GO:0032059

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Name bleb
Categary Component
Go Slim No
Go Link GO:0032059
Unique Molecular Interactions 81
Total Molecular Interactions 101
Total Single Events 943
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for bleb. They are ordered first by their pain relevance and then by number of times they were reported for bleb. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT351380 Ngf Regulation of TPM1 1 0.44 2.17 2.11
2 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
3 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
4 INT281241 Positive_regulation of P2RX7 Negative_regulation of Gene_expression of P2rx3 1 0.03 0.79 0.71
5 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7
6 INT246335 Fig4 Regulation of Localization of P2rx7 1 0.01 0 0.67
7 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67
8 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
9 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56
10 INT282821 TACR1 Regulation of P2RX7 1 0.01 2.06 0.54
11 INT185490 Atp5o Negative_regulation of Gene_expression of P2rx7 1 0.01 0.87 0.53
12 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
13 INT278122 Negative_regulation of P2rx7 Negative_regulation of Binding of P2RX7 1 0.03 0 0.51
14 INT278105 Negative_regulation of TP63 Negative_regulation of Binding of P2RX7 1 0.00 0 0.51
15 INT146276 Binding of P2RX4 and P2RX7 1 0.38 0.38 0.43
16 INT169859 P2rx7 Regulation of Gene_expression of Grin1 1 0.17 0 0.43
17 INT322015 Binding of IL1B and P2RX7 1 0.07 1 0.37
18 INT205704 P2rx7 Regulation of Localization of Il18 1 0.09 0.67 0.35
19 INT191128 Positive_regulation of P2RX7 Positive_regulation of Localization of Il1b 1 0.02 0.71 0.34
20 INT217041 TNF Positive_regulation of Gene_expression of P2RX7 1 0.50 0.81 0.34
21 INT205713 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of IL8 1 0.03 0.77 0.33
22 INT217025 P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
23 INT217024 Regulation of P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
24 INT205703 P2rx7 Regulation of Positive_regulation of Casp1 1 0.11 0.66 0.33
25 INT205711 P2rx7 Regulation of Localization of IL8 1 0.02 0.92 0.33
26 INT145682 Binding of P2rx4 and P2rx7 2 0.25 0.36 0.31
27 INT215789 Fig4 Positive_regulation of Localization of P2rx7 1 0.03 0.53 0.29
28 INT205701 P2rx7 Positive_regulation of Il1 1 0.04 0.8 0.25
29 INT185489 Atp5o Negative_regulation of P2rx7 1 0.01 0.29 0.24
30 INT193031 CHRM2 Positive_regulation of ROCK1 1 0.00 0.12 0.24
31 INT216911 Positive_regulation of P2rx7 Positive_regulation of Localization of Plg 1 0.02 0.13 0.23
32 INT107219 Binding of P2rx7 and Atp5o 1 0.03 0.07 0.21
33 INT216946 P2rx7 Regulation of Il10 1 0.28 0.17 0.21
34 INT107223 APEH Negative_regulation of P2rx7 1 0.00 0.13 0.21
35 INT322011 BSG Regulation of P2RX7 1 0.00 0.48 0.21
36 INT343547 ROCK1 Positive_regulation of Gene_expression of PTHLH 1 0.15 0.2 0.2
37 INT205710 CAMP Positive_regulation of P2rx7 1 0.02 0.47 0.19
38 INT193080 ROCK1 Positive_regulation of Ppp1r14a 1 0.00 0.13 0.18
39 INT270827 P2rx7 Positive_regulation of Localization of Panx1 1 0.41 0.18 0.13
40 INT343542 ROCK1 Positive_regulation of Positive_regulation of PTHLH 1 0.21 0 0.12
41 INT216945 Positive_regulation of P2rx7 Positive_regulation of Positive_regulation of Casp1 1 0.14 0.18 0.12
42 INT322037 Binding of P2RX7 and Myh1 1 0.06 0 0.12
43 INT321965 Rock1 Positive_regulation of Nos3 1 0.28 1.99 0.12
44 INT74504 Binding of P2rx7 and Rp2 1 0.02 0.19 0.11
45 INT270834 CBX1 Negative_regulation of Transcription of Panx1 1 0.06 0.13 0.1
46 INT270837 Negative_regulation of Panx1 Negative_regulation of Transcription of CBX1 1 0.07 0.13 0.1
47 INT205708 Binding of Icam1 and P2rx7 1 0.08 1.03 0.09
48 INT270833 Binding of CASP1 and Panx1 1 0.02 0.14 0.09
49 INT217036 IRF6 Positive_regulation of Gene_expression of P2rx7 1 0.02 0 0.09
50 INT270824 Binding of P2rx7 and Panx1 1 0.34 0.15 0.09
51 INT270830 Panx1 Negative_regulation of CASP1 1 0.03 0.09 0.09
52 INT304464 Binding of P2rx7 and P2rx6 1 0.05 0 0.09
53 INT270832 Negative_regulation of Panx1 Negative_regulation of Gene_expression of CASP1 1 0.03 0.14 0.08
54 INT243156 Positive_regulation of P2rx7 Positive_regulation of NOS1 1 0.00 0.08 0.08
55 INT270829 P2rx7 Positive_regulation of Panx1 1 0.66 0.08 0.08
56 INT340420 Hmmr Regulation of P2rx7 1 0.01 1.12 0.08
57 INT270835 Positive_regulation of P2rx7 Positive_regulation of Localization of DPEP1 1 0.04 0.08 0.07
58 INT340427 Positive_regulation of P2rx7 Positive_regulation of Regulation of Pkhd1 1 0.01 1 0.05
59 INT270825 P2rx7 Positive_regulation of Slc37a4 1 0.01 0 0.04
60 INT263427 Pdgfb Positive_regulation of Phosphorylation of Rock1 1 0.00 0 0.04
61 INT269584 Binding of CFL1 and ROCK1 1 0.03 0.05 0.03
62 INT343546 Negative_regulation of ROCK1 Negative_regulation of Gene_expression of PTHLH 1 0.16 3.28 0.03
63 INT343545 Binding of GLI2 and ROCK1 1 0.07 0.65 0.03
64 INT343537 ROCK1 Regulation of Gene_expression of PTHLH 1 0.08 0.09 0.03
65 INT258209 ROCK1 Regulation of ARR3 1 0.00 0.2 0
66 INT258202 ROCK1 Positive_regulation of MYL2 1 0.14 0.2 0
67 INT217031 Binding of P2rx7 and Positive_regulation of Casp1 1 0.02 0 0
68 INT270831 Positive_regulation of Panx1 Positive_regulation of NLRP3 1 0.18 0.1 0
69 INT217144 MIR21 Negative_regulation of TPM1 1 0.06 1.03 0
70 INT322259 Binding of Hcm and Tpm1 1 0.10 0.85 0
71 INT321969 Negative_regulation of Rock1 Negative_regulation of VEGFA 1 0.03 0.65 0
72 INT217032 Binding of P2rx7 and Positive_regulation of Il1 1 0.02 0 0
73 INT321968 Rock1 Positive_regulation of EZR 1 0.42 1.02 0
74 INT216942 Positive_regulation of P2rx7 Positive_regulation of Casp1 1 0.14 0 0
75 INT307460 P2rx7 Positive_regulation of Phosphorylation of Gsk3a 1 0.02 0 0
76 INT261730 ROCK1 Positive_regulation of Positive_regulation of F2R 1 0.37 0 0
77 INT270836 CBX1 Negative_regulation of Panx1 1 0.09 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for bleb. They are ordered first by their pain relevance and then by number of times they were reported in bleb. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
2 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
3 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
4 INT127046 Gene_expression of P2RX7 65 0.78 34.28 14.76
5 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
6 INT137980 Positive_regulation of P2RX7 30 0.67 22.49 10
7 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
8 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
9 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25
10 INT94608 Regulation of P2rx7 19 0.23 8.06 6.19
11 INT68882 Binding of P2rx7 16 0.23 4.33 6.17
12 INT123563 Negative_regulation of Rock1 7 0.55 16.56 5.78
13 INT145680 Regulation of P2rx7 22 0.61 11.92 5.42
14 INT185484 Positive_regulation of Gene_expression of P2rx7 8 0.31 7.44 4.28
15 INT127047 Negative_regulation of P2RX7 10 0.39 7.17 4.01
16 INT144830 Positive_regulation of Gene_expression of P2rx7 22 0.68 9.78 3.92
17 INT129441 Regulation of Gene_expression of P2rx7 8 0.24 4.29 3.32
18 INT144828 Binding of P2rx7 19 0.47 7.84 3.16
19 INT191120 Regulation of P2RX7 8 0.41 5.29 2.96
20 INT137978 Localization of P2RX7 6 0.73 5.04 2.84
21 INT107216 Negative_regulation of Gene_expression of P2rx7 10 0.56 3.39 2.61
22 INT137972 Binding of P2RX7 12 0.36 8.01 2.18
23 INT144829 Localization of P2rx7 12 0.79 2.92 2.12
24 INT216936 Negative_regulation of Gene_expression of P2rx7 5 0.42 2.59 1.84
25 INT141385 Positive_regulation of Gene_expression of P2RX7 7 0.62 3.95 1.73
26 INT23786 Positive_regulation of Positive_regulation of P2rx7 5 0.44 2.21 1.58
27 INT125735 Transcription of P2rx7 3 0.62 1.34 1.58
28 INT215757 Transcription of P2rx7 3 0.21 1.84 1.45
29 INT205691 Regulation of Gene_expression of P2rx7 5 0.44 3.25 1.42
30 INT205690 Positive_regulation of Positive_regulation of P2rx7 14 0.68 6.26 1.3
31 INT168720 Regulation of Negative_regulation of Rock1 1 0.43 1.31 1.23
32 INT126534 Negative_regulation of ROCK1 18 0.49 14.32 1.13
33 INT263403 Positive_regulation of Rock1 3 0.38 4.68 1.09
34 INT111858 Regulation of Rock1 1 0.41 0.75 1.09
35 INT216661 Regulation of Positive_regulation of P2rx7 1 0.07 0 1
36 INT191121 Regulation of Gene_expression of P2RX7 3 0.36 3.69 0.99
37 INT113887 Positive_regulation of Negative_regulation of P2rx7 1 0.22 1.02 0.96
38 INT215567 Positive_regulation of Positive_regulation of P2RX7 2 0.45 0.07 0.93
39 INT151776 Positive_regulation of Transcription of P2rx7 1 0.03 0.53 0.86
40 INT207735 Negative_regulation of TPM1 3 0.57 2.77 0.83
41 INT271589 Regulation of Transcription of P2rx7 1 0.05 0.5 0.78
42 INT278119 Positive_regulation of Localization of P2RX7 2 0.45 1.14 0.77
43 INT125734 Negative_regulation of Transcription of P2rx7 1 0.38 0.81 0.67
44 INT185485 Negative_regulation of Localization of P2rx7 1 0.26 0.95 0.62
45 INT270809 Gene_expression of Panx1 1 0.69 0.59 0.55
46 INT153099 Negative_regulation of Positive_regulation of P2rx7 1 0.42 0.25 0.5
47 INT215732 Negative_regulation of Binding of P2rx7 1 0.11 0.74 0.49
48 INT278114 Negative_regulation of Negative_regulation of P2rx7 1 0.21 0 0.45
49 INT215741 Positive_regulation of Transcription of P2rx7 1 0.15 1.15 0.43
50 INT263390 Phosphorylation of Rock1 1 0.17 0 0.41
51 INT217017 Transcription of P2RX7 1 0.27 0.36 0.39
52 INT263413 Positive_regulation of Phosphorylation of Rock1 1 0.11 0 0.37
53 INT270810 Localization of Panx1 1 0.67 0.33 0.34
54 INT263400 Positive_regulation of Positive_regulation of Rock1 1 0.11 0.4 0.34
55 INT121239 Regulation of Positive_regulation of P2rx7 2 0.61 1.32 0.32
56 INT185436 Gene_expression of ROCK1 5 0.52 6.85 0.29
57 INT216937 Regulation of Binding of P2rx7 1 0.44 0.08 0.29
58 INT270811 Negative_regulation of Panx1 1 0.52 0.4 0.27
59 INT146278 Negative_regulation of Gene_expression of P2RX7 2 0.42 0.21 0.25
60 INT322030 Regulation of Positive_regulation of P2RX7 1 0.41 0.55 0.24
61 INT216938 Negative_regulation of Localization of P2rx7 1 0.37 0.25 0.24
62 INT258250 Positive_regulation of ROCK1 7 0.51 2.07 0.22
63 INT206746 Gene_expression of TPM1 7 0.75 2.15 0.21
64 INT185443 Regulation of ROCK1 4 0.18 3.32 0.21
65 INT216940 Negative_regulation of Binding of P2rx7 1 0.37 0.15 0.2
66 INT270812 Transcription of Panx1 1 0.54 0.26 0.19
67 INT270803 Negative_regulation of Transcription of Panx1 1 0.33 0.26 0.19
68 INT216889 Phosphorylation of P2rx7 1 0.23 0 0.18
69 INT307467 Regulation of Binding of P2rx7 1 0.08 0 0.16
70 INT270813 Positive_regulation of Localization of P2rx7 1 0.46 0.24 0.15
71 INT195420 Positive_regulation of TPM1 3 0.67 0.07 0.12
72 INT322025 Positive_regulation of Binding of P2RX7 1 0.45 0 0.1
73 INT193893 Gene_expression of Tpm1 5 0.65 1.65 0.09
74 INT307481 Phosphorylation of P2rx7 1 0.15 0.35 0.08
75 INT307480 Positive_regulation of Phosphorylation of P2rx7 1 0.09 0.35 0.08
76 INT270808 Positive_regulation of Gene_expression of Panx1 1 0.62 0.13 0.08
77 INT217224 Regulation of TPM1 2 0.34 2.9 0.07
78 INT321962 Negative_regulation of Positive_regulation of Rock1 1 0.33 1.17 0.07
79 INT270807 Positive_regulation of Localization of Panx1 1 0.39 0.05 0.06
80 INT226169 Positive_regulation of Gene_expression of Tpm1 2 0.49 1.17 0.05
81 INT341887 Positive_regulation of Positive_regulation of ROCK1 1 0.01 0.12 0.05
82 INT351575 Negative_regulation of Positive_regulation of P2RX7 1 0.41 1.81 0.04
83 INT343555 Regulation of Gene_expression of ROCK1 1 0.15 1.02 0.04
84 INT270806 Positive_regulation of Panx1 1 0.62 0.3 0.04
85 INT192237 Phosphorylation of ROCK1 2 0.19 0.39 0.03
86 INT270801 Binding of Panx1 1 0.33 0 0.03
87 INT224008 Regulation of Localization of P2RX7 1 0.22 0.74 0.03
88 INT343556 Positive_regulation of Gene_expression of ROCK1 1 0.23 1.05 0.03
89 INT269651 Positive_regulation of Phosphorylation of ROCK1 1 0.11 0.29 0
90 INT258237 Negative_regulation of Negative_regulation of ROCK1 1 0.32 0.16 0
91 INT248591 Positive_regulation of Gene_expression of TPM1 1 0.67 0.07 0
92 INT193842 Negative_regulation of Tpm1 1 0.09 0 0
93 INT270805 Positive_regulation of Positive_regulation of Panx1 1 0.45 0.13 0
94 INT296937 Localization of TPM1 1 0.73 0.63 0
95 INT195418 Negative_regulation of Binding of TPM1 1 0.41 0.1 0
96 INT321961 Gene_expression of Rock1 1 0.51 0.79 0
97 INT321964 Binding of Rock1 1 0.28 0.96 0
98 INT270799 Negative_regulation of Positive_regulation of Panx1 1 0.33 0 0
99 INT195419 Binding of TPM1 1 0.36 0.09 0
100 INT248559 Positive_regulation of Tpm1 1 0.13 0.07 0
101 INT269645 Negative_regulation of Positive_regulation of ROCK1 1 0.10 0 0
102 INT270802 Negative_regulation of Gene_expression of Panx1 1 0.33 0 0
103 INT270804 Regulation of Panx1 1 0.35 0.06 0
104 INT296939 Positive_regulation of Localization of TPM1 1 0.49 0.63 0
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