GO:0032395

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Name MHC class II receptor activity
Categary Function
Go Slim No
Go Link GO:0032395
Unique Molecular Interactions 128
Total Molecular Interactions 170
Total Single Events 1626
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for MHC class II receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for MHC class II receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT172141 IL10 Negative_regulation of Gene_expression of HLA-DRA 2 0.14 0.89 1.23
2 INT184402 Binding of HLA-DRB4 and HLA-E 1 0.00 3.1 1.19
3 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1
4 INT107265 Binding of HLA-DRB1 and ITGAL 1 0.01 1.41 1.1
5 INT107263 Binding of HLA-DRB1 and NCR3 1 0.40 1.42 1.1
6 INT316128 TCF21 Negative_regulation of Gene_expression of HLA-DRA 1 0.07 0.13 0.99
7 INT340437 Binding of SERPINH1 and HLA-DRB4 1 0.00 2.26 0.84
8 INT169101 Binding of HLA-A and HLA-DRB1 1 0.24 1.09 0.63
9 INT197050 Binding of HLA-DOA and HLA-E 2 0.08 1.73 0.58
10 INT36084 Binding of HLA-DRB4 and Igkv16-104 1 0.04 1.01 0.51
11 INT45035 Binding of HLA-B and HLA-DRB4 2 0.16 0.74 0.44
12 INT174501 Binding of HLA-B and HLA-DOA 2 0.03 1.84 0.42
13 INT316121 IL10 Regulation of Gene_expression of HLA-DRA 1 0.09 0.46 0.42
14 INT184407 Binding of HLA-DRB1 and HLA-DRB4 2 0.09 2.26 0.4
15 INT184406 Binding of HLA-DRB1 and HLA-E 1 0.00 1.03 0.4
16 INT194596 Binding of HLA-DRB4 and TNFSF10 3 0.08 6 0.38
17 INT330517 Binding of CD8A and HLA-DRB4 1 0.08 0.99 0.38
18 INT188391 Binding of CD4 and HLA-DRB1 1 0.05 0.96 0.34
19 INT46145 HLA-DQA1 Negative_regulation of TAC1 1 0.04 0.09 0.34
20 INT252033 Binding of HLA-DQA2 and KLRD1 1 0.00 0.54 0.29
21 INT258861 Binding of HLA-DOA and HLA-DRB1 2 0.14 1.88 0.28
22 INT316791 Binding of HLA-DRB1 and Traf1 1 0.01 0.96 0.27
23 INT171939 Binding of HLA-DOA and TNF 1 0.05 6.8 0.26
24 INT355982 Binding of HLA-DQA2 and DCPS 1 0.00 1.33 0.26
25 INT262640 Binding of HLA-DQA1 and AICDA 1 0.03 5.29 0.2
26 INT171938 Binding of HLA-DOA and ATP2C1 1 0.01 3.88 0.2
27 INT316129 Binding of HLA-DRA and IL10 1 0.12 3.1 0.17
28 INT316123 Binding of HLA-DRA and BCAR1 1 0.02 0.48 0.16
29 INT316124 TLR2 Positive_regulation of Gene_expression of HLA-DRA 1 0.14 0.34 0.16
30 INT258906 Binding of HLA-B and HLA-DRB1 1 0.31 1.36 0.15
31 INT258909 Binding of HLA-DOA and NDUFA2 1 0.03 1.44 0.15
32 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14
33 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14
34 INT316130 IRF6 Positive_regulation of Gene_expression of HLA-DRA 1 0.02 0.27 0.13
35 INT262642 Binding of HLA-DOA and HLA-DQB3 1 0.00 0.63 0.13
36 INT171942 Binding of HLA-DRB1 and ATP2C1 1 0.04 2.18 0.12
37 INT298476 CD40LG Positive_regulation of HLA-DRB1 1 0.01 0.33 0.12
38 INT180345 Binding of HLA-DMA and HLA-DRB4 1 0.00 1.51 0.12
39 INT296029 Binding of HLA-DQA2 and LAG3 1 0.02 0.43 0.12
40 INT298474 IL4 Positive_regulation of HLA-DRB1 1 0.02 0.33 0.12
41 INT182154 Binding of HLA-DRA and DCPS 1 0.01 0.23 0.12
42 INT236311 IGKV2D-38 Positive_regulation of HLA-DRB1 1 0.02 0.13 0.1
43 INT262654 Binding of HLA-DQA1 and Lmx1a 1 0.01 3.15 0.1
44 INT99243 IFNG Regulation of HLA-DRA 1 0.25 0.57 0.1
45 INT316131 IL10 Regulation of Regulation of HLA-DRA 1 0.09 1.31 0.09
46 INT230065 Binding of TOR1A and HLA-DOA 1 0.00 1.65 0.09
47 INT177278 Binding of HLA-DRB4 and NR1H4 1 0.02 0 0.08
48 INT298351 PSMD1 Regulation of Gene_expression of HLA-DRA 1 0.01 0.42 0.08
49 INT316793 Binding of HLA-DRB1 and Stat4 1 0.07 0.33 0.08
50 INT316792 Binding of HLA-DRB1 and Ptpn22 1 0.07 0.33 0.08
51 INT352357 CPZ Positive_regulation of Gene_expression of HLA-DRA 1 0.12 0.13 0.07
52 INT262639 Binding of HLA-DOA and AICDA 1 0.01 2.85 0.07
53 INT262637 Binding of C2 and HLA-DOA 1 0.01 0.5 0.07
54 INT331310 Binding of HLA-A and HLA-DOA 1 0.00 0.85 0.06
55 INT262638 Binding of HLA-DQB1 and AICDA 1 0.03 1.34 0.06
56 INT262636 Binding of HLA-DRB1 and AICDA 1 0.09 1.35 0.06
57 INT323043 Binding of CYP21A1P and HLA-DOA 1 0.04 1.48 0.06
58 INT323042 Binding of CYP21A2 and HLA-DOA 1 0.04 1.49 0.06
59 INT262652 Negative_regulation of Binding of HLA-DQA1 and Lmx1a 1 0.01 1.59 0.05
60 INT13519 Binding of HLA-DQA1 and HLA-DRB4 1 0.03 0.88 0.05
61 INT262643 Binding of HLA-DQB1 and HLA-DRB1 1 0.10 0.45 0.05
62 INT329102 Binding of CD4 and HLA-DQA2 2 0.04 0.92 0.04
63 INT177268 Binding of CXADR and HLA-DRB4 1 0.20 0 0.04
64 INT275125 Binding of HLA-DOA and HSPG2 1 0.01 1.42 0.04
65 INT177292 Binding of HLA-DRB4 and TNFRSF25 1 0.12 0 0.04
66 INT177261 Binding of HLA-DRB4 and FAUP1 1 0.01 0 0.04
67 INT337535 HLA-DRB1 Positive_regulation of Trav6-3 1 0.00 1.14 0.04
68 INT283462 Binding of DLAT and HLA-DRB1 1 0.07 1.06 0.03
69 INT331309 Binding of HLA-DOA and HLA-G 1 0.00 0.16 0.03
70 INT251864 Binding of HLA-DRB1 and IGHE 1 0.04 0.23 0
71 INT258908 Binding of BSG and HLA-DQA1 1 0.00 0.1 0
72 INT247113 Positive_regulation of Binding of HLA-DRB1 and MPZ 1 0.03 1.66 0
73 INT335239 Binding of HLA-DOA and PMEL 1 0.04 0.68 0
74 INT110162 Binding of HLA-B and HLA-DQB1 1 0.09 0 0
75 INT319921 Binding of HLA-DOA and ITIH4 1 0.00 0.07 0
76 INT261124 Binding of HLA-DRB4 and Tnfsf10 1 0.02 0.68 0
77 INT258910 Binding of HLA-DQA1 and HLA-DQB1 1 0.17 0.22 0
78 INT236312 IGKV2D-38 Regulation of HLA-DRB1 1 0.01 0.5 0
79 INT262641 Binding of HLA-DRA and AICDA 1 0.04 0.53 0
80 INT236079 Binding of AGER and HLA-DQB1 1 0.25 1.06 0
81 INT262635 Binding of HLA-DQA1 and HLA-DRA 1 0.05 0.53 0
82 INT331061 Binding of HLA-DQB2 and TRDV1 1 0.00 1.3 0
83 INT247115 Binding of HLA-DRB1 and MPZ 1 0.03 1.66 0
84 INT276137 Binding of COL19A1 and HLA-DRB1 1 0.00 0.62 0
85 INT335241 Binding of GZMA and HLA-DOA 1 0.00 0.13 0
86 INT236077 Binding of HLA-DQB1 and TNF 1 0.29 1.06 0
87 INT261978 Binding of HLA-DRB4 and PDCD1 1 0.23 0.51 0
88 INT236076 Binding of HLA-DQB1 and LTA 1 0.25 1.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for MHC class II receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in MHC class II receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01
2 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96
3 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68
4 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89
5 INT23177 Negative_regulation of Gene_expression of HLA-DRA 50 0.44 16.99 10.55
6 INT6596 Positive_regulation of HLA-DRB1 33 0.61 27.01 7.26
7 INT13520 Binding of HLA-DRB4 30 0.42 32.65 6.74
8 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61
9 INT57256 Gene_expression of HLA-DQA2 52 0.55 23.87 6.27
10 INT17551 Positive_regulation of Gene_expression of HLA-DRA 31 0.70 15.39 6
11 INT18967 Positive_regulation of Gene_expression of HLA-DRB1 14 0.49 13.56 5.99
12 INT52907 Regulation of Gene_expression of HLA-DRA 28 0.34 5.94 5.96
13 INT23401 Gene_expression of HLA-DOA 91 0.30 38.21 5.52
14 INT15133 Regulation of HLA-DRA 19 0.34 5.84 3.9
15 INT123908 Positive_regulation of HLA-DQB1 12 0.21 10.5 3.71
16 INT28249 Positive_regulation of HLA-DRA 25 0.70 13.63 3.25
17 INT271447 Positive_regulation of Positive_regulation of HLA-DQB1 1 0.06 5.87 2.8
18 INT89281 Negative_regulation of Gene_expression of HLA-DRB1 10 0.30 5.9 2.55
19 INT18969 Gene_expression of HLA-DQA1 29 0.65 12.19 2.54
20 INT14854 Regulation of Gene_expression of HLA-DRB1 10 0.39 5.27 2.19
21 INT57339 Negative_regulation of HLA-DRA 17 0.49 7.67 1.96
22 INT155015 Positive_regulation of HLA-DOA 6 0.23 4.45 1.92
23 INT84548 Positive_regulation of HLA-DQA1 5 0.49 1.68 1.75
24 INT150156 Positive_regulation of Gene_expression of HLA-DOA 7 0.20 4.07 1.5
25 INT189302 Positive_regulation of Gene_expression of HLA-DQA2 6 0.06 4.44 1.48
26 INT271448 Regulation of HLA-DQB1 1 0.06 2.73 1.4
27 INT64952 Binding of HLA-DQA2 11 0.10 7.23 1.39
28 INT89426 Binding of HLA-DRB3 2 0.41 1.77 1.32
29 INT100621 Localization of HLA-DRA 7 0.40 2.86 1.2
30 INT37679 Positive_regulation of HLA-DRB4 12 0.34 11.93 1.16
31 INT58042 Binding of HLA-DQA1 8 0.24 5.03 1.14
32 INT56098 Gene_expression of HLA-DRB3 5 0.59 2.89 0.99
33 INT110163 Binding of HLA-DQB1 8 0.25 4.71 0.98
34 INT143114 Positive_regulation of Gene_expression of HLA-DRB4 5 0.29 5.2 0.92
35 INT102352 Regulation of HLA-DQA2 3 0.03 1.92 0.87
36 INT58040 Binding of HLA-DRA 3 0.27 4.95 0.86
37 INT102353 Positive_regulation of HLA-DQA2 6 0.06 4.07 0.82
38 INT236320 Regulation of HLA-DRB1 10 0.45 6 0.69
39 INT257934 Negative_regulation of Gene_expression of HLA-DQA2 6 0.04 3 0.67
40 INT64953 Negative_regulation of HLA-DRB1 9 0.58 5.15 0.56
41 INT285551 Negative_regulation of HLA-DQB1 1 0.03 1.08 0.54
42 INT38704 Negative_regulation of HLA-DRB3 2 0.37 0.9 0.5
43 INT141706 Localization of HLA-DRB1 9 0.75 4.87 0.48
44 INT47280 Negative_regulation of HLA-DRB4 1 0.15 1.01 0.46
45 INT201091 Regulation of HLA-DOA 5 0.20 3.6 0.44
46 INT89425 Positive_regulation of HLA-DRB3 2 0.59 2.38 0.42
47 INT18968 Positive_regulation of Gene_expression of HLA-DQA1 5 0.09 1.89 0.29
48 INT316163 Negative_regulation of Negative_regulation of HLA-DRA 1 0.24 0.09 0.29
49 INT316167 Positive_regulation of Binding of HLA-DRA 1 0.28 0.08 0.29
50 INT316166 Regulation of Negative_regulation of HLA-DRA 1 0.15 0.09 0.29
51 INT50048 Positive_regulation of Positive_regulation of HLA-DRA 1 0.01 0.82 0.25
52 INT316152 Negative_regulation of Regulation of HLA-DRA 1 0.24 1.13 0.25
53 INT169629 Regulation of Gene_expression of HLA-DQA1 2 0.25 2.66 0.24
54 INT330524 Negative_regulation of Gene_expression of HLA-DRB4 1 0.18 1.56 0.22
55 INT58041 Regulation of Binding of HLA-DRA 1 0.03 0.49 0.21
56 INT56652 Protein_catabolism of HLA-DRB1 1 0.00 1.77 0.19
57 INT174520 Negative_regulation of Gene_expression of HLA-DOA 10 0.14 2.62 0.17
58 INT316158 Positive_regulation of Regulation of HLA-DRA 1 0.26 0 0.16
59 INT6595 Positive_regulation of Positive_regulation of HLA-DRB1 1 0.00 0 0.14
60 INT186664 Localization of HLA-DRB4 2 0.16 1.89 0.13
61 INT258918 Negative_regulation of Gene_expression of HLA-DRB3 1 0.22 1.52 0.13
62 INT78787 Regulation of Gene_expression of HLA-DRB4 2 0.38 1.25 0.12
63 INT221121 Regulation of HLA-DQA1 1 0.00 0.17 0.09
64 INT221117 Regulation of HLA-DQB2 1 0.01 0.17 0.09
65 INT222906 Localization of HLA-DOA 5 0.25 2.41 0.08
66 INT181214 Negative_regulation of HLA-DQA2 4 0.03 1.46 0.08
67 INT258875 Regulation of Gene_expression of HLA-DOA 1 0.01 0.32 0.08
68 INT181462 Transcription of HLA-DRB1 1 0.03 1.41 0.08
69 INT98133 Regulation of Positive_regulation of HLA-DRB4 1 0.19 1.69 0.07
70 INT98127 Regulation of HLA-DRB4 1 0.19 1.69 0.07
71 INT141705 Negative_regulation of Localization of HLA-DRB1 1 0.20 0.27 0.06
72 INT141707 Negative_regulation of Localization of HLA-DRA 1 0.17 0.27 0.06
73 INT354841 Regulation of HLA-DRB3 1 0.01 1.88 0.04
74 INT262644 Protein_catabolism of HLA-DQA1 1 0.20 0.4 0.03
75 INT262647 Protein_catabolism of HLA-DOA 1 0.06 0.68 0.03
76 INT191162 Negative_regulation of HLA-DOA 3 0.12 1.24 0
77 INT258915 Gene_expression of HLA-DQB1 2 0.44 0.72 0
78 INT214060 Negative_regulation of HLA-DQA1 1 0.12 0.34 0
79 INT247117 Localization of HLA-DQB1 1 0.01 1.53 0
80 INT258922 Negative_regulation of Binding of HLA-DOA 1 0.14 0.41 0
81 INT201090 Regulation of Regulation of HLA-DOA 1 0.20 0.93 0
82 INT258919 Regulation of Binding of HLA-DOA 1 0.15 0.22 0
83 INT331063 Localization of HLA-DQB2 1 0.04 1.3 0
84 INT177761 Transcription of HLA-DRA 1 0.06 0.13 0
85 INT258921 Negative_regulation of Negative_regulation of HLA-DOA 1 0.12 0.38 0
86 INT258912 Positive_regulation of Binding of HLA-DOA 1 0.17 0.41 0
87 INT258913 Negative_regulation of Gene_expression of HLA-DQA1 1 0.24 0.1 0
88 INT329106 Negative_regulation of Binding of HLA-DQA2 1 0.04 0.16 0
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