GO:0032436

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Name positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Categary Process
Go Slim No
Go Link GO:0032436
Unique Molecular Interactions 613
Total Molecular Interactions 907
Total Single Events 5789
Pain Genes Associated 36

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of proteasomal ubiquitin-dependent protein catabolic process. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
2 INT251170 Clu Positive_regulation of Trpv1 1 0.28 2.61 6.49
3 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
4 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
5 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
6 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
7 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
8 INT251164 Binding of Clu and Trpv1 1 0.19 0.44 2.23
9 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
10 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
11 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
12 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
13 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
14 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
15 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
16 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
17 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
18 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
19 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
20 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
21 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
22 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
23 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
24 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
25 INT317541 Oprd1 Negative_regulation of Akt1 1 0.06 0 0.91
26 INT249012 Binding of Akt1 and Gabrg1 1 0.01 0 0.9
27 INT132226 Binding of Akt1 and Pik3cg 1 0.30 0.49 0.9
28 INT251159 Binding of Clu and Positive_regulation of Trpv1 1 0.16 0 0.87
29 INT199109 Binding of Akt1 and Arhgdia 1 0.02 2.73 0.87
30 INT328501 Sumo1 Negative_regulation of Gene_expression of Pglyrp1 1 0.00 1.54 0.83
31 INT317556 Phosphorylation of Gopc Positive_regulation of Akt1 1 0.10 0.08 0.82
32 INT317514 Akt1 Regulation of Localization of Oprm1 1 0.21 0.07 0.82
33 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
34 INT111888 Akt1 Regulation of Regulation of Oprm1 1 0.04 0 0.77
35 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
36 INT31776 Positive_regulation of Gclc Positive_regulation of G6pd 1 0.29 0.19 0.75
37 INT335592 Ltp Positive_regulation of Positive_regulation of Akt1 1 0.01 0.19 0.74
38 INT106527 Akt1 Positive_regulation of Jun 1 0.05 0.53 0.74
39 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
40 INT166386 Mapk1 Regulation of Gene_expression of Gnb2l1 1 0.46 0.25 0.7
41 INT251169 Clu Regulation of Ca2 1 0.03 0.66 0.7
42 INT251166 Clu Positive_regulation of Trpc3 1 0.09 0.75 0.67
43 INT251171 Clu Positive_regulation of C6 1 0.05 0.75 0.67
44 INT298728 Akt1 Positive_regulation of Rela 1 0.01 1.03 0.67
45 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
46 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
47 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
48 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
49 INT251188 Clu Positive_regulation of TRPV1 1 0.01 0.23 0.64
50 INT134047 Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
51 INT134044 Positive_regulation of Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
52 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61
53 INT282286 Akt1 Positive_regulation of Pak1 1 0.15 0.24 0.61
54 INT166387 Binding of Gnb2l1 and Mdk 1 0.30 0.24 0.61
55 INT139901 Ins1 Positive_regulation of Akt1 9 0.31 4.58 0.6
56 INT166385 Binding of Araf and Gnb2l1 1 0.23 0.24 0.6
57 INT251167 Clu Positive_regulation of Trpc6 1 0.12 0.2 0.6
58 INT251168 Clu Positive_regulation of Trpc7 1 0.15 0.2 0.59
59 INT248994 Binding of Akt1 and Ptar1 1 0.00 0 0.58
60 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
61 INT302832 Tnfsf10 Positive_regulation of Akt1 1 0.04 1.63 0.56
62 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
63 INT282284 Cpox Positive_regulation of Akt1 1 0.02 0.47 0.54
64 INT282282 Ptger2 Positive_regulation of Akt1 1 0.03 0.47 0.54
65 INT162994 Binding of Akt1 and Trib3 1 0.04 0.09 0.54
66 INT127320 Gpx3 Regulation of Akt1 2 0.00 3.11 0.53
67 INT317523 Oprm1 Positive_regulation of Gene_expression of Akt1 1 0.32 0.05 0.53
68 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
69 INT317574 Oprm1 Positive_regulation of Akt1 1 0.22 0.05 0.52
70 INT151221 Negative_regulation of SIGMAR1 Negative_regulation of Akt1 1 0.00 0.13 0.51
71 INT102844 Pdc Regulation of Akt1 1 0.03 0 0.49
72 INT114676 Mdm2 Negative_regulation of p53-ps 1 0.10 0.26 0.48
73 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
74 INT309126 Edc4 Positive_regulation of Akt1 1 0.02 0.99 0.47
75 INT309144 Dlat Positive_regulation of Akt1 1 0.03 0.99 0.47
76 INT276207 Binding of Akt1 and Myo1f 1 0.11 0.05 0.47
77 INT145260 Binding of CLU and App 1 0.00 0.74 0.46
78 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
79 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
80 INT244050 Binding of Gnb2l1 and Prkca 1 0.01 0 0.45
81 INT139900 Kcne2 Positive_regulation of Akt1 1 0.06 2.95 0.44
82 INT348785 Ins1 Positive_regulation of Phosphorylation of Akt1 1 0.17 3.5 0.42
83 INT322396 Hist1h1t Positive_regulation of Akt1 1 0.01 0 0.42
84 INT322395 Akt1 Regulation of Pik3cb 1 0.08 0 0.42
85 INT122749 Cyp3a23/3a1 Positive_regulation of Phosphorylation of Akt1 1 0.07 0.24 0.41
86 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
87 INT276216 Binding of Akt1 and Ins1 2 0.03 2.61 0.4
88 INT231842 Pcdh8 Positive_regulation of Akt1 1 0.00 1.59 0.4
89 INT322409 Positive_regulation of OPRM1 Positive_regulation of Phosphorylation of Akt1 1 0.04 0 0.4
90 INT166155 Ccr9 Positive_regulation of Akt1 1 0.58 2.14 0.39
91 INT51341 Binding of Pomc and Clu 1 0.14 0 0.38
92 INT291616 Cby1 Positive_regulation of Gene_expression of Smad7 1 0.00 0.79 0.38
93 INT148465 Positive_regulation of Ccl4 Positive_regulation of Gclc 1 0.32 0.06 0.38
94 INT146611 Ins1 Positive_regulation of Phosphorylation of Akt1 9 0.23 4.34 0.37
95 INT148467 Ccl4 Positive_regulation of Gclc 1 0.32 0.05 0.37
96 INT148243 Binding of Akt1 and Kit 1 0.03 0.44 0.35
97 INT122758 Positive_regulation of Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
98 INT288208 Binding of Mapk14 and Positive_regulation of Akt1 1 0.01 0.42 0.35
99 INT122756 Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
100 INT309118 Dlat Positive_regulation of Positive_regulation of Akt1 1 0.03 0.32 0.34
101 INT249019 Gabrg1 Positive_regulation of Akt1 1 0.02 0 0.34
102 INT134080 OPA1 Negative_regulation of Phosphorylation of Gnb2l1 1 0.03 0.22 0.34
103 INT196820 Negative_regulation of Ppp1cc Positive_regulation of Akt1 1 0.00 0 0.34
104 INT214377 Akt1 Regulation of Amph 1 0.15 0 0.33
105 INT165580 Binding of Akt1 and Grin2b 1 0.02 0.2 0.32
106 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31
107 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31
108 INT303063 Akt1 Negative_regulation of Gene_expression of Syn1 1 0.09 0.45 0.31
109 INT165921 Tlr4 Positive_regulation of Akt1 1 0.16 0.75 0.31
110 INT165920 Negative_regulation of Tlr4 Positive_regulation of Akt1 1 0.13 0.75 0.31
111 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
112 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
113 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
114 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29
115 INT328500 Sumo1 Positive_regulation of Negative_regulation of Cebpz 1 0.11 1.06 0.29
116 INT132367 Lgals1 Positive_regulation of Akt1 1 0.22 0.13 0.28
117 INT18499 Binding of SUMO1 and SEC1 1 0.12 0 0.28
118 INT317533 Akt1 Positive_regulation of Nos1 1 0.43 0 0.28
119 INT149322 Amph Positive_regulation of Akt1 1 0.39 0 0.27
120 INT328499 Binding of Cebpz and Sumo1 1 0.08 0.84 0.27
121 INT223930 Binding of Akt1 and Pik3cb 1 0.07 0.35 0.26
122 INT223929 Negative_regulation of Binding of Akt1 and Pik3cb 1 0.08 0.36 0.26
123 INT303082 Akt1 Negative_regulation of Gene_expression of Mafk 1 0.20 0.37 0.26
124 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25
125 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25
126 INT314047 THL Negative_regulation of Phosphorylation of Akt1 1 0.14 0.71 0.25
127 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
128 INT326094 Akt1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.49 0.24
129 INT326092 Gene_expression of Akt1 Negative_regulation of Gopc 1 0.03 0.55 0.24
130 INT326093 Akt1 Positive_regulation of Gopc 1 0.03 0.43 0.23
131 INT323173 THRA Positive_regulation of Phosphorylation of Akt1 1 0.00 0 0.22
132 INT260844 NRP2 Positive_regulation of Akt1 1 0.00 0.73 0.22
133 INT116467 Vegfa Positive_regulation of Akt1 1 0.33 1.41 0.21
134 INT323174 DBT Positive_regulation of Phosphorylation of Akt1 1 0.01 0 0.21
135 INT116468 VEGFA Positive_regulation of Akt1 1 0.04 1.39 0.21
136 INT289356 Binding of Akt1 and Fgf2 1 0.03 0.82 0.21
137 INT309661 C5 Positive_regulation of Phosphorylation of Akt1 1 0.51 0.45 0.21
138 INT221237 Prkca Regulation of Phosphorylation of Akt1 1 0.01 0.28 0.2
139 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19
140 INT101812 Binding of KEAP1 and Positive_regulation of Gene_expression of GCLC 1 0.54 0.1 0.19
141 INT101808 Binding of NFE2L2 and Positive_regulation of Gene_expression of GCLC 1 0.54 0.1 0.19
142 INT334631 Igf1r Positive_regulation of Phosphorylation of Akt1 1 0.19 0.5 0.18
143 INT303058 Akt1 Negative_regulation of Gene_expression of Syt1 1 0.21 0.43 0.18
144 INT221231 Pdpk1 Positive_regulation of Akt1 1 0.09 0.13 0.18
145 INT221244 Pdpk1 Positive_regulation of Phosphorylation of Akt1 1 0.09 0.13 0.18
146 INT251162 Clu Positive_regulation of Gene_expression of Trpv1 1 0.20 0.07 0.18
147 INT253129 Ins1 Regulation of Phosphorylation of Akt1 3 0.11 1.66 0.17
148 INT179841 Il11 Regulation of Positive_regulation of Akt1 1 0.08 0.07 0.17
149 INT217074 Binding of Acsm3 and Axin1 1 0.00 5.37 0.17
150 INT282858 Bpifa2 Negative_regulation of Akt1 1 0.05 0.91 0.17
151 INT226209 Pik3cb Positive_regulation of Phosphorylation of Akt1 1 0.10 1.16 0.17
152 INT282861 Bpifa2 Negative_regulation of Phosphorylation of Akt1 1 0.05 0.91 0.17
153 INT218937 Akt1 Positive_regulation of Parn 1 0.01 0.65 0.16
154 INT316484 Akt1 Positive_regulation of Positive_regulation of Stat3 1 0.01 0.87 0.16
155 INT184086 Socs5 Negative_regulation of Binding of Jak1 1 0.20 0 0.16
156 INT343475 Epo Regulation of Akt1 1 0.18 0.41 0.16
157 INT343478 Epo Regulation of Gene_expression of Akt1 1 0.40 0.41 0.16
158 INT171871 Binding of FAS and Sumo1 1 0.02 1.43 0.16
159 INT218930 Akt1 Positive_regulation of Xiap 1 0.06 0.64 0.16
160 INT171870 Binding of Ltbr and Sumo1 1 0.00 1.44 0.16
161 INT224697 TNF Positive_regulation of Akt1 1 0.01 0 0.15
162 INT293698 Positive_regulation of Binding of Akt1 and Plek 1 0.05 0.12 0.15
163 INT292750 Akt1 Positive_regulation of Bcl2 1 0.01 1.67 0.15
164 INT184098 Binding of Il4 and Socs5 1 0.09 2.05 0.15
165 INT293695 Binding of Akt1 and Plek 1 0.03 0.12 0.15
166 INT292749 Akt1 Positive_regulation of Ctnnd2 1 0.09 1.73 0.15
167 INT231844 Pcdh8 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.63 0.15
168 INT224694 Il1 Positive_regulation of Akt1 1 0.01 0 0.15
169 INT293699 Regulation of Binding of Akt1 and Plek 1 0.04 0.12 0.15
170 INT292748 Akt1 Negative_regulation of Positive_regulation of Casp3 1 0.01 1.81 0.15
171 INT213005 Hdl1 Positive_regulation of Akt1 3 0.19 3.81 0.14
172 INT253122 Ins1 Positive_regulation of Akt1 2 0.15 1.81 0.14
173 INT231274 Nrg1 Regulation of Gene_expression of Akt1 1 0.19 0 0.14
174 INT226205 Negative_regulation of Akt1 Positive_regulation of Casp3 1 0.04 0.71 0.14
175 INT355226 VEGFA Positive_regulation of Akt1 1 0.04 0.27 0.14
176 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
177 INT293697 Dock2 Positive_regulation of Akt1 1 0.14 0.08 0.13
178 INT252336 Il2 Positive_regulation of Akt1 1 0.01 0 0.13
179 INT263321 Akt1 Regulation of Bad 1 0.00 0.74 0.13
180 INT282862 Bpifa2 Negative_regulation of Positive_regulation of Akt1 1 0.05 0.75 0.13
181 INT182478 Binding of Akt1 and Cx3cr1 1 0.11 0.12 0.13
182 INT209645 AR Regulation of STUB1 1 0.04 0.93 0.13
183 INT320765 Dsg2 Positive_regulation of Akt1 1 0.48 0.74 0.13
184 INT263318 Akt1 Regulation of Gsk3b 1 0.02 0.75 0.13
185 INT293696 Mthfd1 Positive_regulation of Akt1 1 0.05 0.08 0.13
186 INT153740 TNFRSF11A Positive_regulation of Vcp 1 0.04 1.15 0.13
187 INT224685 L1cam Positive_regulation of Positive_regulation of Akt1 1 0.01 0.34 0.13
188 INT182477 Binding of Akt1 and Cxcr4 1 0.10 0.12 0.13
189 INT221254 Binding of KNG1 and Akt1 1 0.00 0.13 0.13
190 INT182483 Cxcr6 Positive_regulation of Akt1 1 0.22 0.12 0.12
191 INT101809 Gene_expression of NFE2L2 Positive_regulation of Gene_expression of GCLC 1 0.75 0 0.12
192 INT101811 NFE2L2 Regulation of Gene_expression of GCLC 1 0.67 0.06 0.12
193 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
194 INT317891 Binding of Akt1 and Mtf1 1 0.21 1.04 0.11
195 INT256544 Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
196 INT303085 Akt1 Regulation of Gene_expression of Mafk 1 0.12 0.33 0.11
197 INT289765 Akt1 Regulation of Phosphorylation of Gsk3a 1 0.05 0.45 0.11
198 INT240941 Binding of Akt1 and Ins1 1 0.06 0.75 0.11
199 INT163817 Lep Positive_regulation of Phosphorylation of Akt1 1 0.33 0.31 0.11
200 INT289768 Akt1 Regulation of Phosphorylation of Gsk3b 1 0.04 0.45 0.11

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of proteasomal ubiquitin-dependent protein catabolic process. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
2 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
3 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
4 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
5 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
6 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
7 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
8 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
9 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
10 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
11 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
12 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
13 INT114674 Gene_expression of Mdm2 15 0.78 3.51 11.85
14 INT75137 Regulation of Akt1 74 0.48 37.89 9.7
15 INT58986 Gene_expression of Clu 17 0.77 8.35 9.61
16 INT159116 Gene_expression of Gnb2l1 12 0.77 2.79 9.49
17 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98
18 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69
19 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
20 INT114675 Positive_regulation of Gene_expression of Mdm2 1 0.70 1.98 7.9
21 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83
22 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39
23 INT126748 Positive_regulation of Positive_regulation of Akt1 26 0.55 11.15 7.08
24 INT166383 Positive_regulation of Gene_expression of Gnb2l1 1 0.69 2.19 7.02
25 INT117721 Positive_regulation of Gene_expression of Akt1 22 0.69 6.26 6.08
26 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06
27 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
28 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
29 INT159115 Negative_regulation of Gene_expression of Gnb2l1 3 0.42 1.33 5.59
30 INT51337 Binding of Clu 3 0.12 0.05 5.45
31 INT38251 Negative_regulation of Gclc 7 0.57 1.37 5.06
32 INT134657 Localization of Akt1 37 0.68 11.58 4.62
33 INT159122 Positive_regulation of Gnb2l1 8 0.69 2.2 4.61
34 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44
35 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
36 INT75136 Binding of Akt1 27 0.27 8.81 4.15
37 INT139898 Negative_regulation of Positive_regulation of Akt1 15 0.42 4.66 4.06
38 INT120072 Gene_expression of Smad7 38 0.74 20.87 3.69
39 INT132223 Negative_regulation of Negative_regulation of Akt1 6 0.42 2.75 3.66
40 INT136692 Localization of Akt1 12 0.78 2.14 3.65
41 INT157687 Regulation of Gene_expression of Akt1 9 0.62 4.96 3.27
42 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
43 INT117720 Negative_regulation of Gene_expression of Akt1 11 0.37 2.33 3.08
44 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
45 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
46 INT117715 Regulation of Phosphorylation of Akt1 15 0.51 3.23 2.78
47 INT35946 Positive_regulation of Clu 12 0.69 4.92 2.73
48 INT166381 Negative_regulation of Gnb2l1 1 0.43 0.73 2.68
49 INT214355 Binding of Akt1 13 0.36 3.72 2.59
50 INT163544 Binding of Psen1 40 0.36 15.28 2.42
51 INT159117 Regulation of Gene_expression of Gnb2l1 3 0.56 0.5 2.36
52 INT100886 Gene_expression of GCLC 16 0.76 5.63 2.29
53 INT138286 Regulation of Positive_regulation of Akt1 13 0.45 4.93 2.22
54 INT249563 Positive_regulation of Trib3 1 0.45 0.94 2.18
55 INT249555 Localization of Trib3 1 0.73 0.94 2.18
56 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
57 INT60723 Localization of Psen2 5 0.68 2.11 2.02
58 INT100897 Positive_regulation of Gene_expression of GCLC 9 0.68 1.84 1.99
59 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
60 INT49347 Negative_regulation of Clu 4 0.58 1.63 1.79
61 INT159120 Protein_catabolism of Gnb2l1 1 0.26 0.37 1.79
62 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
63 INT174924 Gene_expression of Smad7 6 0.41 3.59 1.76
64 INT142236 Regulation of Phosphorylation of Akt1 13 0.61 5.02 1.75
65 INT174923 Positive_regulation of Gene_expression of Smad7 3 0.37 2.3 1.73
66 INT165332 Negative_regulation of Negative_regulation of Akt1 5 0.42 3.27 1.7
67 INT41395 Positive_regulation of Gclc 9 0.61 1.34 1.66
68 INT117714 Regulation of Positive_regulation of Akt1 3 0.61 0.44 1.61
69 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55
70 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
71 INT18503 Binding of SUMO1 7 0.27 6.21 1.48
72 INT78646 Regulation of Psen2 4 0.20 1.78 1.42
73 INT114671 Positive_regulation of Mdm2 1 0.61 0.5 1.38
74 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
75 INT34140 Negative_regulation of Vcp 2 0.10 0.23 1.32
76 INT35944 Regulation of Clu 4 0.20 0.15 1.3
77 INT120076 Positive_regulation of Gene_expression of Smad7 16 0.65 11.33 1.25
78 INT251180 Phosphorylation of Clu 1 0.29 0.79 1.22
79 INT122988 Gene_expression of CLU 28 0.75 24.07 1.21
80 INT207203 Transcription of Akt1 6 0.67 3.73 1.1
81 INT46734 Positive_regulation of Stub1 6 0.16 1.44 1.09
82 INT100892 Positive_regulation of GCLC 8 0.68 3.44 1.08
83 INT233561 Gene_expression of Clu 14 0.66 45.63 1.07
84 INT191050 Positive_regulation of Negative_regulation of Akt1 6 0.31 1.82 1.03
85 INT238596 Gene_expression of Sumo1 1 0.44 0.25 1.02
86 INT114673 Regulation of Gene_expression of Mdm2 1 0.62 0.23 1.02
87 INT78645 Negative_regulation of Gene_expression of Psen2 1 0.14 0.13 1.01
88 INT134660 Positive_regulation of Localization of Akt1 10 0.32 6.33 0.94
89 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
90 INT163508 Regulation of Gene_expression of Akt1 3 0.45 1.65 0.92
91 INT171851 Gene_expression of Sumo1 13 0.30 10.7 0.89
92 INT100273 Localization of Clu 4 0.61 0.49 0.88
93 INT11198 Negative_regulation of Gclc 3 0.59 0.49 0.87
94 INT94194 Transcription of Gclc 1 0.58 0.53 0.87
95 INT31775 Positive_regulation of Gclc 3 0.38 0.52 0.84
96 INT78647 Positive_regulation of Localization of Psen2 1 0.16 0.14 0.83
97 INT237406 Positive_regulation of Binding of Psen1 1 0.29 0 0.8
98 INT94756 Positive_regulation of PSEN2 8 0.49 4.59 0.77
99 INT286313 Transcription of Psen1 9 0.70 2.26 0.76
100 INT193849 Positive_regulation of Gene_expression of Psen2 5 0.44 4.92 0.76
101 INT70666 Positive_regulation of CLU 16 0.45 12.95 0.74
102 INT78649 Binding of Psen2 7 0.36 5.9 0.73
103 INT151170 Regulation of Regulation of Akt1 2 0.45 3.28 0.73
104 INT78648 Regulation of Binding of Psen2 1 0.14 0.2 0.73
105 INT47481 Localization of SUMO1 1 0.01 0 0.73
106 INT184019 Gene_expression of Socs5 6 0.53 4.94 0.72
107 INT272878 Negative_regulation of Smad7 4 0.41 3.86 0.72
108 INT94233 Positive_regulation of Gene_expression of Clu 3 0.69 2.64 0.71
109 INT61226 Binding of Gclc 1 0.14 0 0.67
110 INT207204 Regulation of Transcription of Akt1 3 0.35 1.41 0.66
111 INT41394 Regulation of Gclc 5 0.43 1.78 0.64
112 INT91765 Positive_regulation of Gene_expression of PSEN2 8 0.49 4.57 0.63
113 INT94232 Negative_regulation of Gene_expression of Clu 2 0.43 1.17 0.63
114 INT281466 Negative_regulation of Regulation of Akt1 1 0.33 0.31 0.63
115 INT196939 Gene_expression of Stub1 10 0.18 1.67 0.59
116 INT135294 Negative_regulation of Positive_regulation of Clu 1 0.37 0.35 0.59
117 INT218900 Regulation of Negative_regulation of Akt1 3 0.15 1.73 0.53
118 INT217394 Regulation of Binding of PSEN1 1 0.44 1.58 0.53
119 INT124774 Binding of Vcp 4 0.44 3.4 0.52
120 INT251182 Regulation of Phosphorylation of Clu 1 0.16 0.13 0.52
121 INT120074 Regulation of Gene_expression of Smad7 1 0.58 2.05 0.5
122 INT276189 Regulation of Localization of Akt1 1 0.43 0.2 0.5
123 INT89258 Localization of STUB1 3 0.14 0.67 0.49
124 INT209013 Regulation of Stub1 1 0.06 0.29 0.46
125 INT210125 Regulation of Axin1 1 0.02 2.45 0.46
126 INT147960 Negative_regulation of GCLC 8 0.28 4.4 0.45
127 INT233552 Positive_regulation of Gene_expression of Clu 3 0.59 9.31 0.45
128 INT316041 Transcription of Psen2 1 0.64 1.1 0.45
129 INT166382 Positive_regulation of Positive_regulation of Gnb2l1 1 0.50 0.2 0.44
130 INT234249 Regulation of PSEN1 6 0.37 2.21 0.43
131 INT224538 Negative_regulation of Gene_expression of Smad7 1 0.09 0.25 0.43
132 INT234257 Regulation of Gene_expression of PSEN1 6 0.44 1.98 0.42
133 INT294003 Gene_expression of CSNK1E 1 0.70 3.57 0.42
134 INT193856 Localization of Psen1 19 0.73 9.79 0.41
135 INT256035 Positive_regulation of Sumo1 2 0.03 1.23 0.41
136 INT36396 Positive_regulation of Psen2 6 0.44 4.57 0.39
137 INT177773 Localization of PSEN1 4 0.73 0.89 0.36
138 INT134072 Negative_regulation of Phosphorylation of Gnb2l1 1 0.11 0.22 0.34
139 INT261682 Positive_regulation of Positive_regulation of PSEN2 1 0.21 0.55 0.33
140 INT321348 Positive_regulation of Localization of Akt1 1 0.30 0.08 0.32
141 INT144854 Gene_expression of STUB1 10 0.13 2.03 0.31
142 INT134840 Gene_expression of SMAD7 1 0.74 2.74 0.31
143 INT123622 Negative_regulation of Vcp 5 0.42 2.51 0.3
144 INT172957 Negative_regulation of Mdm2 4 0.14 4.28 0.3
145 INT134076 Phosphorylation of Gnb2l1 1 0.22 0.22 0.3
146 INT184716 Binding of Smad7 2 0.34 0.91 0.29
147 INT272890 Regulation of Negative_regulation of Smad7 1 0.19 1.33 0.29
148 INT96952 Gene_expression of Gclc 7 0.38 2.08 0.28
149 INT224298 Negative_regulation of PSEN2 6 0.57 2.29 0.28
150 INT86708 Negative_regulation of SUMO1 3 0.18 1.71 0.28
151 INT122985 Negative_regulation of Gene_expression of CLU 4 0.57 4.58 0.27
152 INT145259 Binding of CLU 1 0.03 0.84 0.27
153 INT316045 Negative_regulation of Negative_regulation of Psen1 1 0.42 1.58 0.27
154 INT294013 Negative_regulation of CSNK1E 1 0.39 0.89 0.27
155 INT144855 Positive_regulation of STUB1 3 0.08 0.59 0.26
156 INT18500 Negative_regulation of Binding of SUMO1 1 0.32 0 0.26
157 INT239464 Regulation of Negative_regulation of Akt1 3 0.31 0.37 0.25
158 INT261676 Negative_regulation of Positive_regulation of PSEN1 1 0.36 1.59 0.25
159 INT172525 Localization of PSEN2 5 0.73 4.17 0.24
160 INT86709 Positive_regulation of SUMO1 3 0.19 2.59 0.24
161 INT228793 Negative_regulation of Gene_expression of Smad7 5 0.25 2.33 0.23
162 INT101822 Negative_regulation of Positive_regulation of GCLC 1 0.57 0.07 0.23
163 INT239796 Binding of TAF1 1 0.01 0.33 0.23
164 INT122987 Negative_regulation of CLU 5 0.42 4.58 0.21
165 INT198492 Localization of Sumo1 3 0.24 0 0.21
166 INT198487 Positive_regulation of Localization of Sumo1 1 0.16 0 0.21
167 INT203471 Localization of Stub1 1 0.23 0.5 0.21
168 INT167250 Regulation of Gene_expression of MDM2 1 0.06 0.86 0.21
169 INT88744 Positive_regulation of Gene_expression of MDM2 9 0.43 7.82 0.2
170 INT181508 Regulation of Regulation of Psen1 2 0.33 0.51 0.2
171 INT230483 Protein_catabolism of Akt1 2 0.10 1.11 0.2
172 INT171849 Negative_regulation of Gene_expression of Sumo1 2 0.19 1.81 0.2
173 INT35945 Positive_regulation of Regulation of Clu 1 0.35 0 0.2
174 INT172958 Positive_regulation of Mdm2 4 0.56 2.43 0.19
175 INT276192 Transcription of Akt1 1 0.66 0.47 0.18
176 INT335731 Gene_expression of Vcp 1 0.73 12.21 0.18
177 INT294009 Negative_regulation of Gene_expression of CSNK1E 1 0.39 0.19 0.18
178 INT286317 Positive_regulation of Transcription of Psen1 1 0.37 0.32 0.17
179 INT210123 Localization of Axin1 1 0.04 0.84 0.17
180 INT66933 Binding of AXIN1 6 0.32 1.8 0.16
181 INT96951 Positive_regulation of Gene_expression of Gclc 5 0.34 1.45 0.16
182 INT122984 Localization of CLU 2 0.78 2.46 0.16
183 INT122989 Positive_regulation of Localization of CLU 2 0.45 1.81 0.16
184 INT126733 Regulation of MDM2 2 0.36 0.73 0.16
185 INT113346 Binding of MDM2 10 0.35 5.73 0.15
186 INT228790 Positive_regulation of Smad7 4 0.41 0.58 0.15
187 INT266010 Localization of Mdm2 2 0.75 2.64 0.15
188 INT204054 Negative_regulation of Negative_regulation of Mdm2 2 0.14 2.23 0.15
189 INT101819 Positive_regulation of Positive_regulation of GCLC 2 0.59 1.47 0.15
190 INT286764 Regulation of Localization of Mdm2 1 0.14 1.38 0.15
191 INT286748 Regulation of Mdm2 1 0.14 1.37 0.15
192 INT226185 Protein_catabolism of Akt1 7 0.53 2.43 0.14
193 INT122986 Positive_regulation of Gene_expression of CLU 3 0.67 2.37 0.14
194 INT263410 Negative_regulation of Axin1 1 0.01 0 0.14
195 INT175517 Gene_expression of Mdm2 18 0.78 16.28 0.13
196 INT336359 Positive_regulation of Phosphorylation of Psen1 1 0.33 0.4 0.13
197 INT336361 Phosphorylation of Psen1 1 0.54 0.34 0.13
198 INT237045 Positive_regulation of Vcp 7 0.62 6.96 0.12
199 INT214360 Negative_regulation of Binding of Akt1 2 0.41 0.09 0.12
200 INT355216 Positive_regulation of Binding of Akt1 1 0.37 0.35 0.12
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