GO:0032469

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Name endoplasmic reticulum calcium ion homeostasis
Categary Process
Go Slim No
Go Link GO:0032469
Unique Molecular Interactions 303
Total Molecular Interactions 421
Total Single Events 5121
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for endoplasmic reticulum calcium ion homeostasis. They are ordered first by their pain relevance and then by number of times they were reported for endoplasmic reticulum calcium ion homeostasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
2 INT156008 Bcl2 Regulation of Localization of Aifm1 1 0.17 1.92 1.47
3 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 0.01 2.06 1.34
4 INT142202 FL Positive_regulation of Bcl2 1 0.05 0.39 0.99
5 INT112765 Binding of Nfkb1 and Bcl2 1 0.00 1.37 0.91
6 INT166634 Binding of Bcl2 and Becn1 1 0.20 0.5 0.86
7 INT150864 RYBP Positive_regulation of Positive_regulation of Bcl2 1 0.01 0.66 0.86
8 INT218935 Cyp3a23/3a1 Regulation of Bcl2 1 0.00 1.08 0.74
9 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
10 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
11 INT302839 MIR15A Negative_regulation of Bcl2 1 0.15 1.41 0.47
12 INT238639 Cd86 Negative_regulation of Negative_regulation of Bcl2 1 0.01 0.97 0.46
13 INT112772 Binding of Bcl2 and SGSM3 1 0.02 0.69 0.45
14 INT116609 Lnpep Negative_regulation of Bcl2 1 0.05 0.62 0.43
15 INT116606 Lnpep Regulation of Gene_expression of Bcl2 1 0.07 0.62 0.43
16 INT116607 Lnpep Negative_regulation of Gene_expression of Bcl2 1 0.10 0.62 0.43
17 INT309143 Dlat Positive_regulation of Bcl2 1 0.06 1.04 0.42
18 INT309152 Dlat Positive_regulation of Gene_expression of Bcl2 1 0.04 1.05 0.42
19 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
20 INT235878 Creb1 Positive_regulation of Gene_expression of Bcl2 1 0.05 0.17 0.38
21 INT155062 Csf2 Positive_regulation of Transcription of Bcl2 1 0.31 2.91 0.36
22 INT264555 IL15 Positive_regulation of Gene_expression of BCL2 1 0.02 0.92 0.35
23 INT269962 Bcl2 Negative_regulation of Bcl2l11 1 0.15 2.14 0.34
24 INT155060 Stat3 Negative_regulation of Bcl2 1 0.21 3.7 0.33
25 INT242398 Cyp19a1 Positive_regulation of Bcl2 1 0.00 1.28 0.3
26 INT218928 Cyp3a23/3a1 Regulation of Transcription of Bcl2 1 0.00 0.56 0.28
27 INT260837 NRP2 Negative_regulation of Negative_regulation of Bcl2 1 0.00 0.9 0.28
28 INT172905 Binding of Bad and Bcl2 3 0.08 6.46 0.27
29 INT237927 BCL2 Positive_regulation of BAX 2 0.24 2.22 0.26
30 INT237928 BCL2 Positive_regulation of FAS 1 0.02 1.41 0.26
31 INT272157 Gh1 Negative_regulation of Bcl2 1 0.23 1.2 0.26
32 INT272158 Gh1 Regulation of Bcl2 1 0.15 1.2 0.26
33 INT237925 BCL2 Positive_regulation of Protein_catabolism of PARP1 1 0.02 1.42 0.26
34 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25
35 INT260840 NRP2 Positive_regulation of Gene_expression of Bcl2 1 0.00 0.85 0.24
36 INT302170 PTGER2 Positive_regulation of Gene_expression of BCL2 1 0.04 3.76 0.23
37 INT256706 Binding of Hsp90b1 and Wfs1 1 0.43 5.02 0.2
38 INT176133 AKT1 Regulation of BCL2 2 0.12 1.84 0.17
39 INT285026 Bak1 Regulation of Bcl2 1 0.09 0.71 0.17
40 INT285022 Regulation of Bak1 Regulation of Bcl2 1 0.09 0.71 0.17
41 INT349475 Regulation of Bax Regulation of Bcl2 1 0.07 1.35 0.17
42 INT155233 TXNIP Regulation of BCL2 1 0.23 0.15 0.17
43 INT285024 Bcl2 Regulation of Bak1 1 0.09 0.71 0.17
44 INT229203 Binding of Bcl2 and Cyp2c11 1 0.36 1.2 0.17
45 INT155068 Csf2 Negative_regulation of Bcl2 1 0.12 1.88 0.17
46 INT347445 CD99 Positive_regulation of BCL2 1 0.17 0.95 0.16
47 INT292750 Akt1 Positive_regulation of Bcl2 1 0.01 1.67 0.15
48 INT349476 Bax Regulation of Bcl2 1 0.07 1.33 0.15
49 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14
50 INT95104 TGFBR2 Positive_regulation of BCL2 1 0.08 0.61 0.14
51 INT309139 Edc4 Positive_regulation of Bcl2 1 0.03 0.12 0.13
52 INT148594 Binding of BCL2 and CD34 1 0.39 1.17 0.13
53 INT309142 Edc4 Regulation of Bcl2 1 0.02 0.12 0.13
54 INT246016 Negative_regulation of Timp1 Negative_regulation of Gene_expression of Bcl2 1 0.03 1.07 0.13
55 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13
56 INT348542 BCL2 Negative_regulation of NLRP1 1 0.07 2.02 0.13
57 INT246017 Timp1 Negative_regulation of Gene_expression of Bcl2 1 0.03 1.07 0.13
58 INT172899 Binding of Bcl2 and Bcl2l1 3 0.02 5.54 0.12
59 INT178101 EDN1 Negative_regulation of Phosphorylation of BCL2 1 0.03 1 0.12
60 INT305194 Bcl2 Positive_regulation of Epo 1 0.06 0.29 0.12
61 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
62 INT273063 Negative_regulation of Fas Negative_regulation of Positive_regulation of Bcl2 1 0.01 0.72 0.11
63 INT221684 Binding of Bcl2 and FRTS 1 0.01 1.19 0.11
64 INT265888 BCL2 Regulation of Gene_expression of BAD 1 0.04 1.08 0.1
65 INT265890 BCL2 Regulation of Gene_expression of BAX 1 0.04 1.08 0.1
66 INT239643 Binding of BCL2 and BCL2L11 3 0.16 2.26 0.09
67 INT282094 Apoa2 Negative_regulation of BCL2 1 0.06 1.15 0.09
68 INT275183 Bad Positive_regulation of Gene_expression of Bcl2 1 0.08 0.63 0.09
69 INT265887 IGF1 Negative_regulation of BCL2 1 0.09 1.02 0.09
70 INT294637 Bcl2a1a Positive_regulation of Gene_expression of Bcl2 1 0.15 0.97 0.09
71 INT204300 Bcl2 Negative_regulation of Positive_regulation of Bak1 1 0.02 1.13 0.09
72 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
73 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
74 INT350908 Binding of Bcl2 and Twist1 1 0.04 1.9 0.08
75 INT201456 Hmox1 Positive_regulation of Gene_expression of Bcl2 1 0.06 0.74 0.08
76 INT204299 Bcl2 Negative_regulation of Localization of Aifm1 1 0.06 1.22 0.07
77 INT297733 Cbr1 Regulation of Gene_expression of Bcl2 1 0.05 0.94 0.07
78 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
79 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06
80 INT317426 Binding of CSF2 and PML 1 0.08 1.25 0.06
81 INT302177 PTGER2 Positive_regulation of BCL2 1 0.04 2.08 0.06
82 INT352299 Regulation of Binding of BCL2 and VIM 1 0.10 1.07 0.06
83 INT352298 Binding of BCL2 and VIM 1 0.09 1.06 0.06
84 INT341375 Sod2 Regulation of Bcl2 1 0.08 1.96 0.05
85 INT193967 Binding of PSEN1 and Psen1 1 0.41 1.2 0.05
86 INT193970 Binding of PSEN1 and Psen2 1 0.36 2.06 0.05
87 INT190824 Binding of Cl and Bcl2 1 0.02 1.4 0.05
88 INT333252 Positive_regulation of Binding of Bcl2 and Mcl1 1 0.03 0.88 0.04
89 INT268664 Ptger2 Positive_regulation of Bcl2 1 0.02 0.9 0.04
90 INT333245 Binding of Bcl2 and Bcl2l11 1 0.03 0.87 0.04
91 INT268666 Ptger2 Positive_regulation of Gene_expression of Bcl2 1 0.02 0.9 0.04
92 INT350905 Binding of Bcl2 and Pcsk4 1 0.03 0.96 0.04
93 INT333253 Binding of Bcl2 and Mcl1 1 0.02 2.14 0.04
94 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
95 INT250025 Map3k1 Positive_regulation of Regulation of Bcl2 1 0.01 1.1 0.04
96 INT172902 Binding of Bax and Bcl2 5 0.30 3.19 0.03
97 INT192164 Binding of BAK1 and BCL2 3 0.04 2.8 0.03
98 INT192167 Negative_regulation of Binding of BAK1 and BCL2 2 0.05 1.89 0.03
99 INT331477 PSEN2 Regulation of Gene_expression of Psen1 1 0.00 0.15 0.03
100 INT288538 Il2 Positive_regulation of Gene_expression of Bcl2 1 0.04 1.96 0.03
101 INT217148 MIR21 Regulation of BCL2 1 0.32 0.98 0.03
102 INT101159 Gene_expression of Bcl2 Positive_regulation of Gene_expression of CHAT 1 0.31 0.96 0.03
103 INT256707 Eif2ak3 Regulation of Gene_expression of Wfs1 1 0.10 0.78 0.03
104 INT229204 Olr1254 Negative_regulation of Gene_expression of Bcl2 1 0.02 0.18 0.03
105 INT331478 Psen1 Regulation of Gene_expression of PSEN2 1 0.00 0.15 0.03
106 INT333259 Bcl2 Regulation of Bax 1 0.03 0.32 0.03
107 INT172894 Negative_regulation of Lox Negative_regulation of Gene_expression of Bcl2 1 0.03 1.12 0.03
108 INT220445 Bcl2 Negative_regulation of Positive_regulation of Casp9 1 0.01 1.37 0.03
109 INT333262 Bcl2 Regulation of Bak1 1 0.04 0.31 0.03
110 INT282995 Binding of Bcl2 and Becn1 21 0.03 9.8 0
111 INT283013 Binding of Bak1 and Bcl2 4 0.06 1.03 0
112 INT178861 Binding of BAX and BCL2 3 0.27 3.07 0
113 INT292454 Binding of BAD and BCL2 2 0.03 1.73 0
114 INT144032 STAT3 Regulation of BCL2 2 0.07 0.86 0
115 INT217150 MIR16-2 Regulation of BCL2 2 0.09 1.89 0
116 INT217137 MIR15B Regulation of BCL2 2 0.15 1.88 0
117 INT295047 Binding of Bcl2 and Nr4a1 1 0.04 0.96 0
118 INT254089 EPO Regulation of Gene_expression of Bcl2 1 0.03 0.63 0
119 INT285031 Binding of Bcl2 and Bcl2l1 1 0.27 0.1 0
120 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0
121 INT321406 VEGFA Regulation of BCL2 1 0.01 0.75 0
122 INT256703 Negative_regulation of Hsp90b1 Positive_regulation of Wfs1 1 0.42 0.24 0
123 INT295046 Bcl2 Regulation of Gene_expression of Nr4a1 1 0.02 0.92 0
124 INT292503 Mlph Regulation of Gene_expression of BCL2 1 0.00 0.4 0
125 INT253474 Positive_regulation of Prkaca Positive_regulation of Gene_expression of Bcl2 1 0.04 1.27 0
126 INT193962 Binding of Psen1 and Ncstn 1 0.13 0.08 0
127 INT191058 Binding of Bcl2 and Positive_regulation of Gene_expression of Bax 1 0.21 0.49 0
128 INT334644 Binding of PSEN1 and TTN 1 0.01 0 0
129 INT333688 Trp53 Positive_regulation of Bcl2 1 0.45 2.51 0
130 INT256700 Negative_regulation of Binding of Hsp90b1 and Wfs1 1 0.52 0 0
131 INT348531 Binding of BCL2 and BECN1 1 0.06 0.43 0
132 INT221240 Akt1 Positive_regulation of Phosphorylation of Bcl2 1 0.00 0.89 0
133 INT191062 Esr1 Regulation of Gene_expression of Bcl2 1 0.12 0.73 0
134 INT267255 Bcl2 Positive_regulation of Gene_expression of Ptprj 1 0.04 0.63 0
135 INT191061 Akt1 Positive_regulation of Bcl2 1 0.41 0.33 0
136 INT283003 Igkv1-131 Regulation of Binding of Bcl2 1 0.06 0 0
137 INT280566 Binding of ARAF and BCL2 1 0.02 0.69 0
138 INT283009 Binding of Bcl2 and Pdss2 1 0.03 0.56 0
139 INT100424 Bcl2 Regulation of Pcbd1 1 0.14 0.06 0
140 INT202507 Nfasc Positive_regulation of Gene_expression of Bcl2 1 0.10 0.7 0
141 INT283000 Negative_regulation of Binding of Bcl2 and Becn1 1 0.03 0.71 0
142 INT315060 PAR4 Regulation of BCL2 1 0.53 0.48 0
143 INT327972 Negative_regulation of BCL2 Positive_regulation of BAX 1 0.22 0.82 0
144 INT285028 Binding of Bcl2 and Bax 1 0.32 0.1 0
145 INT268516 Gene_expression of MIR16-2 Positive_regulation of Gene_expression of BCL2 1 0.00 1.15 0
146 INT335953 Binding of BCL2 and Bad 1 0.14 0.37 0
147 INT198021 Binding of BCL2 and MCL1 1 0.17 2.88 0
148 INT331231 Binding of Bcl2 and Mapk8 1 0.01 0.77 0
149 INT283011 Binding of Bcl2 and Igkv1-131 1 0.05 0.8 0
150 INT296670 Binding of Bcl2 and Vim 1 0.00 1.31 0
151 INT191065 Binding of Bcl2 and Negative_regulation of Phosphorylation of Akt1 1 0.22 1.02 0
152 INT292458 Negative_regulation of Binding of BAD and BCL2 1 0.01 0.81 0
153 INT327977 TNFRSF11A Regulation of BCL2 1 0.05 0.67 0
154 INT337707 Naf1 Regulation of Gene_expression of Bcl2 1 0.11 0.57 0
155 INT193955 Binding of Psen1 and Psen2 1 0.37 1.64 0
156 INT193948 Binding of Psen1 and Notch1 1 0.02 0 0
157 INT191059 Bcl2 Positive_regulation of Localization of Il12a 1 0.16 0.77 0
158 INT202503 Gtf3a Positive_regulation of Positive_regulation of Bcl2 1 0.02 0.35 0
159 INT286331 Binding of Psen1 and Ror1 1 0.27 0 0
160 INT286030 Creb1 Regulation of Transcription of Bcl2 1 0.07 0.34 0
161 INT327403 Bcl2 Positive_regulation of Localization of Mmp2 1 0.19 0.93 0
162 INT189673 BCL2 Positive_regulation of Transcription of TERT 1 0.09 0 0
163 INT330056 Bcl2 Regulation of Localization of Cyct 1 0.27 0.97 0
164 INT262515 Positive_regulation of Kcnj6 Positive_regulation of Binding of Bcl2 1 0.00 0.48 0
165 INT256705 Binding of Wfs1 and Xbp1 1 0.19 0.39 0
166 INT193968 Binding of PSEN1 and Ps 1 0.07 0.66 0
167 INT201774 Binding of BCL2 and BCL2L1 1 0.00 0.37 0
168 INT292389 Binding of Itpr1 and Mrvi1 1 0.16 0.05 0
169 INT292461 PTK2 Regulation of BCL2 1 0.02 0.76 0
170 INT283010 Regulation of Binding of Bcl2 and Becn1 1 0.03 1.45 0
171 INT262712 Psen1 Regulation of Gene_expression of Bace1 1 0.22 0.07 0
172 INT217400 Binding of Psen1 and Bace1 1 0.17 1.43 0
173 INT286337 PSENEN Regulation of Psen1 1 0.07 0.37 0
174 INT193958 Binding of Pld1 and Psen1 1 0.17 0 0
175 INT217141 Binding of BCL2 and MIR15B 1 0.21 1.26 0
176 INT305541 Binding of Bcl2 and Trp53 1 0.05 0.9 0
177 INT282997 Binding of Bcl2 and Om 1 0.00 0.45 0
178 INT193965 Binding of BCL2 and Ps 1 0.05 0.59 0
179 INT296684 Binding of CD99 and Bcl2 1 0.01 1.68 0
180 INT193953 Binding of Bcl2l1 and Psen1 1 0.07 0.66 0
181 INT256704 Xbp1 Positive_regulation of Positive_regulation of Wfs1 1 0.26 0.4 0
182 INT283014 Becn1 Regulation of Bcl2 1 0.03 0.88 0
183 INT104536 Binding of Bcl2 and MIB1 1 0.00 1.61 0
184 INT229816 Fos Regulation of Bcl2 1 0.13 0.31 0
185 INT193956 Binding of Psen1 and Rab6a 1 0.15 0 0
186 INT190681 Binding of Bcl2 and Fkbp1a 1 0.01 0.46 0
187 INT352150 Ift88 Negative_regulation of Bcl2 1 0.00 0.19 0
188 INT256702 Binding of Wfs1 and Tmed4 1 0.01 0.61 0
189 INT327976 PNLIP Negative_regulation of Gene_expression of BCL2 1 0.29 0.53 0
190 INT217146 Binding of BCL2 and MIR16-2 1 0.12 1.25 0
191 INT331479 Binding of PSEN2 and Psen1 1 0.00 0.07 0
192 INT282998 Binding of Bcl2 and Bbc3 1 0.00 0.43 0
193 INT242479 Negative_regulation of Ciapin1 Negative_regulation of Bcl2 1 0.14 1.28 0
194 INT327974 GOPC Regulation of Gene_expression of BCL2 1 0.13 0.6 0
195 INT201538 Binding of BCL2 and NPC1 1 0.17 1.41 0
196 INT333687 Trp53 Positive_regulation of Localization of Bcl2 1 0.45 1.24 0
197 INT292385 Binding of Itpr1 and Lrmp 1 0.17 0.05 0
198 INT234221 Negative_regulation of PSEN1 Negative_regulation of Gene_expression of APP 1 0.33 0.32 0
199 INT260393 Hmox1 Regulation of Positive_regulation of Bcl2 1 0.22 0.86 0
200 INT254694 Positive_regulation of Map2k2 Regulation of Bcl2 1 0.02 0.89 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for endoplasmic reticulum calcium ion homeostasis. They are ordered first by their pain relevance and then by number of times they were reported in endoplasmic reticulum calcium ion homeostasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
2 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38
3 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73
4 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
5 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
6 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
7 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18
8 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63
9 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68
10 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
11 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37
12 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27
13 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86
14 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71
15 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41
16 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71
17 INT84685 Regulation of BCL2 67 0.60 72.96 6.65
18 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
19 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7
20 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22
21 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07
22 INT101957 Transcription of Bcl2 30 0.69 16.57 4.3
23 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
24 INT105882 Phosphorylation of Bcl2 11 0.59 8.15 3.73
25 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4
26 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
27 INT81642 Regulation of Gene_expression of Bcl2 20 0.44 16.93 3.19
28 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16
29 INT105884 Binding of Bcl2 19 0.35 15.67 3
30 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
31 INT163544 Binding of Psen1 40 0.36 15.28 2.42
32 INT147349 Localization of Bcl2 13 0.65 7.83 2.31
33 INT142677 Negative_regulation of Positive_regulation of Bcl2 4 0.36 3.09 2.24
34 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
35 INT86671 Negative_regulation of Positive_regulation of Bcl2 6 0.57 3.83 2.03
36 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
37 INT101108 Localization of Bcl2 16 0.72 11.68 1.86
38 INT105883 Positive_regulation of Phosphorylation of Bcl2 8 0.32 5.67 1.86
39 INT95544 Negative_regulation of Itpr1 4 0.59 1.6 1.85
40 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
41 INT97062 Binding of PML 10 0.41 11.63 1.65
42 INT101958 Positive_regulation of Transcription of Bcl2 4 0.50 2.22 1.65
43 INT137513 Negative_regulation of Positive_regulation of BCL2 6 0.35 5.3 1.62
44 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
45 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
46 INT101107 Positive_regulation of Localization of Bcl2 3 0.48 3.13 1.28
47 INT74443 Positive_regulation of PML 11 0.53 12.52 1.21
48 INT243729 Localization of Itpr1 2 0.05 0.37 1.16
49 INT234422 Gene_expression of PML 14 0.75 15.93 1.14
50 INT172855 Binding of Bcl2 37 0.32 23.41 1.09
51 INT70021 Localization of BCL2 23 0.74 21.6 1.09
52 INT262550 Negative_regulation of Localization of Itpr1 1 0.03 0.37 1.09
53 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
54 INT151115 Regulation of Regulation of Bcl2 4 0.21 4.12 0.88
55 INT92117 Phosphorylation of BCL2 26 0.80 9.93 0.86
56 INT151532 Regulation of Itpr1 2 0.01 0.63 0.83
57 INT237406 Positive_regulation of Binding of Psen1 1 0.29 0 0.8
58 INT70019 Binding of BCL2 25 0.47 17.55 0.79
59 INT109404 Transcription of BCL2 6 0.69 4.49 0.77
60 INT75712 Gene_expression of Itpr1 3 0.59 1.89 0.77
61 INT286313 Transcription of Psen1 9 0.70 2.26 0.76
62 INT124844 Regulation of Positive_regulation of Bcl2 3 0.43 2.55 0.75
63 INT155392 Negative_regulation of Negative_regulation of Bcl2 3 0.21 1.64 0.74
64 INT262726 Localization of PML 6 0.57 7.13 0.72
65 INT134444 Positive_regulation of Binding of Bcl2 3 0.47 2.67 0.72
66 INT70025 Positive_regulation of Positive_regulation of BCL2 3 0.27 0.96 0.58
67 INT178128 Negative_regulation of Phosphorylation of BCL2 7 0.27 3.94 0.56
68 INT155090 Regulation of Positive_regulation of BCL2 3 0.26 1.78 0.54
69 INT217394 Regulation of Binding of PSEN1 1 0.44 1.58 0.53
70 INT144696 Regulation of Transcription of Bcl2 5 0.44 2.96 0.51
71 INT134445 Positive_regulation of Positive_regulation of Bcl2 3 0.47 2.43 0.49
72 INT221676 Protein_catabolism of Bcl2 4 0.24 2.77 0.48
73 INT204052 Transcription of Bcl2 5 0.51 3.25 0.45
74 INT140295 Protein_catabolism of BCL2 4 0.64 5.7 0.44
75 INT220424 Positive_regulation of Negative_regulation of Bcl2 2 0.14 1.81 0.44
76 INT234249 Regulation of PSEN1 6 0.37 2.21 0.43
77 INT234257 Regulation of Gene_expression of PSEN1 6 0.44 1.98 0.42
78 INT193856 Localization of Psen1 19 0.73 9.79 0.41
79 INT155724 Negative_regulation of Transcription of Bcl2 6 0.53 2.35 0.37
80 INT256681 Regulation of Wfs1 8 0.43 4.72 0.36
81 INT177773 Localization of PSEN1 4 0.73 0.89 0.36
82 INT178114 Positive_regulation of Phosphorylation of BCL2 11 0.49 4.44 0.28
83 INT336951 Positive_regulation of Binding of PML 1 0.09 2.02 0.28
84 INT316045 Negative_regulation of Negative_regulation of Psen1 1 0.42 1.58 0.27
85 INT289317 Positive_regulation of Localization of PML 1 0.23 1.09 0.26
86 INT256682 Gene_expression of Wfs1 1 0.74 6.63 0.25
87 INT261676 Negative_regulation of Positive_regulation of PSEN1 1 0.36 1.59 0.25
88 INT292743 Negative_regulation of Binding of Bcl2 1 0.05 1.97 0.24
89 INT278513 Regulation of Localization of PML 1 0.34 1.73 0.24
90 INT285003 Positive_regulation of Regulation of Bcl2 1 0.46 0.68 0.23
91 INT108563 Negative_regulation of Regulation of Bcl2 1 0.32 0.74 0.22
92 INT181508 Regulation of Regulation of Psen1 2 0.33 0.51 0.2
93 INT220426 Regulation of Negative_regulation of Bcl2 1 0.05 0.81 0.18
94 INT286317 Positive_regulation of Transcription of Psen1 1 0.37 0.32 0.17
95 INT256696 Positive_regulation of Wfs1 1 0.66 9.14 0.17
96 INT238507 Regulation of Regulation of BCL2 3 0.44 5.14 0.16
97 INT101109 Negative_regulation of Localization of Bcl2 1 0.03 0.62 0.16
98 INT256684 Positive_regulation of Gene_expression of Wfs1 1 0.66 3.62 0.16
99 INT229235 Regulation of Localization of BCL2 2 0.29 3.7 0.15
100 INT102109 Protein_catabolism of Bcl2 1 0.65 0.55 0.15
101 INT110957 Positive_regulation of Positive_regulation of Bcl2 3 0.35 2.3 0.13
102 INT336359 Positive_regulation of Phosphorylation of Psen1 1 0.33 0.4 0.13
103 INT336361 Phosphorylation of Psen1 1 0.54 0.34 0.13
104 INT179038 Positive_regulation of Regulation of Bcl2 1 0.39 3.49 0.12
105 INT124453 Binding of Itpr1 1 0.33 0 0.11
106 INT201694 Negative_regulation of Gene_expression of PSEN1 3 0.41 2.31 0.1
107 INT349072 Positive_regulation of Gene_expression of PML 1 0.13 1.49 0.1
108 INT282824 Regulation of PML 3 0.44 2.66 0.09
109 INT273285 Negative_regulation of Localization of Psen1 1 0.36 0.99 0.09
110 INT256675 Regulation of Gene_expression of Wfs1 1 0.43 2.33 0.09
111 INT256687 Positive_regulation of Transcription of Wfs1 1 0.44 1.95 0.09
112 INT193862 Positive_regulation of Positive_regulation of Psen1 3 0.49 0.9 0.08
113 INT193872 Positive_regulation of Localization of Psen1 3 0.49 1.39 0.08
114 INT256693 Transcription of Wfs1 1 0.68 2.44 0.08
115 INT261678 Positive_regulation of Positive_regulation of PSEN1 1 0.42 0.62 0.08
116 INT193890 Regulation of Positive_regulation of Psen1 1 0.44 0.66 0.08
117 INT193938 Phosphorylation of PSEN1 5 0.79 1.6 0.07
118 INT193859 Negative_regulation of Binding of Psen1 3 0.42 1.85 0.05
119 INT331406 Negative_regulation of Regulation of Psen1 1 0.04 0.09 0.05
120 INT193865 Protein_catabolism of Psen1 10 0.97 0.37 0.04
121 INT302229 Negative_regulation of Negative_regulation of BCL2 3 0.21 2.69 0.04
122 INT356186 Positive_regulation of Regulation of PML 1 0.49 1.14 0.04
123 INT258045 Positive_regulation of Regulation of BCL2 2 0.36 1.78 0.03
124 INT221673 Negative_regulation of Protein_catabolism of Bcl2 1 0.11 0.15 0.03
125 INT123521 Phosphorylation of Bcl2 8 0.81 5 0
126 INT310419 Negative_regulation of Localization of BCL2 3 0.41 2.51 0
127 INT185909 Regulation of Phosphorylation of BCL2 3 0.24 1.63 0
128 INT155391 Positive_regulation of Negative_regulation of Bcl2 2 0.22 0.92 0
129 INT185887 Regulation of Binding of BCL2 2 0.24 2.22 0
130 INT183619 Negative_regulation of Regulation of BCL2 2 0.33 1.01 0
131 INT191056 Negative_regulation of Binding of Bcl2 2 0.37 0.48 0
132 INT153083 Positive_regulation of Negative_regulation of BCL2 2 0.32 2.9 0
133 INT286327 Regulation of Binding of Psen1 1 0.33 0.16 0
134 INT256676 Regulation of Binding of Wfs1 1 0.43 0.35 0
135 INT234250 Positive_regulation of Negative_regulation of PSEN1 1 0.41 0 0
136 INT193886 Regulation of Protein_catabolism of Psen1 1 0.44 0.06 0
137 INT256692 Negative_regulation of Wfs1 1 0.41 0 0
138 INT256671 Regulation of Positive_regulation of Wfs1 1 0.59 1.77 0
139 INT193934 Positive_regulation of Binding of PSEN1 1 0.49 0.92 0
140 INT331407 Negative_regulation of Transcription of Psen1 1 0.04 0.08 0
141 INT256686 Binding of Wfs1 1 0.46 0.91 0
142 INT204053 Negative_regulation of Transcription of Bcl2 1 0.04 0.86 0
143 INT330962 Negative_regulation of Transcription of BCL2 1 0.10 1.21 0
144 INT177774 Transcription of PSEN1 1 0.33 0.09 0
145 INT330665 Negative_regulation of PML 1 0.13 1.15 0
146 INT256677 Regulation of Transcription of Wfs1 1 0.59 0.5 0
147 INT282976 Positive_regulation of Binding of Bcl2 1 0.29 0.76 0
148 INT191048 Positive_regulation of Phosphorylation of Bcl2 1 0.69 0.44 0
149 INT341935 Regulation of Phosphorylation of Bcl2 1 0.04 0 0
150 INT193844 Positive_regulation of Protein_catabolism of Psen1 1 0.49 0.05 0
151 INT282971 Positive_regulation of Localization of Bcl2 1 0.29 0 0
152 INT356124 Positive_regulation of Transcription of BCL2 1 0.45 0.3 0
153 INT234258 Negative_regulation of Phosphorylation of PSEN1 1 0.35 0.49 0
154 INT191049 Regulation of Binding of Bcl2 1 0.39 0.52 0
155 INT256672 Positive_regulation of Positive_regulation of Wfs1 1 0.44 0.24 0
156 INT184508 Positive_regulation of Localization of BCL2 1 0.07 0.87 0
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