GO:0032148

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Name activation of protein kinase B activity
Categary Process
Go Slim No
Go Link GO:0032148
Unique Molecular Interactions 620
Total Molecular Interactions 804
Total Single Events 9755
Pain Genes Associated 27

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of protein kinase B activity. They are ordered first by their pain relevance and then by number of times they were reported for activation of protein kinase B activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
2 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
3 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
4 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
5 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
6 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
7 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
8 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
9 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
10 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
11 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
12 INT18520 Adra2c Positive_regulation of Localization of Ins1 3 0.41 0.63 1.66
13 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
14 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
15 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
16 INT225019 PDGFB Positive_regulation of Gene_expression of Cxcl1 1 0.27 0.54 1.4
17 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
18 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
19 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
20 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
21 INT68157 Alox5 Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.13
22 INT68154 Mthfs Positive_regulation of Pdpk1 1 0.01 0.63 1.12
23 INT68158 Pla2g1b Positive_regulation of Pdpk1 1 0.05 0.63 1.12
24 INT68159 Pla2g1b Positive_regulation of Positive_regulation of Pdpk1 1 0.05 0.64 1.12
25 INT68163 Mthfs Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.12
26 INT68165 Alox5 Positive_regulation of Pdpk1 1 0.01 0.63 1.12
27 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
28 INT99691 Pdpk1 Positive_regulation of Positive_regulation of VEGFA 1 0.01 0.72 1.11
29 INT70270 Binding of ADRA2B and Pnoc 2 0.02 0.15 1.08
30 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
31 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
32 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1
33 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
34 INT143915 Src Regulation of Rbm39 1 0.03 0.18 0.99
35 INT40424 CCK Regulation of Localization of INS 1 0.02 0 0.97
36 INT75283 SST Negative_regulation of Localization of INS 2 0.47 1.45 0.96
37 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
38 INT127263 Adra2a Regulation of Gene_expression of Jun 1 0.07 1.1 0.95
39 INT107335 Pdpk1 Positive_regulation of Regulation of Sigmar1 1 0.02 0 0.93
40 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
41 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
42 INT167767 Prkcz Positive_regulation of Phosphorylation of Sigmar1 1 0.04 0.23 0.9
43 INT167766 Prkcz Positive_regulation of Positive_regulation of Sigmar1 1 0.04 0.23 0.9
44 INT28921 Adra2a Positive_regulation of Localization of Prl 1 0.24 0 0.9
45 INT109103 MMP2 Positive_regulation of INS 1 0.33 1.07 0.89
46 INT249491 Efnb2 Positive_regulation of Phosphorylation of Src 1 0.01 0.5 0.87
47 INT43796 Binding of CDS1 and Adra2a 1 0.06 0 0.86
48 INT69084 Binding of Adrb1 and Positive_regulation of Positive_regulation of Pdpk1 1 0.02 0.08 0.83
49 INT19299 ANG Regulation of AVP 1 0.25 0 0.82
50 INT317513 Oprm1 Regulation of Positive_regulation of Src 1 0.09 0.4 0.82
51 INT317570 Oprm1 Regulation of Src 1 0.04 0.4 0.82
52 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
53 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
54 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
55 INT63544 Adra2a Regulation of Nisch 1 0.18 0 0.79
56 INT56459 ADRA2C Positive_regulation of Localization of AHSP 1 0.23 0 0.78
57 INT167770 Sigmar1 Positive_regulation of Prkcz 1 0.04 0.34 0.77
58 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77
59 INT167768 Regulation of Sigmar1 Positive_regulation of Prkcz 1 0.02 0.34 0.77
60 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
61 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
62 INT84283 Binding of Adra2a and Htr1f 1 0.16 0.15 0.74
63 INT41165 Gtf3a Regulation of INS 1 0.00 0.15 0.74
64 INT41164 Binding of INS and SST 1 0.07 0.14 0.73
65 INT31643 POMC Regulation of INS 1 0.59 0.62 0.73
66 INT290544 Negative_regulation of Crh Positive_regulation of Insr 1 0.01 0.3 0.72
67 INT317547 Src Positive_regulation of Positive_regulation of Grin1 1 0.17 0 0.72
68 INT148453 Gene_expression of Inhbe Positive_regulation of Src 1 0.06 0.68 0.72
69 INT20688 Adra2a Regulation of Localization of Gh1 1 0.26 0.37 0.7
70 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
71 INT81832 Binding of ADRA2C and CRYGS 1 0.06 0 0.66
72 INT132152 Adra2a Regulation of Localization of Abat 1 0.03 0 0.66
73 INT249489 Src Negative_regulation of Phosphorylation of Grin2b 1 0.20 0.63 0.66
74 INT153921 Positive_regulation of Adra2a Regulation of Ednrb 1 0.01 0 0.66
75 INT31418 Positive_regulation of Adra2c Positive_regulation of Gcg 1 0.22 0 0.65
76 INT290549 Gopc Positive_regulation of Positive_regulation of Insr 1 0.01 0.06 0.65
77 INT317560 Binding of Pdpk1 and Pik3r1 1 0.13 0 0.65
78 INT290545 Crh Positive_regulation of Positive_regulation of Insr 1 0.02 0.06 0.64
79 INT290550 Gopc Positive_regulation of Insr 1 0.01 0.06 0.64
80 INT290540 Positive_regulation of Crh Positive_regulation of Insr 1 0.02 0.06 0.64
81 INT255994 Binding of Ang and Il1rn 1 0.09 1.21 0.63
82 INT46493 Binding of Insr and Oxt 1 0.14 0 0.62
83 INT17187 Binding of Adra2a and Fabp6 1 0.16 0.69 0.61
84 INT17186 Positive_regulation of Binding of Adra2a and Fabp6 1 0.21 0.69 0.61
85 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6
86 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
87 INT29847 INS Regulation of Localization of AVP 1 0.23 0.24 0.59
88 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
89 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
90 INT291262 Positive_regulation of INS Positive_regulation of Mapk1 1 0.03 1.78 0.58
91 INT100225 Binding of Egf and Src 1 0.01 0.67 0.58
92 INT291258 INS Positive_regulation of Mapk1 1 0.04 1.77 0.58
93 INT103165 NGF Positive_regulation of Localization of INS 1 0.05 0 0.58
94 INT78580 Binding of Adra2b and Oprd1 1 0.01 0.07 0.57
95 INT73368 Ang1 Negative_regulation of Fabp6 1 0.00 0.44 0.56
96 INT41250 Binding of Adra2a and Eef1a1 1 0.06 0.4 0.56
97 INT29252 Regulation of INS Positive_regulation of GH1 1 0.26 0.08 0.54
98 INT255999 Binding of Ang and H7 1 0.00 0.38 0.54
99 INT5631 Ubqln1 Positive_regulation of Pdpk1 1 0.05 0 0.53
100 INT29253 INS Positive_regulation of GH1 1 0.44 0.08 0.53
101 INT311767 INS Negative_regulation of Gene_expression of SLC1A3 1 0.52 0 0.52
102 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
103 INT160203 Prkcc Positive_regulation of Src 1 0.02 0 0.51
104 INT98737 Src Negative_regulation of Tk1 1 0.22 0.15 0.5
105 INT98735 Src Negative_regulation of Egf 1 0.26 0.15 0.5
106 INT259180 Pdpk1 Positive_regulation of Gene_expression of Gria1 1 0.02 0.4 0.49
107 INT7851 Man2a2 Positive_regulation of Adra2a 1 0.13 0 0.49
108 INT259181 Phosphorylation of Pdpk1 Positive_regulation of Gene_expression of Gria1 1 0.02 0.4 0.49
109 INT135799 Binding of Adra1d and Adra2b 1 0.02 0 0.48
110 INT110031 Positive_regulation of Adra2c Positive_regulation of Mapk14 1 0.25 0 0.48
111 INT146113 Binding of Adra2a and Lrp1 1 0.01 1.07 0.48
112 INT110030 Adra2c Positive_regulation of Mapk14 1 0.25 0 0.48
113 INT110034 Negative_regulation of Adra2c Positive_regulation of Mapk14 1 0.23 0 0.48
114 INT101001 GHRH Regulation of Localization of INS 1 0.28 0 0.47
115 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
116 INT26448 Adra2a Regulation of Positive_regulation of Npy 1 0.06 0 0.46
117 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
118 INT95469 P2ry6 Positive_regulation of Positive_regulation of Pdpk1 1 0.15 0 0.46
119 INT19297 ANG Positive_regulation of AVP 1 0.28 0 0.46
120 INT132580 Binding of ADRA2C and Htr1a 1 0.41 0.27 0.45
121 INT86380 Adra2a Regulation of Gene_expression of Tnf 1 0.15 0.79 0.44
122 INT29254 Positive_regulation of ADRA2C Positive_regulation of Localization of GH1 1 0.13 0.06 0.44
123 INT56576 Adra2a Positive_regulation of Localization of Gnrh1 1 0.44 0 0.43
124 INT15024 Prkcg Regulation of Pdpk1 1 0.09 0 0.43
125 INT55395 Binding of Htr1a and Adra2a 1 0.42 0 0.43
126 INT151184 Pdpk1 Positive_regulation of Trpv1 1 0.08 0 0.42
127 INT151183 Pdpk1 Positive_regulation of Phosphorylation of Trpv1 1 0.08 0 0.42
128 INT19298 ANG Regulation of OXT 1 0.07 0 0.41
129 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4
130 INT145576 Binding of Adra2c and Hcn4 1 0.21 0.19 0.4
131 INT34987 Adra2a Positive_regulation of Localization of Gnrhr 1 0.43 0 0.4
132 INT145575 Binding of Adra2c and Hcn2 1 0.21 0.19 0.4
133 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
134 INT29052 Binding of INS and INSRR 1 0.02 0.23 0.4
135 INT145577 Regulation of Binding of Adra2c and Hcn2 1 0.25 0.19 0.4
136 INT145574 Regulation of Binding of Adra2c and Hcn4 1 0.26 0.19 0.4
137 INT29053 Regulation of Binding of INS and INSRR 1 0.01 0.24 0.4
138 INT78621 PRL Positive_regulation of Localization of INS 2 0.06 0.5 0.39
139 INT291256 INS Negative_regulation of Positive_regulation of Mdk 1 0.01 1.65 0.39
140 INT236111 Binding of Pdpk1 and Ppara 1 0.26 1.21 0.39
141 INT134167 Binding of ADRA2A and APLP1 1 0.09 0.64 0.39
142 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39
143 INT70656 Adra2a Regulation of Gene_expression of Npy 1 0.23 0 0.38
144 INT113040 IHH Regulation of Gene_expression of INS 1 0.12 0.37 0.37
145 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
146 INT156122 Phosphorylation of Src Positive_regulation of Adrbk1 1 0.01 0 0.37
147 INT263380 Binding of Src and Abl1 1 0.21 0 0.37
148 INT134168 Binding of ADRA2B and APLP1 1 0.06 0.7 0.37
149 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
150 INT112617 Pdpk1 Regulation of Il1b 1 0.03 1.11 0.36
151 INT143918 Binding of Src and Rbm39 1 0.02 0.07 0.36
152 INT112618 Pdpk1 Regulation of Tnf 1 0.03 1.11 0.36
153 INT336573 Ptpn2 Regulation of INSR 1 0.00 1.36 0.36
154 INT4382 RIPK2 Regulation of INS 1 0.12 0.58 0.36
155 INT263434 Src Regulation of Abl1 1 0.02 0.29 0.35
156 INT242403 INSR Positive_regulation of Gene_expression of Bdkrb1 1 0.45 0.88 0.35
157 INT183786 IL6 Negative_regulation of INS 1 0.09 1.61 0.35
158 INT31713 Adra2c Regulation of Localization of Ins1 1 0.22 0.31 0.35
159 INT263382 Src Regulation of Trib3 1 0.00 0.29 0.35
160 INT183784 INS Negative_regulation of Binding of TBK1 1 0.01 1.81 0.34
161 INT183783 INS Negative_regulation of TBK1 1 0.01 1.81 0.34
162 INT183793 INS Negative_regulation of Binding of Ros1 1 0.16 1.66 0.34
163 INT183785 INS Positive_regulation of Gene_expression of NFKBIB 1 0.03 1.83 0.34
164 INT183780 INS Negative_regulation of Gene_expression of CYBB 1 0.02 1.74 0.34
165 INT4381 RIPK2 Positive_regulation of Localization of INS 1 0.13 0.53 0.34
166 INT183782 INS Negative_regulation of Gene_expression of TBK1 1 0.01 1.81 0.34
167 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33
168 INT222721 Binding of HTR1A and Pdpk1 1 0.00 0.35 0.33
169 INT67030 Negative_regulation of Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
170 INT67028 Adra2a Negative_regulation of Nts 1 0.06 0.64 0.33
171 INT249490 Phosphorylation of Ephb2 Positive_regulation of Src 1 0.17 0.15 0.33
172 INT67029 Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
173 INT190683 Binding of A2M and INS 4 0.11 4.97 0.32
174 INT31182 Adra2a Regulation of Localization of Gh 1 0.01 0.35 0.32
175 INT238895 Binding of CRP and INS 1 0.00 0.93 0.32
176 INT249480 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Src 1 0.22 0.23 0.31
177 INT40219 Ang Negative_regulation of REN 1 0.00 0 0.3
178 INT225021 PDGFB Positive_regulation of Ccl21 1 0.10 0.07 0.3
179 INT191240 SAE1 Regulation of Localization of INS 1 0.08 1.15 0.3
180 INT225026 PDGFB Positive_regulation of Gene_expression of Ccl21 1 0.10 0.07 0.3
181 INT51275 IGF1 Negative_regulation of INS 2 0.35 0.98 0.29
182 INT202313 Gene_expression of PDGFB Positive_regulation of Positive_regulation of Pdgfrb 1 0.14 1 0.29
183 INT163903 Binding of EFNB1 and Src 1 0.03 0.56 0.29
184 INT202314 Gene_expression of PDGFB Positive_regulation of Phosphorylation of Pdgfrb 1 0.14 1 0.29
185 INT291202 Positive_regulation of INS Positive_regulation of AKT1 1 0.01 0.76 0.29
186 INT71550 GTPBP4 Regulation of Localization of INS 1 0.00 0.16 0.28
187 INT291201 Regulation of INS Positive_regulation of GOPC 1 0.00 0.35 0.28
188 INT26942 Adra2c Positive_regulation of Localization of Ins1 1 0.13 0 0.28
189 INT214615 FOXC1 Positive_regulation of Gene_expression of Ang 1 0.01 0.29 0.28
190 INT162599 Wnt5a Regulation of Gene_expression of IL4I1 1 0.00 0.1 0.28
191 INT291200 INS Positive_regulation of GOPC 1 0.01 0.3 0.28
192 INT7850 Adra2c Regulation of Localization of Gcg 1 0.08 0 0.27
193 INT256001 Ang Negative_regulation of Il1rn 1 0.11 0.25 0.27
194 INT242878 INS Negative_regulation of Gene_expression of SPI1 1 0.04 1.81 0.27
195 INT355734 Pdgfb Regulation of Bdnf 1 0.22 1.5 0.27
196 INT95061 Binding of Adra2a and ADHD1 1 0.02 0.8 0.27
197 INT224406 INS Regulation of Localization of PYY 1 0.11 0.27 0.27
198 INT224405 INS Regulation of Localization of CCK 1 0.12 0.27 0.27
199 INT249493 Binding of Grin2b and Src 1 0.17 0.15 0.26
200 INT18994 Negative_regulation of Pdpk1 Negative_regulation of Regulation of Cck 1 0.10 0 0.26

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of protein kinase B activity. They are ordered first by their pain relevance and then by number of times they were reported in activation of protein kinase B activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT812 Localization of INS 1026 0.81 515.6 145.31
2 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
3 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
4 INT251 Regulation of INS 398 0.62 232.47 55.04
5 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
6 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
7 INT1232 Positive_regulation of Pdpk1 78 0.42 24.33 50.17
8 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
9 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
10 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
11 INT18992 Negative_regulation of Pdpk1 53 0.42 19.02 40.95
12 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
13 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
14 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
15 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
16 INT8691 Localization of Insr 85 0.80 9.27 30.32
17 INT5300 Regulation of Insr 54 0.60 11.33 29.26
18 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28
19 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32
20 INT8248 Binding of Adra2a 43 0.48 6.72 22.17
21 INT48769 Regulation of Pdpk1 20 0.35 9.78 20.36
22 INT3030 Gene_expression of Adra2a 37 0.68 5.58 19.76
23 INT14114 Binding of Adra2a 30 0.48 4.24 18.53
24 INT12875 Regulation of Adra2a 26 0.45 7.51 17.35
25 INT5674 Gene_expression of Adra2a 34 0.77 6.14 15.13
26 INT26733 Gene_expression of Pdpk1 17 0.48 5.74 13.91
27 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
28 INT14572 Binding of INS 205 0.48 175.43 13.38
29 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
30 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83
31 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
32 INT5630 Localization of Pdpk1 10 0.45 5.21 11.36
33 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75
34 INT12455 Negative_regulation of Adra2a 30 0.54 5.63 10.14
35 INT29740 Gene_expression of ANG 55 0.78 24.53 9.86
36 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01
37 INT38173 Gene_expression of Ang 40 0.75 32.63 8.86
38 INT70896 Gene_expression of PDGFB 48 0.65 33.55 8.39
39 INT104013 Negative_regulation of Gene_expression of Pdpk1 4 0.31 2.36 7.89
40 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53
41 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
42 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
43 INT6576 Localization of Adra2a 11 0.71 1.49 7.18
44 INT71824 Phosphorylation of Pdpk1 14 0.38 4.9 6.86
45 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
46 INT21138 Binding of ADRA2A 16 0.48 5.57 6.8
47 INT118151 Positive_regulation of Prkcz 5 0.12 2.35 6.41
48 INT5678 Gene_expression of ADRA2C 17 0.74 2.62 6.24
49 INT55077 Positive_regulation of Positive_regulation of Pdpk1 6 0.26 1.77 5.78
50 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
51 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
52 INT68465 Positive_regulation of Gene_expression of Pdpk1 7 0.19 2.35 5.49
53 INT18443 Positive_regulation of ADRA2C 12 0.69 2.61 5.48
54 INT81326 Positive_regulation of Gene_expression of Ang 17 0.67 18.5 5.46
55 INT100222 Binding of Src 9 0.26 5.41 5.37
56 INT26940 Positive_regulation of Adra2c 9 0.49 2.21 5.27
57 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
58 INT89844 Positive_regulation of Phosphorylation of Src 10 0.43 4.71 4.95
59 INT13650 Positive_regulation of Gene_expression of Adra2a 6 0.50 0.69 4.94
60 INT100220 Negative_regulation of Src 13 0.41 6.37 4.93
61 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
62 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
63 INT7716 Positive_regulation of Positive_regulation of Adra2a 9 0.68 0.8 4.69
64 INT98453 Positive_regulation of Src 19 0.47 7.84 4.62
65 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
66 INT5675 Gene_expression of Adra2c 7 0.75 1.25 4.58
67 INT74531 Regulation of PDGFB 14 0.26 7.57 4.38
68 INT30160 Positive_regulation of ADRA2B 14 0.29 1.92 4.37
69 INT51084 Binding of Insr 13 0.30 4.25 4.23
70 INT1231 Negative_regulation of Positive_regulation of Pdpk1 6 0.35 1.88 4.13
71 INT83035 Binding of INSR 16 0.47 9.29 4.11
72 INT89394 Phosphorylation of INS 37 0.82 35.84 3.9
73 INT13134 Binding of ADRA2C 11 0.46 0.73 3.86
74 INT8711 Binding of Adra2b 6 0.42 0.08 3.78
75 INT122327 Regulation of Src 6 0.59 0.59 3.6
76 INT70897 Positive_regulation of Gene_expression of PDGFB 15 0.57 13.04 3.52
77 INT10116 Localization of INSR 11 0.57 5.43 3.48
78 INT30181 Gene_expression of Adra2b 10 0.62 1.89 3.48
79 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
80 INT277 Negative_regulation of Adra2c 8 0.43 1.89 3.42
81 INT70895 Localization of PDGFB 20 0.52 8.98 3.4
82 INT18459 Regulation of Adra2c 6 0.45 0.42 3.4
83 INT137350 Phosphorylation of Src 13 0.45 4.14 3.32
84 INT70885 Gene_expression of Pdgfb 48 0.67 42.27 3.19
85 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12
86 INT17389 Negative_regulation of Positive_regulation of Adra2a 6 0.58 0.99 3.06
87 INT38760 Positive_regulation of Adra2c 3 0.39 1.82 3.04
88 INT38987 Protein_catabolism of INS 21 0.99 11.92 2.91
89 INT32623 Negative_regulation of Regulation of INS 16 0.43 10.96 2.9
90 INT7931 Positive_regulation of Protein_catabolism of Adra2a 1 0.70 0 2.9
91 INT31923 Positive_regulation of Positive_regulation of Adra2a 7 0.44 1.88 2.89
92 INT118156 Binding of Prkcz 2 0.08 2.68 2.89
93 INT37734 Positive_regulation of Ang 18 0.46 9.17 2.87
94 INT15265 Gene_expression of Adra2c 5 0.54 1.8 2.83
95 INT30870 Negative_regulation of Adra2b 8 0.44 4.5 2.8
96 INT47846 Negative_regulation of Localization of Pdpk1 2 0.33 1.12 2.75
97 INT31451 Negative_regulation of Gene_expression of Adra2a 4 0.43 1.03 2.72
98 INT96763 Positive_regulation of Localization of Pdpk1 1 0.39 2.08 2.65
99 INT225253 Positive_regulation of Phosphorylation of Src 4 0.38 2.36 2.59
100 INT74527 Positive_regulation of PDGFB 14 0.38 13.31 2.54
101 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5
102 INT43212 Regulation of Gene_expression of Adra2a 4 0.45 0.24 2.48
103 INT12456 Negative_regulation of Positive_regulation of Adra2a 4 0.37 1.35 2.42
104 INT7848 Regulation of Adra2c 3 0.33 1.74 2.37
105 INT53540 Gene_expression of ADRA2B 10 0.46 1.78 2.33
106 INT29402 Gene_expression of Src 16 0.74 4.57 2.29
107 INT3315 Negative_regulation of Positive_regulation of INS 31 0.57 14.73 2.27
108 INT53587 Positive_regulation of Binding of Adra2a 1 0.12 0 2.26
109 INT26177 Regulation of Regulation of INS 19 0.44 11.32 2.18
110 INT24621 Regulation of Gene_expression of Insr 9 0.42 2.68 2.18
111 INT34196 Regulation of Binding of Adra2a 2 0.45 0 2.12
112 INT37733 Negative_regulation of Ang 11 0.41 3.23 2.09
113 INT31006 Regulation of Localization of Insr 7 0.50 0.2 2.05
114 INT31262 Positive_regulation of Binding of Adra2a 4 0.10 1.02 2.04
115 INT249530 Positive_regulation of Positive_regulation of Src 3 0.28 1.32 1.9
116 INT23426 Regulation of ADRA2A 8 0.48 1.81 1.88
117 INT114059 Localization of Insr 10 0.46 3.49 1.87
118 INT3866 Positive_regulation of Positive_regulation of INS 30 0.59 21.58 1.86
119 INT26735 Regulation of Gene_expression of Pdpk1 2 0.24 0.56 1.84
120 INT29739 Positive_regulation of ANG 11 0.69 4.37 1.75
121 INT218303 Protein_catabolism of INSR 3 0.29 0.67 1.73
122 INT104014 Negative_regulation of Phosphorylation of Pdpk1 2 0.23 0.59 1.72
123 INT102893 Positive_regulation of Gene_expression of ANG 10 0.69 5.62 1.71
124 INT232645 Transcription of INSR 2 0.09 1.19 1.71
125 INT146943 Gene_expression of Src 13 0.49 6.65 1.65
126 INT114061 Regulation of Gene_expression of Insr 4 0.27 2.03 1.56
127 INT19342 Regulation of Insr 12 0.24 6.11 1.54
128 INT118149 Positive_regulation of Binding of Prkcz 1 0.09 0.58 1.54
129 INT43327 Positive_regulation of ADRA2A 3 0.46 1.54 1.53
130 INT74528 Negative_regulation of PDGFB 11 0.40 10.34 1.48
131 INT98455 Regulation of Src 4 0.20 1.76 1.48
132 INT7780 Positive_regulation of Negative_regulation of Adra2a 2 0.50 0.09 1.48
133 INT74530 Transcription of PDGFB 7 0.65 4.56 1.47
134 INT40907 Localization of Adra2c 3 0.71 0 1.46
135 INT40906 Negative_regulation of Localization of Adra2c 1 0.43 0 1.46
136 INT7932 Protein_catabolism of Adra2a 1 1.00 0 1.44
137 INT118150 Positive_regulation of Positive_regulation of Prkcz 1 0.08 0.49 1.42
138 INT53632 Regulation of Negative_regulation of Adra2a 1 0.23 0.08 1.41
139 INT67464 Positive_regulation of Negative_regulation of Pdpk1 1 0.19 0.15 1.41
140 INT251834 Negative_regulation of Gene_expression of ANG 5 0.59 3.95 1.38
141 INT118927 Positive_regulation of Phosphorylation of Pdpk1 2 0.04 0.76 1.38
142 INT29262 Negative_regulation of Binding of Adra2a 4 0.40 0.25 1.37
143 INT44529 Positive_regulation of Pdgfb 11 0.43 7.98 1.36
144 INT95815 Regulation of Positive_regulation of Adra2a 4 0.45 1.45 1.32
145 INT55318 Localization of ADRA2C 3 0.73 1.39 1.3
146 INT7847 Positive_regulation of Localization of Adra2a 2 0.40 0.22 1.28
147 INT192349 Negative_regulation of Gene_expression of PDGFB 5 0.31 2.64 1.25
148 INT221206 Phosphorylation of Pdpk1 3 0.53 0.13 1.25
149 INT124738 Negative_regulation of Positive_regulation of Insr 5 0.23 3.73 1.24
150 INT109104 Positive_regulation of Protein_catabolism of INS 4 0.50 4.44 1.24
151 INT30161 Negative_regulation of Positive_regulation of ADRA2B 2 0.05 0.25 1.24
152 INT231592 Binding of ADRA2B 5 0.18 0.13 1.23
153 INT82729 Transcription of Adra2b 1 0.02 1.05 1.23
154 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22
155 INT79489 Transcription of Adra2a 2 0.61 2.38 1.22
156 INT104011 Transcription of Pdpk1 1 0.28 0 1.2
157 INT104012 Regulation of Transcription of Pdpk1 1 0.14 0 1.2
158 INT26734 Binding of Pdpk1 4 0.29 1.01 1.19
159 INT70886 Positive_regulation of Gene_expression of Pdgfb 13 0.45 12.57 1.17
160 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17
161 INT3486 Positive_regulation of Regulation of INS 9 0.47 5.65 1.15
162 INT73364 Negative_regulation of Ang1 1 0.05 0.8 1.15
163 INT183046 Transcription of INS 25 0.70 11.14 1.13
164 INT106339 Positive_regulation of Phosphorylation of Insr 1 0.49 0 1.12
165 INT249522 Positive_regulation of Binding of Src 1 0.22 0.68 1.12
166 INT96861 Binding of Ang 11 0.32 4.46 1.1
167 INT6519 Positive_regulation of Gene_expression of ADRA2C 3 0.44 0.71 1.1
168 INT124167 Regulation of Positive_regulation of Src 2 0.13 0.47 1.1
169 INT19303 Regulation of ANG 3 0.62 1.08 1.09
170 INT32354 Negative_regulation of Regulation of Insr 3 0.33 0.13 1.08
171 INT76497 Transcription of Adra2c 2 0.21 0.08 1.07
172 INT87637 Localization of Ang 11 0.63 4.42 1.03
173 INT41043 Regulation of Adra2b 3 0.39 0.47 1.03
174 INT58470 Negative_regulation of Binding of INS 14 0.43 7.2 1.01
175 INT12976 Negative_regulation of ADRA2A 4 0.50 0.16 1.01
176 INT26012 Binding of Adra2c 2 0.48 0 1.01
177 INT317504 Protein_catabolism of Src 1 0.49 0.13 0.97
178 INT68467 Regulation of Regulation of Pdpk1 1 0.05 0.09 0.96
179 INT20687 Positive_regulation of Regulation of Adra2a 1 0.35 1.07 0.95
180 INT171382 Phosphorylation of Insr 6 0.51 3.41 0.94
181 INT100221 Negative_regulation of Phosphorylation of Src 2 0.24 0.74 0.93
182 INT118538 Binding of ANG 5 0.47 3.02 0.92
183 INT18801 Negative_regulation of Negative_regulation of Adra2a 2 0.43 0 0.91
184 INT38172 Regulation of Ang 8 0.31 4.13 0.9
185 INT33665 Positive_regulation of Gene_expression of Adra2c 1 0.50 0.43 0.89
186 INT65230 Negative_regulation of Adra2c 3 0.42 0.44 0.88
187 INT41911 Regulation of Positive_regulation of Insr 2 0.21 0.32 0.88
188 INT167763 Negative_regulation of Prkcz 1 0.04 0.32 0.88
189 INT124538 Positive_regulation of Gene_expression of Adra2c 1 0.27 0.75 0.87
190 INT171376 Positive_regulation of Phosphorylation of Insr 3 0.31 3.05 0.86
191 INT91908 Regulation of Negative_regulation of Insr 1 0.03 0.81 0.86
192 INT167833 Positive_regulation of Ins2 4 0.50 6.52 0.82
193 INT40928 Regulation of Binding of ADRA2C 1 0.43 0 0.82
194 INT109079 Negative_regulation of ANG 4 0.57 2.2 0.8
195 INT14130 Regulation of ADRA2C 4 0.45 1.57 0.79
196 INT143912 Localization of Src 4 0.48 2.51 0.78
197 INT14770 Localization of Adra2a 2 0.60 0.1 0.78
198 INT144759 Regulation of Gene_expression of INSR 2 0.44 3.09 0.77
199 INT249506 Regulation of Phosphorylation of Src 1 0.13 0.48 0.77
200 INT110117 Negative_regulation of Positive_regulation of Adra2c 1 0.12 0.33 0.77
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