GO:0032438

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Name melanosome organization
Categary Process
Go Slim No
Go Link GO:0032438
Unique Molecular Interactions 84
Total Molecular Interactions 117
Total Single Events 761
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for melanosome organization. They are ordered first by their pain relevance and then by number of times they were reported for melanosome organization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT33314 Binding of Ap1m1 and Ap1m2 1 0.07 0.97 5.42
2 INT211710 Binding of Mc1r and a 7 0.44 0.37 4.78
3 INT90929 Binding of Ap1m1 and Insrr 1 0.01 0.19 1.6
4 INT145072 ASIP Negative_regulation of MC1R 1 0.29 0 1.52
5 INT69874 POMC Negative_regulation of TYRP1 1 0.13 0 1.07
6 INT69871 ASIP Negative_regulation of TYRP1 1 0.36 0 1.07
7 INT113224 Binding of ASIP and MC1R 1 0.00 0 0.75
8 INT288371 Binding of Atrn and a 1 0.39 0 0.74
9 INT30130 Binding of TYRP1 and Gast 1 0.06 0.09 0.63
10 INT250054 Positive_regulation of Binding of Gpr143 and Spdya 1 0.04 0.52 0.59
11 INT250053 Binding of Gpr143 and Spdya 1 0.03 0.51 0.59
12 INT93508 Binding of ASIP and Mc1r 1 0.02 0 0.47
13 INT69873 ASIP Negative_regulation of Binding of POMC 1 0.35 0 0.45
14 INT288370 a Positive_regulation of Mc1r 1 0.39 0 0.44
15 INT107726 BIRC2 Regulation of ASIP 1 0.03 0.24 0.35
16 INT227496 PTPN4 Regulation of PMEL 1 0.00 0.45 0.33
17 INT293900 TYRP1 Regulation of IGKC 1 0.01 0.11 0.27
18 INT71642 Binding of HLA-A and PMEL 2 0.20 1.05 0.26
19 INT71643 Binding of HLA-A and TYRP1 1 0.24 0.36 0.26
20 INT71639 Binding of MLANA and PMEL 1 0.27 0.36 0.26
21 INT323346 Positive_regulation of Tyrp1 Positive_regulation of Positive_regulation of Gpr35 1 0.11 0.76 0.21
22 INT288372 Atrn Positive_regulation of a 1 0.52 0 0.19
23 INT288368 Atrn Positive_regulation of Binding of a 1 0.48 0 0.19
24 INT313799 Binding of HLA-B and TYRP1 1 0.01 0.54 0.18
25 INT275318 Binding of Gpr143 and Adamts4 1 0.00 0.6 0.17
26 INT275319 Tg(Ngf)47Kma Positive_regulation of Gpr143 1 0.00 0.59 0.17
27 INT275317 Binding of Gpr143 and Adamts5 1 0.01 0.61 0.17
28 INT178269 Slc11a2 Regulation of a 1 0.06 0.97 0.16
29 INT178266 Raly Regulation of a 1 0.14 0.97 0.16
30 INT97541 Gtf3a Negative_regulation of a 1 0.03 0.08 0.15
31 INT97544 Pomc Negative_regulation of a 1 0.19 0.07 0.15
32 INT293901 Positive_regulation of TYRP1 Regulation of IGKC 1 0.02 0.06 0.15
33 INT97548 KITLG Negative_regulation of a 1 0.01 0.08 0.15
34 INT162776 TYRP1 Regulation of Kcnq2 1 0.24 0.14 0.14
35 INT268083 Ido1 Negative_regulation of Tyrp1 1 0.22 0 0.13
36 INT309724 Regulation of Binding of TYRP1 and TRPV4 1 0.01 0 0.09
37 INT120152 Binding of PMEL and SLC9A7 1 0.07 0 0.09
38 INT309754 Binding of TYRP1 and TRPV4 1 0.02 0 0.09
39 INT120153 Binding of PMEL and SLC9A3 1 0.07 0 0.09
40 INT279707 Positive_regulation of AGTR1 Regulation of TYRP1 1 0.00 0 0.09
41 INT140606 PMEL Negative_regulation of Gene_expression of ATF4 1 0.01 0.74 0.08
42 INT47719 Gpr143 Regulation of Grhpr 1 0.00 0.08 0.08
43 INT140609 PMEL Negative_regulation of Gene_expression of ATF6 1 0.01 0.74 0.08
44 INT94653 Tyrp1 Positive_regulation of Positive_regulation of Tyr 1 0.39 0 0.08
45 INT140605 PMEL Negative_regulation of Transcription of ATF4 1 0.01 0.74 0.08
46 INT268087 Binding of Tyrp1 and Gpr35 1 0.02 0 0.08
47 INT107722 ASIP Negative_regulation of EIF4E1B 1 0.02 0.43 0.07
48 INT107727 ASIP Negative_regulation of RRM2 1 0.29 0.43 0.07
49 INT313807 Binding of TYRP1 and YOD1 1 0.00 0.49 0.06
50 INT107725 ASIP Negative_regulation of EVI2B 1 0.41 0.43 0.06
51 INT107724 ASIP Negative_regulation of NR4A3 1 0.15 0.43 0.06
52 INT309726 Binding of CALM1 and TYRP1 1 0.00 0 0.05
53 INT47717 Gpr143 Regulation of Cyp3a62 1 0.02 0.05 0.05
54 INT309730 Binding of CALM3 and TYRP1 1 0.01 0 0.05
55 INT268085 Tdo2 Regulation of Gene_expression of Tyrp1 1 0.25 0.09 0.04
56 INT268084 Tdo2 Positive_regulation of Tyrp1 1 0.26 0.09 0.04
57 INT47720 Gpr143 Regulation of Nqo1 1 0.01 0 0
58 INT339113 Binding of ASIP and ERBB2 1 0.00 0.64 0
59 INT335240 Binding of CD8A and PMEL 1 0.28 0.81 0
60 INT290482 GPR143 Regulation of Gene_expression of Mitf 1 0.36 0.64 0
61 INT140607 PMEL Positive_regulation of Gene_expression of DDIT3 1 0.01 0.75 0
62 INT335239 Binding of HLA-DOA and PMEL 1 0.04 0.68 0
63 INT313802 Binding of ASIP and YOD1 1 0.00 0.19 0
64 INT178267 Alb Positive_regulation of Gene_expression of a 1 0.19 0.9 0
65 INT178268 Alb Regulation of Gene_expression of a 1 0.18 0.9 0
66 INT287616 Ap3b1 Regulation of Binding of Fmr1 1 0.01 0 0
67 INT180749 Binding of Pmel and ACE2 1 0.20 2.14 0
68 INT180748 Binding of Pmel and MMEL1 1 0.00 1.08 0
69 INT313805 Binding of TYRP1 and SPG16 1 0.00 0 0
70 INT287615 Ap3b1 Regulation of Binding of Fxr1 1 0.00 0 0
71 INT313801 Binding of TYR and TYRP1 1 0.03 0 0
72 INT287617 Ap3b1 Regulation of Fxr1 1 0.00 0 0
73 INT339100 Binding of ASIP and EGFR 1 0.00 0.58 0
74 INT313797 Binding of MET and TYRP1 1 0.00 0 0
75 INT335242 Binding of PMEL and CD160 1 0.36 0.85 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for melanosome organization. They are ordered first by their pain relevance and then by number of times they were reported in melanosome organization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT24780 Binding of Ap1m1 20 0.29 4.75 25.05
2 INT55251 Gene_expression of a 142 0.67 81.21 23.03
3 INT32648 Gene_expression of Tyrp1 80 0.66 17.9 16.59
4 INT85631 Positive_regulation of Tyrp1 40 0.64 18.73 10.84
5 INT93507 Gene_expression of ASIP 14 0.60 3.98 7.55
6 INT250050 Gene_expression of Gpr143 1 0.48 5.76 6.53
7 INT250048 Positive_regulation of Gpr143 12 0.43 5.85 6.1
8 INT49027 Gene_expression of TYRP1 35 0.75 9.81 6.06
9 INT94652 Binding of a 15 0.48 4.18 5.4
10 INT68591 Regulation of TYRP1 14 0.44 3.93 5.05
11 INT178261 Positive_regulation of Gene_expression of a 23 0.55 14.67 4.07
12 INT33313 Gene_expression of Ap1m1 4 0.41 0.44 4.04
13 INT42823 Negative_regulation of Ap1m1 2 0.14 0.3 3.85
14 INT142501 Transcription of Tyrp1 4 0.18 2.09 3.71
15 INT18073 Positive_regulation of TYRP1 11 0.67 1.98 3.36
16 INT211708 Regulation of a 4 0.42 1.92 3.15
17 INT5789 Gene_expression of PMEL 23 0.75 13.18 2.67
18 INT83073 Negative_regulation of Tyrp1 10 0.23 4.4 2.65
19 INT30040 Negative_regulation of TYRP1 11 0.51 2.72 2.54
20 INT37341 Regulation of Tyrp1 4 0.29 4.53 2.42
21 INT178246 Negative_regulation of Gene_expression of a 8 0.43 4.27 2.19
22 INT11388 Positive_regulation of PMEL 11 0.67 5.9 2.09
23 INT178260 Positive_regulation of a 6 0.50 3.09 2.08
24 INT91608 Negative_regulation of ASIP 3 0.40 0.51 2.04
25 INT33306 Negative_regulation of Binding of Ap1m1 2 0.26 0.75 1.88
26 INT88269 Binding of ASIP 4 0.19 0.41 1.82
27 INT30037 Binding of TYRP1 9 0.36 0.45 1.6
28 INT99357 Positive_regulation of Localization of PMEL 1 0.67 0.51 1.52
29 INT145177 Positive_regulation of Gene_expression of Tyrp1 5 0.30 3.31 1.46
30 INT62425 Regulation of Gene_expression of Tyrp1 7 0.29 1.44 1.41
31 INT323338 Positive_regulation of Positive_regulation of Tyrp1 2 0.13 1.53 1.4
32 INT178249 Regulation of Gene_expression of a 4 0.35 2.3 1.39
33 INT162196 Binding of Tyrp1 2 0.31 0.69 1.35
34 INT250046 Regulation of Gene_expression of Gpr143 1 0.28 0.87 1.23
35 INT178255 Localization of a 4 0.65 0.72 1.1
36 INT69309 Positive_regulation of Gene_expression of PMEL 3 0.49 0.9 1.05
37 INT33310 Localization of Ap1m1 1 0.48 0.24 1.05
38 INT33312 Transcription of Ap1m1 1 0.41 0.17 0.98
39 INT38737 Localization of TYRP1 2 0.68 0.5 0.97
40 INT56148 Localization of PMEL 5 0.78 1.87 0.93
41 INT49024 Transcription of TYRP1 3 0.66 0.96 0.9
42 INT178252 Transcription of a 3 0.67 0.73 0.9
43 INT45093 Binding of PMEL 10 0.37 4.77 0.89
44 INT54527 Negative_regulation of Ap3b1 3 0.01 1.24 0.89
45 INT38373 Positive_regulation of Ap3b1 4 0.37 1.01 0.86
46 INT250045 Positive_regulation of Positive_regulation of Gpr143 1 0.31 0.4 0.85
47 INT145073 Regulation of Gene_expression of ASIP 1 0.27 0 0.83
48 INT118986 Positive_regulation of Gene_expression of ASIP 1 0.39 0.97 0.8
49 INT30038 Negative_regulation of Binding of TYRP1 1 0.42 0 0.72
50 INT11387 Negative_regulation of PMEL 3 0.57 1.53 0.56
51 INT163222 Protein_catabolism of a 2 1.00 1.17 0.56
52 INT126213 Regulation of Gene_expression of TYRP1 2 0.44 0.51 0.55
53 INT211707 Positive_regulation of Transcription of a 2 0.51 0.27 0.55
54 INT145676 Binding of Ap3b1 1 0.02 0.38 0.55
55 INT305031 Positive_regulation of GPR143 1 0.49 0.41 0.5
56 INT178248 Negative_regulation of a 4 0.43 1 0.46
57 INT250043 Positive_regulation of Gene_expression of Gpr143 1 0.29 0.56 0.4
58 INT38371 Regulation of Ap3b1 2 0.22 0.58 0.32
59 INT38372 Positive_regulation of Regulation of Ap3b1 1 0.37 0 0.32
60 INT114527 Positive_regulation of Regulation of TYRP1 1 0.45 0.43 0.3
61 INT49022 Transcription of PMEL 1 0.46 0.41 0.28
62 INT250049 Positive_regulation of Localization of Gpr143 1 0.31 0.31 0.25
63 INT250044 Localization of Gpr143 1 0.46 0.31 0.25
64 INT91597 Negative_regulation of Positive_regulation of TYRP1 1 0.41 0.09 0.23
65 INT136228 Phosphorylation of TYRP1 1 0.80 0.17 0.21
66 INT196100 Localization of Tyrp1 3 0.36 0 0.19
67 INT279733 Regulation of Regulation of TYRP1 1 0.01 0 0.18
68 INT178256 Negative_regulation of Binding of a 1 0.33 0.94 0.15
69 INT111770 Regulation of PMEL 2 0.44 0.4 0.12
70 INT323337 Positive_regulation of Negative_regulation of Tyrp1 1 0.15 0.86 0.11
71 INT276280 Regulation of Localization of a 1 0.37 0.33 0.09
72 INT227247 Positive_regulation of Positive_regulation of PMEL 2 0.19 0.37 0.08
73 INT178181 Positive_regulation of Pmel 1 0.15 0.71 0.05
74 INT64844 Protein_catabolism of PMEL 1 0.75 0.22 0.05
75 INT268070 Negative_regulation of Positive_regulation of Tyrp1 1 0.23 0.21 0.03
76 INT210246 Gene_expression of Pmel 3 0.16 2.27 0
77 INT170543 Gene_expression of Ap3b1 2 0.02 1.45 0
78 INT178259 Positive_regulation of Binding of a 1 0.39 0.39 0
79 INT47713 Negative_regulation of Gpr143 1 0.03 0 0
80 INT201587 Negative_regulation of Pmel 1 0.02 0.07 0
81 INT290467 Gene_expression of GPR143 1 0.21 0.32 0
82 INT290465 Regulation of GPR143 1 0.19 0.58 0
83 INT271652 Regulation of Gene_expression of Ap3b1 1 0.01 0.15 0
84 INT178254 Regulation of Transcription of a 1 0.35 0.47 0
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