GO:0032052

From wiki-pain
Jump to: navigation, search
Name bile acid binding
Categary Function
Go Slim No
Go Link GO:0032052
Unique Molecular Interactions 98
Total Molecular Interactions 181
Total Single Events 673
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for bile acid binding. They are ordered first by their pain relevance and then by number of times they were reported for bile acid binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT128860 NR1H4 Negative_regulation of Gene_expression of OPRM1 1 0.15 0.31 0.92
2 INT117604 AKR1C1 Negative_regulation of Positive_regulation of Mpo 1 0.00 1.45 0.78
3 INT177269 Binding of CXADR and NR1H4 1 0.04 0 0.58
4 INT321293 Binding of Nr1h4 and Nr0b2 1 0.18 0.31 0.43
5 INT262189 Binding of Nr1i2 and Nr1h4 1 0.14 0.18 0.36
6 INT262218 Nr1h4 Regulation of Nr1i2 1 0.10 0.15 0.34
7 INT122168 AKR1C1 Regulation of PPARG 1 0.12 0.25 0.31
8 INT156087 Binding of AKR1C3 and Akr1c1 1 0.05 0.31 0.3
9 INT156083 Binding of AKR1C2 and AKR1C3 1 0.05 0.31 0.3
10 INT262144 Nr1h4 Positive_regulation of Positive_regulation of Nr1i2 1 0.19 0.19 0.27
11 INT214658 Fabp1 Regulation of Gene_expression of Il6 1 0.02 0.59 0.27
12 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26
13 INT262180 Nr1h4 Regulation of Sult2a1 1 0.11 0.11 0.25
14 INT262152 Nr1h4 Regulation of Abcc2 1 0.07 0.12 0.25
15 INT173120 Binding of PPARA and NR1H4 8 0.09 2.79 0.23
16 INT262211 Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23
17 INT344714 Nr1h4 Negative_regulation of Gene_expression of Lipg 1 0.02 0.77 0.23
18 INT262159 Positive_regulation of Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23
19 INT90772 Binding of AKR1C4 and AKR1C1 1 0.39 0.08 0.2
20 INT321290 Positive_regulation of Nr1h4 Positive_regulation of Nr0b2 1 0.20 0.2 0.18
21 INT278610 CDCA2 Negative_regulation of NR1H4 1 0.01 0.62 0.13
22 INT264403 NR1H4 Negative_regulation of IL1R2 1 0.04 0.09 0.12
23 INT328370 Binding of CD36 and Fabp1 1 0.01 0.64 0.11
24 INT156056 AKR1C1 Negative_regulation of UMOD 1 0.03 0.41 0.1
25 INT177263 Binding of NR1H4 and FAUP1 1 0.00 0 0.09
26 INT177278 Binding of HLA-DRB4 and NR1H4 1 0.02 0 0.08
27 INT279416 NR1H4 Regulation of PPARA 1 0.01 0.13 0.08
28 INT177265 Binding of CYP3A4 and NR1H4 1 0.03 0 0.08
29 INT279421 Binding of NR1H4 and MLXIPL 1 0.00 0.27 0.07
30 INT177255 Binding of SV2A and NR1H4 1 0.04 0 0.07
31 INT301632 Binding of Dbi and Fabp1 1 0.13 0.49 0.07
32 INT182943 Binding of DR1 and NR1H4 3 0.03 0.14 0.06
33 INT113862 Binding of CA2 and NR1H4 1 0.00 0 0.06
34 INT113861 Binding of CA3 and NR1H4 1 0.00 0 0.06
35 INT177276 Positive_regulation of Binding of CXADR and NR1H4 1 0.04 0 0.05
36 INT177282 Regulation of Binding of CXADR and NR1H4 1 0.02 0 0.05
37 INT177270 Binding of TNFRSF25 and NR1H4 2 0.02 0.21 0.04
38 INT177272 Binding of ABCB1 and NR1H4 1 0.02 0 0.04
39 INT301627 Binding of Fabp1 and Ppara 1 0.21 0.49 0.04
40 INT256418 PPARA Positive_regulation of NR1H4 1 0.01 1.17 0.04
41 INT229811 Fos Positive_regulation of Fabp1 1 0.57 0.2 0.03
42 INT264382 NR1H4 Positive_regulation of VDR 1 0.04 0.09 0.03
43 INT264396 NR1H4 Positive_regulation of THRA 1 0.01 0.09 0.03
44 INT182950 Binding of VDR and NR1H4 5 0.03 1.16 0
45 INT182924 Binding of RARA and NR1H4 3 0.02 1.9 0
46 INT165191 Fabp1 Positive_regulation of Havcr1 1 0.03 0.21 0
47 INT290033 Binding of PPARD and NR1H4 1 0.01 0.39 0
48 INT290027 Binding of PPARG and NR1H4 1 0.03 0.39 0
49 INT290029 Binding of INS and NR1H4 1 0.01 0.47 0
50 INT165198 Positive_regulation of Binding of IL18 and Fabp1 1 0.01 0.55 0
51 INT183014 Binding of NR1H4 and Dre 1 0.00 0.06 0
52 INT182955 Positive_regulation of Binding of VDR and NR1H4 1 0.03 0 0
53 INT301635 Ppara Positive_regulation of Gene_expression of Fabp1 1 0.26 0.29 0
54 INT302303 Binding of NR1H4 and Rdh5 1 0.02 0.11 0
55 INT330956 Binding of TEP1 and NR1H4 1 0.00 1.07 0
56 INT180853 Binding of PLA2G1B and S100A10 1 0.08 0.75 0
57 INT255384 Binding of AKR1C2 and DSG1 1 0.01 1.54 0
58 INT234439 Binding of NR1H4 and HCC 1 0.06 0.82 0
59 INT278605 CDCA2 Positive_regulation of NR1H4 1 0.01 0.36 0
60 INT182930 Binding of TNFRSF10B and NR1H4 1 0.02 0 0
61 INT165196 Binding of IL18 and Fabp1 1 0.01 0.55 0
62 INT135128 Binding of NR1I2 and NR1H4 1 0.09 0.57 0
63 INT182963 Binding of NR1H4 and KCNIP3 1 0.03 0.45 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for bile acid binding. They are ordered first by their pain relevance and then by number of times they were reported in bile acid binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4021 Positive_regulation of PLA2G1B 35 0.70 23.27 8.2
2 INT4022 Negative_regulation of PLA2G1B 30 0.59 10.41 7.58
3 INT14837 Gene_expression of PLA2G1B 12 0.60 10.69 3.58
4 INT43948 Localization of PLA2G1B 17 0.78 6.92 2.99
5 INT132575 Binding of NR1H4 57 0.20 22.06 2.82
6 INT321310 Positive_regulation of Nr1h4 1 0.49 1.75 2.75
7 INT100544 Positive_regulation of Fabp1 16 0.38 6.81 2.63
8 INT169073 Positive_regulation of Nr1h4 8 0.47 2.44 2.45
9 INT214649 Localization of Fabp1 1 0.44 6.06 2.19
10 INT169072 Gene_expression of Nr1h4 7 0.60 6.23 2.18
11 INT114953 Gene_expression of NR1H4 23 0.29 16.58 2.02
12 INT168248 Gene_expression of Fabp1 3 0.43 7.42 1.66
13 INT135132 Positive_regulation of NR1H4 17 0.30 8.63 1.38
14 INT114961 Positive_regulation of Gene_expression of NR1H4 6 0.16 3.55 1.23
15 INT122171 Negative_regulation of AKR1C1 5 0.59 1.92 1.22
16 INT321329 Positive_regulation of Positive_regulation of Nr1h4 1 0.35 0.43 1.07
17 INT41729 Negative_regulation of Positive_regulation of PLA2G1B 3 0.43 2.7 1.02
18 INT91762 Positive_regulation of Gene_expression of PLA2G1B 3 0.17 3.45 0.97
19 INT53852 Binding of Fabp1 1 0.02 0.21 0.85
20 INT163928 Regulation of Fabp1 3 0.34 2.56 0.72
21 INT262091 Negative_regulation of Nr1h4 1 0.15 0.76 0.68
22 INT156085 Negative_regulation of AKR1C2 3 0.54 0.79 0.66
23 INT4020 Regulation of PLA2G1B 2 0.61 0.19 0.64
24 INT115276 Gene_expression of AKR1C1 11 0.77 4.65 0.63
25 INT42098 Regulation of Akr1c1 1 0.37 0 0.6
26 INT78999 Binding of AKR1C1 3 0.36 1.75 0.58
27 INT156077 Negative_regulation of Akr1c1 1 0.09 0.74 0.57
28 INT97664 Binding of AKR1C2 1 0.48 0 0.51
29 INT97663 Localization of AKR1C2 2 0.71 0.43 0.5
30 INT262102 Binding of Nr1h4 1 0.13 0.34 0.43
31 INT122170 Regulation of AKR1C1 1 0.12 0.22 0.42
32 INT234463 Phosphorylation of NR1H4 23 0.34 14.56 0.39
33 INT214657 Positive_regulation of Localization of Fabp1 1 0.38 1.18 0.38
34 INT214650 Positive_regulation of Positive_regulation of Fabp1 1 0.38 0.98 0.35
35 INT214653 Regulation of Positive_regulation of Fabp1 1 0.34 1.45 0.33
36 INT234456 Negative_regulation of Gene_expression of NR1H4 2 0.18 1.05 0.32
37 INT214656 Negative_regulation of Localization of Fabp1 1 0.24 0.81 0.29
38 INT214655 Positive_regulation of Gene_expression of Fabp1 1 0.28 1.29 0.29
39 INT336270 Localization of AKR1C1 1 0.06 1.56 0.29
40 INT168052 Gene_expression of Akr1c1 1 0.40 0 0.28
41 INT154494 Transcription of AKR1C1 4 0.72 0.99 0.27
42 INT156076 Negative_regulation of Localization of Akr1c1 1 0.09 0.43 0.27
43 INT156086 Negative_regulation of Localization of AKR1C2 1 0.10 0.43 0.27
44 INT156078 Localization of Akr1c1 1 0.15 0.43 0.27
45 INT163929 Negative_regulation of Fabp1 3 0.32 1.69 0.26
46 INT123399 Positive_regulation of Positive_regulation of PLA2G1B 1 0.15 0.47 0.26
47 INT292837 Gene_expression of Fabp1 13 0.71 2.73 0.22
48 INT262108 Negative_regulation of Positive_regulation of Nr1h4 1 0.15 0.14 0.22
49 INT173345 Phosphorylation of PLA2G1B 1 0.05 0 0.22
50 INT301533 Positive_regulation of Gene_expression of Fabp1 6 0.37 1.32 0.2
51 INT74514 Binding of PLA2G1B 2 0.48 0.37 0.19
52 INT262261 Negative_regulation of Gene_expression of PLA2G1B 1 0.05 1.07 0.18
53 INT321313 Regulation of Nr1h4 1 0.32 0.37 0.17
54 INT214654 Positive_regulation of Regulation of Fabp1 1 0.28 0.7 0.17
55 INT234469 Negative_regulation of Phosphorylation of NR1H4 2 0.14 1.25 0.16
56 INT1275 Gene_expression of AKR1C2 1 0.75 2.92 0.16
57 INT153084 Positive_regulation of Gene_expression of AKR1C1 4 0.50 1.56 0.14
58 INT234464 Negative_regulation of NR1H4 6 0.19 3.54 0.12
59 INT214652 Regulation of Localization of Fabp1 1 0.25 0.36 0.11
60 INT301590 Binding of Fabp1 6 0.21 2.12 0.1
61 INT234468 Protein_catabolism of NR1H4 2 0.32 0.87 0.09
62 INT177318 Negative_regulation of Binding of NR1H4 5 0.14 3.39 0.08
63 INT214651 Regulation of Gene_expression of Fabp1 1 0.25 0.43 0.08
64 INT266664 Positive_regulation of Localization of PLA2G1B 1 0.12 0.32 0.08
65 INT234477 Localization of NR1H4 3 0.24 2.23 0.07
66 INT321327 Transcription of Nr1h4 1 0.50 0.15 0.07
67 INT321330 Negative_regulation of Transcription of Nr1h4 1 0.30 0.15 0.07
68 INT177877 Positive_regulation of AKR1C1 3 0.50 1.13 0.06
69 INT178538 Transcription of AKR1C2 3 0.67 1.17 0.03
70 INT206951 Gene_expression of Nr1h4 2 0.56 0.68 0.03
71 INT321312 Phosphorylation of Nr1h4 1 0.58 0.23 0.03
72 INT321351 Positive_regulation of Gene_expression of Nr1h4 1 0.49 0.12 0.03
73 INT301528 Positive_regulation of Fabp1 1 0.20 0.12 0.03
74 INT177301 Positive_regulation of Binding of NR1H4 3 0.29 0.45 0
75 INT234451 Positive_regulation of Phosphorylation of NR1H4 1 0.22 5.15 0
76 INT301575 Regulation of Fabp1 1 0.12 0.22 0
77 INT234475 Transcription of NR1H4 1 0.17 1.62 0
78 INT301521 Positive_regulation of Binding of Fabp1 1 0.22 1 0
79 INT207723 Positive_regulation of Transcription of AKR1C1 1 0.33 0.68 0
80 INT178543 Regulation of Gene_expression of AKR1C1 1 0.43 0.32 0
81 INT234470 Positive_regulation of Protein_catabolism of NR1H4 1 0.22 0.93 0
82 INT264439 Regulation of Binding of NR1H4 1 0.19 0 0
83 INT207758 Positive_regulation of AKR1C2 1 0.52 0.67 0
84 INT178546 Negative_regulation of Gene_expression of AKR1C2 1 0.42 0.41 0
85 INT317764 Negative_regulation of Fabp1 1 0.32 0 0
86 INT178533 Negative_regulation of Gene_expression of AKR1C1 1 0.41 0.61 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox