GO:0032331

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Name negative regulation of chondrocyte differentiation
Categary Process
Go Slim No
Go Link GO:0032331
Unique Molecular Interactions 122
Total Molecular Interactions 160
Total Single Events 1479
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of chondrocyte differentiation. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of chondrocyte differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
2 INT178581 CNTN2 Positive_regulation of PTHLH 1 0.24 2.16 0.75
3 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
4 INT116936 Positive_regulation of GLI2 Positive_regulation of JUN 1 0.12 0.07 0.41
5 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
6 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
7 INT178578 Binding of PTHLH and CALCRL 1 0.01 0.68 0.27
8 INT233782 Binding of PTHLH and SCT 1 0.06 0 0.27
9 INT104834 Binding of GLI2 and IGKV2OR2-1 1 0.00 0 0.22
10 INT89475 TGFB1 Positive_regulation of Gene_expression of PTHLH 3 0.61 3.64 0.21
11 INT343547 ROCK1 Positive_regulation of Gene_expression of PTHLH 1 0.15 0.2 0.2
12 INT355364 Regulation of PTHLH Positive_regulation of Tnfsf11 1 0.04 1.51 0.19
13 INT355363 PTHLH Positive_regulation of Tnfsf11 1 0.04 1.47 0.19
14 INT303937 Positive_regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
15 INT303940 Regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
16 INT111152 Pthlh Positive_regulation of Localization of Avp 1 0.53 0.26 0.18
17 INT303938 Binding of GLI2 and CCL5 1 0.01 0 0.18
18 INT346519 Binding of PTHLH and TFIP11 1 0.09 0.12 0.17
19 INT303939 TRAP Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
20 INT303941 CCL2 Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
21 INT104837 IGKV2OR2-1 Negative_regulation of GLI2 1 0.00 0 0.15
22 INT107889 Binding of Pthlh and Pth1r 1 0.06 0 0.14
23 INT107892 Binding of Pthlh and PTH2 1 0.27 0 0.14
24 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
25 INT343542 ROCK1 Positive_regulation of Positive_regulation of PTHLH 1 0.21 0 0.12
26 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
27 INT293416 IL8 Regulation of PTHLH 1 0.04 1.18 0.1
28 INT293414 HRAS Regulation of PTHLH 1 0.00 1.18 0.1
29 INT343538 TGFB1 Positive_regulation of Gene_expression of GLI2 1 0.08 0.2 0.05
30 INT210261 Bmp4 Regulation of Gene_expression of Tff3 1 0.64 0 0.05
31 INT233849 Twist1 Positive_regulation of Snai2 1 0.07 0.58 0.04
32 INT210598 PTHLH Positive_regulation of Gene_expression of TNFSF11 1 0.23 0.98 0.04
33 INT233853 Zeb1 Positive_regulation of Snai2 1 0.09 0.58 0.04
34 INT322891 Sox9 Regulation of Transcription of Col2a1 1 0.10 0.12 0.04
35 INT184208 IL1B Negative_regulation of SOX9 1 0.32 0 0.03
36 INT343546 Negative_regulation of ROCK1 Negative_regulation of Gene_expression of PTHLH 1 0.16 3.28 0.03
37 INT343545 Binding of GLI2 and ROCK1 1 0.07 0.65 0.03
38 INT343537 ROCK1 Regulation of Gene_expression of PTHLH 1 0.08 0.09 0.03
39 INT210260 Sox9 Negative_regulation of Cdx2 1 0.20 0 0.03
40 INT343544 Negative_regulation of GLI2 Negative_regulation of Gene_expression of PTHLH 1 0.24 0.53 0.03
41 INT314865 Binding of Ltbp3 and Tgfb1 1 0.24 0.51 0
42 INT355603 Binding of CTNNA1 and Ctnnb1 1 0.00 1.07 0
43 INT220818 Binding of Ctnnb1 and Myc 1 0.06 0.13 0
44 INT320029 Gene_expression of SOX9 Positive_regulation of Gene_expression of COL7A1 1 0.03 0 0
45 INT314858 Binding of Gdf11 and Ltbp3 1 0.39 0.31 0
46 INT245726 SOX9 Regulation of SGCG 1 0.00 0.29 0
47 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0
48 INT195062 PTHLH Positive_regulation of Gene_expression of Pygm 1 0.00 0.67 0
49 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0
50 INT333879 Shc1 Positive_regulation of SOX9 1 0.01 0 0
51 INT225570 Ncoa6 Regulation of Sox9 1 0.16 0.72 0
52 INT136693 Gtf3a Positive_regulation of Ctnnb1 1 0.05 0 0
53 INT197794 Negative_regulation of Pthlh Regulation of Ihh 1 0.36 1.33 0
54 INT343541 PTHLH Positive_regulation of GYPA 1 0.03 0.95 0
55 INT314862 Binding of Ltbp3 and Tgfb2 1 0.24 0.52 0
56 INT195052 PTHLH Positive_regulation of Positive_regulation of CPOX 1 0.07 0.67 0
57 INT314868 Binding of Ltbp2 and Ltbp3 1 0.29 0.54 0
58 INT212009 Binding of PRL and PTHLH 1 0.32 0.48 0
59 INT89477 PTHLH Negative_regulation of Gene_expression of TNFRSF11B 1 0.14 0.15 0
60 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
61 INT207374 Gene_expression of GLI2 Negative_regulation of Gene_expression of Chol1 1 0.04 0 0
62 INT346524 Binding of PTHLH and PTH2R 1 0.10 0 0
63 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
64 INT343548 GLI2 Positive_regulation of Gene_expression of PTHLH 1 0.28 0.94 0
65 INT220821 Binding of MAX and Ctnnb1 1 0.09 0.13 0
66 INT314870 Binding of Ltbp3 and Tgfb3 1 0.24 0.52 0
67 INT343549 GLI2 Positive_regulation of GYPA 1 0.05 0.95 0
68 INT286561 Binding of Ctnnb1 and Cdh2 1 0.00 1.06 0
69 INT286567 Prkd1 Regulation of Ctnnb1 1 0.01 0.39 0
70 INT196022 Bmp7 Regulation of Bmp4 1 0.06 0.06 0
71 INT207336 Gene_expression of GLI2 Negative_regulation of Gene_expression of CYP27A1 1 0.00 0 0
72 INT270121 Binding of Pth and Pthlh 1 0.08 0.56 0
73 INT195053 PTHLH Regulation of Gene_expression of CPOX 1 0.03 0.71 0
74 INT343539 GLI2 Regulation of PTHLH 1 0.15 0.25 0
75 INT286572 Binding of Ctnnb1 and Pkd1 1 0.02 0.96 0
76 INT245735 SOX9 Regulation of COL5A2 1 0.07 0.29 0
77 INT197793 Pthlh Regulation of Ihh 1 0.22 1.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of chondrocyte differentiation. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of chondrocyte differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85
2 INT12564 Localization of Pthlh 23 0.81 4.37 5.82
3 INT64170 Gene_expression of GLI2 31 0.46 14.96 3.99
4 INT13416 Positive_regulation of Pthlh 19 0.60 14.78 3.74
5 INT62360 Positive_regulation of PTHLH 31 0.70 28.23 3.46
6 INT37363 Localization of PTHLH 14 0.68 13.23 2.92
7 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
8 INT12565 Regulation of Localization of Pthlh 10 0.62 0.71 2.14
9 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
10 INT30153 Regulation of PTHLH 13 0.58 7.72 1.87
11 INT13861 Negative_regulation of Localization of Pthlh 2 0.10 0.08 1.81
12 INT90926 Positive_regulation of GLI2 12 0.45 4.99 1.74
13 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
14 INT62071 Positive_regulation of Gene_expression of PTHLH 13 0.70 19.32 1.73
15 INT46530 Gene_expression of Pthlh 15 0.78 11.23 1.7
16 INT12566 Positive_regulation of Localization of Pthlh 4 0.70 0.13 1.65
17 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
18 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
19 INT72138 Gene_expression of Pthlh 18 0.75 17.68 1.49
20 INT104839 Negative_regulation of GLI2 8 0.35 2.7 1.24
21 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
22 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2
23 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
24 INT32760 Regulation of Gene_expression of PTHLH 4 0.51 6.32 1
25 INT119674 Localization of GLI2 6 0.52 2.84 0.99
26 INT182322 Negative_regulation of Gene_expression of GLI2 6 0.11 2.37 0.98
27 INT166715 Gene_expression of Sox9 16 0.65 6.39 0.92
28 INT114824 Binding of PTHLH 12 0.42 9.5 0.9
29 INT64173 Regulation of Gene_expression of GLI2 4 0.37 2.89 0.88
30 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
31 INT289474 Regulation of GLI2 2 0.06 1.08 0.87
32 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
33 INT62072 Negative_regulation of Gene_expression of PTHLH 3 0.43 4.45 0.85
34 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
35 INT145306 Gene_expression of Sox9 5 0.54 2.47 0.8
36 INT104840 Binding of GLI2 6 0.08 1.89 0.72
37 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
38 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
39 INT80452 Positive_regulation of Gene_expression of Pthlh 4 0.40 3.77 0.62
40 INT184222 Negative_regulation of SOX9 7 0.41 2.68 0.58
41 INT157103 Transcription of SOX9 6 0.59 1.2 0.58
42 INT30943 Negative_regulation of Pthlh 3 0.20 2.75 0.56
43 INT76960 Negative_regulation of Ctnnb1 5 0.57 3.46 0.53
44 INT157104 Positive_regulation of SOX9 6 0.66 1.66 0.52
45 INT50555 Regulation of Pthlh 3 0.16 2.07 0.52
46 INT157105 Positive_regulation of Transcription of SOX9 4 0.58 0.88 0.51
47 INT81175 Localization of Pthlh 4 0.70 7.64 0.5
48 INT40572 Regulation of Localization of PTHLH 1 0.04 0 0.49
49 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47
50 INT145304 Regulation of Gene_expression of Sox9 1 0.43 1.04 0.46
51 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
52 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41
53 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
54 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
55 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4
56 INT110258 Negative_regulation of PTHLH 6 0.56 5.42 0.39
57 INT140982 Negative_regulation of Gene_expression of Pthlh 1 0.30 0.39 0.39
58 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37
59 INT81643 Regulation of Gene_expression of Ctnnb1 3 0.57 1.5 0.37
60 INT108324 Negative_regulation of Gene_expression of Ctnnb1 1 0.06 1.43 0.31
61 INT82118 Positive_regulation of Pthlh 3 0.47 2.46 0.3
62 INT119675 Positive_regulation of Localization of GLI2 1 0.32 0.43 0.3
63 INT234407 Positive_regulation of Binding of GLI2 2 0.05 1.33 0.28
64 INT151719 Negative_regulation of Positive_regulation of Ctnnb1 1 0.23 1.9 0.24
65 INT62070 Transcription of PTHLH 3 0.72 1.57 0.22
66 INT145303 Regulation of Sox9 2 0.28 0.71 0.22
67 INT303943 Protein_catabolism of GLI2 2 0.11 0 0.22
68 INT245763 Regulation of SOX9 4 0.43 1.68 0.21
69 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21
70 INT195061 Phosphorylation of PTHLH 1 0.35 0.46 0.21
71 INT134662 Positive_regulation of Gene_expression of SOX9 9 0.48 1.69 0.19
72 INT197792 Regulation of Pthlh 3 0.24 2.47 0.18
73 INT62359 Negative_regulation of Positive_regulation of PTHLH 3 0.42 2.71 0.18
74 INT120085 Negative_regulation of Gene_expression of Bmp4 5 0.55 0.61 0.17
75 INT99392 Negative_regulation of Localization of Ctnnb1 2 0.59 1.43 0.17
76 INT151721 Negative_regulation of Localization of Ctnnb1 1 0.23 0.96 0.17
77 INT325506 Positive_regulation of Localization of Ctnnb1 1 0.05 0.28 0.17
78 INT182321 Positive_regulation of Gene_expression of GLI2 2 0.28 1.32 0.16
79 INT130374 Transcription of Ctnnb1 1 0.19 0 0.13
80 INT110257 Negative_regulation of Gene_expression of Pthlh 1 0.19 4.01 0.13
81 INT72137 Positive_regulation of Gene_expression of Pthlh 1 0.49 6.45 0.12
82 INT211949 Negative_regulation of Sox9 1 0.31 0.83 0.12
83 INT62073 Negative_regulation of Transcription of PTHLH 1 0.43 0.35 0.11
84 INT184220 Negative_regulation of Gene_expression of SOX9 4 0.36 0.58 0.09
85 INT196033 Negative_regulation of Gene_expression of Bmp4 3 0.21 0.45 0.09
86 INT232200 Phosphorylation of Pthlh 1 0.46 1.19 0.09
87 INT126726 Binding of Pthlh 1 0.03 1.05 0.09
88 INT232202 Positive_regulation of Phosphorylation of Pthlh 1 0.28 1.19 0.09
89 INT211948 Regulation of Gene_expression of Sox9 2 0.33 0.94 0.08
90 INT210243 Negative_regulation of Bmp4 1 0.55 0.55 0.07
91 INT210242 Positive_regulation of Sox9 3 0.43 0.35 0.06
92 INT211939 Regulation of Sox9 1 0.33 0.35 0.06
93 INT196030 Positive_regulation of Bmp4 6 0.62 2.55 0.04
94 INT210238 Positive_regulation of Negative_regulation of Bmp4 1 0.47 0 0.04
95 INT253182 Positive_regulation of Positive_regulation of Bmp4 1 0.45 0.58 0.04
96 INT225365 Binding of Sox9 2 0.28 0.48 0.03
97 INT145302 Positive_regulation of Sox9 2 0.48 1.42 0.03
98 INT210587 Binding of Pthlh 1 0.18 1.17 0.03
99 INT196034 Positive_regulation of Gene_expression of Bmp4 4 0.45 0.63 0
100 INT260779 Negative_regulation of Bmp4 4 0.23 0.94 0
101 INT162339 Regulation of Gene_expression of SOX9 4 0.32 0.42 0
102 INT245757 Localization of SOX9 4 0.62 0.8 0
103 INT211945 Negative_regulation of Gene_expression of Sox9 3 0.44 0.63 0
104 INT76959 Binding of Ctnnb1 2 0.34 0.69 0
105 INT196027 Binding of Bmp4 2 0.13 0.97 0
106 INT142119 Regulation of Bmp4 2 0.58 0.29 0
107 INT293419 Positive_regulation of Localization of PTHLH 2 0.38 1.03 0
108 INT322883 Regulation of Transcription of Sox9 1 0.43 0.18 0
109 INT230651 Phosphorylation of Ctnnb1 1 0.10 0 0
110 INT230674 Positive_regulation of Phosphorylation of Ctnnb1 1 0.06 0 0
111 INT326137 Protein_catabolism of Ctnnb1 1 0.02 1.08 0
112 INT207371 Positive_regulation of Transcription of GLI2 1 0.03 0.08 0
113 INT62069 Positive_regulation of Transcription of PTHLH 1 0.47 0.23 0
114 INT355576 Negative_regulation of Negative_regulation of Ctnnb1 1 0.02 1.14 0
115 INT314833 Binding of Ltbp3 1 0.32 0.82 0
116 INT339667 Localization of Bmp4 1 0.38 0.27 0
117 INT211943 Transcription of Sox9 1 0.50 0.3 0
118 INT323815 Negative_regulation of Transcription of SOX9 1 0.41 0.18 0
119 INT220769 Positive_regulation of Positive_regulation of Ctnnb1 1 0.10 0 0
120 INT254611 Positive_regulation of Negative_regulation of PTHLH 1 0.10 0.14 0
121 INT322886 Transcription of Sox9 1 0.50 0.25 0
122 INT314824 Localization of Ltbp3 1 0.66 0.26 0
123 INT145307 Positive_regulation of Positive_regulation of Sox9 1 0.48 0.07 0
124 INT308354 Gene_expression of Snai2 1 0.58 1.14 0
125 INT308358 Positive_regulation of Gene_expression of Snai2 1 0.45 1.14 0
126 INT245752 Positive_regulation of Binding of SOX9 1 0.41 0.48 0
127 INT314823 Negative_regulation of Ltbp3 1 0.38 0.1 0
128 INT307407 Regulation of Localization of GLI2 1 0.01 0.67 0
129 INT207369 Transcription of GLI2 1 0.05 0.08 0
130 INT245765 Binding of SOX9 1 0.31 0.87 0
131 INT305345 Positive_regulation of Snai2 1 0.16 1.4 0
132 INT312245 Positive_regulation of Localization of SOX9 1 0.10 0 0
133 INT352010 Protein_catabolism of Sox9 1 0.22 0.07 0
134 INT308349 Positive_regulation of Gene_expression of Sox9 1 0.40 0.69 0
135 INT314844 Positive_regulation of Ltbp3 1 0.39 0.5 0
136 INT210585 Positive_regulation of Localization of Pthlh 1 0.24 1.39 0
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