GO:0032405

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Name MutLalpha complex binding
Categary Function
Go Slim No
Go Link GO:0032405
Unique Molecular Interactions 54
Total Molecular Interactions 63
Total Single Events 667
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for MutLalpha complex binding. They are ordered first by their pain relevance and then by number of times they were reported for MutLalpha complex binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT177504 Gabrg1 Positive_regulation of PCNA 1 0.07 0.22 0.52
2 INT344238 MCRS1 Regulation of TREX1 1 0.08 1.02 0.34
3 INT182606 Binding of MSH2 and MSH3 1 0.12 1.4 0.21
4 INT245332 ATR Regulation of IL6 1 0.03 0.35 0.17
5 INT29207 Msh2 Regulation of POMC 1 0.02 0.1 0.14
6 INT245333 ATR Negative_regulation of Protein_catabolism of DCD 1 0.10 0.93 0.14
7 INT184953 Binding of CDC6 and PCNA 1 0.05 0.19 0.13
8 INT166785 NSMAF Negative_regulation of Gene_expression of PCNA 1 0.30 1.26 0.08
9 INT245329 ATR Negative_regulation of DCD 1 0.10 0.91 0.05
10 INT245331 ATR Regulation of IL1B 1 0.03 0.91 0.05
11 INT245330 ATR Regulation of TNF 1 0.04 0.9 0.05
12 INT176224 Binding of CDKN1A and PCNA 4 0.08 2.52 0.03
13 INT326051 Csf2 Positive_regulation of PCNA 1 0.04 0.17 0.03
14 INT176286 Fasl Positive_regulation of Gene_expression of Pcna 1 0.02 0.81 0.03
15 INT326052 Epo Positive_regulation of PCNA 1 0.04 0.17 0.03
16 INT290556 Binding of MLH1 and MSH2 3 0.34 2.74 0
17 INT219412 CDK2 Regulation of PCNA 1 0.20 0.11 0
18 INT57107 Binding of Msh2 and Nts 1 0.22 0.22 0
19 INT269932 Pcna Negative_regulation of Cdkn2b 1 0.09 0.07 0
20 INT286114 Binding of MSH6 and Mutyh 1 0.17 0 0
21 INT330697 PCNA Regulation of INCENP 1 0.00 0.3 0
22 INT326017 Binding of PCNA and HCC 1 0.00 0.99 0
23 INT214902 Binding of Pcna and Trib3 1 0.00 1.51 0
24 INT219405 CCNF Regulation of PCNA 1 0.20 0.11 0
25 INT176289 Pcna Positive_regulation of Phosphorylation of Esr1 1 0.01 0.67 0
26 INT219417 CCNA2 Regulation of PCNA 1 0.10 0.11 0
27 INT218976 Dlst Positive_regulation of Gene_expression of PCNA 1 0.05 0.06 0
28 INT176288 Binding of Cdk2 and Pcna 1 0.01 0.66 0
29 INT269926 Cdkn2b Negative_regulation of Pcna 1 0.08 0.07 0
30 INT330698 PCNA Regulation of RB1 1 0.00 0.3 0
31 INT176291 Fasl Regulation of Gene_expression of Pcna 1 0.01 0.31 0
32 INT338970 Binding of ING1 and PCNA 1 0.11 0.98 0
33 INT315169 Egfr Negative_regulation of PCNA 1 0.03 0.84 0
34 INT219407 Binding of ESR1 and PCNA 1 0.31 0.31 0
35 INT315170 Erbb2 Negative_regulation of PCNA 1 0.03 0.84 0
36 INT188272 Binding of KITLG and PCNA 1 0.01 0.17 0
37 INT238394 Binding of PCNA and SRA1 1 0.00 0.07 0
38 INT269914 Tpt1 Negative_regulation of Pcna 1 0.08 0.07 0
39 INT212525 MSH6 Positive_regulation of Binding of C1qa 1 0.00 0.38 0
40 INT105017 Binding of Slc25a31 and Atr 1 0.16 0.13 0
41 INT176290 Fasl Positive_regulation of Pcna 1 0.02 0.44 0
42 INT271096 Pcna Positive_regulation of Akt1 1 0.00 0.34 0
43 INT176282 Binding of Pcna and p53-ps 1 0.00 0.69 0
44 INT300617 Binding of MSH6 and MLH1 1 0.28 0.53 0
45 INT219422 CCNE2 Regulation of PCNA 1 0.10 0.11 0
46 INT269952 Pcna Negative_regulation of Tpt1 1 0.09 0.07 0
47 INT286109 Binding of Pcna and Mutyh 1 0.30 0 0
48 INT238391 ELANE Positive_regulation of PCNA 1 0.01 0.07 0
49 INT177783 Binding of HDAC1 and PCNA 1 0.09 0.5 0
50 INT269916 Sox17 Positive_regulation of Pcna 1 0.16 0 0
51 INT212528 Binding of MSH6 and Apcs 1 0.00 0.68 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for MutLalpha complex binding. They are ordered first by their pain relevance and then by number of times they were reported in MutLalpha complex binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42
2 INT86369 Positive_regulation of Gene_expression of PCNA 40 0.67 26.66 3.57
3 INT85078 Positive_regulation of PCNA 36 0.49 17.06 2.81
4 INT50558 Negative_regulation of PCNA 31 0.57 13.97 2.3
5 INT101572 Negative_regulation of Gene_expression of PCNA 24 0.53 13.87 2.21
6 INT112868 Gene_expression of Pcna 21 0.75 8.6 2.15
7 INT68952 Localization of PCNA 17 0.62 5.64 1.78
8 INT86909 Negative_regulation of MSH2 9 0.41 12.65 1.7
9 INT107992 Gene_expression of MSH2 39 0.78 37.09 1.6
10 INT167477 Regulation of TREX1 1 0.24 1.04 1.12
11 INT86907 Negative_regulation of MSH6 8 0.33 6.76 0.93
12 INT111485 Gene_expression of Pcna 2 0.75 0 0.83
13 INT332756 Localization of TREX1 1 0.01 0 0.81
14 INT92142 Binding of MSH2 5 0.46 5.64 0.75
15 INT25176 Regulation of Msh2 3 0.37 0.48 0.68
16 INT291268 Gene_expression of Atr 1 0.06 1.48 0.57
17 INT169957 Transcription of PCNA 7 0.34 0.94 0.55
18 INT111484 Positive_regulation of Gene_expression of Pcna 1 0.67 0 0.54
19 INT25175 Gene_expression of Msh2 2 0.55 0.4 0.52
20 INT176264 Binding of PCNA 21 0.21 9.08 0.51
21 INT146545 Negative_regulation of Gene_expression of MSH2 17 0.56 18.87 0.51
22 INT241674 Negative_regulation of Transcription of PCNA 1 0.11 0.33 0.47
23 INT138404 Regulation of Negative_regulation of TREX1 1 0.18 0.18 0.46
24 INT138405 Negative_regulation of TREX1 1 0.37 0.18 0.46
25 INT139399 Regulation of Gene_expression of PCNA 14 0.56 6.06 0.43
26 INT101568 Negative_regulation of Pcna 1 0.41 5.24 0.42
27 INT139391 Regulation of PCNA 10 0.60 3.12 0.33
28 INT118955 Phosphorylation of PCNA 4 0.29 1.54 0.33
29 INT245337 Gene_expression of ATR 3 0.27 2.06 0.29
30 INT107983 Gene_expression of MSH6 6 0.51 5.57 0.27
31 INT344883 Binding of TREX1 1 0.25 0.09 0.21
32 INT216124 Negative_regulation of Pcna 3 0.13 2.06 0.19
33 INT182627 Regulation of MSH2 1 0.26 2.27 0.18
34 INT105012 Negative_regulation of Atr 1 0.34 0.35 0.16
35 INT245341 Regulation of Gene_expression of ATR 1 0.18 0.94 0.14
36 INT238422 Positive_regulation of Positive_regulation of PCNA 4 0.20 2.92 0.13
37 INT256849 Regulation of Pcna 1 0.05 0.3 0.13
38 INT182623 Localization of MSH2 3 0.77 5.49 0.12
39 INT125588 Positive_regulation of Gene_expression of Pcna 5 0.49 1.57 0.11
40 INT181745 Positive_regulation of MSH2 4 0.48 5.73 0.11
41 INT245339 Regulation of ATR 1 0.18 0.92 0.11
42 INT15504 Positive_regulation of Msh2 1 0.33 0.15 0.09
43 INT269893 Negative_regulation of Gene_expression of Pcna 2 0.18 0.86 0.04
44 INT273404 Positive_regulation of Localization of PCNA 2 0.36 0.09 0.03
45 INT306289 Regulation of Positive_regulation of PCNA 1 0.06 0.07 0.03
46 INT176239 Regulation of Gene_expression of Pcna 1 0.04 0.58 0.03
47 INT176250 Positive_regulation of Pcna 6 0.13 3.52 0
48 INT107991 Positive_regulation of Gene_expression of MSH6 3 0.38 1.35 0
49 INT208213 Localization of ATR 2 0.50 0.19 0
50 INT212518 Localization of MSH6 2 0.10 2.66 0
51 INT169956 Positive_regulation of Transcription of PCNA 2 0.10 0.09 0
52 INT201643 Binding of Pcna 2 0.36 0 0
53 INT238425 Negative_regulation of Positive_regulation of PCNA 2 0.05 1.39 0
54 INT206928 Transcription of MSH2 1 0.52 0.4 0
55 INT182625 Positive_regulation of Localization of MSH2 1 0.45 2.47 0
56 INT271087 Phosphorylation of Pcna 1 0.01 0.65 0
57 INT114219 Positive_regulation of Pcna 1 0.06 0.45 0
58 INT201631 Localization of Pcna 1 0.01 0.5 0
59 INT211715 Negative_regulation of Gene_expression of MSH6 1 0.06 1.09 0
60 INT235140 Binding of Atr 1 0.00 1.28 0
61 INT176244 Regulation of Pcna 1 0.02 0.31 0
62 INT107984 Positive_regulation of Gene_expression of MSH2 1 0.11 0 0
63 INT182624 Positive_regulation of Positive_regulation of MSH2 1 0.45 1.24 0
64 INT304071 Binding of MSH6 1 0.28 1.11 0
65 INT252554 Positive_regulation of ATR 1 0.13 0 0
66 INT252988 Negative_regulation of Binding of PCNA 1 0.06 1.25 0
67 INT288825 Positive_regulation of Binding of PCNA 1 0.06 1.29 0
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