GO:0032319

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Name regulation of Rho GTPase activity
Categary Process
Go Slim No
Go Link GO:0032319
Unique Molecular Interactions 51
Total Molecular Interactions 67
Total Single Events 688
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of Rho GTPase activity. They are ordered first by their pain relevance and then by number of times they were reported for regulation of Rho GTPase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT116930 OPRK1 Positive_regulation of Binding of PTK2 1 0.28 0.35 0.93
2 INT116109 VEGFA Positive_regulation of PTK2 1 0.13 0.3 0.83
3 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
4 INT111937 Binding of PIK3CG and PTK2 1 0.08 0.67 0.64
5 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
6 INT116935 Positive_regulation of OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.47
7 INT116939 OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.46
8 INT116928 PTK2 Positive_regulation of JUN 1 0.20 0.15 0.46
9 INT283858 Binding of PTK2 and APOA5 1 0.00 0.67 0.21
10 INT178086 Binding of EDNRA and PTK2 1 0.07 0.82 0.2
11 INT269446 Binding of EPHA3 and HHIP 1 0.01 0 0.2
12 INT178092 EDN3 Positive_regulation of PTK2 1 0.01 1.02 0.17
13 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
14 INT147727 Phosphorylation of PTK2 Regulation of Positive_regulation of RAC1 1 0.34 0.32 0.14
15 INT147726 Phosphorylation of PTK2 Regulation of Positive_regulation of PIK3CA 1 0.09 0.32 0.14
16 INT332687 Ros1 Positive_regulation of Crk 1 0.17 0.77 0.12
17 INT178089 Binding of EDNRA and Positive_regulation of PTK2 1 0.09 0.74 0.09
18 INT221258 Negative_regulation of Binding of VDAC1 and Crk 1 0.00 0.22 0.08
19 INT350700 Binding of Bcl6 and thd 1 0.00 0.21 0.08
20 INT355582 VEGFA Regulation of Positive_regulation of PTK2 1 0.05 1.46 0.08
21 INT221255 Binding of VDAC1 and Crk 1 0.00 0.22 0.08
22 INT350692 Binding of Bcl6 and Hand1 1 0.02 0.16 0.08
23 INT350720 Binding of Bcl6 and TBX21 1 0.07 0.22 0.08
24 INT346280 Binding of COL5A2 and PTK2 1 0.01 0.1 0.05
25 INT292464 Binding of PTK2 and MMRN1 1 0.03 0.26 0
26 INT292505 PTK2 Regulation of Birc5 1 0.29 0.76 0
27 INT292444 BAD Positive_regulation of Phosphorylation of PTK2 1 0.13 0.9 0
28 INT292463 LAMB2 Positive_regulation of Phosphorylation of PTK2 1 0.01 0.7 0
29 INT292497 Mlph Positive_regulation of Phosphorylation of PTK2 1 0.05 7.24 0
30 INT292498 Mlph Regulation of Phosphorylation of PTK2 1 0.02 0.33 0
31 INT292452 Gene_expression of PTK2 Negative_regulation of Positive_regulation of AKT1 1 0.14 0.6 0
32 INT292453 PTK2 Regulation of Gene_expression of GEM 1 0.16 0.42 0
33 INT283863 Binding of MAPK1 and PTK2 1 0.12 0.97 0
34 INT292495 Mlph Regulation of Gene_expression of PTK2 1 0.03 0.21 0
35 INT292461 PTK2 Regulation of BCL2 1 0.02 0.76 0
36 INT225895 Binding of CRK and GAB1 1 0.01 0.1 0
37 INT292451 PTK2 Regulation of BAX 1 0.02 0.76 0
38 INT269562 GOPC Positive_regulation of Gene_expression of EPHA3 1 0.03 0 0
39 INT302368 Binding of Arx and Pafah1b1 1 0.27 1.25 0
40 INT207266 INS Negative_regulation of BCL6 1 0.29 0.08 0
41 INT322470 Binding of Bcl6 and Hif1a 1 0.06 0.52 0
42 INT225872 Binding of CRK and Cbl 1 0.00 0 0
43 INT292448 Positive_regulation of PTK2 Positive_regulation of Phosphorylation of AKT1 1 0.15 0.28 0
44 INT292457 PTK2 Regulation of BAD 1 0.03 0.76 0
45 INT305632 Binding of BCL6 and MME 1 0.00 1.37 0
46 INT257826 PAFAH1B1 Positive_regulation of Paf 1 0.02 1.02 0
47 INT292506 Mlph Regulation of PTK2 1 0.01 0.21 0
48 INT225907 Binding of CRK and DOCK1 1 0.01 0 0
49 INT292460 GEM Positive_regulation of Phosphorylation of PTK2 1 0.20 0.52 0
50 INT268508 MIR221 Positive_regulation of BCL6 1 0.03 1.36 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of Rho GTPase activity. They are ordered first by their pain relevance and then by number of times they were reported in regulation of Rho GTPase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT60161 Gene_expression of EPHA3 43 0.75 3.66 6.25
2 INT87345 Phosphorylation of PTK2 110 0.82 59.39 4.28
3 INT269377 Positive_regulation of EPHA3 22 0.18 0.97 2.55
4 INT126457 Gene_expression of BCL6 34 0.66 22.45 1.75
5 INT257820 Positive_regulation of PAFAH1B1 1 0.68 11.09 1.69
6 INT116110 Positive_regulation of PTK2 20 0.66 10.53 1.64
7 INT111946 Positive_regulation of Phosphorylation of PTK2 8 0.66 11.5 1.53
8 INT168312 Positive_regulation of Gene_expression of EPHA3 8 0.49 0.97 1.32
9 INT87343 Negative_regulation of Phosphorylation of PTK2 34 0.59 18.38 1.19
10 INT87346 Binding of PTK2 6 0.37 4.03 1.18
11 INT87342 Regulation of Phosphorylation of PTK2 3 0.59 5.7 1.05
12 INT257824 Localization of PAFAH1B1 1 0.74 6.58 1
13 INT87344 Gene_expression of PTK2 90 0.78 59.03 0.87
14 INT269642 Binding of EPHA3 4 0.10 0.22 0.8
15 INT87341 Regulation of Gene_expression of PTK2 2 0.62 8.34 0.77
16 INT180752 Gene_expression of PAFAH1B1 3 0.66 9.89 0.75
17 INT257817 Regulation of PAFAH1B1 1 0.60 4.93 0.7
18 INT236711 Gene_expression of Bcl6 15 0.30 12.98 0.58
19 INT257816 Negative_regulation of PAFAH1B1 1 0.58 3.66 0.49
20 INT269613 Negative_regulation of Binding of EPHA3 2 0.11 0.27 0.43
21 INT207299 Binding of BCL6 6 0.30 3.5 0.41
22 INT16932 Localization of EPHA3 3 0.73 0.15 0.38
23 INT181575 Phosphorylation of Crk 1 0.61 1.78 0.36
24 INT181580 Gene_expression of Crk 1 0.75 1.2 0.33
25 INT121388 Positive_regulation of BCL6 2 0.28 2.71 0.32
26 INT235466 Localization of BCL6 3 0.27 5 0.29
27 INT119080 Negative_regulation of PTK2 15 0.56 8.88 0.23
28 INT22405 Positive_regulation of Crk 2 0.09 0.64 0.23
29 INT87338 Regulation of PTK2 10 0.62 4.75 0.21
30 INT144881 Positive_regulation of Gene_expression of BCL6 5 0.43 1.6 0.18
31 INT292483 Negative_regulation of Positive_regulation of PTK2 2 0.41 3.51 0.18
32 INT257825 Binding of PAFAH1B1 1 0.37 0.89 0.17
33 INT257818 Regulation of Gene_expression of PAFAH1B1 1 0.44 0.76 0.15
34 INT147730 Regulation of Positive_regulation of PTK2 1 0.35 0.33 0.15
35 INT236693 Positive_regulation of Gene_expression of Bcl6 3 0.15 2.06 0.14
36 INT258953 Negative_regulation of Gene_expression of Bcl6 1 0.19 1.53 0.14
37 INT257821 Transcription of PAFAH1B1 1 0.61 1.11 0.14
38 INT269628 Regulation of EPHA3 2 0.12 0.2 0.12
39 INT258955 Localization of Bcl6 1 0.23 0.83 0.11
40 INT338914 Negative_regulation of Phosphorylation of CRK 1 0.08 0 0.1
41 INT338913 Phosphorylation of CRK 1 0.12 0 0.1
42 INT221209 Localization of Crk 1 0.05 0.25 0.09
43 INT221203 Binding of Crk 1 0.06 0.22 0.08
44 INT350635 Transcription of Bcl6 1 0.09 0.16 0.08
45 INT147735 Regulation of Binding of PTK2 1 0.35 0.23 0.08
46 INT350649 Negative_regulation of Transcription of Bcl6 1 0.06 0.16 0.08
47 INT229469 Gene_expression of Pafah1b1 1 0.15 0.32 0.07
48 INT144400 Positive_regulation of Gene_expression of PTK2 33 0.70 21.24 0.06
49 INT329775 Regulation of Regulation of PTK2 1 0.11 0.49 0.05
50 INT269400 Positive_regulation of Phosphorylation of EPHA3 1 0.11 0.05 0.05
51 INT269388 Phosphorylation of EPHA3 3 0.21 0.16 0.04
52 INT207276 Transcription of BCL6 3 0.45 0.64 0.03
53 INT269599 Negative_regulation of Positive_regulation of EPHA3 1 0.11 0.47 0.03
54 INT269649 Positive_regulation of Localization of EPHA3 1 0.13 0 0.03
55 INT269618 Negative_regulation of Localization of EPHA3 1 0.11 0 0.03
56 INT292474 Negative_regulation of Gene_expression of PTK2 8 0.41 5.17 0
57 INT262779 Localization of PTK2 3 0.71 2.75 0
58 INT144882 Negative_regulation of Gene_expression of BCL6 2 0.26 0.93 0
59 INT322454 Positive_regulation of Bcl6 2 0.10 1.6 0
60 INT292478 Negative_regulation of Negative_regulation of PTK2 1 0.41 0.97 0
61 INT329769 Positive_regulation of Localization of PTK2 1 0.17 1.42 0
62 INT207269 Regulation of BCL6 1 0.38 0.1 0
63 INT188315 Positive_regulation of Crk 1 0.49 0.09 0
64 INT269607 Regulation of Positive_regulation of EPHA3 1 0.12 0 0
65 INT269634 Positive_regulation of Positive_regulation of EPHA3 1 0.18 0 0
66 INT269626 Negative_regulation of Phosphorylation of EPHA3 1 0.11 0.11 0
67 INT269667 Regulation of Phosphorylation of EPHA3 1 0.12 0.11 0
68 INT277796 Binding of Bcl6 1 0.17 1.33 0
69 INT347438 Regulation of Gene_expression of BCL6 1 0.07 0.7 0
70 INT269633 Regulation of Localization of EPHA3 1 0.12 0 0
71 INT176248 Binding of Pafah1b1 1 0.07 0.45 0
72 INT292481 Negative_regulation of Localization of PTK2 1 0.41 0.07 0
73 INT225843 Positive_regulation of CRK 1 0.04 0 0
74 INT269612 Negative_regulation of EPHA3 1 0.11 0.17 0
75 INT329766 Positive_regulation of Positive_regulation of PTK2 1 0.11 0.51 0
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