GO:0032516

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Name positive regulation of phosphoprotein phosphatase activity
Categary Process
Go Slim No
Go Link GO:0032516
Unique Molecular Interactions 114
Total Molecular Interactions 136
Total Single Events 839
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of phosphoprotein phosphatase activity. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of phosphoprotein phosphatase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
2 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
3 INT41862 Agtr2 Regulation of Cpe 1 0.00 0 0.84
4 INT41859 Agtr2 Regulation of Cck 1 0.00 0 0.84
5 INT41860 Agtr2 Regulation of Vip 1 0.02 0 0.84
6 INT101439 Cck Positive_regulation of Agtr2 1 0.24 0.33 0.8
7 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
8 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
9 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
10 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
11 INT232622 Magi2 Regulation of Cysltr1 1 0.01 0.58 0.67
12 INT9824 Binding of Agtr2 and Bcl2a1a 1 0.16 0.24 0.64
13 INT50883 Binding of AGTR2 and ALB 1 0.37 0.19 0.56
14 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
15 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
16 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
17 INT134045 Jak2 Regulation of Stat3 1 0.26 0.13 0.47
18 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
19 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
20 INT134050 Positive_regulation of Jak2 Regulation of Stat3 1 0.44 0.13 0.47
21 INT182489 Gene_expression of AGTR2 Positive_regulation of Gene_expression of AGTR1 1 0.26 0.92 0.4
22 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39
23 INT328828 Binding of Jak2 and Jak1 1 0.24 0 0.38
24 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
25 INT328820 Binding of Il6 and Jak2 1 0.09 0 0.38
26 INT184084 Jak2 Positive_regulation of Stat1 1 0.33 0.3 0.33
27 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
28 INT230752 Gene_expression of Agtr2 Positive_regulation of Gene_expression of Mcpt1 1 0.01 1.34 0.3
29 INT200640 Agtr2 Positive_regulation of Gene_expression of TGFB1 1 0.03 1.35 0.29
30 INT202313 Gene_expression of PDGFB Positive_regulation of Positive_regulation of Pdgfrb 1 0.14 1 0.29
31 INT118545 Binding of Agtr2 and Msr1 1 0.00 0.09 0.29
32 INT202314 Gene_expression of PDGFB Positive_regulation of Phosphorylation of Pdgfrb 1 0.14 1 0.29
33 INT182499 Binding of AGTR1 and AGTR2 3 0.20 2.79 0.28
34 INT114066 Agtr2 Regulation of Gene_expression of Cpox 1 0.08 0.62 0.27
35 INT131357 Agtr2 Regulation of Ren 1 0.04 0.88 0.27
36 INT114069 Negative_regulation of Agtr2 Positive_regulation of Ptgs2 1 0.08 0.49 0.26
37 INT297258 Binding of Agt and Agtr2 1 0.23 0.7 0.25
38 INT230748 Agtr2 Positive_regulation of Gene_expression of Ros1 2 0.05 1.04 0.23
39 INT230751 Agtr2 Positive_regulation of Gene_expression of Serpine1 1 0.03 1.3 0.23
40 INT155158 Agtr2 Regulation of Rtn4 1 0.00 0.1 0.22
41 INT297257 Agtr1a Positive_regulation of Agtr2 1 0.27 0.59 0.22
42 INT281351 Tenc1 Regulation of Agtr2 1 0.06 0.8 0.21
43 INT240536 Il12a Positive_regulation of Jak2 1 0.10 0.74 0.21
44 INT304882 Agtr2 Positive_regulation of Mapk1 1 0.07 0.95 0.2
45 INT85334 Agtr2 Regulation of Regulation of Tgfb1 1 0.23 0.68 0.17
46 INT320883 Agtr2 Positive_regulation of Localization of VEGFA 1 0.08 2.8 0.17
47 INT138305 Binding of PNN and Agtr2 1 0.01 0.73 0.15
48 INT144027 Binding of Slc6a4 and Pdgfrb 1 0.23 0.25 0.14
49 INT256020 Ace Negative_regulation of Gene_expression of Agtr2 1 0.03 0.37 0.13
50 INT192330 UBR7 Negative_regulation of Positive_regulation of PDGFRB 1 0.01 0.54 0.12
51 INT304188 Agtr2 Negative_regulation of Gene_expression of VEGFA 1 0.06 0.6 0.12
52 INT329325 ACE Regulation of Negative_regulation of Agtr2 1 0.01 0.93 0.12
53 INT119158 Binding of NOS1 and Agtr2 1 0.01 0 0.11
54 INT119157 Agt Positive_regulation of Positive_regulation of Agtr2 1 0.06 0 0.11
55 INT188358 Binding of Csf2 and Positive_regulation of Jak2 1 0.34 0.19 0.11
56 INT169340 Binding of UGT8 and Jak2 1 0.36 0.15 0.11
57 INT281905 Binding of AGTR2 and NOS3 1 0.08 0.37 0.1
58 INT281912 Binding of AGTR2 and ANG 1 0.13 0.37 0.1
59 INT304887 Agtr2 Positive_regulation of Positive_regulation of Mapk1 1 0.10 0.45 0.09
60 INT304886 Agtr2 Positive_regulation of Ros1 1 0.03 0.45 0.09
61 INT304883 Agtr2 Positive_regulation of Agtrap 1 0.10 0.46 0.09
62 INT233907 Positive_regulation of Binding of AGTR2 and NLRP3 1 0.01 1.09 0.08
63 INT325489 Agtr2 Positive_regulation of Ephx2 1 0.04 0.51 0.08
64 INT233906 Binding of AGTR2 and NLRP3 1 0.01 1.09 0.08
65 INT244639 AGK Negative_regulation of PDGFRB 1 0.01 0.69 0.08
66 INT320880 Chi3l1 Positive_regulation of Agtr2 1 0.01 1.22 0.08
67 INT298006 CHDM Positive_regulation of Gene_expression of PDGFRB 1 0.16 1.08 0.07
68 INT192329 UBR7 Negative_regulation of Phosphorylation of PDGFRB 1 0.01 0.06 0.07
69 INT242480 Ciapin1 Positive_regulation of Gene_expression of Jak2 1 0.27 1.05 0.07
70 INT200634 Binding of Agtr2 and Ace2 1 0.00 0.91 0.06
71 INT200807 Jak2 Positive_regulation of Mvd 1 0.18 3.46 0.06
72 INT279291 PDGFA Positive_regulation of PDGFRB 1 0.16 1.02 0.06
73 INT200638 Binding of ACE and Agtr2 1 0.10 0.93 0.06
74 INT289769 Positive_regulation of Agtr2 Negative_regulation of Gene_expression of Col7a1 1 0.00 0.1 0.05
75 INT279287 PDGFRB Regulation of CDCP1 1 0.01 0.98 0.05
76 INT252801 PPP2R4 Regulation of Positive_regulation of CREB1 1 0.01 2.71 0.04
77 INT202310 Binding of PDGFB and Pdgfrb 1 0.11 0.39 0.04
78 INT292092 Binding of PDGFRB and TXK 1 0.05 1.53 0.04
79 INT223086 Binding of Pdgfb and Pdgfrb 1 0.33 0.46 0.04
80 INT252780 Positive_regulation of CREB1 Positive_regulation of PPP2R4 1 0.01 2.71 0.04
81 INT320882 Agtr2 Positive_regulation of Gene_expression of VEGFA 1 0.08 0.9 0.04
82 INT252818 PPP2R4 Regulation of Positive_regulation of DDIT3 1 0.04 3.07 0.04
83 INT292079 Negative_regulation of Binding of PDGFRB and TXK 1 0.06 1.54 0.04
84 INT200821 Binding of Jak2 and Mvd 1 0.14 0.68 0.04
85 INT200813 Jak2 Positive_regulation of Akt1 1 0.26 1.46 0.03
86 INT253578 Csnk2a2 Negative_regulation of Jak2 1 0.09 0 0.03
87 INT253573 Binding of Jak2 and Pik3r1 1 0.06 0 0.03
88 INT200816 Jak2 Positive_regulation of Binding of Mvd 1 0.19 1.51 0.03
89 INT200810 Jak2 Positive_regulation of Src 1 0.29 1.46 0.03
90 INT249597 Jak2 Positive_regulation of Phosphorylation of Stat1 1 0.20 0.13 0.03
91 INT253575 Binding of Jak2 and Pik3r2 1 0.00 0 0.03
92 INT302908 Agtr2 Positive_regulation of Gene_expression of Agt 1 0.00 0.22 0.03
93 INT200815 Binding of Epo and Jak2 1 0.36 0.98 0.03
94 INT279277 PDGFB Positive_regulation of PDGFRB 1 0.14 0.52 0.03
95 INT200822 Akt1 Regulation of Jak2 1 0.25 1.48 0.03
96 INT241030 Agtr2 Positive_regulation of Phosphorylation of Mapk1 1 0.06 0.19 0
97 INT340502 Agtr1a Negative_regulation of Phosphorylation of Jak2 1 0.12 2.32 0
98 INT253366 Il6 Positive_regulation of Phosphorylation of Jak2 1 0.31 0.2 0
99 INT344401 Agtr2 Positive_regulation of Gene_expression of Spp1 1 0.01 3.21 0
100 INT200819 Epo Positive_regulation of Gene_expression of Jak2 1 0.49 0.91 0
101 INT320877 Agtr2 Positive_regulation of Pla2g2a 1 0.10 0.67 0
102 INT149883 Agtr2 Positive_regulation of Gene_expression of Ptgs2 1 0.06 0.31 0
103 INT293357 RORC Regulation of PPP2R4 1 0.00 0 0
104 INT292091 MIR1200 Negative_regulation of PDGFRB 1 0.01 1.24 0
105 INT320878 Positive_regulation of Agtr2 Positive_regulation of Pla2g2a 1 0.10 0.67 0
106 INT279283 TXK Regulation of PDGFRB 1 0.06 0.68 0
107 INT229362 Negative_regulation of Agtr1a Positive_regulation of Positive_regulation of Agtr2 1 0.05 1 0
108 INT241535 Abl1 Regulation of Positive_regulation of Jak2 1 0.10 0.53 0
109 INT241027 Positive_regulation of Agtr2 Positive_regulation of Protein_catabolism of Sypl 1 0.00 0.85 0
110 INT295426 Binding of KIT and PDGFRB 1 0.24 0.4 0
111 INT277703 Binding of Pdgfrb and Pdgfb 1 0.02 0.23 0
112 INT205612 Gm6668 Negative_regulation of Pdgfrb 1 0.00 1.57 0
113 INT284184 Binding of Akt1 and Pdgfrb 1 0.00 0.14 0
114 INT213584 Binding of AGTR2 and ACE 1 0.17 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of phosphoprotein phosphatase activity. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of phosphoprotein phosphatase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT13499 Gene_expression of Agtr2 68 0.76 35.64 10.59
2 INT29583 Positive_regulation of Agtr2 30 0.45 21.47 7.04
3 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
4 INT127914 Gene_expression of AGTR2 23 0.68 26.87 4.69
5 INT78995 Negative_regulation of Agtr2 26 0.42 13.05 4.56
6 INT17818 Gene_expression of Agtr2 24 0.56 12.96 4.41
7 INT68099 Positive_regulation of Agtr2 21 0.48 16.63 4.07
8 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
9 INT9822 Binding of Agtr2 9 0.36 3 3.93
10 INT17819 Regulation of Agtr2 10 0.51 9.33 3.9
11 INT39986 Regulation of Agtr2 13 0.45 10.39 3.55
12 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09
13 INT31925 Negative_regulation of Agtr2 13 0.43 7.59 2.94
14 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
15 INT137908 Phosphorylation of Pdgfrb 14 0.81 8.44 2.45
16 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
17 INT163545 Gene_expression of PDGFRB 39 0.78 25.5 2.2
18 INT49731 Transcription of Agtr2 4 0.44 0.95 2.06
19 INT53036 Binding of Agtr2 9 0.33 3.74 1.99
20 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
21 INT137906 Positive_regulation of Phosphorylation of Pdgfrb 6 0.50 2.55 1.94
22 INT144020 Positive_regulation of Pdgfrb 30 0.69 24.8 1.92
23 INT112668 Positive_regulation of Gene_expression of Agtr2 7 0.50 3.8 1.58
24 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
25 INT68100 Positive_regulation of Positive_regulation of Agtr2 2 0.08 0.83 1.51
26 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37
27 INT44147 Positive_regulation of Gene_expression of Agtr2 11 0.50 9.02 1.28
28 INT114822 Negative_regulation of PPP2R4 2 0.57 1.89 1.28
29 INT144019 Negative_regulation of Pdgfrb 21 0.58 14.93 1.26
30 INT61100 Localization of Agtr2 7 0.51 2.53 1.13
31 INT142777 Phosphorylation of PPP2R4 2 0.61 1.03 1.07
32 INT142776 Positive_regulation of Phosphorylation of PPP2R4 1 0.45 1.04 1.07
33 INT205912 Negative_regulation of Gene_expression of Jak2 8 0.42 5.1 1.04
34 INT169336 Binding of Jak2 2 0.42 1.31 0.93
35 INT134040 Regulation of Jak2 3 0.41 1.07 0.92
36 INT182513 Regulation of AGTR2 4 0.14 4.31 0.91
37 INT184027 Phosphorylation of Jak2 6 0.82 2.58 0.87
38 INT134037 Positive_regulation of Phosphorylation of Jak2 1 0.46 0.25 0.86
39 INT237408 Positive_regulation of Positive_regulation of Jak2 1 0.28 1.56 0.79
40 INT137080 Positive_regulation of Positive_regulation of Agtr2 3 0.26 2.34 0.74
41 INT164756 Negative_regulation of PDGFRB 32 0.57 21.69 0.72
42 INT137081 Positive_regulation of Regulation of Agtr2 1 0.24 0.54 0.72
43 INT103886 Negative_regulation of Negative_regulation of Agtr2 5 0.31 2.16 0.71
44 INT85023 Negative_regulation of Gene_expression of Agtr2 4 0.57 2.97 0.71
45 INT141062 Negative_regulation of Gene_expression of Agtr2 2 0.18 1.61 0.7
46 INT171364 Localization of Pdgfrb 6 0.37 4.98 0.68
47 INT91172 Positive_regulation of Gene_expression of Pdgfrb 4 0.38 2.83 0.68
48 INT171380 Positive_regulation of Localization of Pdgfrb 1 0.21 0.48 0.66
49 INT112666 Positive_regulation of Transcription of Agtr2 1 0.32 0.74 0.65
50 INT144024 Negative_regulation of Phosphorylation of Pdgfrb 6 0.42 3.48 0.51
51 INT233916 Positive_regulation of AGTR2 5 0.37 3.67 0.51
52 INT73200 Positive_regulation of PDGFRB 10 0.67 9.67 0.48
53 INT184062 Binding of Jak2 5 0.37 3.13 0.47
54 INT182508 Positive_regulation of Gene_expression of AGTR2 1 0.26 3.13 0.46
55 INT192342 Phosphorylation of PDGFRB 11 0.80 1.68 0.43
56 INT205890 Transcription of Jak2 1 0.41 0.22 0.43
57 INT145854 Gene_expression of Jak2 4 0.67 3.08 0.41
58 INT107462 Localization of Jak2 2 0.60 0.78 0.4
59 INT229697 Negative_regulation of Phosphorylation of Jak2 1 0.15 0.54 0.39
60 INT192344 Negative_regulation of Phosphorylation of PDGFRB 4 0.54 1.26 0.38
61 INT182510 Negative_regulation of Gene_expression of AGTR2 1 0.23 0.78 0.37
62 INT200786 Positive_regulation of Gene_expression of Jak2 9 0.69 6.03 0.35
63 INT205910 Negative_regulation of Positive_regulation of Jak2 1 0.33 0.26 0.35
64 INT126578 Regulation of Gene_expression of Agtr2 2 0.49 1.08 0.34
65 INT356392 Negative_regulation of Positive_regulation of Agtr2 1 0.07 1.01 0.32
66 INT192348 Positive_regulation of Gene_expression of PDGFRB 5 0.64 3.57 0.3
67 INT182515 Binding of AGTR2 3 0.32 2.4 0.29
68 INT182509 Regulation of Gene_expression of AGTR2 1 0.24 1.72 0.29
69 INT144021 Binding of Pdgfrb 9 0.37 5.53 0.28
70 INT136741 Protein_catabolism of Agtr2 1 0.07 0 0.26
71 INT223078 Negative_regulation of Gene_expression of Pdgfrb 4 0.35 3.64 0.25
72 INT279296 Localization of PDGFRB 4 0.54 2.71 0.24
73 INT209345 Negative_regulation of AGTR2 5 0.17 4.83 0.2
74 INT31926 Negative_regulation of Negative_regulation of Agtr2 1 0.00 0.19 0.2
75 INT17822 Regulation of Gene_expression of Agtr2 1 0.05 0.1 0.18
76 INT268208 Transcription of Agtr2 1 0.05 3.15 0.17
77 INT328811 Negative_regulation of Localization of Jak2 1 0.34 0.13 0.17
78 INT200802 Regulation of Jak2 5 0.61 2.86 0.16
79 INT326469 Positive_regulation of Negative_regulation of AGTR2 1 0.09 2.96 0.16
80 INT236359 Negative_regulation of Positive_regulation of Agtr2 2 0.07 1.61 0.15
81 INT192339 Positive_regulation of Positive_regulation of PDGFRB 2 0.46 1.02 0.14
82 INT78375 Localization of PPP2R4 1 0.73 0.43 0.14
83 INT241008 Phosphorylation of Agtr2 1 0.09 0.13 0.14
84 INT144023 Negative_regulation of Positive_regulation of Pdgfrb 2 0.42 1.43 0.13
85 INT278143 Positive_regulation of Negative_regulation of Jak2 1 0.16 0.54 0.11
86 INT356371 Localization of Agtr2 1 0.04 0.74 0.11
87 INT143360 Regulation of Negative_regulation of Agtr2 1 0.27 0.56 0.1
88 INT200792 Regulation of Gene_expression of Jak2 5 0.61 5.69 0.09
89 INT192341 Negative_regulation of Gene_expression of PDGFRB 3 0.40 0.85 0.08
90 INT223082 Regulation of Pdgfrb 3 0.25 2.14 0.08
91 INT184018 Negative_regulation of Protein_catabolism of Jak2 1 0.36 1.76 0.08
92 INT184023 Protein_catabolism of Jak2 1 0.61 1.75 0.08
93 INT192338 Positive_regulation of Phosphorylation of PDGFRB 4 0.45 0.48 0.07
94 INT277162 Positive_regulation of Binding of Pdgfrb 1 0.06 1.1 0.07
95 INT288913 Regulation of Positive_regulation of AGTR2 1 0.28 0.43 0.06
96 INT223616 Binding of PDGFRB 3 0.32 2.33 0.05
97 INT192340 Regulation of PDGFRB 4 0.45 3.83 0.03
98 INT202302 Regulation of Gene_expression of Pdgfrb 1 0.22 1.03 0.03
99 INT279297 Positive_regulation of Localization of PDGFRB 1 0.36 0.5 0.03
100 INT336195 Negative_regulation of Negative_regulation of PDGFRB 1 0.03 0.19 0
101 INT338265 Positive_regulation of Binding of PDGFRB 1 0.25 1.38 0
102 INT240985 Positive_regulation of Binding of Agtr2 1 0.07 0.83 0
103 INT328279 Positive_regulation of Regulation of PDGFRB 1 0.37 0.74 0
104 INT103887 Positive_regulation of Negative_regulation of Agtr2 1 0.08 0.1 0
105 INT200104 Regulation of Gene_expression of PDGFRB 1 0.18 0.29 0
106 INT293342 Regulation of PPP2R4 1 0.03 0 0
107 INT292121 Regulation of Regulation of PDGFRB 1 0.22 0.93 0
108 INT202420 Transcription of Jak2 1 0.56 0.91 0
109 INT240996 Protein_catabolism of Agtr2 1 0.12 0.18 0
110 INT240990 Positive_regulation of Protein_catabolism of Agtr2 1 0.07 0.18 0
111 INT292128 Positive_regulation of Negative_regulation of PDGFRB 1 0.25 1.08 0
112 INT277697 Positive_regulation of Positive_regulation of Pdgfrb 1 0.06 0.49 0
113 INT241016 Negative_regulation of Protein_catabolism of Agtr2 1 0.06 0.18 0
114 INT277698 Transcription of Pdgfrb 1 0.09 2.67 0
115 INT328277 Negative_regulation of Positive_regulation of PDGFRB 1 0.36 1.64 0
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