GO:0032090

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Name Pyrin domain binding
Categary Function
Go Slim No
Go Link GO:0032090
Unique Molecular Interactions 42
Total Molecular Interactions 68
Total Single Events 363
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for Pyrin domain binding. They are ordered first by their pain relevance and then by number of times they were reported for Pyrin domain binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT317836 Binding of Fibp and Pycard 1 0.00 2.68 0.98
2 INT289173 PYCARD Regulation of MFGE8 1 0.05 0 0.96
3 INT278812 PYCARD Positive_regulation of VTA1 1 0.09 0.11 0.71
4 INT150391 Binding of MEFV and PYCARD 4 0.14 3 0.48
5 INT338086 PYCARD Positive_regulation of TCEA1 1 0.10 0 0.47
6 INT338083 Binding of LEFTY1 and PYCARD 1 0.02 0 0.46
7 INT316694 Binding of BLZF1 and Nlrp2 1 0.00 0.75 0.45
8 INT228323 PYCARD Positive_regulation of FIG4 1 0.17 0 0.42
9 INT338085 Binding of PYCARD and GOPC 1 0.05 0 0.39
10 INT278813 Binding of NOVA2 and PYCARD 1 0.13 0 0.38
11 INT349664 PYCARD Negative_regulation of Localization of AR 1 0.05 0 0.32
12 INT349662 Binding of PYCARD and Negative_regulation of Localization of AR 1 0.05 0 0.32
13 INT289178 Regulation of PYCARD Regulation of MFGE8 1 0.05 0 0.32
14 INT289175 PYCARD Regulation of behavior 1 0.03 0 0.31
15 INT289179 PYCARD Regulation of TW 1 0.02 0 0.3
16 INT274584 Binding of PSTPIP1 and PYCARD 1 0.13 1.34 0.22
17 INT289174 PYCARD Positive_regulation of MFGE8 1 0.05 0 0.21
18 INT258456 PYCARD Negative_regulation of Localization of Tms 1 0.02 0.05 0.21
19 INT258455 Tms Negative_regulation of Localization of PYCARD 1 0.02 0.05 0.21
20 INT349668 Binding of HRH1 and PYCARD 1 0.00 0.37 0.21
21 INT289176 PYCARD Regulation of Localization of MFGE8 1 0.05 0 0.18
22 INT289177 PYCARD Regulation of Gene_expression of TW 1 0.03 0 0.18
23 INT349659 PYCARD Positive_regulation of ADRB2 1 0.06 0.19 0.17
24 INT137647 PYCARD Positive_regulation of NLN 1 0.02 0.08 0.15
25 INT137646 Negative_regulation of PYCARD Positive_regulation of NLN 1 0.02 0.08 0.15
26 INT97515 Binding of Mefv and Pycard 1 0.00 0.78 0.14
27 INT97517 Binding of PYCARD and Mefv 1 0.07 0.78 0.14
28 INT349660 Binding of INSR and PYCARD 1 0.01 0 0.09
29 INT349663 Binding of TFPI and PYCARD 1 0.04 0 0.04
30 INT349661 PYCARD Positive_regulation of AR 1 0.08 0 0.03
31 INT345282 Binding of CASP1 and Pycard 1 0.01 0.3 0.03
32 INT274573 Positive_regulation of Binding of MEFV and PYCARD 1 0.09 0.06 0.03
33 INT278385 Binding of Pycard and Nlrp3 1 0.06 0 0
34 INT336288 PYCARD Positive_regulation of SMN1 1 0.13 0 0
35 INT164181 NLRP2 Negative_regulation of Localization of CNDP2 1 0.05 0 0
36 INT349666 Binding of AR and PYCARD 1 0.06 0 0
37 INT278395 Binding of Pycard and Hps5 1 0.04 0 0
38 INT164183 NLRP2 Negative_regulation of Localization of SLPI 1 0.23 0 0
39 INT164184 NLRP2 Negative_regulation of CNDP2 1 0.05 0 0
40 INT278381 Binding of Akt1 and Pycard 1 0.00 0 0
41 INT278372 Binding of Syk and Pycard 1 0.06 0 0
42 INT164185 SLPI Negative_regulation of Localization of NLRP2 1 0.23 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for Pyrin domain binding. They are ordered first by their pain relevance and then by number of times they were reported in Pyrin domain binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27
2 INT97516 Binding of PYCARD 46 0.36 7.06 7.85
3 INT1766 Negative_regulation of PYCARD 25 0.37 6.54 6.76
4 INT137052 Positive_regulation of PYCARD 30 0.43 4.72 6.17
5 INT166765 Localization of PYCARD 21 0.70 3.89 5.66
6 INT133231 Regulation of PYCARD 18 0.39 5.02 4.44
7 INT228328 Positive_regulation of Gene_expression of PYCARD 7 0.34 0.27 1.23
8 INT267652 Negative_regulation of Gene_expression of PYCARD 6 0.37 2.35 1.22
9 INT209912 Gene_expression of Pycard 17 0.22 12.04 1.04
10 INT307280 Regulation of Gene_expression of PYCARD 2 0.39 0.27 1.02
11 INT228326 Positive_regulation of Localization of PYCARD 3 0.41 0 0.8
12 INT138235 Positive_regulation of Pycard 2 0.33 1.66 0.62
13 INT138239 Localization of Pycard 2 0.53 1.05 0.58
14 INT138238 Positive_regulation of Localization of Pycard 1 0.33 0.66 0.58
15 INT209914 Gene_expression of Nlrp2 2 0.31 0.88 0.46
16 INT254317 Negative_regulation of Pycard 5 0.42 3.13 0.45
17 INT349671 Phosphorylation of PYCARD 1 0.33 0 0.35
18 INT209911 Protein_catabolism of Pycard 2 0.11 1.58 0.33
19 INT228331 Positive_regulation of Negative_regulation of PYCARD 1 0.34 0 0.32
20 INT273978 Gene_expression of Pycard 2 0.10 1.96 0.29
21 INT164194 Localization of NLRP2 2 0.73 0.41 0.27
22 INT307281 Regulation of Regulation of PYCARD 1 0.30 0 0.24
23 INT338089 Negative_regulation of Regulation of PYCARD 1 0.35 0 0.24
24 INT216978 Binding of Pycard 6 0.25 2.93 0.22
25 INT262796 Positive_regulation of Pycard 12 0.22 6.5 0.14
26 INT97512 Binding of Pycard 1 0.01 0.78 0.14
27 INT349674 Regulation of Positive_regulation of PYCARD 2 0.11 0.34 0.05
28 INT354591 Negative_regulation of Positive_regulation of PYCARD 1 0.05 0.34 0.05
29 INT326432 Regulation of Positive_regulation of Pycard 1 0.07 0.31 0.04
30 INT262801 Regulation of Gene_expression of Pycard 1 0.08 1.8 0.04
31 INT307913 Negative_regulation of Binding of PYCARD 1 0.37 0 0.04
32 INT349816 Regulation of Pycard 1 0.26 0.56 0.04
33 INT302535 Gene_expression of NLRP2 3 0.65 2.14 0.03
34 INT274594 Positive_regulation of Binding of PYCARD 1 0.09 0.07 0.03
35 INT262795 Localization of Pycard 2 0.26 1.61 0
36 INT262800 Positive_regulation of Binding of Pycard 1 0.09 0.75 0
37 INT244152 Transcription of NLRP2 1 0.59 0.1 0
38 INT327083 Positive_regulation of Gene_expression of NLRP2 1 0.49 0.45 0
39 INT270800 Positive_regulation of Gene_expression of Pycard 1 0.04 0.2 0
40 INT326434 Regulation of Pycard 1 0.07 0.38 0
41 INT244156 Negative_regulation of Transcription of NLRP2 1 0.36 0.1 0
42 INT244144 Transcription of PYCARD 1 0.49 0.49 0
43 INT278333 Phosphorylation of Pycard 1 0.11 0 0
44 INT326433 Protein_catabolism of Pycard 1 0.10 0 0
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