GO:0032410

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Name negative regulation of transporter activity
Categary Process
Go Slim No
Go Link GO:0032410
Unique Molecular Interactions 63
Total Molecular Interactions 89
Total Single Events 1330
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of transporter activity. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of transporter activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
2 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
3 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
4 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
5 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
6 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
7 INT275850 Binding of NDUFAB1 and SNCA 1 0.00 3.78 3.16
8 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
9 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
10 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
11 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
12 INT290544 Negative_regulation of Crh Positive_regulation of Insr 1 0.01 0.3 0.72
13 INT290549 Gopc Positive_regulation of Positive_regulation of Insr 1 0.01 0.06 0.65
14 INT290545 Crh Positive_regulation of Positive_regulation of Insr 1 0.02 0.06 0.64
15 INT290550 Gopc Positive_regulation of Insr 1 0.01 0.06 0.64
16 INT290540 Positive_regulation of Crh Positive_regulation of Insr 1 0.02 0.06 0.64
17 INT46493 Binding of Insr and Oxt 1 0.14 0 0.62
18 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
19 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
20 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
21 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
22 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
23 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
24 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39
25 INT336573 Ptpn2 Regulation of INSR 1 0.00 1.36 0.36
26 INT242403 INSR Positive_regulation of Gene_expression of Bdkrb1 1 0.45 0.88 0.35
27 INT328407 Nlrp1a Negative_regulation of Gene_expression of Snca 1 0.07 0.31 0.29
28 INT328410 Nlrp1a Negative_regulation of Snca 1 0.07 0.31 0.29
29 INT41406 Binding of Insr and Thtpa 1 0.05 0 0.25
30 INT89158 Grpr Positive_regulation of Localization of Insr 1 0.02 0 0.23
31 INT317322 Snca Regulation of Positive_regulation of Th 1 0.01 0.23 0.17
32 INT158141 Binding of HOXD13 and SNCA 1 0.54 0.41 0.11
33 INT328413 Binding of Snca and Nlrp1a 1 0.06 0.75 0.1
34 INT349660 Binding of INSR and PYCARD 1 0.01 0 0.09
35 INT83270 Snca Regulation of Napepld 1 0.14 0 0.09
36 INT325059 Insr Positive_regulation of Ang 1 0.02 1.4 0.08
37 INT115258 Insr Positive_regulation of Phosphorylation of Irs1 1 0.19 0.26 0.08
38 INT17920 Penk Positive_regulation of Insr 1 0.05 0.14 0.06
39 INT184123 Socs3 Positive_regulation of Protein_catabolism of Insr 1 0.03 0.41 0.05
40 INT325060 Binding of Insr and Hand1 1 0.00 0.16 0.05
41 INT184085 Socs1 Positive_regulation of Protein_catabolism of Insr 1 0.04 0.41 0.05
42 INT342170 Insr Regulation of Localization of Cd320 1 0.08 0.92 0.04
43 INT225800 Binding of Insr and Enpp1 1 0.05 0.67 0.04
44 INT144761 Binding of INSR and Insr 1 0.05 0 0
45 INT289672 Binding of GNRH1 and INSR 1 0.02 0 0
46 INT235623 Binding of INS and INSR 1 0.14 0.47 0
47 INT317313 Atp13a2 Negative_regulation of Snca 1 0.13 0.59 0
48 INT144754 Negative_regulation of Binding of Insr and Slc2a2 1 0.01 0 0
49 INT277315 Binding of Insr and Mbnl1 1 0.18 1.1 0
50 INT235624 INS Regulation of Phosphorylation of INSR 1 0.08 0.26 0
51 INT271281 Gene_expression of Stat1 Positive_regulation of Insr 1 0.19 0.51 0
52 INT271287 Gene_expression of IFNA1 Positive_regulation of Insr 1 0.03 0.51 0
53 INT308664 Akt1 Positive_regulation of Phosphorylation of Insr 1 0.02 0.43 0
54 INT144760 Binding of ABCA1 and Insr 1 0.00 0 0
55 INT317315 Gene_expression of Snca Negative_regulation of Psmb10 1 0.00 0.52 0
56 INT317320 Binding of Snca and Atp13a2 1 0.08 0.58 0
57 INT218307 Grb10 Positive_regulation of Protein_catabolism of INSR 1 0.03 0 0
58 INT144753 Binding of Insr and Slc2a2 1 0.01 0 0
59 INT311383 Mbnl1 Regulation of Insr 1 0.00 0.24 0
60 INT144762 Negative_regulation of Binding of INSR and Insr 1 0.06 0 0
61 INT311386 Celf1 Regulation of Insr 1 0.00 0.24 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of transporter activity. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of transporter activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
2 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
3 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
4 INT8691 Localization of Insr 85 0.80 9.27 30.32
5 INT5300 Regulation of Insr 54 0.60 11.33 29.26
6 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
7 INT123593 Gene_expression of Snca 58 0.78 35.76 12.87
8 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
9 INT127123 Positive_regulation of Snca 35 0.70 14.76 10.1
10 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
11 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
12 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
13 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
14 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
15 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
16 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
17 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
18 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
19 INT123594 Negative_regulation of Snca 19 0.59 4.43 4.59
20 INT127122 Positive_regulation of Gene_expression of Snca 11 0.69 15.36 4.56
21 INT51084 Binding of Insr 13 0.30 4.25 4.23
22 INT83035 Binding of INSR 16 0.47 9.29 4.11
23 INT10116 Localization of INSR 11 0.57 5.43 3.48
24 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
25 INT119412 Gene_expression of Snca 15 0.66 11.27 3.39
26 INT110245 Gene_expression of SNCA 11 0.77 8.29 3.36
27 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12
28 INT123595 Regulation of Snca 7 0.62 4.3 3.06
29 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5
30 INT24621 Regulation of Gene_expression of Insr 9 0.42 2.68 2.18
31 INT31006 Regulation of Localization of Insr 7 0.50 0.2 2.05
32 INT127124 Regulation of Gene_expression of Snca 2 0.62 0.17 2.03
33 INT127125 Localization of Snca 6 0.81 8.24 1.88
34 INT114059 Localization of Insr 10 0.46 3.49 1.87
35 INT148266 Positive_regulation of SNCA 5 0.67 3.17 1.74
36 INT218303 Protein_catabolism of INSR 3 0.29 0.67 1.73
37 INT232645 Transcription of INSR 2 0.09 1.19 1.71
38 INT114061 Regulation of Gene_expression of Insr 4 0.27 2.03 1.56
39 INT19342 Regulation of Insr 12 0.24 6.11 1.54
40 INT201271 Phosphorylation of Snca 3 0.82 4.22 1.45
41 INT124247 Negative_regulation of Gene_expression of Snca 12 0.59 3.87 1.39
42 INT124738 Negative_regulation of Positive_regulation of Insr 5 0.23 3.73 1.24
43 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22
44 INT110244 Positive_regulation of Gene_expression of SNCA 5 0.69 4.66 1.19
45 INT106339 Positive_regulation of Phosphorylation of Insr 1 0.49 0 1.12
46 INT151753 Transcription of Snca 6 0.69 1.99 1.11
47 INT32354 Negative_regulation of Regulation of Insr 3 0.33 0.13 1.08
48 INT292945 Positive_regulation of Positive_regulation of Snca 4 0.69 2.42 1.05
49 INT286344 Positive_regulation of Gene_expression of Snca 1 0.41 2.84 1.03
50 INT171382 Phosphorylation of Insr 6 0.51 3.41 0.94
51 INT151752 Positive_regulation of Transcription of Snca 2 0.50 0.99 0.92
52 INT124246 Binding of Snca 10 0.37 6.53 0.9
53 INT41911 Regulation of Positive_regulation of Insr 2 0.21 0.32 0.88
54 INT171376 Positive_regulation of Phosphorylation of Insr 3 0.31 3.05 0.86
55 INT91908 Regulation of Negative_regulation of Insr 1 0.03 0.81 0.86
56 INT144759 Regulation of Gene_expression of INSR 2 0.44 3.09 0.77
57 INT117392 Binding of Insr 8 0.23 4.88 0.68
58 INT171366 Positive_regulation of Localization of Insr 3 0.18 0.63 0.66
59 INT18445 Regulation of Transcription of Insr 1 0.12 0.84 0.63
60 INT18446 Transcription of Insr 2 0.18 0.84 0.62
61 INT308979 Regulation of Localization of Insr 1 0.24 0.44 0.53
62 INT148264 Transcription of SNCA 1 0.40 0.25 0.42
63 INT114062 Negative_regulation of Localization of Insr 1 0.19 0.31 0.39
64 INT343972 Negative_regulation of Binding of SNCA 1 0.36 0.2 0.39
65 INT144755 Negative_regulation of INSR 5 0.41 2.09 0.36
66 INT169628 Binding of SNCA 4 0.47 3.53 0.36
67 INT83030 Positive_regulation of Binding of INSR 2 0.49 2.35 0.31
68 INT343973 Localization of SNCA 1 0.63 0.07 0.3
69 INT278530 Regulation of Positive_regulation of Insr 1 0.01 1.96 0.28
70 INT124735 Positive_regulation of Positive_regulation of Insr 1 0.08 0 0.25
71 INT115253 Negative_regulation of Phosphorylation of Insr 1 0.27 0.56 0.25
72 INT142052 Binding of Snca 4 0.47 1.02 0.22
73 INT292944 Regulation of Positive_regulation of Snca 1 0.45 0.36 0.21
74 INT257418 Negative_regulation of Transcription of Snca 1 0.43 0.93 0.19
75 INT166361 Phosphorylation of SNCA 1 0.70 0.72 0.17
76 INT157084 Localization of Snca 1 0.51 0.17 0.16
77 INT343974 Negative_regulation of Gene_expression of SNCA 1 0.31 0.09 0.16
78 INT319289 Protein_catabolism of Snca 1 0.35 0.93 0.15
79 INT286343 Negative_regulation of Gene_expression of Snca 1 0.26 0.65 0.15
80 INT92634 Negative_regulation of Binding of Insr 1 0.25 0.08 0.12
81 INT308981 Positive_regulation of Negative_regulation of Insr 1 0.27 0.95 0.11
82 INT323945 Positive_regulation of Binding of Insr 1 0.08 0.94 0.11
83 INT288642 Negative_regulation of Positive_regulation of Snca 1 0.07 0.93 0.09
84 INT292946 Positive_regulation of Localization of Snca 1 0.50 0.52 0.06
85 INT184013 Protein_catabolism of Insr 1 0.05 0.4 0.04
86 INT117362 Positive_regulation of Positive_regulation of INSR 1 0.22 0.1 0.03
87 INT235634 Phosphorylation of INSR 24 0.70 3.64 0
88 INT215947 Positive_regulation of Gene_expression of INSR 2 0.14 0.25 0
89 INT144758 Negative_regulation of Negative_regulation of INSR 1 0.41 0 0
90 INT317275 Positive_regulation of Binding of Snca 1 0.37 0.53 0
91 INT235628 Negative_regulation of Phosphorylation of INSR 1 0.16 0.25 0
92 INT230481 Positive_regulation of Regulation of Insr 1 0.01 0.24 0
93 INT144756 Positive_regulation of Negative_regulation of INSR 1 0.49 0 0
94 INT144757 Negative_regulation of Gene_expression of INSR 1 0.41 0 0
95 INT343971 Positive_regulation of Positive_regulation of SNCA 1 0.42 0.35 0
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