GO:0032675

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Name regulation of interleukin-6 production
Categary Process
Go Slim No
Go Link GO:0032675
Unique Molecular Interactions 76
Total Molecular Interactions 119
Total Single Events 1133
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of interleukin-6 production. They are ordered first by their pain relevance and then by number of times they were reported for regulation of interleukin-6 production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT174503 Binding of HLA-B and KIR3DL1 6 0.37 3.48 1.61
2 INT107965 Binding of HLA-B and Mefv 2 0.34 3.91 1.61
3 INT174508 Binding of CD4 and HLA-B 1 0.14 4.68 1.53
4 INT55837 Binding of HLA-B and PHB2 3 0.20 3.52 1.37
5 INT230019 Binding of HLA-B and ERAL1 1 0.00 2.23 1.1
6 INT143323 Binding of HLA-B and HP 1 0.04 0.95 0.93
7 INT80132 Binding of HLA-B and TNF 1 0.04 1.15 0.89
8 INT166983 Binding of HLA-B and HSPG2 4 0.08 4.66 0.88
9 INT250959 Binding of HLA-B and SOD1 1 0.05 0.75 0.75
10 INT28711 Binding of HLA-B and MRAP 2 0.23 0.96 0.69
11 INT174500 Positive_regulation of Binding of CD4 and HLA-B 1 0.21 2.33 0.63
12 INT219277 Mapkapk2 Positive_regulation of Pla2g1b 1 0.03 0.46 0.61
13 INT219278 Mapkapk2 Positive_regulation of Pla2g2a 1 0.05 0.46 0.61
14 INT122096 Binding of HLA-B and SFTPA1 2 0.04 1.81 0.6
15 INT174504 Binding of HLA-B and KIR3DL2 2 0.24 1.69 0.59
16 INT87683 Binding of HLA-B and Prnd 1 0.00 0.59 0.59
17 INT341594 Binding of ESR1 and HLA-B 1 0.01 0.72 0.57
18 INT36143 Binding of SERPINH1 and HLA-B 1 0.00 0.66 0.49
19 INT348173 Binding of HLA-B and IL23R 1 0.15 0.92 0.49
20 INT348177 Binding of HLA-B and ERAP1 1 0.14 0.92 0.49
21 INT328936 Binding of HLA-B and KIR3DS1 1 0.25 0.7 0.48
22 INT340440 Binding of HLA-B and BTG3 1 0.05 1.57 0.47
23 INT48848 Binding of HLA-B and HLA-E 3 0.34 1.95 0.45
24 INT45035 Binding of HLA-B and HLA-DRB4 2 0.16 0.74 0.44
25 INT79151 Binding of HLA-B and OLAH 1 0.01 0.79 0.44
26 INT174507 Binding of HLA-B and LILRB4 1 0.02 1.16 0.43
27 INT79150 HLA-B Positive_regulation of OLAH 1 0.02 0.77 0.43
28 INT174501 Binding of HLA-B and HLA-DOA 2 0.03 1.84 0.42
29 INT349290 Binding of HLA-B and SPATA19 1 0.00 1.25 0.4
30 INT127587 Binding of HLA-B and CD300A 1 0.00 0.84 0.38
31 INT250956 Positive_regulation of Binding of HLA-B and SOD1 1 0.07 0.38 0.38
32 INT118285 Binding of EFNA1 and HLA-B 1 0.03 0.29 0.37
33 INT227760 Binding of HLA-A and HLA-B 1 0.20 3.35 0.3
34 INT160923 Binding of ACLS and HLA-B 1 0.03 1.44 0.29
35 INT45048 Binding of HLA-B and TNFRSF10B 1 0.21 0.44 0.29
36 INT181843 PHB2 Regulation of HLA-B 1 0.03 1.4 0.28
37 INT174506 Binding of HLA-B and HLA-G 1 0.01 0.41 0.26
38 INT353808 HLA-DMA Regulation of HLA-B 1 0.00 1.72 0.19
39 INT66279 Binding of FLNB and HLA-B 1 0.41 0.57 0.19
40 INT313799 Binding of HLA-B and TYRP1 1 0.01 0.54 0.18
41 INT194696 TTPA Positive_regulation of Phosphorylation of MAPKAPK2 1 0.01 0.08 0.17
42 INT194737 Binding of TTPA and MAPKAPK2 1 0.01 0.08 0.17
43 INT19645 Binding of HLA-B and KLRD1 1 0.00 0.73 0.15
44 INT258906 Binding of HLA-B and HLA-DRB1 1 0.31 1.36 0.15
45 INT327326 Binding of Mapkapk2 and Ttpa 1 0.02 0.34 0.14
46 INT68736 Binding of HLA-B and Tyr 1 0.01 0.23 0.14
47 INT98565 HLA-B Positive_regulation of Cd8a 1 0.03 0.63 0.14
48 INT327322 Mapkapk2 Regulation of Il6 1 0.02 0.26 0.13
49 INT142845 Binding of HLA-B and SAT1 1 0.35 0.61 0.12
50 INT181844 Binding of CD8A and HLA-B 1 0.14 1.82 0.12
51 INT2993 Binding of HLA-B and SUGT1 1 0.00 0.6 0.1
52 INT92671 Binding of CEL and HLA-B 1 0.38 0.19 0.1
53 INT194671 MAPKAPK2 Positive_regulation of CREB1 1 0.06 0.05 0.1
54 INT194689 MAPKAPK2 Positive_regulation of TFAM 1 0.00 0.05 0.1
55 INT88238 HLA-B Regulation of Gene_expression of Gbp1 1 0.03 0.27 0.1
56 INT132266 Binding of HLA-B and B2m 1 0.02 0.14 0.09
57 INT125089 Binding of HLA-B and TDGF1 1 0.24 0.18 0.09
58 INT147774 Binding of HLA-B and ABCB6 2 0.40 1.03 0.08
59 INT75234 Binding of HLA-B and BW6 1 0.39 0.06 0.06
60 INT97430 Binding of B2M and HLA-B 1 0.00 0.66 0.04
61 INT92381 Binding of HLA-B and Tap1 1 0.01 0 0
62 INT300244 Binding of HLA-B and HSR 1 0.08 0.95 0
63 INT215470 Binding of HLA-B and CRAMP1L 1 0.05 0.94 0
64 INT110162 Binding of HLA-B and HLA-DQB1 1 0.09 0 0
65 INT303336 MAPKAPK2 Positive_regulation of Hspb2 1 0.04 0.24 0
66 INT250954 Binding of HLA-B and USO1 1 0.06 0.18 0
67 INT90819 Binding of HLA-B and MICA 1 0.05 0 0
68 INT202398 Mapk14 Regulation of Phosphorylation of Mapkapk2 1 0.44 0.1 0
69 INT74066 Binding of DR1 and HLA-B 1 0.00 0.08 0
70 INT250955 Binding of HLA-B and SETDB1 1 0.01 0.08 0
71 INT150180 KIT Negative_regulation of Gene_expression of HLA-B 1 0.39 0.09 0
72 INT201082 Binding of APOE and HLA-B 1 0.54 1.54 0
73 INT313800 Binding of HLA-B and TYR 1 0.04 0.1 0
74 INT285399 Binding of DEFB1 and HLA-B 1 0.01 1.33 0
75 INT201079 Binding of HLA-B and HLA-C 1 0.40 1.36 0
76 INT174502 HLA-B Regulation of CD4 1 0.13 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of interleukin-6 production. They are ordered first by their pain relevance and then by number of times they were reported in regulation of interleukin-6 production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1878 Binding of HLA-B 440 0.48 321.16 127.36
2 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37
3 INT1876 Positive_regulation of HLA-B 82 0.69 52.16 21.08
4 INT3925 Negative_regulation of HLA-B 29 0.42 20.19 9.46
5 INT3353 Localization of HLA-B 25 0.75 16.05 8.62
6 INT5284 Regulation of HLA-B 25 0.59 12.91 7.74
7 INT4697 Positive_regulation of Gene_expression of HLA-B 32 0.61 17.32 5.97
8 INT16959 Positive_regulation of Binding of HLA-B 8 0.50 6.77 2.96
9 INT2249 Negative_regulation of Binding of HLA-B 5 0.54 6.82 2.94
10 INT122951 Regulation of Binding of HLA-B 4 0.39 3.08 1.65
11 INT748 Transcription of HLA-B 6 0.67 1.56 0.91
12 INT126523 Phosphorylation of Mapkapk2 19 0.79 7.76 0.82
13 INT131433 Phosphorylation of MAPKAPK2 3 0.30 0.99 0.73
14 INT10710 Positive_regulation of Positive_regulation of HLA-B 2 0.38 0.83 0.73
15 INT5285 Regulation of Gene_expression of HLA-B 4 0.41 3.39 0.68
16 INT202385 Gene_expression of Mapkapk2 4 0.57 2.86 0.64
17 INT11700 Negative_regulation of Gene_expression of HLA-B 3 0.50 2.61 0.6
18 INT272875 Localization of Mapkapk2 1 0.23 0.9 0.34
19 INT158048 Gene_expression of MAPKAPK2 2 0.28 0.79 0.29
20 INT126522 Positive_regulation of Phosphorylation of Mapkapk2 7 0.59 3.8 0.28
21 INT44012 Phosphorylation of HLA-B 3 0.81 0.96 0.27
22 INT131426 Negative_regulation of Phosphorylation of Mapkapk2 1 0.04 0.41 0.23
23 INT158050 Regulation of MAPKAPK2 1 0.00 0.8 0.22
24 INT131432 Negative_regulation of Phosphorylation of MAPKAPK2 1 0.11 0.4 0.21
25 INT131434 Binding of MAPKAPK2 2 0.17 0.42 0.2
26 INT126521 Positive_regulation of Mapkapk2 13 0.49 5.9 0.17
27 INT250970 Positive_regulation of Localization of HLA-B 1 0.48 0.57 0.17
28 INT156328 Protein_catabolism of HLA-B 1 0.09 0.17 0.17
29 INT275513 Regulation of Mapkapk2 1 0.01 0.86 0.16
30 INT194790 Positive_regulation of Phosphorylation of MAPKAPK2 1 0.19 0.09 0.16
31 INT327236 Positive_regulation of Gene_expression of Mapkapk2 1 0.36 1.01 0.15
32 INT186409 Negative_regulation of MAPKAPK2 1 0.20 0.06 0.03
33 INT201086 Regulation of Phosphorylation of HLA-B 2 0.45 0.41 0
34 INT54611 Positive_regulation of Regulation of HLA-B 1 0.37 0 0
35 INT186410 Positive_regulation of MAPKAPK2 1 0.22 0 0
36 INT250968 Positive_regulation of Phosphorylation of HLA-B 1 0.48 0.08 0
37 INT291177 Binding of Mapkapk2 1 0.08 0.3 0
38 INT291178 Positive_regulation of Binding of Mapkapk2 1 0.10 0.3 0
39 INT136090 Positive_regulation of Transcription of HLA-B 1 0.34 0.15 0
40 INT291179 Positive_regulation of Positive_regulation of Mapkapk2 1 0.10 0.36 0
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