp3 Negative_regulation of Casp7 1 0.07 0.44 0.1
82 INT304000 Lep Negative_regulation of Positive_regulation of CASP8 1 0.04 0.25 0.1
83 INT287880 Binding of CREB1 and EP300 1 0.01 0 0.08
84 INT119266 CDKN1A Regulation of EP300 1 0.47 0.44 0.07
85 INT302162 CASP8 Positive_regulation of CASP3 2 0.01 2.07 0.04
86 INT332438 CASP8 Positive_regulation of Gene_expression of BID 1 0.02 1.33 0.03
87 INT247847 Narfl Positive_regulation of Positive_regulation of Casp3 1 0.02 0.79 0
88 INT303251 HMBS Positive_regulation of Protein_catabolism of Dlgap1 1 0.01 0 0
89 INT268520 MIR19B1 Regulation of CASP8 1 0.14 1 0
90 INT287875 EP300 Negative_regulation of HDAC9 1 0.04 0.51 0
91 INT243373 Binding of CASP8 and SERPINH1 1 0.28 1.49 0
92 INT304135 Binding of CEL and Positive_regulation of CASP8 1 0.00 0.52 0
93 INT336035 Positive_regulation of CASP8 Positive_regulation of BID 1 0.03 0.5 0
94 INT348540 TP63 Positive_regulation of CASP8 1 0.03 0.55 0
95 INT172604 Binding of EP300 and TP53 1 0.00 0 0
96 INT322413 Binding of ATF1 and EWSR1 1 0.26 1.3 0
97 INT322553 TNFSF10 Positive_regulation of CASP8 1 0.05 1.79 0
98 INT348528 TRAF2 Positive_regulation of Positive_regulation of CASP8 1 0.02 0.44 0
99 INT172606 EP300 Positive_regulation of CREBBP 1 0.00 0.07 0
100 INT229824 Fos Regulation of Casp9 1 0.07 0.32 0
101 INT229809 Fos Regulation of Casp3 1 0.06 0.32 0
102 INT178938 Binding of Casp9 and Apaf1 1 0.01 0.74 0
103 INT336037 CASP8 Positive_regulation of Positive_regulation of CASP9 1 0.01 0.59 0
104 INT172605 Positive_regulation of Binding of EP300 and TP53 1 0.00 0 0
105 INT237923 CFLAR Positive_regulation of Localization of CASP8 1 0.02 1.54 0
106 INT323708 Binding of CASP8 and FAF1 1 0.07 0.73 0
107 INT200644 HDAC4 Positive_regulation of CASP8 1 0.07 0.92 0
108 INT265455 CSPG4 Negative_regulation of Positive_regulation of CASP8 1 0.04 0.27 0
109 INT242159 Wnt2 Positive_regulation of Localization of Casp3 1 0.05 0.25 0
110 INT336034 CASP8 Positive_regulation of BID 1 0.03 0.5 0
111 INT122482 Negative_regulation of CASP3 Negative_regulation of Positive_regulation of CASP8 1 0.14 1.15 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to cobalt ion. They are ordered first by their pain relevance and then by number of times they were reported in response to cobalt ion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07
2 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68
3 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92
4 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78
5 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63
6 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77
7 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7
8 INT29704 Regulation of Casp3 51 0.56 22.13 22.79
9 INT22547 Regulation of Gene_expression of Casp3 23 0.62 8.04 16.78
10 INT29705 Regulation of Positive_regulation of Casp3 13 0.48 5.37 10.45
11 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08
12 INT152668 Negative_regulation of EP300 13 0.38 7.78 9.03
13 INT88919 Positive_regulation of Casp9 39 0.70 28.64 8.18
14 INT98178 Localization of Casp3 32 0.65 21.01 7.77
15 INT57232 Binding of Casp3 22 0.36 9.42 6.2
16 INT15542 Negative_regulation of CASP8 20 0.41 17.3 5.63
17 INT2213 Regulation of EP300 10 0.54 4.72 4.5
18 INT41878 Positive_regulation of EP300 13 0.61 5.24 3.95
19 INT137656 Negative_regulation of Binding of Casp3 4 0.21 0.7 3.09
20 INT15509 Negative_regulation of HMBS 14 0.58 13.13 2.78
21 INT88852 Protein_catabolism of Casp3 28 0.65 23.57 2.74
22 INT15543 Gene_expression of CASP8 32 0.75 25.6 2.61
23 INT131112 Phosphorylation of Casp3 7 0.63 4.1 2.46
24 INT171511 Gene_expression of EP300 14 0.53 4.17 2.29
25 INT129280 Gene_expression of Casp9 9 0.68 5.48 2.25
26 INT98176 Positive_regulation of Localization of Casp3 7 0.33 6.85 2.12
27 INT3784 Regulation of Hmbs 4 0.38 2.79 2.11
28 INT171514 Binding of EP300 13 0.32 4.32 2.01
29 INT22591 Negative_regulation of Hmbs 6 0.51 5.04 1.74
30 INT121964 Positive_regulation of Positive_regulation of Casp9 8 0.32 5.52 1.73
31 INT172622 Localization of EP300 8 0.65 2.56 1.72
32 INT88916 Negative_regulation of Casp9 5 0.33 3.01 1.67
33 INT15544 Regulation of CASP8 6 0.41 5.83 1.63
34 INT88920 Negative_regulation of Positive_regulation of Casp9 7 0.59 5.27 1.57
35 INT106749 Negative_regulation of Negative_regulation of Casp3 6 0.34 5.12 1.48
36 INT140843 Regulation of Phosphorylation of Casp3 1 0.25 0.37 1.44
37 INT74178 Gene_expression of HMBS 24 0.76 9.62 1.36
38 INT171690 Transcription of Casp3 8 0.55 2.62 1.36
39 INT97943 Positive_regulation of Protein_catabolism of Casp3 7 0.28 7.4 1.35
40 INT15541 Positive_regulation of Negative_regulation of CASP8 2 0.31 1.23 1.31
41 INT93702 Localization of Hmbs 1 0.81 4.84 1.26
42 INT167650 Binding of Ep300 1 0.09 0.14 1
43 INT22592 Positive_regulation of Hmbs 2 0.48 2.27 0.87
44 INT131105 Positive_regulation of Negative_regulation of Casp3 3 0.29 3.15 0.84
45 INT57135 Gene_expression of Hmbs 1 0.32 0.55 0.82
46 INT181667 Regulation of Regulation of Casp3 1 0.22 1.7 0.77
47 INT50291 Positive_regulation of HMBS 10 0.67 8.89 0.73
48 INT129490 Negative_regulation of Protein_catabolism of Casp3 4 0.22 3.91 0.71
49 INT351454 Regulation of Transcription of Casp3 1 0.02 0.51 0.67
50 INT104442 Transcription of ATF1 5 0.06 4.96 0.65
51 INT22593 Negative_regulation of Positive_regulation of Hmbs 1 0.41 1.58 0.64
52 INT125867 Protein_catabolism of CASP8 9 0.65 8.5 0.57
53 INT181673 Negative_regulation of Transcription of Casp3 3 0.34 0.61 0.55
54 INT162721 Negative_regulation of Positive_regulation of CASP8 3 0.12 3.17 0.52
55 INT129281 Positive_regulation of Gene_expression of Casp9 1 0.31 0.84 0.48
56 INT129144 Regulation of Localization of Casp3 1 0.26 0.84 0.44
57 INT235471 Regulation of HMBS 6 0.13 1.8 0.43
58 INT74177 Positive_regulation of Gene_expression of HMBS 6 0.49 2.77 0.3
59 INT135546 Positive_regulation of Positive_regulation of CASP8 13 0.31 10.97 0.28
60 INT176260 Binding of CASP8 5 0.36 2.73 0.27
61 INT159323 Negative_regulation of Protein_catabolism of CASP8 1 0.31 0.59 0.27
62 INT131132 Protein_catabolism of HMBS 5 0.86 1.02 0.24
63 INT325492 Regulation of Ep300 1 0.04 0.29 0.24
64 INT141820 Positive_regulation of Binding of Casp3 1 0.12 0.55 0.24
65 INT120656 Localization of HMBS 3 0.16 2.6 0.23
66 INT195018 Regulation of Negative_regulation of Casp3 1 0.21 0.48 0.2
67 INT212787 Negative_regulation of Binding of EP300 1 0.13 0.53 0.2
68 INT256666 Regulation of Gene_expression of EP300 1 0.14 0.07 0.2
69 INT256661 Regulation of Positive_regulation of EP300 1 0.23 0.07 0.2
70 INT131133 Binding of HMBS 9 0.36 2.13 0.19
71 INT325490 Positive_regulation of Ep300 1 0.03 0.22 0.19
72 INT141821 Binding of Casp9 2 0.18 0.58 0.18
73 INT141822 Positive_regulation of Binding of Casp9 1 0.24 0.53 0.18
74 INT298653 Positive_regulation of Binding of EP300 1 0.11 0.8 0.15
75 INT235464 Regulation of Gene_expression of HMBS 1 0.44 0.23 0.1
76 INT185901 Localization of CASP8 7 0.55 5.38 0.09
77 INT158692 Negative_regulation of Gene_expression of HMBS 1 0.25 0.67 0.09
78 INT120657 Positive_regulation of Localization of HMBS 1 0.00 0.83 0.09
79 INT171688 Positive_regulation of Transcription of Casp3 3 0.28 1.16 0.08
80 INT235472 Negative_regulation of Binding of HMBS 1 0.09 0.28 0.07
81 INT235465 Regulation of Binding of HMBS 1 0.10 0.28 0.07
82 INT322421 Gene_expression of ATF1 2 0.39 1.41 0.05
83 INT292252 Phosphorylation of EP300 1 0.20 0.55 0.05
84 INT336053 Regulation of Positive_regulation of CASP8 2 0.04 1.44 0.04
85 INT237978 Negative_regulation of Negative_regulation of CASP8 1 0.07 1.65 0.03
86 INT216420 Regulation of Gene_expression of Casp9 1 0.03 0.92 0.03
87 INT234430 Negative_regulation of Gene_expression of CASP8 4 0.06 3.79 0
88 INT265477 Positive_regulation of Gene_expression of CASP8 2 0.17 1.57 0
89 INT234423 Regulation of Gene_expression of CASP8 2 0.07 3.03 0
90 INT203927 Positive_regulation of Localization of CASP8 2 0.08 1.98 0
91 INT229834 Localization of Casp9 2 0.20 1.24 0
92 INT222914 Negative_regulation of Gene_expression of EP300 1 0.02 0.05 0
93 INT234405 Regulation of Negative_regulation of CASP8 1 0.09 3.05 0
94 INT194799 Positive_regulation of ATF1 1 0.24 0.17 0
95 INT235463 Regulation of Protein_catabolism of HMBS 1 0.10 0.2 0
96 INT330037 Regulation of Casp9 1 0.03 0.58 0
97 INT237443 Positive_regulation of Phosphorylation of Casp3 1 0.39 0.09 0
98 INT322579 Positive_regulation of Binding of CASP8 1 0.09 0.25 0
99 INT242155 Negative_regulation of Localization of Casp3 1 0.04 0.25 0
100 INT330032 Negative_regulation of Gene_expression of Casp9 1 0.05 0.38 0
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