GO:0032451

From wiki-pain
Jump to: navigation, search
Name demethylase activity
Categary Function
Go Slim No
Go Link GO:0032451
Unique Molecular Interactions 83
Total Molecular Interactions 98
Total Single Events 984
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for demethylase activity. They are ordered first by their pain relevance and then by number of times they were reported for demethylase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
2 INT81583 Cyp3a23/3a1 Positive_regulation of st 1 0.04 0 1.08
3 INT81580 Cyp3a23/3a1 Positive_regulation of Nudt14 1 0.01 0 1.08
4 INT130282 Cyp3a23/3a1 Positive_regulation of Gene_expression of Npy 1 0.15 0 0.94
5 INT279166 Binding of Cyp3a23/3a1 and Nr3c2 1 0.00 0.61 0.9
6 INT56273 RYBP Negative_regulation of Cyp1a2 1 0.01 0.17 0.9
7 INT253995 Binding of Cxcl12 and Cyp3a23/3a1 1 0.06 1.28 0.85
8 INT65807 Nr3c1 Positive_regulation of Cyp3a23/3a1 1 0.14 0 0.82
9 INT56275 RYBP Positive_regulation of Negative_regulation of Cyp1a2 1 0.01 0.17 0.81
10 INT102630 Cyp3a62 Negative_regulation of Cyp1a2 1 0.40 0 0.81
11 INT135781 Cyp3a23/3a1 Positive_regulation of Positive_regulation of Col1a1 1 0.01 0.78 0.8
12 INT130283 Cyp3a23/3a1 Positive_regulation of Transcription of Npy 1 0.10 0 0.79
13 INT56272 Cyp2e1 Positive_regulation of Cyp1a2 1 0.52 0.17 0.77
14 INT218935 Cyp3a23/3a1 Regulation of Bcl2 1 0.00 1.08 0.74
15 INT218933 Cyp3a23/3a1 Regulation of Alpi 1 0.00 1.07 0.73
16 INT28184 Binding of CYP1A2 and CYP2D6 1 0.00 0 0.7
17 INT253994 Cyp3a23/3a1 Positive_regulation of Localization of Mif 1 0.09 0.96 0.69
18 INT113685 Binding of Cyp3a23/3a1 and Cyp2c11 1 0.35 0 0.65
19 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63
20 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62
21 INT52816 Cyp3a23/3a1 Regulation of Localization of LH 1 0.03 0.16 0.6
22 INT43692 Cyp3a23/3a1 Negative_regulation of Gh1 1 0.04 0 0.59
23 INT102671 Cyp1a2 Regulation of RYBP 1 0.00 0 0.58
24 INT102666 Cyp2e1 Regulation of Cyp1a2 1 0.20 0 0.58
25 INT43693 Cyp3a23/3a1 Positive_regulation of Localization of Prl 1 0.10 0 0.57
26 INT253998 Cyp3a23/3a1 Positive_regulation of Binding of Cxcl12 1 0.10 0.65 0.55
27 INT253990 Cyp3a23/3a1 Positive_regulation of Cxcl12 1 0.09 0.65 0.55
28 INT147575 Binding of Ahr and Cyp1a1 2 0.15 0.15 0.54
29 INT147579 Binding of ATF4 and Cyp1a1 1 0.01 0.15 0.54
30 INT162500 AHR Regulation of CYP1A1 3 0.19 0.18 0.51
31 INT162503 AHR Regulation of CYP1A2 3 0.61 0.18 0.5
32 INT92803 Binding of CYP1A2 and VKORC1 1 0.31 0.12 0.48
33 INT92804 Positive_regulation of Binding of CYP1A2 and VKORC1 1 0.41 0.12 0.48
34 INT281982 Cyp3a23/3a1 Negative_regulation of Gene_expression of MDK 1 0.00 0.67 0.47
35 INT218932 Cyp3a23/3a1 Regulation of Gene_expression of Alpi 1 0.00 0.53 0.46
36 INT122749 Cyp3a23/3a1 Positive_regulation of Phosphorylation of Akt1 1 0.07 0.24 0.41
37 INT78064 Cyp3a23/3a1 Regulation of Localization of Il6 1 0.08 0.07 0.32
38 INT104932 AHR Positive_regulation of CYP1A1 1 0.43 0.83 0.31
39 INT281970 Cyp3a23/3a1 Negative_regulation of Gene_expression of Tie1 1 0.00 0.46 0.3
40 INT218934 Cyp3a23/3a1 Negative_regulation of Ephb1 1 0.01 0.95 0.28
41 INT335134 PPARA Negative_regulation of Cyp1a1 1 0.47 0 0.28
42 INT218928 Cyp3a23/3a1 Regulation of Transcription of Bcl2 1 0.00 0.56 0.28
43 INT78065 Cyp3a23/3a1 Negative_regulation of Gene_expression of Il6 1 0.12 0.07 0.27
44 INT218931 Cyp3a23/3a1 Regulation of Gene_expression of Akp3 1 0.00 0.55 0.27
45 INT78061 Cyp3a23/3a1 Negative_regulation of Localization of Il6 1 0.12 0.07 0.27
46 INT130678 CYP2C9 Regulation of Cyp1a2 1 0.06 0 0.26
47 INT262353 TRIP10 Negative_regulation of Cyp1a2 1 0.03 0.8 0.26
48 INT162502 NEUROD1 Regulation of CYP1A1 2 0.07 0.09 0.25
49 INT162501 NEUROD1 Regulation of CYP1A2 2 0.22 0.09 0.25
50 INT130663 Cyp1a2 Regulation of Binding of Ugt2b7 1 0.12 0 0.25
51 INT57171 Binding of RYBP and Cyp1a1 1 0.01 0 0.23
52 INT351318 Binding of CYP2C19 and Cyp1a2 1 0.01 0.28 0.22
53 INT57964 Myo5a Regulation of Negative_regulation of Cyp1a1 1 0.00 0.1 0.2
54 INT134196 Ahr Regulation of Transcription of Cyp1a1 1 0.11 0.14 0.16
55 INT65883 Binding of CYP1A1 and PPP4C 1 0.02 0 0.15
56 INT273561 Binding of CYP1A1 and CYP3A4 1 0.02 0.12 0.15
57 INT57170 Binding of Cyp1a1 and Cyp2b1 1 0.39 0 0.13
58 INT254002 Binding of Cyp3a23/3a1 and Positive_regulation of Gene_expression of Mif 1 0.08 0.56 0.13
59 INT134201 Positive_regulation of Binding of AHR and Cyp1a1 1 0.21 0.07 0.1
60 INT134200 Binding of AHR and Cyp1a1 1 0.16 0.07 0.1
61 INT264106 Cyp1a2 Regulation of CYP2D6 1 0.06 0 0.09
62 INT162506 Gtf3a Regulation of CYP1A1 1 0.00 0.09 0.09
63 INT162507 Gtf3a Regulation of CYP1A2 1 0.00 0.09 0.09
64 INT264104 Cyp1a2 Regulation of CYP2C9 1 0.04 0 0.09
65 INT264102 Cyp1a2 Regulation of CYP3A4 1 0.03 0 0.09
66 INT168368 Binding of Cyp1a2 and Cyp2e1 1 0.37 0.08 0.07
67 INT22568 Cyp1a1 Positive_regulation of Tcf21 1 0.04 0 0.06
68 INT22567 Cyp1a2 Positive_regulation of Tcf21 1 0.04 0 0.06
69 INT345925 IL6 Negative_regulation of Gene_expression of CYP1A2 1 0.13 0.18 0.06
70 INT264568 Binding of STS and CYP1A2 1 0.20 0.18 0.06
71 INT180372 CYP2A6 Regulation of Cyp1a2 1 0.03 2.02 0.05
72 INT235313 Cyp3a23/3a1 Positive_regulation of Ins1 1 0.14 0.82 0.05
73 INT285385 Ass1 Positive_regulation of Transcription of Cyp1a2 1 0.00 0.09 0.03
74 INT125648 Cyp2c11 Positive_regulation of Transcription of Cyp3a23/3a1 1 0.42 0 0
75 INT20322 Binding of CYP1A2 and CYP26A1 1 0.00 0 0
76 INT125659 Cyp2b2 Positive_regulation of Transcription of Cyp3a23/3a1 1 0.06 0 0
77 INT20326 Binding of CYP1A2 and CYP21A2 1 0.01 0 0
78 INT197295 Positive_regulation of Binding of Ahr and Cyp1a1 1 0.20 0 0
79 INT53286 Binding of CYP1A2 and OPN1LW 1 0.03 0 0
80 INT157283 CYP1A2 Positive_regulation of Gm7100 1 0.00 0 0
81 INT125654 Cyp2e1 Positive_regulation of Transcription of Cyp3a23/3a1 1 0.43 0 0
82 INT95055 Binding of CYP1A2 and TXNRD1 1 0.04 0 0
83 INT125649 Cyp2c6 Positive_regulation of Transcription of Cyp3a23/3a1 1 0.40 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for demethylase activity. They are ordered first by their pain relevance and then by number of times they were reported in demethylase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22
2 INT8765 Positive_regulation of Cyp3a23/3a1 63 0.67 22.28 20.39
3 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35
4 INT32706 Gene_expression of Cyp3a23/3a1 51 0.65 19.48 15.06
5 INT18191 Negative_regulation of Cyp3a23/3a1 48 0.57 10.21 13.38
6 INT28014 Localization of Cyp3a23/3a1 34 0.77 9.8 12.96
7 INT71189 Gene_expression of Cyp1a2 24 0.78 11.39 11.12
8 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66
9 INT47860 Negative_regulation of Cyp1a2 20 0.57 6.06 10
10 INT17867 Positive_regulation of Cyp1a2 39 0.69 2.58 7.57
11 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92
12 INT28015 Regulation of Cyp3a23/3a1 19 0.40 6.32 5.79
13 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73
14 INT185 Regulation of Cyp1a1 18 0.54 2.71 5.56
15 INT2435 Negative_regulation of Cyp1a1 15 0.58 3.32 5.16
16 INT186 Positive_regulation of Cyp1a1 30 0.70 5 5.02
17 INT49292 Positive_regulation of Cyp1a2 17 0.69 6.16 4.96
18 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75
19 INT65514 Gene_expression of Cyp1a2 25 0.77 6.12 4.6
20 INT140199 Positive_regulation of Gene_expression of Cyp3a23/3a1 9 0.45 4.91 4.56
21 INT71199 Positive_regulation of Gene_expression of Cyp1a2 4 0.69 1.41 3.36
22 INT8764 Positive_regulation of Positive_regulation of Cyp3a23/3a1 5 0.45 1.62 3.33
23 INT71195 Transcription of Cyp1a2 6 0.53 2.41 3.24
24 INT69564 Binding of Cyp3a23/3a1 11 0.34 4.67 3.2
25 INT22212 Gene_expression of CYP1A1 34 0.76 10.11 2.77
26 INT87822 Binding of Cyp1a2 8 0.47 0.84 2.72
27 INT126498 Positive_regulation of Negative_regulation of Cyp1a2 2 0.41 1.21 2.64
28 INT113081 Negative_regulation of Gene_expression of Cyp1a2 6 0.58 1.68 2.39
29 INT56337 Regulation of Cyp1a2 8 0.27 1.09 2.33
30 INT20332 Positive_regulation of Positive_regulation of CYP1A2 4 0.69 0.68 2.17
31 INT53390 Negative_regulation of Positive_regulation of Cyp1a2 2 0.35 0 2.03
32 INT36267 Positive_regulation of CYP1A1 29 0.69 11.09 2.01
33 INT65424 Positive_regulation of Gene_expression of CYP1A2 6 0.70 2.01 2.01
34 INT19409 Binding of Cyp1a1 12 0.48 2.58 1.97
35 INT113683 Positive_regulation of Negative_regulation of Cyp3a23/3a1 2 0.49 0.48 1.94
36 INT113684 Negative_regulation of Gene_expression of Cyp3a23/3a1 5 0.36 2.04 1.71
37 INT17862 Localization of Cyp1a1 5 0.74 0.34 1.34
38 INT13674 Gene_expression of Cyp1a1 13 0.65 2.22 1.25
39 INT94396 Regulation of Cyp1a2 4 0.60 0.37 1.15
40 INT134955 Positive_regulation of Transcription of Cyp1a2 2 0.38 0.52 1.14
41 INT68220 Binding of CYP1A1 8 0.48 0.8 0.99
42 INT207325 Positive_regulation of Localization of Cyp3a23/3a1 1 0.42 0.61 0.98
43 INT79635 Localization of Cyp1a2 2 0.74 0.26 0.97
44 INT130671 Regulation of Gene_expression of Cyp1a2 2 0.43 1.27 0.87
45 INT77927 Negative_regulation of Gene_expression of Cyp1a2 3 0.42 1.23 0.78
46 INT157282 Localization of CYP1A2 5 0.75 0.54 0.76
47 INT17868 Localization of Cyp1a2 3 0.75 0.05 0.75
48 INT94193 Transcription of Cyp1a2 4 0.65 1.29 0.74
49 INT17865 Regulation of Positive_regulation of Cyp1a2 2 0.45 0 0.74
50 INT331008 Positive_regulation of Localization of CYP1A2 1 0.42 0.06 0.7
51 INT351280 Negative_regulation of Negative_regulation of CYP1A2 1 0.27 0.53 0.69
52 INT71188 Binding of Cyp1a2 5 0.44 0.58 0.68
53 INT207326 Regulation of Localization of Cyp3a23/3a1 1 0.43 0.74 0.65
54 INT53396 Regulation of Gene_expression of Cyp3a23/3a1 7 0.38 3.04 0.63
55 INT115823 Transcription of Cyp3a23/3a1 3 0.54 0.82 0.61
56 INT115826 Transcription of Cyp1a1 4 0.52 1.15 0.53
57 INT2438 Regulation of Regulation of Cyp1a1 1 0.27 0 0.52
58 INT139306 Positive_regulation of Transcription of Cyp3a23/3a1 1 0.45 0.31 0.52
59 INT80929 Negative_regulation of Positive_regulation of Cyp3a23/3a1 3 0.43 0.83 0.48
60 INT28016 Negative_regulation of Localization of Cyp3a23/3a1 2 0.04 0 0.43
61 INT27414 Positive_regulation of Negative_regulation of Cyp1a1 1 0.49 0.44 0.41
62 INT115835 Negative_regulation of Positive_regulation of Cyp1a1 2 0.32 1.35 0.36
63 INT84396 Positive_regulation of Positive_regulation of Cyp1a2 2 0.24 0.22 0.34
64 INT273509 Positive_regulation of Gene_expression of Cyp1a2 2 0.14 1.2 0.33
65 INT13676 Negative_regulation of Gene_expression of Cyp1a1 1 0.33 0.1 0.29
66 INT144387 Positive_regulation of Negative_regulation of CYP1A2 2 0.39 0.64 0.28
67 INT96886 Positive_regulation of Gene_expression of CYP1A1 8 0.64 3.15 0.27
68 INT99628 Positive_regulation of Gene_expression of Cyp1a1 4 0.25 1.3 0.27
69 INT115926 Negative_regulation of Positive_regulation of CYP1A1 1 0.30 0.16 0.27
70 INT52176 Positive_regulation of Binding of Cyp1a1 1 0.44 0 0.26
71 INT248664 Phosphorylation of Cyp3a23/3a1 2 0.14 0.94 0.24
72 INT115834 Positive_regulation of Transcription of Cyp1a1 2 0.38 0.64 0.23
73 INT17861 Positive_regulation of Localization of Cyp1a2 2 0.50 0.05 0.21
74 INT65885 Negative_regulation of CYP1A1 2 0.18 0.64 0.2
75 INT96884 Regulation of Gene_expression of CYP1A1 2 0.60 0.54 0.2
76 INT96889 Negative_regulation of Gene_expression of CYP1A1 2 0.42 0.9 0.2
77 INT344068 Negative_regulation of Binding of CYP1A2 1 0.15 0.05 0.17
78 INT134195 Regulation of Transcription of Cyp1a1 1 0.13 0.14 0.16
79 INT314338 Positive_regulation of Transcription of Cyp1a2 1 0.13 0.38 0.14
80 INT231567 Negative_regulation of Gene_expression of CYP1A2 2 0.36 0.06 0.13
81 INT70583 Negative_regulation of Binding of Cyp3a23/3a1 1 0.30 0.09 0.12
82 INT162937 Regulation of Regulation of CYP1A2 1 0.45 0 0.12
83 INT17866 Positive_regulation of Localization of Cyp1a1 1 0.49 0 0.12
84 INT162936 Regulation of Gene_expression of CYP1A2 1 0.45 0 0.12
85 INT349935 Transcription of CYP1A1 1 0.47 1.22 0.12
86 INT137619 Protein_catabolism of Cyp1a2 1 0.33 0 0.11
87 INT68218 Regulation of Positive_regulation of CYP1A1 3 0.45 2.35 0.1
88 INT17863 Regulation of Positive_regulation of Cyp1a1 1 0.27 0 0.09
89 INT115832 Negative_regulation of Transcription of Cyp3a23/3a1 1 0.34 0.51 0.09
90 INT135458 Negative_regulation of Negative_regulation of Cyp1a2 1 0.35 0.36 0.09
91 INT115836 Regulation of Regulation of Cyp3a23/3a1 1 0.17 0.49 0.09
92 INT274054 Localization of CYP1A1 1 0.12 0 0.07
93 INT274055 Protein_catabolism of CYP1A2 1 0.47 0 0.06
94 INT274056 Protein_catabolism of CYP1A1 1 0.15 0 0.06
95 INT73220 Regulation of Gene_expression of Cyp1a2 1 0.62 1.01 0.06
96 INT68219 Positive_regulation of Binding of CYP1A1 1 0.50 0 0.05
97 INT306772 Positive_regulation of Negative_regulation of Cyp1a2 1 0.08 0.06 0.04
98 INT167112 Regulation of CYP1A1 3 0.26 0.37 0
99 INT303488 Negative_regulation of Positive_regulation of Cyp1a2 1 0.18 0.96 0
100 INT294588 Positive_regulation of Positive_regulation of CYP1A1 1 0.07 0.25 0
101 INT83244 Regulation of Positive_regulation of CYP1A2 1 0.43 1.18 0
102 INT158582 Negative_regulation of Positive_regulation of CYP1A2 1 0.41 0 0
103 INT85223 Regulation of Localization of Cyp1a1 1 0.03 0.1 0
104 INT253980 Positive_regulation of Binding of Cyp3a23/3a1 1 0.08 0 0
105 INT167111 Regulation of Binding of CYP1A1 1 0.43 0 0
106 INT167110 Regulation of Binding of CYP1A2 1 0.45 0 0
107 INT248670 Negative_regulation of Regulation of Cyp3a23/3a1 1 0.08 0.16 0
108 INT197269 Regulation of Gene_expression of Cyp1a1 1 0.16 0 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox