GO:0032147

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Name activation of protein kinase activity
Categary Process
Go Slim No
Go Link GO:0032147
Unique Molecular Interactions 1347
Total Molecular Interactions 2120
Total Single Events 26488
Pain Genes Associated 38

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of protein kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for activation of protein kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69886 Ngf Positive_regulation of Calca 8 0.76 2.98 12.77
2 INT166591 Binding of CALCA and DCLK3 4 0.30 0.69 12.18
3 INT180785 Gdnf Positive_regulation of Calca 1 0.23 1.96 8.04
4 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
5 INT69888 Ngf Positive_regulation of Localization of Calca 4 0.52 0.51 4.95
6 INT102122 Binding of Calca and RT1-M4 7 0.29 5.83 4.94
7 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
8 INT24742 Binding of Calca and Vip 1 0.37 0.18 4.68
9 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
10 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
11 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
12 INT128998 Cxcl1 Positive_regulation of Localization of Calca 1 0.66 2.96 4.15
13 INT13969 Binding of Calca and Sst 3 0.32 0.6 4.02
14 INT13966 Calca Positive_regulation of Localization of Sst 5 0.49 0.75 3.91
15 INT85541 Ngf Positive_regulation of Gene_expression of Calca 2 0.55 1.84 3.71
16 INT87491 CALCA Positive_regulation of Gene_expression of IL8 1 0.72 0.92 3.52
17 INT24710 Binding of Calca and SUB1P1 1 0.01 2.09 3.48
18 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
19 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
20 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
21 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
22 INT108471 Binding of CALCA and PNOC 1 0.29 0.64 3.25
23 INT74159 Ngf Regulation of Gene_expression of Calca 2 0.60 1.66 3.22
24 INT29657 Binding of Calca and Calcb 1 0.26 0 3.16
25 INT37162 Binding of Calca and Cckar 1 0.04 0.55 3.01
26 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
27 INT100835 Binding of Calca and Akap12 1 0.07 0.41 2.92
28 INT166592 Binding of CALCA and RAMP1 2 0.35 0.33 2.91
29 INT73821 CALCA Positive_regulation of Localization of IL8 1 0.25 2.37 2.91
30 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
31 INT194409 Binding of CALCA and IGKV1D-8 1 0.15 0 2.84
32 INT169134 Binding of Calca and Trpa1 1 0.37 3.37 2.79
33 INT180779 Bdnf Regulation of Calca 1 0.09 0.23 2.71
34 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
35 INT53648 Acot1 Positive_regulation of Localization of Calca 2 0.23 0 2.61
36 INT57624 Calca Regulation of Positive_regulation of Trh 1 0.50 0 2.53
37 INT48526 Binding of Calca and Penk 1 0.24 1.03 2.51
38 INT136129 Calca Positive_regulation of ATP8A2 1 0.38 0.89 2.4
39 INT13967 Calca Positive_regulation of Sst 1 0.45 0 2.3
40 INT152900 TRPV1 Regulation of Gene_expression of CALCA 1 0.69 0.73 2.29
41 INT152901 TRPV1 Regulation of Localization of CALCA 1 0.44 0.73 2.29
42 INT69887 Ngf Regulation of Calca 2 0.49 0.1 2.19
43 INT79470 Mgat4a Regulation of Localization of Calca 1 0.08 1.72 2.1
44 INT89733 Binding of Calca and Nrm 1 0.31 0.71 2.09
45 INT63873 SRPX Positive_regulation of Localization of Calca 1 0.02 0.49 2.04
46 INT115042 Gdnf Regulation of Calca 1 0.53 0.25 2.03
47 INT26221 Calca Regulation of Gt(pU21)50Imeg 1 0.01 0 2.02
48 INT128996 Ccl2 Positive_regulation of Localization of Calca 1 0.68 1.43 2
49 INT213968 Binding of Calca and Mthfd1 1 0.05 0.16 1.99
50 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 0.51 0.48 1.92
51 INT24942 Calca Regulation of TAC1 1 0.13 0.7 1.89
52 INT271408 NGF Positive_regulation of Gene_expression of CALCA 1 0.09 4.89 1.88
53 INT168723 Positive_regulation of Trpv1 Positive_regulation of Gene_expression of Calca 1 0.48 1.1 1.84
54 INT163514 Ngf Positive_regulation of Gene_expression of Calca 1 0.30 2.21 1.82
55 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
56 INT24934 Calca Regulation of Nka1 3 0.05 0.43 1.73
57 INT148090 Binding of CALCA and NCOR2 1 0.00 0.65 1.71
58 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
59 INT94617 KNG1 Positive_regulation of Localization of Calca 1 0.00 0.75 1.7
60 INT56134 CALCA Positive_regulation of POMC 2 0.71 0.72 1.68
61 INT102447 Binding of CALCA and CALCRL 2 0.26 0.33 1.67
62 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
63 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
64 INT94618 KNG1 Positive_regulation of Calca 1 0.00 0.75 1.66
65 INT144213 Nppa Positive_regulation of Localization of Calca 1 0.71 2.8 1.65
66 INT23889 Calca Positive_regulation of Localization of Tacr1 1 0.11 0.45 1.65
67 INT24157 Binding of CALCA and SFTPA1 2 0.07 0.96 1.64
68 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 1 0.12 0.54 1.63
69 INT160578 Binding of CALCA and TAC1 1 0.07 0.91 1.61
70 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
71 INT148935 Ramp1 Regulation of Calca 1 0.27 0.69 1.56
72 INT13968 Calca Negative_regulation of Positive_regulation of Sst 1 0.34 0 1.55
73 INT13970 Positive_regulation of Calca Positive_regulation of Sst 1 0.37 0 1.53
74 INT13965 Calca Positive_regulation of Positive_regulation of Sst 1 0.37 0 1.53
75 INT96784 Binding of CALCA and Calca 3 0.23 0.27 1.47
76 INT180791 Negative_regulation of Gdnf Regulation of Calca 1 0.17 0 1.47
77 INT180767 Bdnf Positive_regulation of Gene_expression of Calca 1 0.17 0 1.45
78 INT276681 Calca Regulation of Nav1 1 0.07 0.74 1.45
79 INT276686 Calca Regulation of Nav1 1 0.26 0.74 1.45
80 INT84434 Calca Negative_regulation of Negative_regulation of Hrh1 1 0.06 0.19 1.44
81 INT95325 HTR1B Negative_regulation of Calca 1 0.47 0.69 1.43
82 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
83 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
84 INT151514 Olfr155 Negative_regulation of Gene_expression of VEGFA 1 0.00 1.8 1.42
85 INT134760 Ghrl Regulation of Transcription of Calca 1 0.24 2.71 1.42
86 INT144122 Binding of Calca and P2rx6 1 0.10 0 1.4
87 INT169163 Binding of Calca and Ctbs 1 0.00 0.51 1.4
88 INT225019 PDGFB Positive_regulation of Gene_expression of Cxcl1 1 0.27 0.54 1.4
89 INT51213 Vip Regulation of Localization of Calca 1 0.38 0 1.39
90 INT8719 Npy Negative_regulation of Localization of Calca 1 0.06 0.26 1.39
91 INT168724 Creb1 Negative_regulation of Gene_expression of Calca 1 0.46 1.09 1.38
92 INT168721 Positive_regulation of Creb1 Positive_regulation of Calca 1 0.53 1.07 1.37
93 INT279165 Calca Regulation of Gene_expression of Fdft1 1 0.02 0.41 1.37
94 INT180810 Gopc Positive_regulation of Calca 1 0.02 0.28 1.36
95 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
96 INT168722 Creb1 Positive_regulation of Calca 1 0.73 1.05 1.35
97 INT351205 VEGFA Positive_regulation of Binding of MRGPRX1 1 0.08 0.65 1.35
98 INT151771 Binding of P2RX3 and Calca 1 0.04 0.89 1.34
99 INT298455 Calca Positive_regulation of Gene_expression of Ceacam3 1 0.17 0.47 1.34
100 INT180786 Calca Regulation of Positive_regulation of Ngf 1 0.40 0 1.32
101 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32
102 INT180764 Calca Regulation of Positive_regulation of Gdnf 1 0.21 0 1.32
103 INT180807 Calca Regulation of Sorbs1 1 0.02 0 1.32
104 INT180771 Calca Regulation of Positive_regulation of Bdnf 1 0.18 0 1.32
105 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
106 INT121096 Binding of Calca and Trpv1 3 0.37 1.23 1.29
107 INT148775 Binding of Calca and Usf1 1 0.43 0.85 1.29
108 INT194408 Regulation of Binding of CALCA and DCLK3 1 0.15 0 1.29
109 INT138210 Mzb1 Regulation of Calca 1 0.25 0.41 1.29
110 INT22501 Binding of Calca and Pth 1 0.21 0.07 1.28
111 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
112 INT88635 Ptger3 Positive_regulation of Localization of Calca 2 0.05 0 1.24
113 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
114 INT103031 Calca Positive_regulation of Ptgs1 2 0.46 0.98 1.22
115 INT151454 Binding of Calca and Insrr 1 0.02 0.31 1.22
116 INT87586 RPL7AP5 Negative_regulation of Gene_expression of Calca 1 0.00 0.05 1.21
117 INT79471 Mgat4a Regulation of Calca 1 0.06 1.09 1.21
118 INT87585 RPL7AP5 Negative_regulation of Calca 1 0.00 0.05 1.21
119 INT124874 Gnat3 Positive_regulation of Localization of Calca 2 0.08 0.75 1.2
120 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
121 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2
122 INT116730 Rac1 Regulation of Localization of Calca 1 0.13 1.32 1.19
123 INT194403 Negative_regulation of Binding of CALCA and DCLK3 1 0.22 0 1.18
124 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
125 INT338053 F2r Positive_regulation of Localization of Calca 1 0.06 0.47 1.15
126 INT91394 Negative_regulation of MMP2 Positive_regulation of CALCA 1 0.25 0.15 1.15
127 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13
128 INT22176 Calca Regulation of Localization of Prl 4 0.69 0.39 1.11
129 INT99691 Pdpk1 Positive_regulation of Positive_regulation of VEGFA 1 0.01 0.72 1.11
130 INT4752 Gal Negative_regulation of Localization of Calca 1 0.41 0.06 1.11
131 INT282065 Binding of Calca and Ngf 1 0.14 0.85 1.11
132 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1
133 INT4753 Sst Negative_regulation of Localization of Calca 1 0.39 0.06 1.1
134 INT70495 CALCA Positive_regulation of CALCB 2 0.40 0 1.08
135 INT352453 Calca Positive_regulation of Trib3 1 0.00 0.8 1.08
136 INT69889 Ngf Regulation of Localization of Calca 1 0.49 0.1 1.08
137 INT352468 Calca Positive_regulation of Prkaca 1 0.11 0.8 1.08
138 INT91395 MMP2 Positive_regulation of CALCA 1 0.36 0.17 1.07
139 INT79372 Calca Regulation of Pnoc 1 0.34 0 1.07
140 INT107938 POMC Positive_regulation of Gene_expression of TGFBR2 1 0.42 1.09 1.07
141 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
142 INT139225 Calca Negative_regulation of Icam1 1 0.44 1.13 1.06
143 INT139229 Calca Negative_regulation of Cmklr1 1 0.19 1.12 1.06
144 INT139231 Calca Negative_regulation of Timp1 1 0.36 1.11 1.05
145 INT139226 Icam1 Negative_regulation of Calca 1 0.44 1.12 1.05
146 INT48260 Binding of Adcyap1 and Calca 1 0.35 0 1.04
147 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
148 INT130167 Trpv1 Regulation of Localization of Calca 2 0.38 0.69 1.03
149 INT86073 Med15 Regulation of Calca 1 0.49 0.2 1.03
150 INT114555 Binding of Calca and St3gal3 1 0.01 0.44 1.03
151 INT114552 Binding of Calca and Col4a4 1 0.01 0.44 1.02
152 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
153 INT51260 Calca Negative_regulation of Nts 1 0.10 0.08 1.01
154 INT51261 Calca Negative_regulation of Sst 1 0.20 0.08 1.01
155 INT298298 Calca Negative_regulation of Gene_expression of Runx1 1 0.19 0.33 1
156 INT21332 Binding of Drd2 and Gm5195 1 0.01 0.26 1
157 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1
158 INT112163 Calca Positive_regulation of Mpo 1 0.49 1.23 1
159 INT298274 Gene_expression of Runx1 Negative_regulation of Calca 1 0.19 0.33 1
160 INT162299 Negative_regulation of Adarb1 Negative_regulation of Gene_expression of Calca 1 0.01 0.93 1
161 INT49163 Binding of Pax3 and Calca 1 0.03 0.37 0.98
162 INT24395 Binding of CALCA and CLPP 1 0.03 0.17 0.96
163 INT206857 Binding of Calca and Calcrl 4 0.37 1.9 0.95
164 INT161231 Positive_regulation of Htr1a Positive_regulation of Gene_expression of VEGFA 1 0.67 0.16 0.95
165 INT127263 Adra2a Regulation of Gene_expression of Jun 1 0.07 1.1 0.95
166 INT148772 Usf1 Regulation of Calca 1 0.40 0.69 0.95
167 INT180787 Calca Regulation of Gdnf 1 0.18 0.28 0.95
168 INT137922 VEGFA Positive_regulation of Oprm1 1 0.06 0 0.94
169 INT352447 Gse1 Negative_regulation of Gene_expression of Calca 1 0.03 0.98 0.94
170 INT24938 TAC1 Regulation of Calca 1 0.22 0.35 0.94
171 INT24939 TAC3 Regulation of Calca 1 0.01 0.35 0.94
172 INT331109 Tpnr1 Regulation of Gene_expression of Calca 1 0.06 0.97 0.94
173 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
174 INT137921 VEGFA Positive_regulation of Ephb2 1 0.03 0 0.93
175 INT248186 Cxcl1 Positive_regulation of Localization of CALCA 1 0.39 0.88 0.93
176 INT28656 Calca Negative_regulation of Localization of Gnrhr 1 0.19 0 0.91
177 INT28921 Adra2a Positive_regulation of Localization of Prl 1 0.24 0 0.9
178 INT53155 Rac1 Positive_regulation of Gene_expression of Calca 1 0.06 0 0.89
179 INT63943 Il1b Positive_regulation of Localization of Calca 2 0.46 0.98 0.88
180 INT53153 fut10 Positive_regulation of Gene_expression of Calca 1 0.01 0 0.88
181 INT28655 Calca Negative_regulation of Localization of Gh1 1 0.34 0 0.88
182 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
183 INT213976 Calca Negative_regulation of Gene_expression of Il2 1 0.03 0.25 0.86
184 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
185 INT43796 Binding of CDS1 and Adra2a 1 0.06 0 0.86
186 INT311612 Binding of Drd2 and Sert1 1 0.12 0.65 0.86
187 INT113542 Binding of Calca and Adarb1 2 0.00 0.44 0.85
188 INT351323 Nts Regulation of Localization of Calca 1 0.01 0.6 0.85
189 INT36008 Negative_regulation of Binding of Drd2 and Prl 1 0.01 2.11 0.85
190 INT28654 Calca Regulation of Localization of Gh1 1 0.36 0 0.84
191 INT342991 HCL1 Positive_regulation of CALCA 1 0.03 0.71 0.84
192 INT111363 TRPV1 Positive_regulation of Localization of Calca 1 0.11 0 0.83
193 INT116108 VEGFA Positive_regulation of SEC23IP 1 0.10 0.3 0.83
194 INT116109 VEGFA Positive_regulation of PTK2 1 0.13 0.3 0.83
195 INT225691 TRPV1 Positive_regulation of Localization of CALCA 1 0.18 0.7 0.83
196 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
197 INT87490 CALCA Positive_regulation of Gene_expression of CCL5 1 0.30 0.14 0.81
198 INT103178 Mastl Positive_regulation of Localization of Calca 1 0.13 0.36 0.81
199 INT87494 CALCA Positive_regulation of IL8 1 0.48 0.15 0.81
200 INT107937 POMC Regulation of Gene_expression of TGFBR2 1 0.28 0.82 0.81

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of protein kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in activation of protein kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 2008 0.81 518.3 1408.65
2 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84
3 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08
4 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04
5 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38
6 INT2649 Regulation of Calca 433 0.62 146.05 330.95
7 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2
8 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45
9 INT626 Localization of CALCA 289 0.81 125.39 221.15
10 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57
11 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2
12 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47
13 INT2541 Binding of Calca 200 0.48 67.14 134.62
14 INT5008 Localization of Calca 204 0.81 80.35 125.16
15 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75
16 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61
17 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
18 INT5780 Regulation of Gene_expression of Calca 90 0.62 59.52 85.03
19 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65
20 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73
21 INT6761 Binding of CALCA 100 0.48 26.71 62.05
22 INT4760 Negative_regulation of Gene_expression of Calca 93 0.59 34.19 60.3
23 INT4241 Regulation of CALCA 87 0.62 28.19 55.29
24 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
25 INT4891 Transcription of Calca 81 0.72 35.27 53.75
26 INT8700 Positive_regulation of Positive_regulation of Calca 56 0.67 21.69 53.66
27 INT97674 Positive_regulation of Localization of Calca 70 0.69 27.71 51.79
28 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34
29 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
30 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
31 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53
32 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8
33 INT28265 Positive_regulation of Calca 62 0.70 29.1 41.17
34 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
35 INT101992 Localization of VEGFA 413 0.81 258.23 36.15
36 INT13501 Binding of Drd2 65 0.48 23.76 35.6
37 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
38 INT8784 Negative_regulation of Positive_regulation of Calca 40 0.59 14.67 33.49
39 INT8746 Negative_regulation of Calca 50 0.59 21.22 33.45
40 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
41 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52
42 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
43 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1
44 INT8691 Localization of Insr 85 0.80 9.27 30.32
45 INT5300 Regulation of Insr 54 0.60 11.33 29.26
46 INT23463 Positive_regulation of Gene_expression of CALCA 47 0.70 18.14 28.76
47 INT22499 Regulation of Calca 42 0.62 17.32 28.02
48 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28
49 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
50 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32
51 INT12484 Binding of Drd2 45 0.48 15.17 24.72
52 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
53 INT8248 Binding of Adra2a 43 0.48 6.72 22.17
54 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51
55 INT48692 Binding of VEGFA 345 0.48 210.3 21.31
56 INT49774 Binding of DRD2 48 0.48 17.42 20.73
57 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14
58 INT3030 Gene_expression of Adra2a 37 0.68 5.58 19.76
59 INT14114 Binding of Adra2a 30 0.48 4.24 18.53
60 INT12875 Regulation of Adra2a 26 0.45 7.51 17.35
61 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03
62 INT35998 Positive_regulation of Gene_expression of Calca 31 0.70 16.16 16.98
63 INT6150 Positive_regulation of Negative_regulation of Calca 20 0.68 4.06 16.26
64 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
65 INT5674 Gene_expression of Adra2a 34 0.77 6.14 15.13
66 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89
67 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
68 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
69 INT65109 Negative_regulation of Transcription of Calca 16 0.59 8.63 12.84
70 INT26217 Binding of Calca 22 0.48 5.22 12.57
71 INT11244 Transcription of CALCA 21 0.69 3.61 12.27
72 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
73 INT15136 Regulation of Positive_regulation of Calca 12 0.62 3.02 12.16
74 INT6151 Negative_regulation of Negative_regulation of Calca 14 0.58 4.86 11.81
75 INT5779 Positive_regulation of Transcription of Calca 15 0.62 5.61 10.86
76 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
77 INT101203 Negative_regulation of Gene_expression of Calca 12 0.59 7.06 10.72
78 INT12455 Negative_regulation of Adra2a 30 0.54 5.63 10.14
79 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48
80 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46
81 INT13296 Transcription of Drd2 17 0.66 2.7 9.07
82 INT103251 Negative_regulation of Localization of Calca 13 0.43 9.36 8.86
83 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82
84 INT70896 Gene_expression of PDGFB 48 0.65 33.55 8.39
85 INT8761 Negative_regulation of Binding of Calca 12 0.43 3.59 8.32
86 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
87 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38
88 INT25220 Positive_regulation of Binding of Calca 7 0.69 3.78 7.34
89 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
90 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
91 INT73760 Transcription of Drd2 14 0.72 2.11 7.19
92 INT6576 Localization of Adra2a 11 0.71 1.49 7.18
93 INT124264 Regulation of Localization of Calca 10 0.33 1.39 7.14
94 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
95 INT21138 Binding of ADRA2A 16 0.48 5.57 6.8
96 INT43721 Gene_expression of Vegfa 49 0.77 36.18 6.63
97 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55
98 INT24460 Localization of Drd2 12 0.73 2.96 6.46
99 INT88245 Gene_expression of Slc11a1 42 0.53 18.86 6.2
100 INT86772 Localization of Drd2 14 0.80 1.93 6.17
101 INT178604 Gene_expression of TPX2 13 0.37 20.29 6.04
102 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93
103 INT52813 Regulation of Localization of CALCA 8 0.62 3.16 5.89
104 INT111545 Phosphorylation of VEGFA 50 0.76 22.19 5.88
105 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78
106 INT6681 Positive_regulation of Gene_expression of Drd2 10 0.65 1.78 5.78
107 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
108 INT86982 Transcription of Calca 9 0.69 2.98 5.74
109 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
110 INT5778 Regulation of Transcription of Calca 4 0.45 2.47 5.37
111 INT14715 Negative_regulation of Positive_regulation of CALCA 5 0.43 2.22 5.2
112 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19
113 INT27261 Regulation of Regulation of Calca 7 0.45 2.8 5.08
114 INT37148 Negative_regulation of Gene_expression of CALCA 7 0.43 1.91 4.98
115 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
116 INT13650 Positive_regulation of Gene_expression of Adra2a 6 0.50 0.69 4.94
117 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9
118 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
119 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
120 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79
121 INT14125 Positive_regulation of Positive_regulation of Drd2 3 0.35 0.85 4.78
122 INT52251 Negative_regulation of Binding of CALCA 3 0.41 0.57 4.71
123 INT7716 Positive_regulation of Positive_regulation of Adra2a 9 0.68 0.8 4.69
124 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
125 INT54987 Regulation of Gene_expression of Calca 6 0.62 3.44 4.59
126 INT71676 Transcription of DRD2 5 0.69 1.19 4.47
127 INT74531 Regulation of PDGFB 14 0.26 7.57 4.38
128 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36
129 INT51084 Binding of Insr 13 0.30 4.25 4.23
130 INT103153 Positive_regulation of Transcription of VEGFA 34 0.69 22.16 4.22
131 INT156097 Negative_regulation of Localization of VEGFA 70 0.58 34.96 4.17
132 INT83035 Binding of INSR 16 0.47 9.29 4.11
133 INT118835 Positive_regulation of Vegfa 18 0.59 11.2 3.91
134 INT24677 Regulation of Negative_regulation of Calca 6 0.44 0.73 3.9
135 INT209018 Positive_regulation of Slc11a1 11 0.55 7.12 3.83
136 INT75485 Gene_expression of Tgfbr2 10 0.57 10.98 3.76
137 INT70897 Positive_regulation of Gene_expression of PDGFB 15 0.57 13.04 3.52
138 INT10116 Localization of INSR 11 0.57 5.43 3.48
139 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
140 INT70895 Localization of PDGFB 20 0.52 8.98 3.4
141 INT119524 Regulation of Camkk2 4 0.25 1.62 3.35
142 INT99687 Negative_regulation of Transcription of VEGFA 17 0.43 10.3 3.25
143 INT111547 Negative_regulation of Phosphorylation of VEGFA 13 0.42 5.08 3.22
144 INT70885 Gene_expression of Pdgfb 48 0.67 42.27 3.19
145 INT102209 Negative_regulation of Gene_expression of Drd2 5 0.59 0.46 3.17
146 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12
147 INT51151 Positive_regulation of Regulation of Calca 8 0.50 1.77 3.08
148 INT17389 Negative_regulation of Positive_regulation of Adra2a 6 0.58 0.99 3.06
149 INT137609 Localization of Vegfa 22 0.78 14.67 3.01
150 INT27146 Negative_regulation of Regulation of Calca 4 0.43 1.18 2.9
151 INT7931 Positive_regulation of Protein_catabolism of Adra2a 1 0.70 0 2.9
152 INT31923 Positive_regulation of Positive_regulation of Adra2a 7 0.44 1.88 2.89
153 INT132773 Negative_regulation of Acvr2b 3 0.41 1.55 2.87
154 INT60672 Regulation of Gene_expression of CALCA 3 0.61 1.76 2.85
155 INT95720 Phosphorylation of Calca 2 0.80 2.04 2.8
156 INT57354 Positive_regulation of Positive_regulation of Calca 3 0.60 1.42 2.78
157 INT95105 Gene_expression of TGFBR2 15 0.64 16.36 2.74
158 INT8840 Positive_regulation of Positive_regulation of CALCA 8 0.50 1.8 2.74
159 INT31451 Negative_regulation of Gene_expression of Adra2a 4 0.43 1.03 2.72
160 INT178606 Positive_regulation of Gene_expression of TPX2 4 0.08 8.73 2.71
161 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
162 INT43719 Positive_regulation of Vegfa 21 0.69 5.15 2.64
163 INT108468 Negative_regulation of Gene_expression of Drd2 3 0.41 0.67 2.58
164 INT74527 Positive_regulation of PDGFB 14 0.38 13.31 2.54
165 INT19292 Protein_catabolism of CALCA 7 0.76 0.8 2.53
166 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5
167 INT43212 Regulation of Gene_expression of Adra2a 4 0.45 0.24 2.48
168 INT113164 Regulation of Regulation of VEGFA 6 0.36 5.96 2.43
169 INT12456 Negative_regulation of Positive_regulation of Adra2a 4 0.37 1.35 2.42
170 INT209019 Localization of Slc11a1 12 0.33 4.33 2.33
171 INT123528 Negative_regulation of Gene_expression of Vegfa 10 0.57 7.08 2.31
172 INT43723 Regulation of Vegfa 9 0.34 4.96 2.28
173 INT53587 Positive_regulation of Binding of Adra2a 1 0.12 0 2.26
174 INT118672 Regulation of Camkk1 2 0.56 1.37 2.23
175 INT24621 Regulation of Gene_expression of Insr 9 0.42 2.68 2.18
176 INT103881 Positive_regulation of Binding of DRD2 4 0.69 2.01 2.18
177 INT209027 Positive_regulation of Positive_regulation of Slc11a1 3 0.14 2.41 2.18
178 INT96841 Regulation of Slc11a1 9 0.36 6.83 2.14
179 INT34196 Regulation of Binding of Adra2a 2 0.45 0 2.12
180 INT46849 Regulation of TPX2 5 0.24 6.27 2.1
181 INT58752 Positive_regulation of Binding of CALCA 3 0.49 0.73 2.09
182 INT152902 Positive_regulation of Transcription of CALCA 5 0.66 0.99 2.07
183 INT105247 Positive_regulation of Gene_expression of Vegfa 12 0.67 12.07 2.05
184 INT31006 Regulation of Localization of Insr 7 0.50 0.2 2.05
185 INT31262 Positive_regulation of Binding of Adra2a 4 0.10 1.02 2.04
186 INT136818 Positive_regulation of Phosphorylation of VEGFA 4 0.46 0.81 2.02
187 INT54986 Negative_regulation of Positive_regulation of Calca 2 0.43 0.93 2.02
188 INT25411 Positive_regulation of Positive_regulation of Drd2 2 0.48 0.5 1.98
189 INT122195 Regulation of Localization of VEGFA 13 0.57 10.61 1.92
190 INT24291 Positive_regulation of Negative_regulation of CALCA 3 0.61 0.67 1.91
191 INT23426 Regulation of ADRA2A 8 0.48 1.81 1.88
192 INT114059 Localization of Insr 10 0.46 3.49 1.87
193 INT218303 Protein_catabolism of INSR 3 0.29 0.67 1.73
194 INT232645 Transcription of INSR 2 0.09 1.19 1.71
195 INT118833 Positive_regulation of Gene_expression of Vegfa 11 0.65 8.14 1.7
196 INT90646 Negative_regulation of Camkk2 2 0.31 0 1.69
197 INT12442 Localization of Vegfa 11 0.73 4.85 1.68
198 INT96842 Binding of Slc11a1 16 0.34 7.15 1.66
199 INT241566 Negative_regulation of Negative_regulation of Calca 1 0.03 0.72 1.63
200 INT105248 Negative_regulation of Vegfa 8 0.47 6.19 1.61
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