GO:0032431

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Name activation of phospholipase A2 activity
Categary Process
Go Slim No
Go Link GO:0032431
Unique Molecular Interactions 54
Total Molecular Interactions 65
Total Single Events 388
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of phospholipase A2 activity. They are ordered first by their pain relevance and then by number of times they were reported for activation of phospholipase A2 activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT19299 ANG Regulation of AVP 1 0.25 0 0.82
2 INT255994 Binding of Ang and Il1rn 1 0.09 1.21 0.63
3 INT73368 Ang1 Negative_regulation of Fabp6 1 0.00 0.44 0.56
4 INT255999 Binding of Ang and H7 1 0.00 0.38 0.54
5 INT19297 ANG Positive_regulation of AVP 1 0.28 0 0.46
6 INT19298 ANG Regulation of OXT 1 0.07 0 0.41
7 INT40219 Ang Negative_regulation of REN 1 0.00 0 0.3
8 INT214615 FOXC1 Positive_regulation of Gene_expression of Ang 1 0.01 0.29 0.28
9 INT256001 Ang Negative_regulation of Il1rn 1 0.11 0.25 0.27
10 INT242215 Binding of ANG and OLR1 1 0.02 1.63 0.25
11 INT316375 Ang Positive_regulation of Nfkb1 1 0.08 0.73 0.23
12 INT316370 Ang Positive_regulation of Xdh 1 0.07 0.62 0.2
13 INT323757 Negative_regulation of ACE2 Negative_regulation of ANG 1 0.18 1.73 0.17
14 INT323756 Negative_regulation of ACE2 Positive_regulation of ANG 1 0.19 1.73 0.17
15 INT316376 Binding of Ang and Atp6ap2 1 0.06 0.87 0.16
16 INT206070 ANG Positive_regulation of Transcription of IL6 1 0.05 1.5 0.15
17 INT102885 Binding of ANG and ACE 2 0.17 0.37 0.13
18 INT281911 Binding of ANG and MAS1 1 0.05 0.39 0.13
19 INT304187 Ang Negative_regulation of Gene_expression of VEGFA 1 0.05 0.16 0.13
20 INT306921 Ang Positive_regulation of Gene_expression of Ephx2 1 0.15 0.79 0.12
21 INT161174 Binding of Ang and Trpc6 1 0.29 0.74 0.11
22 INT281912 Binding of AGTR2 and ANG 1 0.13 0.37 0.1
23 INT281899 Binding of ANG and NOS3 1 0.12 0.37 0.1
24 INT320881 Ang Positive_regulation of Agtrap 1 0.12 1.35 0.08
25 INT206072 ANG Positive_regulation of IL6 1 0.05 0.5 0.08
26 INT21649 ANG Regulation of Alb 1 0.04 0.64 0.07
27 INT307805 Ace Positive_regulation of Ang 1 0.32 1.52 0.07
28 INT206080 ANG Regulation of Gene_expression of IL6 1 0.03 0.4 0.07
29 INT206063 ANG Positive_regulation of Gene_expression of KRT20 1 0.00 1.01 0.07
30 INT304186 Ang Positive_regulation of Gene_expression of VEGFA 2 0.05 2.5 0.06
31 INT281906 BDKRB2 Positive_regulation of ANG 1 0.11 0.51 0.05
32 INT316371 Ang Negative_regulation of Ren1 1 0.16 0.64 0.05
33 INT336132 Binding of AGTR1 and ANG 1 0.00 0.38 0.05
34 INT102887 Binding of ANG and SGCG 1 0.37 0 0.03
35 INT161177 Ang Positive_regulation of Trpc6 1 0.31 0.5 0
36 INT206079 ANG Regulation of KRT20 1 0.00 0.54 0
37 INT325607 Positive_regulation of Gopc Regulation of Ang 1 0.15 0.26 0
38 INT325602 Binding of Ang and Pde2a 1 0.07 0.15 0
39 INT161176 Ang Positive_regulation of Positive_regulation of Trpc6 1 0.31 0.5 0
40 INT206069 ANG Positive_regulation of Gene_expression of IL6 1 0.05 0.51 0
41 INT325590 Gopc Regulation of Ang 1 0.13 0.25 0
42 INT325595 Nppa Negative_regulation of Ang 1 0.25 0.46 0
43 INT336129 Binding of ANG and EXTL3 1 0.01 0.38 0
44 INT325587 Binding of Ang and Nppa 1 0.21 0.24 0
45 INT180853 Binding of PLA2G1B and S100A10 1 0.08 0.75 0
46 INT336131 Binding of ANG and ATP6AP2 1 0.00 0.38 0
47 INT325594 Binding of Ang and Olfml3 1 0.01 0.1 0
48 INT325606 Negative_regulation of Nppa Negative_regulation of Ang 1 0.25 0.46 0
49 INT281904 ANG Positive_regulation of PTGIS 1 0.04 0 0
50 INT325598 Ang Positive_regulation of Camk2a 1 0.21 0.29 0
51 INT161179 Positive_regulation of Ang Positive_regulation of Trpc6 1 0.31 0.5 0
52 INT336130 Binding of ANG and REN 1 0.06 0.38 0
53 INT109815 Ace2 Positive_regulation of Ang 1 0.06 0.3 0
54 INT325601 Ang Positive_regulation of Phosphorylation of Camk2a 1 0.21 0.29 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of phospholipase A2 activity. They are ordered first by their pain relevance and then by number of times they were reported in activation of phospholipase A2 activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT29740 Gene_expression of ANG 55 0.78 24.53 9.86
2 INT38173 Gene_expression of Ang 40 0.75 32.63 8.86
3 INT4021 Positive_regulation of PLA2G1B 35 0.70 23.27 8.2
4 INT4022 Negative_regulation of PLA2G1B 30 0.59 10.41 7.58
5 INT81326 Positive_regulation of Gene_expression of Ang 17 0.67 18.5 5.46
6 INT14837 Gene_expression of PLA2G1B 12 0.60 10.69 3.58
7 INT43948 Localization of PLA2G1B 17 0.78 6.92 2.99
8 INT37734 Positive_regulation of Ang 18 0.46 9.17 2.87
9 INT37733 Negative_regulation of Ang 11 0.41 3.23 2.09
10 INT29739 Positive_regulation of ANG 11 0.69 4.37 1.75
11 INT102893 Positive_regulation of Gene_expression of ANG 10 0.69 5.62 1.71
12 INT251834 Negative_regulation of Gene_expression of ANG 5 0.59 3.95 1.38
13 INT73364 Negative_regulation of Ang1 1 0.05 0.8 1.15
14 INT96861 Binding of Ang 11 0.32 4.46 1.1
15 INT19303 Regulation of ANG 3 0.62 1.08 1.09
16 INT87637 Localization of Ang 11 0.63 4.42 1.03
17 INT41729 Negative_regulation of Positive_regulation of PLA2G1B 3 0.43 2.7 1.02
18 INT91762 Positive_regulation of Gene_expression of PLA2G1B 3 0.17 3.45 0.97
19 INT118538 Binding of ANG 5 0.47 3.02 0.92
20 INT38172 Regulation of Ang 8 0.31 4.13 0.9
21 INT109079 Negative_regulation of ANG 4 0.57 2.2 0.8
22 INT81325 Transcription of Ang 2 0.52 1.43 0.76
23 INT81327 Positive_regulation of Transcription of Ang 1 0.45 1.32 0.76
24 INT4020 Regulation of PLA2G1B 2 0.61 0.19 0.64
25 INT143278 Regulation of Gene_expression of ANG 2 0.62 1.13 0.59
26 INT102890 Localization of ANG 9 0.72 0.41 0.26
27 INT123399 Positive_regulation of Positive_regulation of PLA2G1B 1 0.15 0.47 0.26
28 INT173345 Phosphorylation of PLA2G1B 1 0.05 0 0.22
29 INT96860 Positive_regulation of Binding of Ang 3 0.33 1.4 0.21
30 INT74514 Binding of PLA2G1B 2 0.48 0.37 0.19
31 INT161173 Negative_regulation of Localization of Ang 3 0.39 2.19 0.18
32 INT262261 Negative_regulation of Gene_expression of PLA2G1B 1 0.05 1.07 0.18
33 INT324893 Positive_regulation of Localization of Ang 1 0.10 0.59 0.16
34 INT307797 Negative_regulation of Gene_expression of Ang 2 0.39 1.3 0.11
35 INT266664 Positive_regulation of Localization of PLA2G1B 1 0.12 0.32 0.08
36 INT320864 Negative_regulation of Positive_regulation of Ang 1 0.19 1.37 0.08
37 INT242229 Negative_regulation of Positive_regulation of ANG 1 0.08 0.63 0.06
38 INT336137 Negative_regulation of Binding of ANG 1 0.08 0.38 0.05
39 INT291194 Gene_expression of Ang1 2 0.32 0.71 0
40 INT323760 Protein_catabolism of ANG 1 0.24 0.44 0
41 INT316365 Positive_regulation of Negative_regulation of Ang 1 0.33 0.76 0
42 INT303276 Regulation of Gene_expression of Ang 1 0.24 0.89 0
43 INT325550 Positive_regulation of Regulation of Ang 1 0.33 0.27 0
44 INT281924 Transcription of ANG 1 0.39 0.1 0
45 INT291196 Positive_regulation of Gene_expression of Ang1 1 0.24 0.72 0
46 INT281916 Negative_regulation of Transcription of ANG 1 0.23 0.1 0
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