GO:0032259

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Name methylation
Categary Process
Go Slim No
Go Link GO:0032259
Unique Molecular Interactions 107
Total Molecular Interactions 135
Total Single Events 1186
Pain Genes Associated 24

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for methylation. They are ordered first by their pain relevance and then by number of times they were reported for methylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
2 INT172203 Binding of Comt and Maoa 1 0.31 0.98 1.43
3 INT128913 Binding of COMT and PENK 1 0.30 0.07 1.41
4 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39
5 INT27425 Mtr Positive_regulation of Gene_expression of Il1f5 1 0.06 0 1.3
6 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29
7 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
8 INT107563 Penk Regulation of Mtr 1 0.00 0.1 1.04
9 INT107565 Hps4 Regulation of Mtr 1 0.00 0.1 1.04
10 INT265649 TBK1 Negative_regulation of COMT 1 0.01 0.61 0.94
11 INT165627 Binding of COMT and SLTM 1 0.09 0.86 0.88
12 INT91273 Mtr Positive_regulation of Localization of Il6 1 0.17 0 0.88
13 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
14 INT282506 ocd Positive_regulation of Gene_expression of Comt 1 0.32 1.26 0.84
15 INT340115 Comt Regulation of Localization of Dusp1 1 0.12 0.83 0.83
16 INT340114 Comt Regulation of Localization of Pain1 1 0.02 0.83 0.83
17 INT340113 Comt Regulation of Bdnf 1 0.21 0.74 0.82
18 INT54669 Mtr Regulation of Gene_expression of Il1 1 0.02 0.2 0.77
19 INT54668 Mtr Regulation of Gene_expression of Il1f5 1 0.00 0.2 0.76
20 INT266100 Binding of COMT and SH2B2 1 0.25 1.22 0.74
21 INT327707 Binding of Comt and Drd1a 1 0.18 0.27 0.74
22 INT266108 Binding of COMT and HPS1 1 0.23 1.21 0.74
23 INT327702 Binding of Comt and Drd2 1 0.28 0.27 0.74
24 INT327712 Binding of Comt and Rbm39 1 0.00 0.27 0.74
25 INT46657 Mtr Regulation of Gnrh1 1 0.01 0 0.71
26 INT28184 Binding of CYP1A2 and CYP2D6 1 0.00 0 0.7
27 INT46656 Mtr Regulation of Prl 1 0.05 0 0.7
28 INT38820 Binding of MTR and PDYN 1 0.03 0.19 0.65
29 INT27426 Mtr Positive_regulation of Localization of Il1f5 1 0.06 0 0.63
30 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63
31 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62
32 INT50935 Mtr Regulation of Gene_expression of Il6 1 0.00 0 0.53
33 INT162503 AHR Regulation of CYP1A2 3 0.61 0.18 0.5
34 INT92803 Binding of CYP1A2 and VKORC1 1 0.31 0.12 0.48
35 INT92804 Positive_regulation of Binding of CYP1A2 and VKORC1 1 0.41 0.12 0.48
36 INT101327 Binding of Cnr1 and Amt 1 0.25 0 0.47
37 INT28863 Mtr Negative_regulation of Dhfr 1 0.04 0.87 0.45
38 INT330464 Setd1a Regulation of Gene_expression of RT1-CE1 1 0.00 0.47 0.35
39 INT16382 Binding of Grin1 and Gnmt 1 0.04 0.17 0.32
40 INT327701 Comt Regulation of Npcd 1 0.01 0 0.29
41 INT327706 Comt Regulation of Gopc 1 0.10 0 0.29
42 INT216040 Binding of Comt and Prodh 1 0.30 1.71 0.26
43 INT162501 NEUROD1 Regulation of CYP1A2 2 0.22 0.09 0.25
44 INT101326 Negative_regulation of Binding of Cnr1 and Amt 1 0.29 0 0.25
45 INT330463 Setd1a Positive_regulation of Regulation of Adh1 1 0.00 0.09 0.23
46 INT266103 Binding of COMT and SNRNP70 1 0.04 0.78 0.21
47 INT202252 COMT Regulation of DRD2 1 0.31 0 0.21
48 INT50934 Mtr Positive_regulation of Gene_expression of Il6 1 0.00 0 0.2
49 INT195423 COMT Negative_regulation of GBE1 1 0.00 0.22 0.19
50 INT327700 Binding of Comt and 4930579C15Rik 1 0.08 0 0.15
51 INT202253 Binding of COMT and TCN1 1 0.16 0 0.12
52 INT327703 Cish Regulation of Transcription of Comt 1 0.13 0.77 0.12
53 INT83827 Negative_regulation of Binding of Adrb1 and Pnmt 1 0.02 0 0.1
54 INT83828 Binding of Adrb1 and Pnmt 1 0.01 0 0.1
55 INT327709 Uts2r Positive_regulation of Comt 1 0.14 0.47 0.1
56 INT48194 Pdgfb Positive_regulation of Setd1a 1 0.23 0 0.09
57 INT162507 Gtf3a Regulation of CYP1A2 1 0.00 0.09 0.09
58 INT66171 Negative_regulation of Adra2a Negative_regulation of Positive_regulation of Pnmt 1 0.38 0 0.08
59 INT66166 Negative_regulation of Binding of Pnmt and Adra2a 1 0.38 0 0.07
60 INT245985 Binding of MTR and Mtrr 1 0.06 0.8 0.07
61 INT66167 Negative_regulation of Pnmt Negative_regulation of Adra2a 1 0.38 0 0.07
62 INT66172 Binding of Pnmt and Adra2a 1 0.33 0 0.07
63 INT312940 Chol1 Positive_regulation of Setd1a 1 0.00 0 0.06
64 INT345925 IL6 Negative_regulation of Gene_expression of CYP1A2 1 0.13 0.18 0.06
65 INT264568 Binding of STS and CYP1A2 1 0.20 0.18 0.06
66 INT245986 MTR Regulation of Mthfr 1 0.07 0.18 0.05
67 INT245966 TCN1 Regulation of MTR 1 0.02 0.18 0.05
68 INT245967 Negative_regulation of TCN1 Regulation of MTR 1 0.02 0.18 0.05
69 INT290727 Binding of Prdm6 and Arsi 1 0.01 0.17 0.04
70 INT245987 Binding of MTR and Mthfr 1 0.11 0.48 0.03
71 INT332938 Suv39h1 Positive_regulation of Hist1h3f 1 0.06 0.12 0.03
72 INT332937 Hnmt Positive_regulation of Hist1h3f 1 0.01 0.12 0.03
73 INT183412 Dnmt3a Positive_regulation of Tbx15 1 0.05 0.27 0
74 INT301474 Binding of Helz and Smyd2 1 0.40 0.14 0
75 INT225550 Binding of Mybbp1a and Carm1 1 0.06 0 0
76 INT339096 Ezh2 Regulation of Rcc1 1 0.02 1.1 0
77 INT20322 Binding of CYP1A2 and CYP26A1 1 0.00 0 0
78 INT299889 Binding of MAT1A and MPP6 1 0.03 0.39 0
79 INT301464 Binding of Smyd3 and Dhx8 1 0.05 0.08 0
80 INT183413 Dnmt3a Positive_regulation of Gene_expression of Dnmt3b 1 0.10 0.28 0
81 INT301473 Binding of Dhx8 and Smyd2 1 0.06 0.14 0
82 INT225521 Binding of Prmt1 and Mybbp1a 1 0.05 0 0
83 INT183415 Dnmt3b Positive_regulation of Gene_expression of Dnmt3a 1 0.10 0.28 0
84 INT301466 Smyd2 Negative_regulation of Binding of Trp53 1 0.20 0.3 0
85 INT301468 Smyd2 Negative_regulation of Trp53 1 0.20 0.31 0
86 INT301467 Binding of Smyd3 and Helz 1 0.30 0.08 0
87 INT20326 Binding of CYP1A2 and CYP21A2 1 0.01 0 0
88 INT301469 Negative_regulation of Binding of Sin3a and Smyd2 1 0.28 0.31 0
89 INT53286 Binding of CYP1A2 and OPN1LW 1 0.03 0 0
90 INT312939 Binding of Hes3 and Setd1a 1 0.01 0.66 0
91 INT157283 CYP1A2 Positive_regulation of Gm7100 1 0.00 0 0
92 INT183410 Dnmt3b Positive_regulation of Tbx15 1 0.05 0.27 0
93 INT301475 Binding of Sin3a and Smyd2 1 0.32 0.31 0
94 INT312945 ANTXR1 Regulation of Setd1a 1 0.00 0.36 0
95 INT225537 Binding of Paxip1 and Mll2 1 0.12 0 0
96 INT301472 Binding of Polr2a and Smyd3 1 0.06 0.08 0
97 INT301470 Binding of Smyd2 and Hdac1 1 0.35 0.31 0
98 INT95055 Binding of CYP1A2 and TXNRD1 1 0.04 0 0
99 INT297846 Nanos2 Regulation of Dnmt3l 1 0.34 0.6 0
100 INT301463 Negative_regulation of Smyd2 Positive_regulation of Gene_expression of Smyd1 1 0.54 0.1 0
101 INT342096 Binding of Polr2f and Ehmt1 1 0.00 0.73 0
102 INT225544 Binding of Prmt1 and Pprc1 1 0.00 0 0
103 INT254850 Setd1a Negative_regulation of Rac1 1 0.00 0 0
104 INT301471 Binding of Smyd1 and Smyd2 1 0.40 0.2 0
105 INT301476 Binding of Polr2a and Smyd2 1 0.08 0.13 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for methylation. They are ordered first by their pain relevance and then by number of times they were reported in methylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49
2 INT101120 Gene_expression of Comt 63 0.77 34.75 26.13
3 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05
4 INT135629 Binding of COMT 33 0.48 16.68 19.37
5 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35
6 INT1672 Gene_expression of Mtr 18 0.67 3.39 13.32
7 INT101119 Negative_regulation of Comt 19 0.58 8.77 13.09
8 INT18539 Gene_expression of Pnmt 33 0.78 3.08 12.47
9 INT17619 Regulation of COMT 12 0.45 8.46 12.22
10 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66
11 INT144736 Negative_regulation of Gene_expression of COMT 13 0.58 6.47 9.28
12 INT3922 Negative_regulation of Pnmt 29 0.59 3.18 8.96
13 INT122952 Positive_regulation of COMT 13 0.50 8.1 8.89
14 INT44537 Positive_regulation of Comt 7 0.69 2.62 7.78
15 INT9802 Positive_regulation of Mtr 9 0.60 3.69 7.43
16 INT101121 Regulation of Comt 19 0.53 10.66 7.22
17 INT144739 Regulation of Gene_expression of COMT 11 0.61 3.07 7.08
18 INT23132 Positive_regulation of Pnmt 17 0.67 2.02 6.84
19 INT46518 Localization of Mtr 12 0.65 1.31 6.55
20 INT150825 Binding of Comt 13 0.42 6.65 6.42
21 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92
22 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73
23 INT10006 Regulation of Mtr 9 0.23 3.56 5.42
24 INT12250 Negative_regulation of Mtr 19 0.50 6.9 5.35
25 INT14455 Transcription of Pnmt 17 0.72 2.13 4.95
26 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75
27 INT12380 Localization of Pnmt 10 0.80 0.07 4.7
28 INT9803 Positive_regulation of Gene_expression of Mtr 3 0.60 1.45 4.36
29 INT172197 Positive_regulation of Gene_expression of Comt 12 0.69 7.61 4.06
30 INT18538 Regulation of Pnmt 11 0.60 1.03 3.84
31 INT172198 Protein_catabolism of Comt 7 0.88 2.78 3.6
32 INT206598 Regulation of Gene_expression of Comt 9 0.60 6 3.56
33 INT195964 Transcription of Comt 8 0.71 4.72 3.4
34 INT24751 Gene_expression of Mtr 8 0.36 1.34 3.34
35 INT194289 Transcription of COMT 3 0.72 3.56 2.72
36 INT202257 Localization of COMT 7 0.75 2.13 2.65
37 INT206593 Negative_regulation of Gene_expression of Comt 3 0.56 1.68 2.52
38 INT265662 Negative_regulation of Binding of COMT 4 0.37 1.29 2.42
39 INT20332 Positive_regulation of Positive_regulation of CYP1A2 4 0.69 0.68 2.17
40 INT136962 Protein_catabolism of COMT 4 0.89 1.12 2.14
41 INT28468 Positive_regulation of Transcription of Pnmt 4 0.67 0.63 2.04
42 INT68638 Negative_regulation of Hnmt 1 0.58 0.63 2.04
43 INT65424 Positive_regulation of Gene_expression of CYP1A2 6 0.70 2.01 2.01
44 INT25582 Regulation of Mtr 2 0.03 0.4 1.76
45 INT265659 Positive_regulation of Negative_regulation of COMT 1 0.43 0.78 1.57
46 INT47446 Regulation of Localization of Mtr 1 0.05 0.07 1.42
47 INT28478 Regulation of Gene_expression of Pnmt 5 0.44 0 1.41
48 INT79361 Negative_regulation of Prdm6 5 0.51 3.79 1.4
49 INT9217 Negative_regulation of MTR 17 0.58 1.13 1.32
50 INT48192 Gene_expression of Setd1a 8 0.42 4.41 1.26
51 INT2595 Binding of Mtr 1 0.29 0 1.24
52 INT101323 Negative_regulation of Amt 1 0.40 0 1.14
53 INT28469 Positive_regulation of Gene_expression of Pnmt 4 0.49 0.73 1.11
54 INT47131 Negative_regulation of Localization of Mtr 1 0.41 0 1.06
55 INT157361 Localization of MTR 2 0.31 1.4 1.05
56 INT24750 Negative_regulation of Mtr 1 0.22 0.06 1.04
57 INT246088 Negative_regulation of Negative_regulation of COMT 2 0.37 2.01 1
58 INT170813 Gene_expression of Prdm6 11 0.65 4.35 0.88
59 INT31014 Negative_regulation of Setd1a 4 0.27 1.11 0.88
60 INT282479 Regulation of Protein_catabolism of Comt 2 0.45 1.17 0.85
61 INT47518 Negative_regulation of Positive_regulation of Pnmt 2 0.42 0.32 0.8
62 INT265663 Positive_regulation of Gene_expression of COMT 2 0.50 0.26 0.79
63 INT157282 Localization of CYP1A2 5 0.75 0.54 0.76
64 INT195983 Localization of Comt 2 0.74 0.93 0.76
65 INT136963 Regulation of Protein_catabolism of COMT 1 0.24 0.49 0.72
66 INT24584 Positive_regulation of MTR 4 0.44 0.07 0.7
67 INT331008 Positive_regulation of Localization of CYP1A2 1 0.42 0.06 0.7
68 INT12379 Regulation of Localization of Pnmt 1 0.17 0 0.69
69 INT351280 Negative_regulation of Negative_regulation of CYP1A2 1 0.27 0.53 0.69
70 INT68639 Regulation of Hnmt 1 0.45 0.15 0.68
71 INT307096 Regulation of Prmt1 1 0.01 0.92 0.63
72 INT307095 Negative_regulation of Regulation of Prmt1 1 0.02 0.93 0.63
73 INT10007 Regulation of Gene_expression of Mtr 2 0.23 1.17 0.61
74 INT14109 Positive_regulation of Mtr 1 0.03 0.49 0.6
75 INT78090 Gene_expression of MAT1A 2 0.65 0.93 0.52
76 INT265655 Regulation of Positive_regulation of COMT 1 0.39 0.38 0.49
77 INT327677 Regulation of Transcription of Comt 2 0.60 1.49 0.48
78 INT66991 Positive_regulation of Prdm6 2 0.16 0.86 0.44
79 INT24583 Protein_catabolism of MTR 1 0.57 0 0.42
80 INT156944 Positive_regulation of Setd1a 2 0.30 1.31 0.41
81 INT266128 Positive_regulation of Transcription of COMT 1 0.44 0.35 0.41
82 INT306690 Negative_regulation of Dnmt3b 1 0.00 0.56 0.39
83 INT54952 Binding of Mtr 1 0.03 0.58 0.37
84 INT160666 Binding of Prdm6 2 0.31 0.73 0.35
85 INT26194 Regulation of MTR 1 0.19 1.1 0.33
86 INT16380 Positive_regulation of Gnmt 1 0.05 0.25 0.33
87 INT166893 Negative_regulation of Gene_expression of Mtr 1 0.03 0.57 0.33
88 INT156943 Negative_regulation of Negative_regulation of Setd1a 1 0.18 0.71 0.32
89 INT266123 Negative_regulation of Transcription of COMT 1 0.59 0.65 0.3
90 INT144387 Positive_regulation of Negative_regulation of CYP1A2 2 0.39 0.64 0.28
91 INT156942 Positive_regulation of Gene_expression of Setd1a 1 0.21 0.58 0.28
92 INT83525 Negative_regulation of Transcription of Pnmt 3 0.57 0 0.27
93 INT282213 Negative_regulation of Regulation of Mtr 1 0.01 0.82 0.27
94 INT266127 Regulation of Binding of COMT 1 0.39 0.54 0.27
95 INT83526 Negative_regulation of Gene_expression of Pnmt 1 0.41 0 0.25
96 INT266124 Positive_regulation of Binding of COMT 1 0.44 0 0.23
97 INT70913 Gene_expression of MTR 2 0.12 0.44 0.21
98 INT266122 Regulation of Localization of COMT 1 0.39 0 0.21
99 INT327698 Regulation of Binding of Comt 1 0.39 0 0.2
100 INT16756 Regulation of Transcription of Pnmt 2 0.39 0.08 0.18
101 INT327691 Negative_regulation of Transcription of Comt 1 0.37 0.33 0.18
102 INT48193 Regulation of Setd1a 3 0.15 0.92 0.17
103 INT273293 Gene_expression of Hnmt 1 0.46 0.34 0.17
104 INT301442 Gene_expression of Smyd2 1 0.77 2.97 0.17
105 INT327679 Regulation of Positive_regulation of Comt 1 0.39 0.39 0.17
106 INT344068 Negative_regulation of Binding of CYP1A2 1 0.15 0.05 0.17
107 INT223333 Negative_regulation of Gene_expression of MTR 1 0.07 0.16 0.16
108 INT55773 Binding of MTR 2 0.30 0.74 0.14
109 INT291670 Negative_regulation of Dnmt3a 1 0.31 0.7 0.14
110 INT231567 Negative_regulation of Gene_expression of CYP1A2 2 0.36 0.06 0.13
111 INT162937 Regulation of Regulation of CYP1A2 1 0.45 0 0.12
112 INT162936 Regulation of Gene_expression of CYP1A2 1 0.45 0 0.12
113 INT299895 Binding of MAT1A 1 0.18 0.36 0.09
114 INT12251 Regulation of Negative_regulation of Mtr 1 0.19 0 0.09
115 INT266125 Regulation of Transcription of COMT 1 0.24 0.88 0.08
116 INT66162 Positive_regulation of Binding of Pnmt 1 0.49 0 0.08
117 INT66164 Negative_regulation of Binding of Pnmt 1 0.41 0 0.08
118 INT66163 Binding of Pnmt 1 0.36 0 0.08
119 INT55772 Negative_regulation of Negative_regulation of MTR 1 0.41 0 0.07
120 INT274055 Protein_catabolism of CYP1A2 1 0.47 0 0.06
121 INT175365 Localization of Prdm6 2 0.54 0.1 0.05
122 INT288754 Negative_regulation of Positive_regulation of Mtr 1 0.11 0.1 0.05
123 INT339094 Gene_expression of Ezh2 1 0.78 67.79 0.05
124 INT301438 Negative_regulation of Smyd2 1 0.58 0.73 0.05
125 INT183393 Gene_expression of Dnmt3a 3 0.43 1.08 0.04
126 INT291678 Regulation of Dnmt3a 1 0.28 0.48 0.04
127 INT288765 Positive_regulation of Negative_regulation of Mtr 1 0.12 0.09 0.04
128 INT237668 Regulation of Prdm6 3 0.20 1.49 0.03
129 INT332923 Localization of Hnmt 1 0.12 0.11 0.03
130 INT332918 Localization of Suv39h1 1 0.73 0.11 0.03
131 INT342085 Positive_regulation of Ehmt1 1 0.01 0.4 0
132 INT299896 Positive_regulation of MAT1A 1 0.23 0.4 0
133 INT339087 Binding of Ezh2 1 0.37 1.14 0
134 INT301448 Transcription of Smyd2 1 0.69 0.3 0
135 INT83244 Regulation of Positive_regulation of CYP1A2 1 0.43 1.18 0
136 INT301436 Positive_regulation of Gene_expression of Smyd2 1 0.50 0 0
137 INT301205 Negative_regulation of Gene_expression of Dnmt3l 1 0.20 0.81 0
138 INT301444 Positive_regulation of Carm1 1 0.04 0 0
139 INT47058 Positive_regulation of Negative_regulation of MTR 1 0.41 0 0
140 INT158582 Negative_regulation of Positive_regulation of CYP1A2 1 0.41 0 0
141 INT47059 Positive_regulation of Positive_regulation of MTR 1 0.44 0 0
142 INT86107 Regulation of Negative_regulation of Setd1a 1 0.04 0.14 0
143 INT239565 Localization of Setd1a 1 0.01 0.85 0
144 INT301437 Regulation of Carm1 1 0.02 0.06 0
145 INT301226 Gene_expression of Dnmt3l 1 0.37 0.76 0
146 INT301450 Localization of Smyd2 1 0.75 1.04 0
147 INT225404 Binding of Prmt1 1 0.14 0 0
148 INT342075 Negative_regulation of Ehmt1 1 0.01 0.69 0
149 INT301455 Regulation of Smyd2 1 0.27 0.66 0
150 INT225430 Gene_expression of Mll2 1 0.33 0 0
151 INT183396 Positive_regulation of Gene_expression of Dnmt3a 1 0.20 0.59 0
152 INT225388 Binding of Carm1 1 0.17 0 0
153 INT76171 Regulation of Regulation of Pnmt 1 0.19 0 0
154 INT301433 Binding of Smyd2 1 0.48 0.68 0
155 INT339090 Positive_regulation of Ezh2 1 0.47 0.82 0
156 INT183391 Positive_regulation of Gene_expression of Dnmt3b 1 0.20 0.59 0
157 INT301445 Positive_regulation of Smyd2 1 0.50 0.79 0
158 INT183398 Gene_expression of Dnmt3b 1 0.27 0.59 0
159 INT301443 Gene_expression of Smyd3 1 0.57 0 0
160 INT297825 Regulation of Dnmt3l 1 0.39 0.59 0
161 INT339091 Positive_regulation of Gene_expression of Ezh2 1 0.70 11.65 0
162 INT292012 Positive_regulation of Localization of COMT 1 0.44 0.13 0
163 INT339095 Negative_regulation of Gene_expression of Ezh2 1 0.59 4.48 0
164 INT167110 Regulation of Binding of CYP1A2 1 0.45 0 0
165 INT339089 Regulation of Gene_expression of Ezh2 1 0.45 3.76 0
166 INT301432 Negative_regulation of Gene_expression of Smyd2 1 0.58 0.58 0
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