GO:0032393

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Name MHC class I receptor activity
Categary Function
Go Slim No
Go Link GO:0032393
Unique Molecular Interactions 160
Total Molecular Interactions 261
Total Single Events 2135
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for MHC class I receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for MHC class I receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT152035 Binding of HLA-A and MRAP 2 0.31 6.95 3.4
2 INT172047 Binding of HLA-A and LRRC23 1 0.22 3.32 1.64
3 INT174503 Binding of HLA-B and KIR3DL1 6 0.37 3.48 1.61
4 INT107965 Binding of HLA-B and Mefv 2 0.34 3.91 1.61
5 INT174508 Binding of CD4 and HLA-B 1 0.14 4.68 1.53
6 INT55837 Binding of HLA-B and PHB2 3 0.20 3.52 1.37
7 INT184402 Binding of HLA-DRB4 and HLA-E 1 0.00 3.1 1.19
8 INT197051 Binding of HLA-E and ATP8A1 1 0.00 6.52 1.14
9 INT107269 Binding of HLA-A and NCR3 1 0.35 1.42 1.1
10 INT122889 Ifng Positive_regulation of Gene_expression of HLA-E 1 0.02 0.97 1.1
11 INT230019 Binding of HLA-B and ERAL1 1 0.00 2.23 1.1
12 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1
13 INT143323 Binding of HLA-B and HP 1 0.04 0.95 0.93
14 INT80132 Binding of HLA-B and TNF 1 0.04 1.15 0.89
15 INT166983 Binding of HLA-B and HSPG2 4 0.08 4.66 0.88
16 INT250959 Binding of HLA-B and SOD1 1 0.05 0.75 0.75
17 INT172097 Binding of HLA-E and Trav6-3 10 0.02 3.71 0.71
18 INT240729 Binding of CRP and HLA-A 1 0.11 2.18 0.71
19 INT28711 Binding of HLA-B and MRAP 2 0.23 0.96 0.69
20 INT169101 Binding of HLA-A and HLA-DRB1 1 0.24 1.09 0.63
21 INT174500 Positive_regulation of Binding of CD4 and HLA-B 1 0.21 2.33 0.63
22 INT122096 Binding of HLA-B and SFTPA1 2 0.04 1.81 0.6
23 INT174504 Binding of HLA-B and KIR3DL2 2 0.24 1.69 0.59
24 INT202018 Binding of KIR3DS1 and MRAP 1 0.13 0.59 0.59
25 INT87683 Binding of HLA-B and Prnd 1 0.00 0.59 0.59
26 INT197050 Binding of HLA-DOA and HLA-E 2 0.08 1.73 0.58
27 INT162742 Binding of HLA-A and KIR3DL1 1 0.40 0.68 0.58
28 INT341594 Binding of ESR1 and HLA-B 1 0.01 0.72 0.57
29 INT230532 LILRB1 Positive_regulation of Gene_expression of Mmp2 1 0.14 1.04 0.5
30 INT341593 Binding of HLA-E and IL23R 1 0.15 1.15 0.5
31 INT230533 LILRB1 Positive_regulation of Positive_regulation of Mmp9 1 0.20 1.03 0.5
32 INT36143 Binding of SERPINH1 and HLA-B 1 0.00 0.66 0.49
33 INT348173 Binding of HLA-B and IL23R 1 0.15 0.92 0.49
34 INT348177 Binding of HLA-B and ERAP1 1 0.14 0.92 0.49
35 INT172096 Binding of HLA-E and Il27ra 2 0.01 1.32 0.48
36 INT328936 Binding of HLA-B and KIR3DS1 1 0.25 0.7 0.48
37 INT340440 Binding of HLA-B and BTG3 1 0.05 1.57 0.47
38 INT48848 Binding of HLA-B and HLA-E 3 0.34 1.95 0.45
39 INT45035 Binding of HLA-B and HLA-DRB4 2 0.16 0.74 0.44
40 INT79151 Binding of HLA-B and OLAH 1 0.01 0.79 0.44
41 INT174507 Binding of HLA-B and LILRB4 1 0.02 1.16 0.43
42 INT79150 HLA-B Positive_regulation of OLAH 1 0.02 0.77 0.43
43 INT174501 Binding of HLA-B and HLA-DOA 2 0.03 1.84 0.42
44 INT328935 Binding of HLA-G and KIR2DS4 1 0.39 0.75 0.41
45 INT184406 Binding of HLA-DRB1 and HLA-E 1 0.00 1.03 0.4
46 INT349290 Binding of HLA-B and SPATA19 1 0.00 1.25 0.4
47 INT183924 Binding of CHI3L1 and HLA-E 1 0.08 0.9 0.39
48 INT127587 Binding of HLA-B and CD300A 1 0.00 0.84 0.38
49 INT250956 Positive_regulation of Binding of HLA-B and SOD1 1 0.07 0.38 0.38
50 INT118285 Binding of EFNA1 and HLA-B 1 0.03 0.29 0.37
51 INT204091 Binding of HLA-G and KIR2DL1 1 0.15 0.86 0.32
52 INT227760 Binding of HLA-A and HLA-B 1 0.20 3.35 0.3
53 INT160923 Binding of ACLS and HLA-B 1 0.03 1.44 0.29
54 INT160924 Binding of ACLS and HLA-A 1 0.01 1.44 0.29
55 INT250951 Binding of HLA-E and SFTPA1 1 0.01 0.44 0.29
56 INT250958 Binding of HLA-A and SFTPA1 1 0.01 0.45 0.29
57 INT45048 Binding of HLA-B and TNFRSF10B 1 0.21 0.44 0.29
58 INT141882 Binding of CD8A and HLA-A 1 0.32 0.9 0.29
59 INT174499 Binding of CD4 and HLA-E 1 0.04 1.08 0.29
60 INT181843 PHB2 Regulation of HLA-B 1 0.03 1.4 0.28
61 INT71640 Binding of HLA-A and TYR 1 0.16 0.36 0.27
62 INT71642 Binding of HLA-A and PMEL 2 0.20 1.05 0.26
63 INT71643 Binding of HLA-A and TYRP1 1 0.24 0.36 0.26
64 INT174506 Binding of HLA-B and HLA-G 1 0.01 0.41 0.26
65 INT71641 Binding of MLANA and HLA-A 1 0.28 0.36 0.26
66 INT162743 Binding of HLA-A and TNFRSF10B 1 0.40 0.4 0.25
67 INT260870 Binding of HLA-E and IL7R 1 0.19 0.5 0.22
68 INT156251 Binding of HLA-A and Drb1 2 0.15 0.64 0.19
69 INT353808 HLA-DMA Regulation of HLA-B 1 0.00 1.72 0.19
70 INT66279 Binding of FLNB and HLA-B 1 0.41 0.57 0.19
71 INT76078 Binding of HLA-A and TNFRSF10A 1 0.34 0.91 0.18
72 INT313799 Binding of HLA-B and TYRP1 1 0.01 0.54 0.18
73 INT222785 Binding of MR1 and ERVW-1 1 0.01 1.02 0.17
74 INT19645 Binding of HLA-B and KLRD1 1 0.00 0.73 0.15
75 INT115356 Binding of HLA-G and ATP8A1 1 0.00 0.52 0.15
76 INT258906 Binding of HLA-B and HLA-DRB1 1 0.31 1.36 0.15
77 INT194134 Binding of HLA-E and IGAD1 1 0.02 1.01 0.15
78 INT194136 Binding of HLA-E and INS 1 0.01 0.95 0.15
79 INT194135 Binding of CD79A and HLA-E 1 0.07 1.01 0.15
80 INT68736 Binding of HLA-B and Tyr 1 0.01 0.23 0.14
81 INT98565 HLA-B Positive_regulation of Cd8a 1 0.03 0.63 0.14
82 INT222783 Binding of MR1 and PTPRC 1 0.00 0.46 0.14
83 INT222777 IL4 Positive_regulation of Positive_regulation of MR1 1 0.03 0.45 0.12
84 INT142845 Binding of HLA-B and SAT1 1 0.35 0.61 0.12
85 INT181844 Binding of CD8A and HLA-B 1 0.14 1.82 0.12
86 INT222780 IL4 Positive_regulation of MR1 1 0.02 0.45 0.12
87 INT298059 Binding of HLA-A and Vip 1 0.00 0.97 0.12
88 INT289629 Binding of HLA-DMB and HLA-E 1 0.10 0.84 0.11
89 INT289627 Binding of HLA-E and RS1 1 0.01 0.83 0.11
90 INT2993 Binding of HLA-B and SUGT1 1 0.00 0.6 0.1
91 INT92671 Binding of CEL and HLA-B 1 0.38 0.19 0.1
92 INT88238 HLA-B Regulation of Gene_expression of Gbp1 1 0.03 0.27 0.1
93 INT167041 Binding of HLA-A and Aip 1 0.02 0.54 0.1
94 INT219155 Binding of HLA-G and LILRB2 1 0.15 0.23 0.1
95 INT152034 Binding of HLA-A and RDBP 1 0.05 0.34 0.1
96 INT158011 KLRF1 Positive_regulation of ENG 1 0.03 0.39 0.09
97 INT132266 Binding of HLA-B and B2m 1 0.02 0.14 0.09
98 INT125089 Binding of HLA-B and TDGF1 1 0.24 0.18 0.09
99 INT147774 Binding of HLA-B and ABCB6 2 0.40 1.03 0.08
100 INT222784 IL13 Positive_regulation of Gene_expression of MR1 1 0.01 0.53 0.08
101 INT222788 IL4 Positive_regulation of Gene_expression of MR1 1 0.02 0.96 0.08
102 INT294116 CIITA Regulation of Gene_expression of HLA-E 1 0.05 0.05 0.08
103 INT222775 Binding of HLA-DQB3 and MR1 1 0.00 0.35 0.07
104 INT331310 Binding of HLA-A and HLA-DOA 1 0.00 0.85 0.06
105 INT75234 Binding of HLA-B and BW6 1 0.39 0.06 0.06
106 INT203638 Binding of MR1 and GOPC 1 0.04 1.43 0.05
107 INT356238 Binding of HLA-E and PI3 1 0.02 0 0.05
108 INT346303 Binding of MR1 and Col2a1 1 0.00 0.09 0.04
109 INT97430 Binding of B2M and HLA-B 1 0.00 0.66 0.04
110 INT177948 IFNG Positive_regulation of Gene_expression of HLA-E 1 0.04 0.59 0.03
111 INT298058 Binding of HLA-A and Bpifa2 1 0.00 0.66 0.03
112 INT331324 Binding of HLA-G and Atp8a1 1 0.03 0.16 0.03
113 INT236235 HLA-A Positive_regulation of CD8A 1 0.01 1 0.03
114 INT331309 Binding of HLA-DOA and HLA-G 1 0.00 0.16 0.03
115 INT177947 IFN1@ Positive_regulation of Gene_expression of HLA-E 1 0.09 0.59 0.03
116 INT207031 Binding of HLA-C and HLA-E 1 0.35 0.1 0
117 INT186502 Binding of AMELX and HLA-A 1 0.00 0.71 0
118 INT92381 Binding of HLA-B and Tap1 1 0.01 0 0
119 INT276136 Binding of DIO2 and HLA-E 1 0.26 0 0
120 INT252020 Binding of HLA-A and ELOVL1 1 0.01 1.41 0
121 INT300244 Binding of HLA-B and HSR 1 0.08 0.95 0
122 INT336764 ERAP2 Regulation of Gene_expression of HLA-E 1 0.24 0 0
123 INT247114 Binding of HLA-A and MPZ 1 0.00 6.26 0
124 INT275123 Binding of HLA-E and SUGT1 1 0.00 0.93 0
125 INT164332 Binding of HLA-E and KLRC2 1 0.00 0 0
126 INT215470 Binding of HLA-B and CRAMP1L 1 0.05 0.94 0
127 INT301675 Binding of APC and HLA-E 1 0.01 1.48 0
128 INT110162 Binding of HLA-B and HLA-DQB1 1 0.09 0 0
129 INT201080 Binding of APOE and HLA-C 1 0.41 0.31 0
130 INT346284 Binding of ELANE and MR1 1 0.00 0.31 0
131 INT261977 Binding of HLA-A and PDCD1 1 0.07 0.52 0
132 INT276138 Binding of COL19A1 and HLA-E 1 0.01 0.62 0
133 INT349077 Binding of HLA-E and KLRD1 1 0.00 0.16 0
134 INT250954 Binding of HLA-B and USO1 1 0.06 0.18 0
135 INT286501 Binding of PKD1 and LILRB1 1 0.01 1.07 0
136 INT90819 Binding of HLA-B and MICA 1 0.05 0 0
137 INT346285 Binding of COL11A1 and MR1 1 0.00 0.63 0
138 INT229176 LILRB1 Negative_regulation of KIR3DL1 1 0.02 0.29 0
139 INT74066 Binding of DR1 and HLA-B 1 0.00 0.08 0
140 INT258911 Binding of CD4 and HLA-G 1 0.04 0.06 0
141 INT336762 Negative_regulation of ERAP2 Negative_regulation of HLA-E 1 0.23 0.31 0
142 INT250955 Binding of HLA-B and SETDB1 1 0.01 0.08 0
143 INT150180 KIT Negative_regulation of Gene_expression of HLA-B 1 0.39 0.09 0
144 INT201082 Binding of APOE and HLA-B 1 0.54 1.54 0
145 INT258907 Binding of CD8A and HLA-G 1 0.05 0.07 0
146 INT301676 Binding of CD8A and HLA-E 1 0.02 2.24 0
147 INT313800 Binding of HLA-B and TYR 1 0.04 0.1 0
148 INT285399 Binding of DEFB1 and HLA-B 1 0.01 1.33 0
149 INT254374 MR1 Negative_regulation of TNF 1 0.01 0.96 0
150 INT201079 Binding of HLA-B and HLA-C 1 0.40 1.36 0
151 INT335242 Binding of PMEL and CD160 1 0.36 0.85 0
152 INT286594 Binding of LILRB1 and Pkd1 1 0.01 1.07 0
153 INT336763 Binding of CD19 and HLA-A 1 0.01 0 0
154 INT174502 HLA-B Regulation of CD4 1 0.13 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for MHC class I receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in MHC class I receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1878 Binding of HLA-B 440 0.48 321.16 127.36
2 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37
3 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72
4 INT19330 Binding of HLA-A 99 0.48 76.26 22.85
5 INT1876 Positive_regulation of HLA-B 82 0.69 52.16 21.08
6 INT11696 Gene_expression of HLA-A 50 0.78 41.25 14.1
7 INT11699 Binding of HLA-E 85 0.47 52.51 13.41
8 INT3925 Negative_regulation of HLA-B 29 0.42 20.19 9.46
9 INT3353 Localization of HLA-B 25 0.75 16.05 8.62
10 INT28671 Positive_regulation of Gene_expression of HLA-E 43 0.67 22.85 8.39
11 INT5284 Regulation of HLA-B 25 0.59 12.91 7.74
12 INT4697 Positive_regulation of Gene_expression of HLA-B 32 0.61 17.32 5.97
13 INT177584 Gene_expression of MR1 80 0.58 46.48 5.48
14 INT64767 Negative_regulation of Gene_expression of HLA-E 18 0.57 12.64 5.23
15 INT15797 Positive_regulation of HLA-E 36 0.67 15.17 5.07
16 INT174195 Negative_regulation of HLA-E 31 0.42 11.98 3.88
17 INT19331 Positive_regulation of HLA-A 12 0.49 7.72 3.28
18 INT16959 Positive_regulation of Binding of HLA-B 8 0.50 6.77 2.96
19 INT2249 Negative_regulation of Binding of HLA-B 5 0.54 6.82 2.94
20 INT153439 Gene_expression of KIR3DS1 3 0.66 2.77 2.92
21 INT65472 Binding of HLA-G 9 0.36 6.06 2.6
22 INT176892 Binding of MR1 36 0.32 15.55 2.58
23 INT50006 Regulation of HLA-E 12 0.44 8.78 2.37
24 INT34644 Binding of HLA-C 19 0.47 9.41 2.2
25 INT153444 Positive_regulation of KIR3DS1 3 0.67 2.34 2.18
26 INT117545 Regulation of Gene_expression of HLA-A 2 0.33 2.3 1.99
27 INT101013 Regulation of HLA-A 7 0.33 6.7 1.8
28 INT176888 Positive_regulation of MR1 29 0.67 11.68 1.71
29 INT122951 Regulation of Binding of HLA-B 4 0.39 3.08 1.65
30 INT62430 Negative_regulation of HLA-A 5 0.32 4.3 1.63
31 INT8707 Localization of LILRB1 2 0.60 1.5 1.5
32 INT202035 Gene_expression of LILRB1 5 0.75 4.78 1.41
33 INT85611 Localization of CD160 1 0.01 0.09 1.41
34 INT69398 Regulation of Gene_expression of HLA-E 14 0.60 3.54 1.27
35 INT203640 Regulation of MR1 7 0.34 3.8 1.26
36 INT202022 Binding of KIR3DS1 2 0.30 1.43 1.2
37 INT177593 Positive_regulation of Gene_expression of MR1 17 0.43 9.36 1.13
38 INT147336 Gene_expression of HLA-G 12 0.75 7.27 1.08
39 INT64903 Positive_regulation of HLA-C 3 0.49 2.54 0.93
40 INT748 Transcription of HLA-B 6 0.67 1.56 0.91
41 INT240736 Localization of HLA-A 7 0.21 6.88 0.86
42 INT328959 Localization of HLA-G 3 0.73 2.22 0.83
43 INT11698 Positive_regulation of Gene_expression of HLA-A 5 0.67 4.64 0.76
44 INT10710 Positive_regulation of Positive_regulation of HLA-B 2 0.38 0.83 0.73
45 INT5285 Regulation of Gene_expression of HLA-B 4 0.41 3.39 0.68
46 INT48970 Positive_regulation of LILRB1 7 0.67 11.38 0.67
47 INT11700 Negative_regulation of Gene_expression of HLA-B 3 0.50 2.61 0.6
48 INT177951 Transcription of HLA-E 7 0.67 2.36 0.52
49 INT134418 Regulation of LILRB1 3 0.44 2.7 0.5
50 INT178834 Localization of MR1 8 0.21 6.52 0.48
51 INT8706 Positive_regulation of Localization of LILRB1 1 0.00 0.69 0.47
52 INT178830 Negative_regulation of MR1 16 0.50 7.63 0.44
53 INT328952 Negative_regulation of Localization of HLA-G 1 0.41 1.07 0.43
54 INT328956 Positive_regulation of Localization of HLA-G 1 0.49 1.03 0.4
55 INT177954 Negative_regulation of Positive_regulation of HLA-E 2 0.07 0.61 0.33
56 INT188706 Localization of HLA-E 8 0.33 2.43 0.32
57 INT201084 Localization of HLA-C 2 0.73 1.04 0.3
58 INT230527 Regulation of Gene_expression of LILRB1 1 0.44 1.73 0.3
59 INT254388 Negative_regulation of Gene_expression of MR1 8 0.32 6.52 0.28
60 INT44012 Phosphorylation of HLA-B 3 0.81 0.96 0.27
61 INT147335 Positive_regulation of Gene_expression of HLA-G 2 0.49 2.38 0.27
62 INT160925 Transcription of HLA-A 1 0.31 1.41 0.24
63 INT294137 Positive_regulation of Positive_regulation of HLA-E 1 0.09 0.33 0.2
64 INT177956 Positive_regulation of Transcription of HLA-E 3 0.49 1.02 0.19
65 INT250970 Positive_regulation of Localization of HLA-B 1 0.48 0.57 0.17
66 INT156328 Protein_catabolism of HLA-B 1 0.09 0.17 0.17
67 INT230524 Binding of LILRB1 2 0.35 2.14 0.15
68 INT230522 Regulation of Regulation of LILRB1 1 0.44 0.87 0.15
69 INT328942 Negative_regulation of Binding of HLA-G 1 0.41 0.39 0.13
70 INT202034 Regulation of Positive_regulation of KIR3DS1 1 0.23 0.41 0.13
71 INT197053 Negative_regulation of Binding of HLA-E 1 0.20 1.07 0.12
72 INT308408 Positive_regulation of KLRF1 1 0.09 1.11 0.11
73 INT222802 Negative_regulation of Binding of MR1 1 0.06 0.49 0.11
74 INT178833 Positive_regulation of Localization of MR1 3 0.14 2.62 0.1
75 INT254385 Regulation of Gene_expression of MR1 1 0.03 2.54 0.08
76 INT298569 Negative_regulation of LILRB1 2 0.05 1.97 0.05
77 INT178831 Positive_regulation of Positive_regulation of MR1 2 0.38 1.37 0.05
78 INT321875 Regulation of HLA-G 1 0.00 0.99 0.05
79 INT230526 Positive_regulation of Positive_regulation of LILRB1 1 0.49 0.67 0.04
80 INT254338 Positive_regulation of Localization of HLA-E 1 0.03 0.26 0.03
81 INT351824 Regulation of Binding of HLA-E 1 0.03 0.89 0.03
82 INT356246 Negative_regulation of Transcription of HLA-E 1 0.41 0.05 0.03
83 INT201086 Regulation of Phosphorylation of HLA-B 2 0.45 0.41 0
84 INT215472 Protein_catabolism of HLA-A 2 0.53 0.34 0
85 INT54611 Positive_regulation of Regulation of HLA-B 1 0.37 0 0
86 INT308196 Negative_regulation of Negative_regulation of HLA-E 1 0.28 0 0
87 INT276139 Regulation of Negative_regulation of HLA-E 1 0.39 0.07 0
88 INT222795 Phosphorylation of MR1 1 0.09 0.16 0
89 INT201088 Negative_regulation of Binding of HLA-C 1 0.42 0.61 0
90 INT250968 Positive_regulation of Phosphorylation of HLA-B 1 0.48 0.08 0
91 INT275143 Positive_regulation of Binding of HLA-E 1 0.16 0.32 0
92 INT264190 Negative_regulation of Gene_expression of HLA-A 1 0.04 0.57 0
93 INT245872 Positive_regulation of HLA-G 1 0.02 0.78 0
94 INT214061 Negative_regulation of HLA-G 1 0.41 0.34 0
95 INT222794 Positive_regulation of Binding of MR1 1 0.10 0.76 0
96 INT201087 Regulation of Phosphorylation of HLA-C 1 0.44 0.32 0
97 INT221119 Negative_regulation of Negative_regulation of HLA-A 1 0.01 0.61 0
98 INT201083 Gene_expression of HLA-C 1 0.66 0.17 0
99 INT136090 Positive_regulation of Transcription of HLA-B 1 0.34 0.15 0
100 INT145383 Negative_regulation of HLA-C 1 0.12 0 0
101 INT150063 Positive_regulation of Positive_regulation of HLA-A 1 0.05 0.08 0
102 INT201089 Phosphorylation of HLA-C 1 0.80 0.32 0
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