GO:0032088

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Name negative regulation of NF-kappaB transcription factor activity
Categary Process
Go Slim No
Go Link GO:0032088
Unique Molecular Interactions 407
Total Molecular Interactions 527
Total Single Events 4715
Pain Genes Associated 53

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of NF-kappaB transcription factor activity. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of NF-kappaB transcription factor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
2 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
3 INT131257 ITIH4 Positive_regulation of Gene_expression of Nfkbia 1 0.23 1.41 2.3
4 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
5 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
6 INT282398 Binding of Mefv and Nlrp3 1 0.40 6.8 1.72
7 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
8 INT125845 Positive_regulation of Pag1 Positive_regulation of Gene_expression of Arrb2 1 0.09 0.46 1.48
9 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
10 INT131256 Positive_regulation of Nfkb1 Positive_regulation of Gene_expression of Nfkbia 1 0.38 0.94 1.31
11 INT94367 Binding of ARRB1 and TP53INP2 1 0.25 0 1.3
12 INT42580 CAT Negative_regulation of POMC 1 0.20 0.42 1.26
13 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
14 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
15 INT139230 Icam1 Negative_regulation of Cmklr1 1 0.19 1.13 1.07
16 INT139229 Calca Negative_regulation of Cmklr1 1 0.19 1.12 1.06
17 INT56990 Cat Regulation of Efs 1 0.26 0 1.05
18 INT146097 Positive_regulation of Binding of Rgs9 and Arrb2 1 0.28 0 1.04
19 INT146098 Binding of Rgs9 and Arrb2 1 0.19 0 1.03
20 INT143916 Arrb2 Regulation of Rbm39 1 0.04 0.18 1
21 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98
22 INT130232 Binding of Cat and Sod1 1 0.35 0.3 0.98
23 INT130231 Positive_regulation of Binding of Cat and Sod1 1 0.46 0.3 0.98
24 INT111632 Arrb2 Negative_regulation of Regulation of Rbm39 1 0.03 0 0.96
25 INT81329 Binding of ARRB1 and OPRK1 1 0.05 0.1 0.93
26 INT129034 Nfkbia Positive_regulation of Nfkb1 1 0.02 0.67 0.89
27 INT134311 Tnf Positive_regulation of Protein_catabolism of Nfkbia 1 0.18 0.57 0.88
28 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
29 INT77393 Binding of ARRB1 and OPRM1 1 0.15 0 0.82
30 INT139745 Positive_regulation of Binding of Oprm1 and Arrb2 1 0.28 0.14 0.81
31 INT85686 Binding of Arrb1 and Arrb2 1 0.14 0.09 0.79
32 INT296787 Tbrs1 Positive_regulation of Gene_expression of Tlr9 1 0.06 1.37 0.78
33 INT168457 Sult1a1 Positive_regulation of Cat 1 0.15 1.56 0.78
34 INT296797 Tlr9 Regulation of Positive_regulation of TNF 1 0.03 1.37 0.77
35 INT296788 Tlr9 Regulation of Positive_regulation of Il1 1 0.07 1.37 0.77
36 INT296792 Tlr9 Regulation of Gene_expression of Il6 1 0.06 1.36 0.76
37 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73
38 INT153123 NFKBIA Negative_regulation of Phosphorylation of RELA 1 0.03 2.01 0.71
39 INT125543 Arsa Negative_regulation of Phosphorylation of Nfkbia 1 0.00 0.52 0.68
40 INT94366 Binding of ARRB1 and OPRD1 1 0.11 0 0.67
41 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
42 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
43 INT233669 gr Positive_regulation of Transcription of Nfkbia 1 0.26 0.33 0.64
44 INT168416 MIR146A Regulation of Irak1 1 0.24 0.99 0.59
45 INT77394 Binding of ARRB1 and GIPC1 1 0.01 0 0.56
46 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52
47 INT81330 ARRB1 Regulation of OPRK1 1 0.04 0.09 0.47
48 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
49 INT296795 Binding of Tlr9 and Tlr3 2 0.22 1.29 0.45
50 INT87934 Phosphorylation of Nfkbia Positive_regulation of Nfkb1 1 0.02 0.1 0.45
51 INT241912 Cat Positive_regulation of Ros1 1 0.03 0.76 0.44
52 INT87936 Nfkbia Positive_regulation of Nfkb1 1 0.03 0.1 0.44
53 INT36743 NLRP3 Regulation of Mbp 1 0.01 0 0.43
54 INT292634 IL4 Positive_regulation of Gene_expression of FOXP3 1 0.10 0.42 0.43
55 INT247760 Binding of Cmklr1 and Rarres2 1 0.05 0.75 0.41
56 INT339493 Binding of Irak1 and Irak3 1 0.02 0.17 0.41
57 INT158032 Binding of CDKN2A and KRT20 1 0.28 0.59 0.4
58 INT209918 Positive_regulation of Nlrp3 Positive_regulation of Localization of Il1 1 0.42 1.06 0.4
59 INT207113 Nfkbia Negative_regulation of Nfkb1 1 0.11 0.96 0.4
60 INT191493 Binding of AGTR1 and NLRP3 2 0.03 2.35 0.39
61 INT339504 Binding of Irak1 and Tlr4 1 0.08 0.12 0.38
62 INT116678 Binding of ARRB1 and Oxtr 1 0.13 0.15 0.38
63 INT339506 Binding of Irak1 and Traf6 1 0.03 0.12 0.37
64 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
65 INT143914 Binding of Rbm39 and Arrb2 1 0.03 0.07 0.37
66 INT255803 Cat Negative_regulation of Gene_expression of Il6 1 0.05 0.35 0.35
67 INT204071 HP Positive_regulation of Gene_expression of CDKN2A 1 0.00 3.48 0.34
68 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
69 INT330377 Positive_regulation of Binding of TLR2 and TLR9 1 0.09 2.79 0.32
70 INT330381 Binding of TLR2 and TLR9 1 0.07 2.77 0.32
71 INT263978 Binding of ADRB2 and TNFAIP3 1 0.01 0.5 0.32
72 INT108879 Negative_regulation of PTGS2 Positive_regulation of Protein_catabolism of Nfkbia 1 0.00 0.43 0.31
73 INT317835 Nlrp3 Positive_regulation of Il18 1 0.08 1.49 0.31
74 INT191499 CMA1 Positive_regulation of NLRP3 1 0.02 0.42 0.3
75 INT191502 Binding of CMA1 and NLRP3 1 0.01 0.42 0.3
76 INT137159 Binding of TLR7 and TLR9 1 0.27 0.33 0.29
77 INT137163 Binding of TLR5 and TLR9 1 0.25 0.33 0.29
78 INT143724 Binding of Ikbkg and Nfkbia 1 0.02 0.79 0.29
79 INT143723 Positive_regulation of Binding of Ikbkg and Nfkbia 1 0.02 0.8 0.29
80 INT191501 NLRP3 Positive_regulation of ECE1 1 0.01 1.09 0.28
81 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28
82 INT324801 Positive_regulation of Binding of Chuk and Irak1 1 0.03 0.86 0.28
83 INT324810 Binding of Chuk and Irak1 1 0.02 0.85 0.28
84 INT279265 Binding of MEFV and NLRP3 1 0.07 2.79 0.28
85 INT191495 NLRP3 Positive_regulation of Protein_catabolism of ECE1 1 0.01 1.09 0.28
86 INT80873 Positive_regulation of Nfkb1 Positive_regulation of Protein_catabolism of Nfkbia 2 0.01 0.58 0.27
87 INT306018 Binding of Tlr4 and Tlr9 1 0.15 0.92 0.27
88 INT288497 Binding of Tlr7 and Tlr9 1 0.21 0.97 0.27
89 INT219156 NLRP3 Positive_regulation of IL1B 1 0.01 1.03 0.27
90 INT191497 Binding of REN and NLRP3 1 0.02 0.55 0.27
91 INT241911 Binding of Cat and Ros1 1 0.03 0.85 0.27
92 INT191504 CPN2 Positive_regulation of NLRP3 1 0.00 0.37 0.27
93 INT219194 Nlrp3 Positive_regulation of IL1B 1 0.04 1.03 0.26
94 INT108878 ZNF236 Regulation of Protein_catabolism of Nfkbia 1 0.00 0.38 0.26
95 INT219193 Nlrp3 Positive_regulation of Positive_regulation of NLRP3 1 0.24 1.03 0.26
96 INT108880 ZNF236 Regulation of Gene_expression of Nfkbia 1 0.00 0.38 0.26
97 INT108877 ZNF236 Regulation of Phosphorylation of Nfkbia 1 0.00 0.38 0.26
98 INT148629 Binding of Cat and Casp3 1 0.08 0.09 0.26
99 INT147593 Binding of CDK4 and CDKN2A 1 0.42 0.23 0.26
100 INT317833 Nlrp3 Positive_regulation of Localization of Il1 1 0.06 1.38 0.26
101 INT147592 Positive_regulation of Binding of CDK4 and CDKN2A 1 0.44 0.23 0.26
102 INT108881 ZNF236 Regulation of Transcription of Nfkbia 1 0.00 0.36 0.26
103 INT191498 Binding of CTSG and NLRP3 1 0.07 0.37 0.25
104 INT191496 CTSG Positive_regulation of NLRP3 1 0.09 0.37 0.25
105 INT191536 Klk1c2 Positive_regulation of NLRP3 1 0.02 0.36 0.24
106 INT334256 Binding of Tlr9 and Iars 1 0.02 0.68 0.24
107 INT191537 Binding of Klk1c2 and NLRP3 1 0.02 0.36 0.24
108 INT224135 Binding of ARRB2 and Adora2b 1 0.14 0.07 0.23
109 INT191492 Binding of AGT and NLRP3 1 0.01 0.35 0.23
110 INT120583 Gsta4 Regulation of Cat 1 0.03 0 0.23
111 INT333394 CFD Negative_regulation of Gene_expression of Cat 1 0.03 0.79 0.22
112 INT144241 CGA Negative_regulation of Phosphorylation of NFKBIA 1 0.10 0.34 0.22
113 INT144244 TNF Positive_regulation of Protein_catabolism of NFKBIA 1 0.28 0.34 0.22
114 INT144253 TNF Positive_regulation of Phosphorylation of NFKBIA 1 0.39 0.34 0.22
115 INT144247 CGA Positive_regulation of Protein_catabolism of NFKBIA 1 0.11 0.34 0.22
116 INT144243 CGA Positive_regulation of Phosphorylation of NFKBIA 1 0.11 0.34 0.22
117 INT260440 Negative_regulation of Tlr9 Negative_regulation of Positive_regulation of IFNA1 1 0.03 0.96 0.21
118 INT334379 Ros1 Regulation of Cat 1 0.04 0.08 0.21
119 INT353285 Prdx2 Regulation of Gene_expression of Col1a2 1 0.02 0.73 0.21
120 INT260436 Positive_regulation of Tlr9 Negative_regulation of Positive_regulation of Tlr7 1 0.14 0.65 0.2
121 INT306067 Binding of ADH5 and CYLD 1 0.02 3.13 0.19
122 INT329068 Tlr9 Positive_regulation of Localization of IFNA1 1 0.03 1.54 0.19
123 INT286965 Binding of STAT3 and FOXP3 1 0.27 1.84 0.19
124 INT159788 Tnf Positive_regulation of Phosphorylation of Nfkbia 1 0.01 0.39 0.19
125 INT186098 EGF Positive_regulation of MAP2K5 1 0.01 0.19 0.18
126 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
127 INT247755 Binding of Cmklr1 and Ccrl2 1 0.05 0.53 0.17
128 INT233904 NLRP3 Positive_regulation of AGT 1 0.06 0.81 0.17
129 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
130 INT296081 Binding of FOXP3 and Gtf3a 1 0.00 1.16 0.16
131 INT278398 Hps5 Positive_regulation of Nlrp3 1 0.26 1.38 0.16
132 INT296030 Binding of NFKB1 and FOXP3 1 0.17 1.18 0.16
133 INT224136 ARRB2 Positive_regulation of Adora2b 1 0.19 0 0.16
134 INT23165 Binding of NLRP3 and BDNF-AS 1 0.01 0.83 0.16
135 INT204791 Binding of Spg7 and Nod2 1 0.03 0.5 0.16
136 INT23164 Negative_regulation of Binding of NLRP3 and BDNF-AS 1 0.01 0.83 0.16
137 INT204789 Binding of Tlr2 and Nod2 1 0.23 0.44 0.16
138 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
139 INT136855 Arf5 Positive_regulation of Cdkn2a 1 0.07 1.8 0.15
140 INT241177 Abl2 Regulation of Cat 1 0.14 0.3 0.15
141 INT318305 Binding of NOD2 and NLRP3 1 0.08 1.76 0.15
142 INT318306 Binding of DPEP1 and NLRP3 1 0.03 1.77 0.15
143 INT224132 ARRB2 Negative_regulation of Positive_regulation of Adora2b 1 0.14 0.28 0.15
144 INT296082 Binding of Rel and FOXP3 1 0.35 1.14 0.15
145 INT314856 Binding of Cdc7 and Cdkn2a 1 0.28 1.34 0.14
146 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
147 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
148 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
149 INT34431 NLRP3 Positive_regulation of Localization of POMC 1 0.41 0.31 0.14
150 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
151 INT345146 Binding of Trip6 and Siva1 1 0.02 1.6 0.14
152 INT333271 Tlr9 Positive_regulation of Localization of Ccl20 1 0.24 0.16 0.14
153 INT145830 Mdp1 Positive_regulation of Nod2 1 0.34 0.52 0.13
154 INT334257 Binding of Irak1 and Irak4 1 0.33 0.49 0.12
155 INT139790 PRSS53 Negative_regulation of Phosphorylation of NFKBIA 1 0.01 0.9 0.11
156 INT306265 Binding of NFKB1 and NFKBIA 1 0.21 0.48 0.11
157 INT278397 Hps5 Positive_regulation of Tlr9 1 0.15 0.21 0.11
158 INT139789 TNFAIP8 Positive_regulation of Phosphorylation of NFKBIA 1 0.02 0.89 0.11
159 INT139788 TNFAIP8 Positive_regulation of NFKBIA 1 0.01 0.88 0.11
160 INT219152 NLRP3 Positive_regulation of Positive_regulation of CASP1 1 0.02 0.83 0.1
161 INT286969 IL2 Regulation of Gene_expression of FOXP3 1 0.04 1.05 0.1
162 INT211921 Gene_expression of Nek1 Positive_regulation of Cat 1 0.01 0.26 0.1
163 INT186246 Binding of CAT and SCN5A 1 0.03 0.47 0.1
164 INT294777 PAM Positive_regulation of TLR9 1 0.00 0.17 0.1
165 INT186245 Binding of AGRP and CAT 1 0.02 0.53 0.1
166 INT241913 AAVS1 Positive_regulation of Cat 1 0.04 0.46 0.1
167 INT294773 IRF6 Positive_regulation of TLR9 1 0.06 0.17 0.1
168 INT263449 Binding of NFKBIA and TBK1 1 0.07 0.2 0.1
169 INT339498 Binding of Il1rap and Positive_regulation of Irak1 1 0.01 0 0.1
170 INT334266 Binding of Irak1 and Myd88 2 0.35 0.16 0.09
171 INT334268 Irak4 Positive_regulation of Irak1 1 0.47 0.37 0.09
172 INT335771 MIR155 Regulation of IRAK1 1 0.04 0.29 0.09
173 INT334255 Irak4 Positive_regulation of Phosphorylation of Irak1 1 0.32 0.38 0.09
174 INT263450 NFKB2 Positive_regulation of Protein_catabolism of NFKBIA 1 0.17 0.17 0.09
175 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
176 INT247781 Binding of MERTK and Cmklr1 1 0.07 0 0.09
177 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
178 INT233907 Positive_regulation of Binding of AGTR2 and NLRP3 1 0.01 1.09 0.08
179 INT302178 CDKN1C Regulation of CDKN2A 1 0.09 0.26 0.08
180 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
181 INT23896 Positive_regulation of Rtcd1 Positive_regulation of Cat 1 0.25 0 0.08
182 INT233906 Binding of AGTR2 and NLRP3 1 0.01 1.09 0.08
183 INT188007 NLRP3 Regulation of Binding of TP53BP1 1 0.28 0.62 0.08
184 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
185 INT136856 Cdkn2a Positive_regulation of Arf5 1 0.01 0.9 0.08
186 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
187 INT302139 LAMTOR1 Regulation of CDKN2A 1 0.08 0.26 0.08
188 INT302157 MRPL28 Regulation of CDKN2A 1 0.09 0.26 0.08
189 INT296039 Binding of FOXP3 and IL17RB 1 0.01 0.63 0.08
190 INT296034 FOXP3 Negative_regulation of Gene_expression of IL7R 1 0.10 0.63 0.08
191 INT193694 IgG2a Positive_regulation of Tlr9 1 0.05 0.07 0.08
192 INT302148 IFI27 Regulation of CDKN2A 1 0.11 0.26 0.08
193 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
194 INT350708 Foxp3 Regulation of Socs1 1 0.08 0.21 0.07
195 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
196 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
197 INT166919 Binding of CAT and GSTK1 1 0.09 0.16 0.07
198 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
199 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
200 INT312645 Binding of DNAJA3 and Musk 1 0.08 0.96 0.07

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of NF-kappaB transcription factor activity. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of NF-kappaB transcription factor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16721 Negative_regulation of Cat 56 0.59 44.44 22.84
2 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61
3 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04
4 INT12950 Gene_expression of Cat 85 0.75 35.94 15.76
5 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
6 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
7 INT149985 Gene_expression of Tlr9 32 0.75 29.83 11.86
8 INT94981 Gene_expression of Arrb2 12 0.70 2.11 11.75
9 INT22132 Positive_regulation of CAT 41 0.67 18.64 10.67
10 INT81538 Phosphorylation of Nfkbia 27 0.62 8.86 10.49
11 INT79720 Positive_regulation of Cat 57 0.70 31.81 10.11
12 INT120509 Gene_expression of Cat 65 0.77 50.9 9.75
13 INT155944 Gene_expression of Foxp3 66 0.66 24.37 9.12
14 INT182137 Gene_expression of TLR9 137 0.78 48.48 9.05
15 INT80872 Protein_catabolism of Nfkbia 28 0.92 10.56 8.62
16 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4
17 INT95297 Gene_expression of Nfkbia 14 0.68 7.61 8.24
18 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47
19 INT81532 Negative_regulation of Protein_catabolism of Nfkbia 21 0.54 8.92 7.38
20 INT77404 Gene_expression of ARRB1 19 0.62 1.53 7.22
21 INT93481 Negative_regulation of Protein_catabolism of Nfkbia 14 0.39 7.24 7.21
22 INT4228 Gene_expression of CAT 50 0.75 20.62 7.18
23 INT88498 Protein_catabolism of Nfkbia 14 0.82 6.94 7.1
24 INT81541 Negative_regulation of Nfkbia 12 0.51 5.73 6.79
25 INT100079 Positive_regulation of Gene_expression of Arrb2 7 0.63 2.26 6.77
26 INT207892 Binding of Tlr9 35 0.46 26.66 6.61
27 INT77408 Binding of ARRB1 11 0.36 0.31 6.51
28 INT23174 Gene_expression of NLRP3 51 0.72 35.49 6.47
29 INT94979 Regulation of Arrb2 6 0.54 0.51 6.45
30 INT80447 Negative_regulation of ARRB2 5 0.39 3.12 6.3
31 INT94986 Positive_regulation of Arrb2 5 0.61 1.3 6.24
32 INT47976 Protein_catabolism of NFKBIA 17 0.88 7.57 5.79
33 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56
34 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
35 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47
36 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38
37 INT35536 Negative_regulation of CAT 26 0.57 14.39 5.38
38 INT38366 Regulation of Cat 45 0.62 23.45 5.34
39 INT120511 Positive_regulation of Gene_expression of Cat 26 0.69 19.82 5.2
40 INT81535 Negative_regulation of Phosphorylation of Nfkbia 15 0.44 5.74 5.18
41 INT85685 Gene_expression of Arrb2 5 0.74 0.66 5.13
42 INT143234 Gene_expression of Nfkbia 10 0.62 5.2 5.02
43 INT88496 Positive_regulation of Protein_catabolism of Nfkbia 8 0.53 3.05 4.78
44 INT85681 Negative_regulation of Arrb2 5 0.47 0.79 4.71
45 INT131253 Positive_regulation of Gene_expression of Nfkbia 4 0.41 3.28 4.71
46 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
47 INT36221 Positive_regulation of Nlrp3 25 0.68 19.7 4.5
48 INT188672 Positive_regulation of Tlr9 15 0.67 13.1 4.48
49 INT99020 Gene_expression of Nlrp3 23 0.75 18.86 4.4
50 INT108935 Transcription of Arrb2 5 0.59 0.5 4.38
51 INT87210 Positive_regulation of Nfkbia 9 0.61 3.89 4.35
52 INT92797 Regulation of Arrb2 4 0.44 0.81 4.28
53 INT94985 Regulation of Gene_expression of Arrb2 2 0.40 0.43 4.2
54 INT149986 Positive_regulation of Gene_expression of Tlr9 5 0.67 8.18 4.15
55 INT81543 Positive_regulation of Phosphorylation of Nfkbia 7 0.37 2.51 4.1
56 INT108868 Transcription of Nfkbia 2 0.57 2.91 4.03
57 INT204529 Positive_regulation of TLR9 18 0.62 15.62 3.99
58 INT85679 Binding of Arrb2 4 0.39 0.79 3.82
59 INT15982 Positive_regulation of NLRP3 25 0.65 23.19 3.57
60 INT45132 Positive_regulation of Dap 14 0.69 0.62 3.5
61 INT94983 Negative_regulation of Arrb2 2 0.52 0.26 3.47
62 INT141148 Gene_expression of BMP7 24 0.71 14.34 3.44
63 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28
64 INT11245 Negative_regulation of Dap 15 0.59 1.95 3.18
65 INT12948 Positive_regulation of Gene_expression of Cat 17 0.67 6.46 3.12
66 INT85682 Positive_regulation of Arrb2 4 0.46 0.22 3.05
67 INT260424 Negative_regulation of Tlr9 8 0.41 8.19 2.92
68 INT79722 Regulation of Cat 14 0.62 5.88 2.86
69 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8
70 INT204524 Binding of TLR9 17 0.43 11.69 2.76
71 INT80880 Gene_expression of ARRB2 4 0.65 3.51 2.71
72 INT106833 Positive_regulation of ARRB1 4 0.39 1.21 2.71
73 INT233606 Transcription of Nfkbia 1 0.66 1.55 2.71
74 INT93401 Positive_regulation of Protein_catabolism of Nfkbia 11 0.46 3.89 2.7
75 INT107968 Positive_regulation of NFKBIA 9 0.46 5.27 2.69
76 INT47974 Negative_regulation of Protein_catabolism of NFKBIA 7 0.49 2.38 2.69
77 INT113892 Binding of Cat 6 0.48 3.95 2.65
78 INT108869 Localization of Nfkbia 5 0.56 1.04 2.63
79 INT188344 Positive_regulation of Gene_expression of Foxp3 10 0.36 5.97 2.56
80 INT122003 Phosphorylation of NFKBIA 9 0.59 5.44 2.51
81 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48
82 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46
83 INT22129 Positive_regulation of Gene_expression of CAT 11 0.67 4.23 2.37
84 INT108937 Negative_regulation of Transcription of Arrb2 1 0.38 0.31 2.31
85 INT10612 Localization of NLRP3 13 0.78 8.91 2.27
86 INT77396 Regulation of ARRB1 6 0.35 2.04 2.22
87 INT92260 Binding of Nlrp3 14 0.46 8.94 2.13
88 INT145196 Gene_expression of Irak3 5 0.23 4.23 2.13
89 INT145195 Positive_regulation of Irak3 4 0.15 3.65 2.12
90 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
91 INT108939 Regulation of Transcription of Arrb2 1 0.24 0.19 2.1
92 INT108250 Regulation of Prdx2 5 0.25 2.02 2.08
93 INT94772 Gene_expression of Cdkn2a 14 0.75 8.25 2.04
94 INT129318 Negative_regulation of NFKBIA 10 0.38 6.19 2.02
95 INT221431 Negative_regulation of FOXP3 8 0.40 9.92 1.98
96 INT77410 Positive_regulation of Gene_expression of ARRB1 3 0.55 0.21 1.98
97 INT26317 Gene_expression of NFKBIA 5 0.45 2.97 1.96
98 INT24453 Binding of NLRP3 18 0.48 13.7 1.93
99 INT56080 Transcription of NFKBIA 2 0.40 2.16 1.93
100 INT208890 Gene_expression of Irak1 7 0.65 2.42 1.87
101 INT123873 Positive_regulation of Negative_regulation of Cat 7 0.50 2.86 1.86
102 INT151269 Positive_regulation of Localization of Nfkbia 1 0.37 0 1.86
103 INT80885 Positive_regulation of Gene_expression of ARRB2 3 0.49 1.36 1.82
104 INT221426 Positive_regulation of Gene_expression of FOXP3 9 0.48 5.98 1.72
105 INT113539 Positive_regulation of Binding of ARRB1 1 0.02 0.11 1.72
106 INT126236 Positive_regulation of Positive_regulation of NFKBIA 4 0.46 2.18 1.69
107 INT125844 Positive_regulation of Gene_expression of Arrb2 2 0.48 0.45 1.66
108 INT126759 Negative_regulation of Nlrp3 5 0.41 2.95 1.58
109 INT163666 Localization of Cat 8 0.80 5.84 1.57
110 INT23171 Negative_regulation of NLRP3 7 0.37 4.15 1.53
111 INT47972 Positive_regulation of Protein_catabolism of NFKBIA 5 0.46 2.09 1.53
112 INT247709 Gene_expression of Cmklr1 1 0.14 0.68 1.52
113 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
114 INT204530 Positive_regulation of Gene_expression of TLR9 14 0.70 6.85 1.48
115 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
116 INT158184 Localization of ARRB2 2 0.52 1.3 1.47
117 INT167872 Negative_regulation of Gene_expression of Foxp3 8 0.50 4.14 1.46
118 INT233612 Regulation of Transcription of Nfkbia 1 0.36 0.55 1.43
119 INT59725 Regulation of Dap 6 0.45 0.83 1.42
120 INT108936 Positive_regulation of Positive_regulation of Arrb2 1 0.41 0.25 1.4
121 INT87215 Localization of Nfkbia 5 0.69 1.64 1.39
122 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38
123 INT287241 Positive_regulation of BMP7 10 0.43 2.68 1.38
124 INT108249 Negative_regulation of Prdx2 3 0.32 1.85 1.36
125 INT158183 Positive_regulation of Negative_regulation of ARRB2 1 0.35 1.13 1.33
126 INT233638 Positive_regulation of Transcription of Nfkbia 1 0.56 1.01 1.33
127 INT37436 Localization of Dap 3 0.71 0 1.31
128 INT77398 Negative_regulation of ARRB1 1 0.47 0 1.31
129 INT204766 Gene_expression of Nod2 4 0.75 4.14 1.3
130 INT136574 Regulation of TNFAIP3 2 0.11 1.33 1.3
131 INT131254 Positive_regulation of Transcription of Nfkbia 1 0.36 0.99 1.28
132 INT106830 Positive_regulation of Positive_regulation of ARRB1 1 0.16 0.13 1.28
133 INT151567 Gene_expression of Tlr9 6 0.72 3.63 1.26
134 INT106832 Localization of ARRB1 2 0.22 0.3 1.21
135 INT166013 Positive_regulation of Gene_expression of NFKBIA 2 0.32 1.15 1.2
136 INT91122 Localization of CAT 6 0.78 4.13 1.19
137 INT116537 Binding of ARRB2 1 0.34 0.3 1.19
138 INT302068 Phosphorylation of Arrb2 1 0.01 0.27 1.19
139 INT148228 Positive_regulation of Regulation of Cat 1 0.49 1.16 1.19
140 INT191527 Positive_regulation of Gene_expression of NLRP3 6 0.50 8.65 1.15
141 INT12952 Negative_regulation of Gene_expression of Cat 16 0.57 7.44 1.14
142 INT229562 Negative_regulation of Foxp3 6 0.36 3.7 1.14
143 INT77411 Regulation of Gene_expression of ARRB1 3 0.36 0.61 1.12
144 INT125356 Negative_regulation of Negative_regulation of Cat 4 0.42 2.66 1.06
145 INT42104 Regulation of Cdkn2a 4 0.44 5.67 1.06
146 INT129726 Regulation of Nfkbia 2 0.06 1.63 1.05
147 INT107971 Regulation of NFKBIA 3 0.24 2.03 1.04
148 INT106835 Positive_regulation of Localization of ARRB1 1 0.15 0.11 1.04
149 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
150 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
151 INT81542 Regulation of Protein_catabolism of Nfkbia 2 0.04 0.43 1.02
152 INT143235 Positive_regulation of Gene_expression of Nfkbia 2 0.56 0.97 1.01
153 INT124198 Negative_regulation of Nfkbia 4 0.37 2.58 0.97
154 INT12945 Negative_regulation of Positive_regulation of Cat 3 0.41 2.61 0.97
155 INT76004 Negative_regulation of Localization of Dap 1 0.43 0 0.97
156 INT108943 Positive_regulation of Negative_regulation of Arrb2 1 0.61 0.06 0.97
157 INT53682 Regulation of Gene_expression of CAT 2 0.60 0.36 0.96
158 INT108243 Positive_regulation of Prdx2 3 0.34 0.85 0.95
159 INT278350 Regulation of Nlrp3 3 0.38 2.8 0.95
160 INT338168 Positive_regulation of Binding of CDKN2A 1 0.49 0.52 0.94
161 INT219135 Positive_regulation of Gene_expression of Nlrp3 4 0.49 3.52 0.93
162 INT156976 Gene_expression of TNFAIP3 4 0.65 5.25 0.93
163 INT55052 Binding of Cat 10 0.36 5.46 0.92
164 INT81540 Positive_regulation of Nfkbia 4 0.22 1.37 0.92
165 INT66314 Negative_regulation of Positive_regulation of CAT 4 0.42 0.8 0.91
166 INT181177 Gene_expression of CYLD 5 0.69 24.96 0.89
167 INT142919 Regulation of Gene_expression of Cat 2 0.32 0.33 0.89
168 INT93747 Localization of Cat 9 0.56 4.25 0.88
169 INT254188 Positive_regulation of Irak1 7 0.44 3.46 0.87
170 INT143714 Phosphorylation of Nfkbia 4 0.64 2.94 0.87
171 INT130188 Positive_regulation of Negative_regulation of Cat 5 0.45 2.26 0.86
172 INT347182 Negative_regulation of TNFAIP3 3 0.23 5.6 0.84
173 INT221427 Positive_regulation of FOXP3 6 0.45 2.74 0.83
174 INT143720 Negative_regulation of Phosphorylation of Nfkbia 3 0.33 2.68 0.83
175 INT159548 Regulation of Protein_catabolism of Nfkbia 1 0.18 0.62 0.82
176 INT157492 Transcription of Foxp3 4 0.61 1.69 0.81
177 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
178 INT144429 Positive_regulation of Cdkn2a 7 0.58 4.05 0.78
179 INT85678 Binding of Arrb1 1 0.20 0.09 0.78
180 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76
181 INT150251 Transcription of FOXP3 7 0.61 0.43 0.76
182 INT141150 Localization of BMP7 4 0.56 2.84 0.76
183 INT233630 Regulation of Nfkbia 1 0.42 0.27 0.76
184 INT233646 Regulation of Localization of Nfkbia 1 0.42 0.27 0.76
185 INT294787 Localization of TLR9 2 0.67 2.35 0.75
186 INT116081 Negative_regulation of Binding of ARRB1 1 0.41 0 0.72
187 INT50855 Gene_expression of TRIM21 4 0.65 3.07 0.71
188 INT95298 Negative_regulation of Gene_expression of Nfkbia 2 0.38 0.62 0.71
189 INT89801 Positive_regulation of Positive_regulation of Cat 2 0.49 0.21 0.71
190 INT331594 Localization of Tlr9 1 0.41 1.66 0.71
191 INT331595 Positive_regulation of Localization of Tlr9 1 0.28 1.66 0.71
192 INT77406 Negative_regulation of Negative_regulation of ARRB1 1 0.47 0 0.71
193 INT221428 Negative_regulation of Negative_regulation of FOXP3 1 0.35 1.97 0.7
194 INT81533 Negative_regulation of Negative_regulation of Nfkbia 1 0.04 0.36 0.7
195 INT77401 Regulation of Regulation of ARRB1 1 0.25 0 0.69
196 INT143719 Negative_regulation of Gene_expression of Nfkbia 2 0.43 1.31 0.68
197 INT168411 Binding of Irak1 1 0.18 1.08 0.68
198 INT166019 Regulation of Gene_expression of NFKBIA 1 0.05 0.64 0.65
199 INT264003 Positive_regulation of Transcription of TNFAIP3 1 0.38 1.01 0.65
200 INT193672 Gene_expression of Prdx2 3 0.50 2.75 0.64
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