GO:0032091

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Name negative regulation of protein binding
Categary Process
Go Slim No
Go Link GO:0032091
Unique Molecular Interactions 517
Total Molecular Interactions 627
Total Single Events 6125
Pain Genes Associated 27

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of protein binding. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT334928 Binding of pr and Aes 1 0.00 1.49 3.38
2 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
3 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
4 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
5 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
6 INT21570 Binding of Cck and Mapk8 1 0.06 0 1.6
7 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
8 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
9 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
10 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
11 INT167429 Negative_regulation of Mapk8 Negative_regulation of RYBP 1 0.01 1.11 1.09
12 INT142661 Binding of IFIT1 and NPY2R 1 0.00 2.49 1.08
13 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
14 INT223875 Negative_regulation of Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.31 0 1.07
15 INT73467 PTPLA Positive_regulation of Transcription of Myc 1 0.29 0.97 0.94
16 INT203101 Binding of Aes and Mtx1 2 0.25 0.24 0.88
17 INT116269 Binding of Myc and Mycbp2 1 0.19 0.5 0.87
18 INT222024 Mapk8 Regulation of Mapk14 2 0.17 0.83 0.79
19 INT158684 MAPK8 Positive_regulation of Gene_expression of BCL2L11 1 0.51 0.44 0.78
20 INT152234 Mapk8 Positive_regulation of Localization of Nfkb1 1 0.33 0.26 0.78
21 INT152235 Mapk8 Positive_regulation of Localization of Tlr4 1 0.38 0.26 0.78
22 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
23 INT98179 Aap Positive_regulation of Mapk8 1 0.01 0.75 0.74
24 INT168420 Positive_regulation of Mapk8 Positive_regulation of Phosphorylation of Jun 1 0.30 0.88 0.74
25 INT128813 Mapk8 Regulation of Gene_expression of Nos2 1 0.23 0.46 0.74
26 INT223873 Mapk8 Regulation of Positive_regulation of Ltp 1 0.24 0 0.71
27 INT223869 Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.20 0 0.68
28 INT110458 Binding of Atf2 and Mapk8 1 0.35 0 0.66
29 INT330046 Mapk8 Negative_regulation of Prkcg 1 0.13 0.4 0.66
30 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
31 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
32 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
33 INT158685 ROS1 Regulation of Positive_regulation of MAPK8 1 0.21 0.39 0.64
34 INT100030 TNF Positive_regulation of Mapk8 1 0.12 1.57 0.63
35 INT169295 PTPLA Positive_regulation of MAPK8 1 0.10 0.15 0.63
36 INT128812 Mapk8 Negative_regulation of Gene_expression of Nos2 1 0.19 0.37 0.61
37 INT112699 Bid Regulation of Bax 1 0.25 0.51 0.61
38 INT178437 Mapk8 Positive_regulation of Jun 3 0.40 2.69 0.58
39 INT261372 Gsk3b Regulation of Gene_expression of Ifi205 1 0.00 0.24 0.58
40 INT239500 Binding of Aes and Atic 1 0.20 0.4 0.56
41 INT278689 TNF Positive_regulation of MAPK8 1 0.04 0.79 0.56
42 INT200913 Dio1 Positive_regulation of Mapk8 1 0.00 0 0.53
43 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
44 INT120383 PRKCD Positive_regulation of Localization of EPHB2 1 0.29 0.42 0.52
45 INT120384 PRKCD Positive_regulation of Localization of HSPG2 1 0.29 0.42 0.51
46 INT120382 PRKCD Positive_regulation of Localization of DYT10 1 0.29 0.42 0.51
47 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
48 INT352892 Binding of CAV1 and ITGA2 1 0.20 1.61 0.47
49 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
50 INT254225 Mapk14 Positive_regulation of Mapk8 1 0.02 0.87 0.46
51 INT254198 Mapk1 Positive_regulation of Mapk8 1 0.01 0.87 0.46
52 INT69637 Binding of CAV1 and Zfp354a 1 0.00 0 0.46
53 INT238638 Gopc Negative_regulation of Gene_expression of Bax 1 0.04 0.85 0.45
54 INT353109 Binding of VEGFA and Aes 1 0.02 3.93 0.43
55 INT116613 Lnpep Negative_regulation of Gene_expression of BAX 1 0.42 0.62 0.43
56 INT278950 MAPK8 Negative_regulation of Localization of EPHB2 1 0.25 0.47 0.43
57 INT264476 Il1a Positive_regulation of Gene_expression of Mapk8 1 0.04 0 0.43
58 INT116931 OPRK1 Regulation of MAPK8 1 0.31 0.07 0.43
59 INT264475 Il1a Positive_regulation of Mapk8 1 0.04 0 0.43
60 INT116612 Lnpep Negative_regulation of BAX 1 0.42 0.62 0.42
61 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
62 INT319312 Socs4 Positive_regulation of Mapk8 1 0.05 0.68 0.41
63 INT288545 Gsk3b Negative_regulation of gr 1 0.25 0.38 0.38
64 INT179938 Negative_regulation of Mapk8 Negative_regulation of TNF 1 0.02 1.09 0.37
65 INT187233 Positive_regulation of Mapk8 Positive_regulation of Jun 1 0.12 0.92 0.37
66 INT264480 Il1a Positive_regulation of Phosphorylation of Mapk8 1 0.04 0 0.37
67 INT309120 Edc4 Negative_regulation of Positive_regulation of Mapk8 1 0.01 1.03 0.36
68 INT152453 Gsk3b Regulation of Nfkb1 1 0.02 1.68 0.36
69 INT308653 Proc Regulation of Gene_expression of Mapk8 1 0.00 1.48 0.36
70 INT172213 Binding of BAX and BCL2L1 3 0.22 4.02 0.35
71 INT66369 Pomc Regulation of Positive_regulation of Gsk3b 1 0.07 0 0.35
72 INT239503 Binding of Adora2a and Aes 1 0.24 0.85 0.35
73 INT330106 Racgap1 Positive_regulation of Positive_regulation of Mapk8 1 0.01 1.32 0.35
74 INT155061 Stat3 Negative_regulation of Bax 1 0.22 3.71 0.34
75 INT330105 Rac1 Positive_regulation of Mapk8 1 0.15 1.47 0.34
76 INT321366 Gsk3b Regulation of Gene_expression of CYP8B1 1 0.01 0.21 0.33
77 INT330103 Rac1 Positive_regulation of Positive_regulation of Mapk8 1 0.14 1.24 0.32
78 INT348016 Binding of Mapk8 and Mapk8ip3 1 0.04 2.09 0.32
79 INT110461 Binding of Mapk8 and Gtf3a 1 0.03 0 0.32
80 INT282421 Mapk8 Negative_regulation of Ins1 1 0.06 2.48 0.31
81 INT253153 TNF Positive_regulation of Mapk8 1 0.18 0.61 0.31
82 INT167983 Mapk8 Negative_regulation of gr 1 0.02 0.5 0.31
83 INT253155 TNF Positive_regulation of Positive_regulation of Mapk8 1 0.19 0.62 0.31
84 INT342810 Binding of Adarb1 and Gsk3b 1 0.00 0.36 0.3
85 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
86 INT112795 Positive_regulation of CASP1 Positive_regulation of MAPK8 1 0.02 0.16 0.3
87 INT224131 Binding of CAV1 and Agtr1a 1 0.00 0.08 0.3
88 INT112803 CASP1 Positive_regulation of MAPK8 1 0.02 0.16 0.29
89 INT159964 Tnf Positive_regulation of Phosphorylation of Mapk8 1 0.11 0.94 0.29
90 INT226505 Il1rl1 Positive_regulation of Mapk8 1 0.04 0.4 0.29
91 INT226509 Il1rl1 Positive_regulation of Gene_expression of Mapk8 1 0.05 0.4 0.29
92 INT309122 Edc4 Positive_regulation of Phosphorylation of Mapk8 1 0.02 0.73 0.28
93 INT237679 IRF6 Positive_regulation of MAPK8 1 0.00 0.56 0.28
94 INT325530 Positive_regulation of Gsk3b Negative_regulation of Gene_expression of Wnt2 1 0.03 0.63 0.28
95 INT141870 Binding of Slc2a4 and Cav1 1 0.36 0.38 0.28
96 INT312894 Binding of Gsk3b and Positive_regulation of Gene_expression of Hdac6 1 0.08 1.3 0.27
97 INT132368 Mapk8 Positive_regulation of Nfkb1 1 0.17 0.11 0.27
98 INT132369 Mapk8 Positive_regulation of Positive_regulation of Nfkb1 1 0.18 0.12 0.27
99 INT132366 Lgals1 Positive_regulation of Mapk8 1 0.38 0.13 0.27
100 INT132370 Mapk8 Positive_regulation of Ephb1 1 0.15 0.12 0.27
101 INT237927 BCL2 Positive_regulation of BAX 2 0.24 2.22 0.26
102 INT237919 BAX Positive_regulation of Protein_catabolism of PARP1 1 0.03 1.41 0.26
103 INT179928 Binding of Ephb1 and Mapk8 1 0.11 0.91 0.26
104 INT171907 MAPK8 Positive_regulation of Gene_expression of MAPK14 1 0.06 0.77 0.26
105 INT171913 MAPK8 Positive_regulation of MAPK9 1 0.07 0.78 0.26
106 INT327300 Binding of Hnrnpd and Myc 1 0.12 1.02 0.25
107 INT130056 PPARG Positive_regulation of CAV1 1 0.02 0.53 0.25
108 INT330053 Binding of Ros1 and Mapk8 1 0.02 0.88 0.24
109 INT95741 Creb1 Regulation of Mapk8 1 0.39 0 0.23
110 INT292554 MAP3K5 Positive_regulation of MAPK8 1 0.08 0 0.23
111 INT288582 Binding of Cav1 and Kcnma1 1 0.11 0 0.22
112 INT309124 Dlat Negative_regulation of Positive_regulation of Mapk8 1 0.02 0.27 0.22
113 INT220528 Ugt1a6b Positive_regulation of Cav1 1 0.01 1.31 0.22
114 INT309116 Edc4 Negative_regulation of Mapk8 1 0.01 0.43 0.22
115 INT112802 IL4I1 Positive_regulation of Positive_regulation of MAPK8 1 0.04 0 0.22
116 INT223828 Binding of GSTP1 and MAPK8 1 0.06 1.8 0.21
117 INT270433 PLAT Positive_regulation of Positive_regulation of Gsk3b 1 0.04 0.5 0.21
118 INT330051 Mapk8 Positive_regulation of Bcl2l11 1 0.13 0.46 0.21
119 INT131718 Mapk8 Regulation of Penk 1 0.46 0.16 0.2
120 INT266414 Binding of HMGB1 and Mapk8 1 0.03 0.91 0.2
121 INT179935 Binding of Jun and Mapk8 1 0.04 0.61 0.19
122 INT209934 IL1B Positive_regulation of MAPK8 1 0.06 0.37 0.19
123 INT222023 Gpx3 Regulation of Mapk8 1 0.01 1.43 0.18
124 INT299370 Binding of Mapk8 and Life1 1 0.04 0.73 0.18
125 INT261401 Binding of Gsk3b and ADHD1 1 0.00 1.62 0.18
126 INT155063 Csf2 Negative_regulation of Gene_expression of Bax 1 0.27 1.46 0.18
127 INT284445 Dep1 Positive_regulation of Mapk8 1 0.00 0.58 0.17
128 INT155066 Csf2 Negative_regulation of Bax 1 0.12 1.89 0.17
129 INT148103 MAPK8 Positive_regulation of STK24 1 0.47 1.82 0.17
130 INT349475 Regulation of Bax Regulation of Bcl2 1 0.07 1.35 0.17
131 INT220520 Ugt1a6b Positive_regulation of Gene_expression of Cav1 1 0.01 0.81 0.17
132 INT108663 Lrpap1 Negative_regulation of Positive_regulation of Ephb1 1 0.11 0.28 0.17
133 INT295439 Binding of AES and IFNA1 1 0.25 0.46 0.17
134 INT108664 Lrpap1 Negative_regulation of Positive_regulation of Trpv1 1 0.26 0.28 0.17
135 INT155232 TXNIP Regulation of BAX 1 0.23 0.15 0.17
136 INT348034 Mapk8ip3 Negative_regulation of Mapk8 1 0.05 0.98 0.16
137 INT255736 Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.14 2.31 0.16
138 INT348019 Negative_regulation of Binding of Mapk8 and Mapk8ip3 1 0.05 1.04 0.16
139 INT336891 Epo Negative_regulation of Transcription of Bax 1 0.10 0.68 0.16
140 INT116268 Binding of Myc and Acsl1 1 0.08 0.19 0.16
141 INT349476 Bax Regulation of Bcl2 1 0.07 1.33 0.15
142 INT329168 MAPK8 Positive_regulation of Localization of JUN 1 0.12 0.56 0.15
143 INT155644 Binding of CAV1 and HSD11B1 1 0.39 0.77 0.15
144 INT179934 Mapk8 Regulation of Gene_expression of Mmp9 1 0.06 0.48 0.15
145 INT329172 Phosphorylation of MAPK8 Positive_regulation of Localization of JUN 1 0.12 0.62 0.15
146 INT208264 Park7 Negative_regulation of Pten 1 0.16 1.16 0.15
147 INT130918 HMHA1 Positive_regulation of BAX 1 0.04 1.37 0.14
148 INT177914 PRKG1 Positive_regulation of Phosphorylation of MAPK8 1 0.02 1.07 0.14
149 INT177911 PRKG1 Positive_regulation of MAPK8 1 0.02 1.07 0.14
150 INT315030 Binding of Cav1 and Tmie 1 0.03 0.25 0.14
151 INT134400 Positive_regulation of PRKG1 Positive_regulation of Phosphorylation of MAPK8 1 0.30 1.13 0.14
152 INT315032 Binding of Cav1 and Ryr1 1 0.27 0.2 0.14
153 INT273040 Vip Regulation of Bax 1 0.23 1.69 0.13
154 INT201722 Myc Regulation of Gene_expression of Ccnd1 1 0.03 0.79 0.13
155 INT312893 Gsk3b Positive_regulation of Hdac6 1 0.07 0.65 0.13
156 INT263320 Gsk3b Regulation of Uts2r 1 0.02 0.68 0.13
157 INT320261 Binding of Myc and Ntrk2 1 0.01 0.36 0.13
158 INT201791 JUP Regulation of Gene_expression of Myc 1 0.49 0.8 0.13
159 INT263318 Akt1 Regulation of Gsk3b 1 0.02 0.75 0.13
160 INT273041 Adcyap1 Regulation of Bax 1 0.21 1.69 0.13
161 INT354327 Gsk3b Positive_regulation of Gene_expression of Ide 1 0.17 0.33 0.13
162 INT266531 Mapk8 Positive_regulation of Phosphorylation of Olr447 1 0.00 0 0.13
163 INT344314 PDPN Positive_regulation of Phosphorylation of MAPK8 1 0.35 0.67 0.13
164 INT134399 Negative_regulation of MAPK3 Positive_regulation of Phosphorylation of MAPK8 1 0.39 1.14 0.13
165 INT182886 Ros1 Positive_regulation of Mapk8 3 0.09 2.3 0.12
166 INT226192 Protein_catabolism of Bax Positive_regulation of Gtf3a 1 0.00 0.53 0.12
167 INT173200 PPA1 Positive_regulation of Myc 1 0.08 0.5 0.12
168 INT182481 Binding of Cav1 and Ighg2b 1 0.10 0 0.12
169 INT182482 Binding of Cav1 and Cxcl16 1 0.07 0 0.12
170 INT352467 Dusp1 Negative_regulation of Mapk8 1 0.02 0.23 0.12
171 INT204996 Binding of Park7 and Pink1 2 0.34 1.09 0.11
172 INT311871 Cav1 Regulation of Mch 1 0.01 0.24 0.11
173 INT348786 Tlr4 Positive_regulation of Mapk8 1 0.33 1.09 0.11
174 INT285030 Binding of Bax and Slc25a4 1 0.03 0.84 0.11
175 INT291251 Map3k8 Regulation of Gene_expression of MAPK8 1 0.05 0.52 0.11
176 INT143648 Negative_regulation of Mapk8 Negative_regulation of Gene_expression of Fas 1 0.39 0.21 0.11
177 INT268634 Ptpn2 Positive_regulation of Positive_regulation of Gsk3b 1 0.02 1.08 0.11
178 INT289768 Akt1 Regulation of Phosphorylation of Gsk3b 1 0.04 0.45 0.11
179 INT266904 Plat Positive_regulation of Positive_regulation of Mapk8 1 0.03 0.6 0.11
180 INT181076 Map4k4 Positive_regulation of Mapk8 1 0.11 0.47 0.11
181 INT268626 Mpz Positive_regulation of Positive_regulation of Gsk3b 1 0.29 1.08 0.11
182 INT240903 Mapk8 Positive_regulation of Ros1 2 0.09 1.01 0.1
183 INT265890 BCL2 Regulation of Gene_expression of BAX 1 0.04 1.08 0.1
184 INT265889 BAX Regulation of Gene_expression of BAD 1 0.06 1.08 0.1
185 INT32546 Gsk3b Negative_regulation of Localization of Gnrh1 1 0.05 0 0.1
186 INT32547 Gsk3b Negative_regulation of Localization of LH 1 0.04 0 0.1
187 INT181569 Binding of Edn1 and Mapk8 1 0.09 2.7 0.1
188 INT220517 Negative_regulation of Ugt1a6b Positive_regulation of Cav1 1 0.01 0.35 0.1
189 INT348042 Positive_regulation of Mapk8 Regulation of Gene_expression of VEGFA 1 0.03 0.85 0.1
190 INT223827 MAPK8 Positive_regulation of Gene_expression of GSTP1 1 0.12 0.88 0.1
191 INT310743 TP53 Regulation of BAX 1 0.09 1.11 0.1
192 INT292555 Binding of MAPK8 and GTPBP4 1 0.00 0.36 0.09
193 INT302977 Binding of Cav1 and Smpd2 1 0.08 0.71 0.09
194 INT220511 Cav1 Negative_regulation of Transcription of Ccnd1 1 0.03 0.83 0.09
195 INT221653 Binding of Myc and Gopc 2 0.12 0.51 0.08
196 INT292569 F2RL1 Positive_regulation of Negative_regulation of MAPK8 1 0.22 0 0.08
197 INT348025 Mapk8 Regulation of Gene_expression of Proc 1 0.00 0.58 0.08
198 INT268627 Ptpn2 Positive_regulation of Gsk3b 1 0.02 1.7 0.08
199 INT309159 Binding of Cav1 and Positive_regulation of Localization of Esr1 1 0.04 0 0.08
200 INT301631 Gene_expression of Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.09 0.72 0.08

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of protein binding. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
2 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98
3 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52
4 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2
5 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48
6 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25
7 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94
8 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
9 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24
10 INT104493 Negative_regulation of Mapk8 56 0.53 27.76 16.86
11 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
12 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51
13 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36
14 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35
15 INT95738 Positive_regulation of Phosphorylation of Mapk8 40 0.70 23.46 13.88
16 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
17 INT86698 Gene_expression of Cav1 38 0.78 16.37 11.75
18 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65
19 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44
20 INT158070 Localization of Aes 23 0.65 19.93 10.9
21 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16
22 INT145695 Regulation of Mapk8 26 0.62 14.67 9.83
23 INT102110 Positive_regulation of Gene_expression of Bax 42 0.67 35.77 9.51
24 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28
25 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28
26 INT73596 Positive_regulation of Gene_expression of BAX 43 0.67 40.97 9.22
27 INT111998 Positive_regulation of Positive_regulation of Mapk8 23 0.69 9.33 8.97
28 INT104481 Regulation of Mapk8 21 0.50 13.87 8.41
29 INT96912 Positive_regulation of Phosphorylation of Mapk8 29 0.69 18.33 8.14
30 INT150422 Positive_regulation of Aes 24 0.43 15.63 8
31 INT73595 Positive_regulation of BAX 61 0.61 56.97 7.82
32 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
33 INT99071 Positive_regulation of Gene_expression of Mapk8 16 0.55 9.87 7.58
34 INT102107 Negative_regulation of Gene_expression of Bax 30 0.57 29.48 7.33
35 INT264641 Binding of AES 25 0.42 18.56 6.98
36 INT52180 Binding of Aes 38 0.42 23.16 6.7
37 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41
38 INT188844 Gene_expression of AES 44 0.58 33.94 5.85
39 INT17892 Gene_expression of Myc 57 0.75 36.37 5.82
40 INT124370 Positive_regulation of Gene_expression of Gsk3b 47 0.67 24.56 5.4
41 INT128922 Negative_regulation of Gene_expression of Mapk8 6 0.34 3.93 5.36
42 INT145929 Regulation of Bax 20 0.60 18.12 5.35
43 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23
44 INT135291 Positive_regulation of Positive_regulation of Mapk8 24 0.64 19.37 5.16
45 INT201130 Localization of AES 31 0.63 25.45 5.12
46 INT109513 Positive_regulation of Gene_expression of Bax 37 0.67 29.52 5.06
47 INT131717 Positive_regulation of Gene_expression of Mapk8 18 0.55 14.25 5.02
48 INT135374 Binding of Gsk3b 46 0.48 24.36 4.75
49 INT210885 Regulation of SLPI 8 0.44 7.15 4.61
50 INT99504 Negative_regulation of Bax 19 0.56 8.89 4.44
51 INT125005 Negative_regulation of SLPI 9 0.42 5.79 4.43
52 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28
53 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27
54 INT146355 Negative_regulation of Aes 15 0.51 7.83 4.25
55 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21
56 INT109935 Positive_regulation of Phosphorylation of MAPK8 35 0.68 13.13 4.18
57 INT101858 Negative_regulation of BAX 25 0.57 23.77 4.16
58 INT84686 Regulation of BAX 26 0.49 28.54 4.13
59 INT110181 Negative_regulation of Phosphorylation of MAPK8 20 0.57 9.43 4.06
60 INT141443 Phosphorylation of Cav1 6 0.82 4.39 4.03
61 INT123752 Regulation of Bax 19 0.60 16.45 4
62 INT112692 Localization of Bax 31 0.80 20.97 3.98
63 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94
64 INT153666 Gene_expression of CAV1 156 0.77 120.99 3.9
65 INT116642 Negative_regulation of Gsk3b 13 0.57 7.16 3.83
66 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53
67 INT192951 Negative_regulation of AES 15 0.38 6.38 3.5
68 INT32517 Positive_regulation of LRPAP1 13 0.49 7.4 3.44
69 INT21569 Binding of Mapk8 8 0.48 5.55 3.44
70 INT124579 Localization of BAX 35 0.78 30.31 3.43
71 INT275878 Positive_regulation of Gene_expression of Aes 4 0.23 4.54 3.39
72 INT200443 Positive_regulation of AES 27 0.60 22.46 3.22
73 INT163529 Negative_regulation of Positive_regulation of Mapk8 14 0.43 8.37 3.2
74 INT66367 Gene_expression of Gsk3b 16 0.45 9.75 3.07
75 INT110755 Negative_regulation of Positive_regulation of Mapk8 15 0.46 9.91 2.98
76 INT36886 Transcription of Myc 6 0.69 3.16 2.86
77 INT86703 Positive_regulation of Gene_expression of Cav1 7 0.70 3.58 2.73
78 INT95735 Regulation of Phosphorylation of Mapk8 7 0.50 1.88 2.69
79 INT73460 Positive_regulation of Gene_expression of Myc 26 0.67 20.44 2.61
80 INT95739 Negative_regulation of Phosphorylation of Mapk8 11 0.42 6.77 2.61
81 INT102146 Phosphorylation of Bax 4 0.66 3.48 2.35
82 INT136614 Positive_regulation of Cav1 5 0.46 2.28 2.23
83 INT40565 Gene_expression of SLPI 15 0.75 7.25 2.21
84 INT109908 Localization of MAPK8 10 0.73 3.86 2.14
85 INT103966 Negative_regulation of Gene_expression of BAX 9 0.56 7.95 2.14
86 INT77627 Regulation of Gene_expression of BAX 14 0.44 15.09 2.12
87 INT154970 Localization of Bax 15 0.74 11.12 2.11
88 INT156270 Regulation of Positive_regulation of Mapk8 3 0.41 2.31 2.08
89 INT248325 Positive_regulation of Localization of Aes 4 0.26 1.88 2.07
90 INT152696 Negative_regulation of Negative_regulation of Mapk8 1 0.32 0.35 2
91 INT109313 Binding of Mapk8 6 0.48 1.78 1.98
92 INT112089 Gene_expression of Cav1 73 0.75 23.8 1.97
93 INT96916 Negative_regulation of Phosphorylation of Mapk8 16 0.52 9.68 1.97
94 INT98836 Transcription of Bax 6 0.69 5.04 1.96
95 INT134442 Transcription of Bax 14 0.67 7.6 1.9
96 INT135540 Negative_regulation of Bax 16 0.48 11.8 1.89
97 INT204018 Localization of Gsk3b 27 0.71 13.67 1.87
98 INT134443 Binding of Bax 10 0.47 5.62 1.84
99 INT164864 Positive_regulation of Negative_regulation of Mapk8 1 0.31 1.33 1.82
100 INT275875 Negative_regulation of Localization of Aes 2 0.19 3.87 1.8
101 INT299365 Transcription of Mapk8 9 0.72 5.91 1.75
102 INT104883 Positive_regulation of Positive_regulation of Bax 4 0.45 4.05 1.74
103 INT141444 Positive_regulation of Phosphorylation of Cav1 1 0.70 1.76 1.69
104 INT168714 Negative_regulation of Binding of Mapk8 1 0.36 0.18 1.62
105 INT150215 Localization of LRPAP1 1 0.73 1.52 1.62
106 INT135955 Positive_regulation of Cav1 17 0.48 7.73 1.61
107 INT64821 Positive_regulation of SLPI 11 0.67 5.08 1.48
108 INT146785 Positive_regulation of Localization of Bax 7 0.69 6.16 1.47
109 INT109512 Negative_regulation of Gene_expression of Bax 12 0.42 8.04 1.44
110 INT254298 Protein_catabolism of AES 6 0.55 9.79 1.43
111 INT172452 Gene_expression of Myc 121 0.78 69.56 1.36
112 INT116265 Binding of Myc 9 0.36 4.28 1.36
113 INT112695 Negative_regulation of Protein_catabolism of Bax 3 0.36 1.72 1.3
114 INT164706 Positive_regulation of Park7 2 0.50 2.28 1.28
115 INT154969 Positive_regulation of Localization of Bax 4 0.64 3.42 1.27
116 INT141862 Binding of Cav1 11 0.36 1.32 1.25
117 INT125079 Negative_regulation of Gene_expression of MAPK8 9 0.39 4.87 1.25
118 INT203099 Negative_regulation of Aes 3 0.25 0.82 1.25
119 INT154048 Negative_regulation of Gene_expression of Mapk8 5 0.43 4.43 1.22
120 INT112693 Protein_catabolism of Bax 5 0.74 3.17 1.2
121 INT167283 Negative_regulation of Phosphorylation of Gsk3b 12 0.59 7.94 1.16
122 INT242414 Regulation of Aes 5 0.23 1.82 1.16
123 INT134036 Regulation of Gsk3b 4 0.60 1.42 1.15
124 INT139764 Negative_regulation of CAV1 10 0.58 6.57 1.14
125 INT141189 Negative_regulation of Transcription of Bax 1 0.41 1.42 1.14
126 INT32545 Localization of Gsk3b 9 0.07 2.88 1.11
127 INT208536 Positive_regulation of Positive_regulation of Gsk3b 6 0.30 4.83 1.11
128 INT71848 Positive_regulation of Transcription of Myc 1 0.67 0.16 1.11
129 INT116646 Regulation of Negative_regulation of Gsk3b 2 0.44 0.39 0.99
130 INT102070 Regulation of Gene_expression of Myc 4 0.60 2.68 0.96
131 INT136613 Negative_regulation of Cav1 2 0.57 2.28 0.96
132 INT175507 Regulation of Gene_expression of Bax 13 0.50 10.91 0.95
133 INT98134 Binding of BAX 17 0.39 11.45 0.93
134 INT17894 Regulation of Myc 10 0.60 5.65 0.93
135 INT153670 Positive_regulation of Gene_expression of CAV1 26 0.69 44.27 0.92
136 INT261360 Binding of Gsk3b 5 0.36 2.85 0.9
137 INT141442 Negative_regulation of Phosphorylation of Cav1 1 0.59 0.94 0.87
138 INT120393 Negative_regulation of PRKCD 3 0.22 1.07 0.86
139 INT137512 Positive_regulation of Positive_regulation of BAX 5 0.49 4.91 0.85
140 INT120396 Positive_regulation of Localization of PRKCD 1 0.26 0.42 0.85
141 INT200900 Localization of Mapk8 9 0.40 5.76 0.84
142 INT239497 Binding of Aes 8 0.29 3.61 0.84
143 INT287954 Gene_expression of DVL1 8 0.24 2.48 0.83
144 INT120392 Localization of PRKCD 1 0.39 0.4 0.83
145 INT167285 Positive_regulation of Phosphorylation of Gsk3b 17 0.50 5.92 0.82
146 INT156945 Positive_regulation of Negative_regulation of Gsk3b 6 0.38 4.58 0.82
147 INT144697 Regulation of Gene_expression of Bax 8 0.37 9.5 0.81
148 INT66365 Positive_regulation of Gene_expression of Gsk3b 2 0.07 0.95 0.81
149 INT82896 Transcription of BAX 3 0.67 4.61 0.8
150 INT112090 Negative_regulation of Gene_expression of Cav1 8 0.57 3.5 0.78
151 INT116644 Phosphorylation of Gsk3b 4 0.61 0.68 0.78
152 INT204002 Negative_regulation of Gene_expression of Gsk3b 15 0.55 8.57 0.77
153 INT130057 Positive_regulation of CAV1 12 0.65 8.96 0.77
154 INT182293 Binding of MAPK8 11 0.34 4.6 0.77
155 INT148984 Positive_regulation of Localization of BAX 6 0.48 5.29 0.77
156 INT165104 Negative_regulation of Negative_regulation of Mapk8 5 0.43 4.21 0.77
157 INT165105 Localization of Mapk8 7 0.69 4.45 0.76
158 INT239496 Gene_expression of Aes 4 0.52 1.45 0.76
159 INT164489 Regulation of Gene_expression of Mapk8 2 0.44 0.65 0.74
160 INT112088 Regulation of Cav1 2 0.44 0.51 0.73
161 INT237709 Negative_regulation of Negative_regulation of MAPK8 6 0.25 2.09 0.72
162 INT153667 Localization of CAV1 15 0.76 11.92 0.68
163 INT242137 Negative_regulation of Positive_regulation of Gsk3b 7 0.39 2.99 0.67
164 INT142662 Binding of IFIT1 2 0.02 2.26 0.66
165 INT40698 Positive_regulation of Aes 3 0.32 3.84 0.65
166 INT77914 Binding of LRPAP1 5 0.47 1.1 0.64
167 INT177936 Positive_regulation of Negative_regulation of MAPK8 3 0.50 2.1 0.63
168 INT86700 Regulation of Cav1 7 0.54 0.92 0.61
169 INT204006 Negative_regulation of Localization of Gsk3b 6 0.40 1.66 0.6
170 INT158689 Positive_regulation of Regulation of MAPK8 1 0.46 0.41 0.6
171 INT131001 Regulation of CAV1 6 0.44 3.77 0.59
172 INT141863 Negative_regulation of Gene_expression of Cav1 4 0.49 1.77 0.58
173 INT230679 Positive_regulation of Binding of Gsk3b 3 0.42 1.42 0.58
174 INT56481 Regulation of Lrpap1 2 0.05 1.25 0.58
175 INT28931 Negative_regulation of LRPAP1 6 0.57 1.42 0.57
176 INT327116 Positive_regulation of Localization of AES 4 0.22 2.69 0.55
177 INT350386 Regulation of AES 2 0.36 1.55 0.55
178 INT176242 Binding of Bax 10 0.42 10.18 0.52
179 INT208537 Regulation of Gene_expression of Gsk3b 4 0.36 2.15 0.52
180 INT109926 Positive_regulation of Localization of MAPK8 4 0.49 0.87 0.52
181 INT224486 Regulation of Phosphorylation of MAPK8 2 0.33 0.52 0.52
182 INT120390 Phosphorylation of PRKCD 1 0.33 0.38 0.49
183 INT102108 Protein_catabolism of Bax 8 0.64 5.69 0.48
184 INT200442 Positive_regulation of Gene_expression of AES 5 0.42 5.12 0.48
185 INT134446 Positive_regulation of Binding of Bax 1 0.49 0.72 0.48
186 INT86702 Localization of Cav1 8 0.69 0.76 0.47
187 INT229243 Negative_regulation of Phosphorylation of BAX 1 0.18 2.32 0.47
188 INT153672 Negative_regulation of Negative_regulation of CAV1 1 0.25 0.2 0.46
189 INT301056 Transcription of Mapk8 1 0.06 1.22 0.45
190 INT220504 Positive_regulation of Gene_expression of Cav1 11 0.39 6.26 0.43
191 INT217067 Regulation of Positive_regulation of MAPK8 7 0.45 3.09 0.43
192 INT288540 Negative_regulation of Binding of Gsk3b 4 0.53 2.12 0.43
193 INT166240 Regulation of Gene_expression of Cav1 3 0.51 1.03 0.43
194 INT208552 Negative_regulation of Negative_regulation of Gsk3b 3 0.31 1.8 0.43
195 INT235064 Regulation of Positive_regulation of Gsk3b 3 0.41 1.5 0.42
196 INT152059 Regulation of Transcription of Bax 1 0.26 0.07 0.42
197 INT120394 Positive_regulation of PRKCD 2 0.26 1.58 0.41
198 INT105888 Phosphorylation of BAX 9 0.80 4.78 0.4
199 INT90354 Negative_regulation of Myc 6 0.57 4.24 0.4
200 INT239498 Localization of Aes 2 0.58 2.22 0.4
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